Search Results - (Author, Cooperation:P. Bousquet)

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  1. 1
    Staff View
    Publication Date:
    2018-09-20
    Publisher:
    The American Society for Pharmacology and Experimental Therapeutics (ASPET)
    Print ISSN:
    0031-6997
    Electronic ISSN:
    1521-0081
    Topics:
    Chemistry and Pharmacology
    Medicine
    Published by:
    http://www.aspet.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2016-03-11
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Agriculture/statistics & numerical data ; Asia ; Atmosphere/*chemistry ; Carbon Dioxide/analysis/*metabolism ; *Ecosystem ; Global Warming/prevention & control/*statistics & numerical data ; Greenhouse Effect/prevention & control/*statistics & numerical data ; Human Activities/statistics & numerical data ; Methane/analysis/*metabolism ; Nitrous Oxide/analysis/*metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    E. G. Nisbet ; E. J. Dlugokencky ; P. Bousquet
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-02-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Air ; Atmosphere/*chemistry ; *Climate Change ; Coal ; Geography ; Greenhouse Effect/prevention & control ; Humans ; Industry ; Methane/*analysis ; Seasons ; Wetlands
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2012-09-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Atmosphere/*chemistry ; Carbon Dioxide/*analysis ; *Climate Change
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Heemskerk, F. M. J. ; Dontenwill, M. ; Greney, H. ; Vonthron, C. ; Bousquet, P.

    Oxford, UK : Blackwell Science Ltd
    Published 1998
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: Nonadrenergic imidazoline-specific binding sites were characterized pharmacologically in crude cerebral membrane preparations, but little is known about their subcellular localization in neurons. As in the brain-stem these sites are involved in cardiovascular regulation and peripherally imidazolines modulate neurotransmitter release, we tried to determine a possible (pre)synaptic localization in brainstem. We found a specific enrichment in (entire) synaptosome, purified synaptosomal plasma membrane (37 fmol/mg), and mitochondrial (83 fmol/mg) fractions as compared with other membrane fractions (3–8 fmol/mg). Synaptosomes appeared to be free of postsynaptic structures, and purified synaptosomal plasma membranes were devoid of mitochondrial material, as determined by electron microscopy and by comparison with the distribution of marker enzymes such as monoamine oxidase. These results show for the first time that these extramitochondrial imidazoline-specific sites are neuronal and are located on presynaptic terminals. We found high affinities for unlabeled p-iodoclonidine (subnanomolar), clonidine (0.2 nM), and efaroxan (11 nM), but idazoxan did not compete significantly for the p-[125I]iodoclonidine binding in these membranes. Therefore, these sites can be classified as I1 imidazoline receptors. In summary, we describe for the first time that high-affinity I1 receptors of the bovine brainstem are located on (pre)synaptic membranes.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1471-4159.1998.71052193.x

    Articles: DFG German National Licenses
  6. 6
    BRASILI, L. ; PIGINI, M. ; EHRHARDT, J. D. ; MOLINES, A. ; GRENEY, H. ; BOUSQUET, P. ; DONTENWILL, M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1995.tb32399.x

    Articles: DFG German National Licenses
  7. 7
    Bousquet, P. J. ; Fabbro-Peray, P. ; Janin, N. ; Annesi-Maesano, I. ; Neukirch, F. ; Daures, J.-P. ; Bousquet, J.

    Oxford, UK : Munksgaard International Publishers
    Published 2004
    Staff View
    ISSN:
    1398-9995
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1398-9995.2004.00579.x

    Articles: DFG German National Licenses
  8. 8
    Bousquet, P. J. ; Gallega, M. P. ; Dhivert-Donnadieu, H. ; Demoly, P.

    Oxford, UK : Munksgaard International Publishers
    Published 2005
    Staff View
    ISSN:
    1398-9995
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1398-9995.2004.00667.x

    Articles: DFG German National Licenses
  9. 9
    Bousquet, P ; Monassier, L ; Feldman, J

    Melbourne, Australia : Blackwell Science Pty
    Published 2001
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. The autonomic nervous system plays a pivotal role in modulating all the components of the cardiovascular regulation. Therefore, one can assume that drugs targeting this system may be useful in the management of several cardiovascular diseases.2. Drugs acting on central nervous system centres seem to be modulators rather than blockers; as such, they are expected to preserve the contraregulatory processes and to generate only a few side effects.3. Because the sympathetic nervous system is largely involved in the regulation of vasomotor tone, centrally acting antihypertensive drugs were developed first.4. Recently, new leader compounds selective for non- adrenergic imidazoline recepetors have been synthetized. Although such drugs have no capacity to activate α2-adrenoceptors, they have been proven to be hypotensive. These drugs are expected to be even better tolerated than the currently available centrally active drugs. They may also have additional beneficial effects.5. Here, the experimental evidence suggesting that such drugs may be useful in the management of some cardiac arrhythmias and/or left ventricular dysfunction will be reviewed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1440-1681.2001.03563.x

