Quiralte, J. ;
Llanes, E. ;
Barral, P. ;
Arias de Saavedra, J. M. ;
Sáenz de San Pedro, B. ;
Villalba, M. ;
Florido, J. F. ;
Rodríguez, R. ;
Lahoz, C. ;
Cárdaba, B.
Oxford, UK : Munksgaard International Publishers
Published 2005
Staff View
|
ISSN:
|
1398-9995
|
|
Source:
|
Blackwell Publishing Journal Backfiles 1879-2005
|
|
Topics:
|
Medicine
|
|
Notes:
|
Background: The clinical characteristics in olive pollen allergy are dependent on the antigenic load, the allergens profile, and the genetic restrictions. Our objective was to determine specific response pattern in Ole e 2 and Ole e 10 sensitization at those levels.Methods: We studied 146 patients with seasonal rhinitis and/or asthma and positive prick test to Olea europaea pollen. IgE against Ole e 2 and Ole e 10 were detected by skin prick test and ELISA. HLA-DRB1 and HLA-DQB1 loci were typed by polymerase chain reaction sequence-specific primers method.Results: A total of 102 (69.9%) and 79 (54.0%) patients showed significant IgE antibody response against Ole e 2 and Ole e 10, respectively. There was a significant association between Ole e 2 (OR 2.2, P = 0.04) and Ole e 10 reactivities (OR 2.8, P = 0.007) with asthma. In addition, total and specific IgE antibody levels significantly correlated with asthma (P 〈 0.05). Patients who reacted to both allergens reached the highest asthma risk factor (OR 4.3, P = 0.002). Phenotypic frequency of DR7 (OR 5.4, Pc = 0.003) and DQ2 (OR 3.6, Pc = 0.02) were increased in positive Ole e 2 patients compared with control subjects. DR2(15) phenotypic frequency was significantly increased (OR 5.6, Pc = 0.02) in positive Ole e 10 patients compared with control subjects.Conclusions: Our data suggest an association of Ole e 2 and Ole e 10 with bronchial asthma. Also, we found a genetic control of Ole e 2 and Ole e 10 IgE-specific responses that could be relevant to clinical disease in olive pollen allergy.
|
|
Type of Medium:
|
Electronic Resource
|
|
URL:
|
|