Search Results - (Author, Cooperation:P. C. Phillips)

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  1. 1
    Staff View
    Publication Date:
    2010-12-18
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adult ; Cerebellar Neoplasms/*genetics/metabolism ; Child ; DNA Copy Number Variations ; DNA-Binding Proteins/genetics/metabolism ; *Genes, Neoplasm ; Genes, Tumor Suppressor ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Histones/metabolism ; Humans ; Medulloblastoma/*genetics/metabolism ; Methylation ; MicroRNAs/genetics ; *Mutation ; Neoplasm Proteins/genetics/metabolism ; Oligonucleotide Array Sequence Analysis ; Point Mutation ; Sequence Analysis, DNA ; Signal Transduction
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Kasimatis, K. R., Phillips, P. C.
    Genetics Society of America (GSA)
    Published 2018
    Staff View
    Publication Date:
    2018-01-05
    Publisher:
    Genetics Society of America (GSA)
    Electronic ISSN:
    2160-1836
    Topics:
    Biology
    Published by:
    http://www.genetics-gsa.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Kasimatis, K. R., Moerdyk-Schauwecker, M. J., Phillips, P. C.
    Genetics Society of America (GSA)
    Published 2018
    Staff View
    Publication Date:
    2018-08-01
    Publisher:
    Genetics Society of America (GSA)
    Electronic ISSN:
    2160-1836
    Topics:
    Biology
    Published by:
    http://www.genetics-gsa.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    ISSN:
    1420-9071
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Zusammenfassung Von mehreren (±) 3-Oxy- und (±) 3-Methoxy-13-alkylgona-1,3,5(10)trien-17-onen und verwandten Verbindungen, einschliesslich von Vertretern der (±) 13-Alkylgon-4-en-3-on-Reihe, werden Totalsynthese und biologische Wirksamkeit beschrieben.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02171503

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1432-1920
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We describe the clinical and imaging findings of brain stem tumours in patients with neurofibromatosis type 1 (NF1). The NF1 patients imaged between January 1984 and January 1996 were reviewed and 25 patients were identified with a brain stem tumour. Clinical, radiographical and pathological results were obtained by review of records and images. Brain stem tumour identification occurred much later than the clinical diagnosis of NF1. Medullary enlargement was most frequent (68 %), followed by pontine (52 %) and midbrain enlargement (44 %). Patients were further subdivided into those with diffuse (12 patients) and those with focal (13 patients) tumours. Treatment for hydrocephalus was required in 67 % of the first group and only 15 % of the second group. Surgery was performed in four patients and revealed fibrillary astrocytomas, one of which progressed to an anaplastic astrocytoma. In 40 % of patients both brain stem and optic pathway tumours were present. The biological behaviour of brain stem tumours in NF1 is unknown. Diffuse tumours in the patients with NF1 appear to have a much more favourable prognosis than patients with similar tumours without neurofibromatosis type 1.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002340050484

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1432-1920
    Keywords:
    Key words Proton magnetic resonance spectroscopy ; Brain tumor ; pediatric ; Neuro-oncology ; Brain tumors ; prognosis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We studied 14 young people with newly diagnosed hemisphere tumors, aged from 3 to 20 years (average 10 years). All underwent surgery following MR imaging (MRI) and spectroscopy (MRS). The tumors studied were three glioblastomas, one each of ganglio-glioblastoma, primitive neuroectodermal tumor (PNET), rhabdoid teratoid tumor, pilocytic astrocytoma, ependymoma, anaplastic ependymoma, and gliomatosis cerebri, and four gangliogliomas. Four patients died; ten patients are alive (five with stable residual tumor, five with no evident tumor). Images and spectra were acquired on a 1.5-T imager. Proton MRS was performed before gadolinium injection in all but one case. Single-voxel techniques were utilized in all cases, using a spin-echo or STEAM sequence with a long echo time (135 or 270 ms). Peak areas of N -acetyl aspartate (NAA), choline (Cho), and creatine and phosphocreatine (Cr) were assessed. The NAA/Cho peak-area ratio was very low in the patients who died (mean ± s. d. 0.20 ± 0.14), and higher in the patients who are alive (0.74 ± 0.47; P = 0.007 by two-tailed t -test). The Cr/Cho peak-area ratio also followed a similar trend for the two groups (mean ± s. d. 0.17 ± 0.07 and 0.49 ± 0.30, respectively; P = 0.01 by two-tailed t -test).
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002340050551

    Articles: DFG German National Licenses