    Articles: DFG German National Licenses
  10. 10
    Bousquet, P. ; Monassier, L. ; Feldman, J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1998
    Staff View
    ISSN:
    1440-1681
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    1. Drugs acting within the autonomic nervous system (ANS) are of particular interest when autonomic abnormalities are implicated in the development and maintenance of various cardiovascular pathologies. For example, it has been documented that in the early stages of hypertensive disease (i.e. hyperkinetic borderline hypertension) a sympathetic hyperactivity associated with a decreased parasympathetic activity results in increased cardiac output and heart rate.2. Several classes of drugs acting within the central, as well as the peripheral ANS, are very efficient in treating hypertensive disease. One of these classes of drugs, the second generation of centrally acting drugs, has proved beneficial in this respect because, in addition to their therapeutic efficacy, these drugs are well tolerated.3. The central nervous system may also be the target for drugs with the potential to treat other cardiovascular diseases. Some recent experimental and clinical data supporting such new perspectives concerning idiopathic dysrhythmias, angina pectoris and congestive heart failure will be summarized.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1440-1681.1998.tb02231.x

    Articles: DFG German National Licenses
  11. 11
    Bousquet, P. Marc

    Brunswick, Me., etc. : Periodicals Archive Online (PAO)
    Published 1994
    Staff View
    ISSN:
    0028-4866
    Topics:
    English, American Studies
    Notes:
    RECONSIDERATIONS
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1170-1994-067-04-000004

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Methane is an important greenhouse gas, and its atmospheric concentration has nearly tripled since pre-industrial times. The growth rate of atmospheric methane is determined by the balance between surface emissions and photochemical destruction by the hydroxyl radical, the major atmospheric ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/nature05132

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Knowledge of carbon exchange between the atmosphere, land and the oceans is important, given that the terrestrial and marine environments are currently absorbing about half of the carbon dioxide that is emitted by fossil-fuel combustion. This carbon uptake is therefore limiting the extent of ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/35102500

    Articles: DFG German National Licenses
  14. 14
    Bousquet, P. J. ; Co-Minh, H.-B. ; Demoly, P.

    Oxford, UK : Munksgaard International Publishers
    Published 2005
    Staff View
    ISSN:
    1398-9995
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1398-9995.2005.00754.x

    Articles: DFG German National Licenses
  15. 15
    Bousquet, P. J. ; Daures, J.-P.

    Oxford, UK : Munksgaard International Publishers
    Published 2005
    Staff View
    ISSN:
    1398-9995
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1398-9995.2005.00755.x

    Articles: DFG German National Licenses
  16. 16
    DONTENWILL, M. ; MOLINES, A. ; BENNAI, F. ; FELDMAN, J. ; BRICCA, G. ; BELCOURT, A. ; BOUSQUET, P.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1995.tb32420.x

    Articles: DFG German National Licenses
  17. 17
    GRENEY, H. ; DONTENWILL, M. ; BRICCA, G. ; BELCOURT, A. ; BOUSQUET, P.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1995.tb32445.x

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1432-1912
    Keywords:
    Key words Baclofen ; Saclofen ; Spinal cord ; Myocardial oxygen demand ; Paraventricular nucleus of the hypothalamus
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  In a previous study in anaesthetized rabbits we observed that electrical stimulation of the hypothalamic paraventricular nucleus (PVN) elicited substantial rises in the maximum rate of change of left ventricular pressure (dP/dt max) and in myocardial oxygen demand indexes (rate-pressure product and triple product), similar to the changes observed during stress or physical effort. Baclofen, a selective GABAB receptor agonist, injected intravenously prevented these responses. In the present study, we show that low doses of baclofen (0.1, 0.3 and 1 μg/kg), injected intrathecally (i.t.) at the T9 level, reduced the myocardial oxygen demand during PVN stimulation. After 0.3 μg/kg baclofen i.t., the peak value of the triple product during stimulation was 140±20 compared with 193±20 before treatment. An i.t. injection (500 μg/kg), of saclofen, a selective GABAB receptor antagonist, did not modify the resting haemodynamics significantly but attenuated the inhibitory effects of baclofen (3 mg/kg i.v.). These results suggest that the main site of the effects of baclofen is located within the spinal cord and that GABAB receptors probably mediate these effects by modulating the central control of cardiac function. In conclusion, baclofen might be a useful tool to prevent the centrally evoked increases of myocardial oxygen demand.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00169390

    Articles: DFG German National Licenses
  19. 19
    Bousquet, P. ; Pelletier, E.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0040-6090
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0040-6090(78)90091-3

    Articles: DFG German National Licenses
  20. 20
    Bousquet, P. ; Pelletier, E.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0040-6090
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0040-6090(81)90373-4

    Articles: DFG German National Licenses