Search Results - (Author, Cooperation:Ossenkopp)

Online

2023

Psychosoziale Belastung ; Familie ; Kind ; Herzkrankheit ; Erbkrankheit ; Dissertation ; Selbsthilfe ; Selbsthilfegruppe ; Chronisch krankes Kind ; Deutschland

German

Dissertation, Universität Siegen, 2023.

0023-9690

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Education

Psychology

Electronic Resource

0376-6357

Emotional reactivity ; Exploratory behavior ; Factor analysis ; Open-field ; PARAFAC analysis ; Rat ; Temporal changes

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Psychology

Electronic Resource

0196-9781

Body rotation ; MIF-1 ; Meadow vole ; Mu opioid ; Naloxone ; Stress-induced analgesia ; Tyr-MIF-1 ; β-Funaltrexamine

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

1574-6968

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Abstract Seventy-three Helicobacter pylori-positive patients were treated with a combination of clarithromycin and ranitidine in order to eradicate the bacterium. Eradication was successful in 79.5%. In 15 patients eradication failed, and in 11 cases this was due to clarithromycin resistance. In one patient the infecting strain was resistant at the onset of treatment, while in the remaining 10 patients resistance developed during therapy. These isolates had also become resistant to various other antibiotics. Random amplified polymorphic DNA and restriction fragment end-labeling analysis of the isolates showed close genetic relatedness between pre- and post-treatment isolates, indicating that resistance was the result of selection of variants of the infecting strain rather then infection with an exogenous resistant strain. Nucleotide sequence comparisons revealed that all resistant isolates had a single base pair mutation in the 23S rRNA. Since this single point mutation results in co-resistance to various antibiotics at high frequencies, caution should be taken when using clarithromycin as a single antibiotic.

Electronic Resource

1437-1596

Springer Online Journal Archives 1860-2000

Medicine

Law

Electronic Resource

1437-1596

Springer Online Journal Archives 1860-2000

Medicine

Law

Electronic Resource

1432-1254

Springer Online Journal Archives 1860-2000

Geography

Physics

Zusammenfassung In drei Untersuchungen (I, II, IV) wurden männliche, 115–150 Tage alte Ratten entweder einem 0,5–3 oder einem 3–30 Gauss ELF (0,5 Hz) rotierenden magnetischen Feld (RMF) für 5, 10 oder 26 Tage ausgesetzt. Die Ratten, die dem RMF für 10 und 26 Tage ausgesetzt waren, hatten einen signifikant (p 〈 0,05) höheren Wasserkonsum als die Kontrollgruppe. Auch die Tiere, die dem RMF für 5 Tage ausgesetzt waren, tranken mehr Wasser (p 〉 0,05). Die exponierten Tiere zeigten auch eine fortschreitende Abnahme (p 〈 0,02) des relativen Schilddrüsengewichts, dagegen eine grössere Gewichtszunahme (p 〈 0,001) bei bis zu 10 Tagen Exponierung und Zunahme des relativen Hodengewichts (p 〈 0,05) bei bis zu 26 Tagen Exponierung. Die Unterschiede in der Zahl der zirkulierenden Esinophilen und im relativen Nebennierengewicht waren nicht signifikant. In der vierten Untersuchung (III) mit Ratten die bei Versuchsbeginn 80 Tage alt waren fanden sich nach 21 Tagen Exponierung keine Unterschiede beim Vergleich mit der Kontrollgruppe. Die physiologischen Veränderungen durch ELF-Exponierung, werden über eine Wirkung auf der Schilddrüse und ihre möglichen flüssigen und kristallinen Eigenschaften erklärt.

Resume Lors de trois essais (I, II et IV), on a exposé des rats mâles, adultes, âgés de 115 à 150 jours à un champ magnétique tournant (CMT) d'une très basse fréquence (FTB) — de 0,5 Hz — soit de 0,5 à 3 Gauss, soit de 3 à 30 gauss, et cela durant 5, 10 ou 26 jours. Les rats exposés au CMT durant 10 ou 26 jours ont bu plus d'eau que des rats de contrôle et cela de façon significative (p 〈 0,05). Le groupe exposé au CMT durant 5 jours seulement a aussi bu davantage d'eau, mais la différence n'est alors pas significative. Les rats exposés à la fois au CMT et au FTB ont aussi montré une diminution significative (p 〈 0,02) du poids relatif de la glande thyroïde, une augmentation du poids du corps (p〈 0,001) jusqu'au 10ème jour d'exposition et une augmentation du poids des testicules pour 26 jours d'exposition. On n'a par contre pas constaté de différences significatives entre les groupes quant au nombre d'oesinophiles circulant dans le sang, ni quant au poids des glandes surrénales, bien que ces différences augmentassent avec la durée d'exposition. Dans un quatrième essai (III), des rats âgés de 80 jours au début d'une période d'exposition de 21 jours n'ont présenté aucune différence quant aux paramètres mentionnés ci-dessus. Les changements du comportement et de la physiologie dûs à une exposition au FTB sont discutés par rapport aux répercussions d'une telle exposition sur la thyroïde et ses propriétés liquides et cristalline.

Abstract In three Experiments (I, II, IV), adult male rats, between 115 and 150 days of age were exposed to either a 0.5–3 or 3–30 gauss ELF (0.5 Hz) rotating magnetic field (RMF), for 5, 10, or 26 days. The rats exposed to the RMF for 10 and 26 days averaged significantly (p〈 0,05) greater water consumption than controls. The group exposed to the RMF for 5 days also consumed more water, although the difference was not significant. ELF-RMF-exposed rats also showed a progressive decrease (p 〈0.02) in relative thyroid weights, but increase in body weight gain (p 〈0.001) up to 10 days of exposure, and increase in testicle weights (p 〈 0.05) up to 26 days of exposure. No significant differences were found between groups for circulating blood eosinophil counts or relative adrenal weights, although again the differences did increase with duration of exposure. In a fourth Experiment (III), rats that were 80 days of age at the beginning of 21 days of exposure did not show any significant differences in the above measures from the control group. The changes in behavior and physiology associated with ELF exposure is discussed in terms of its effects upon the thyroid and its probable liquid crystalline properties.

Electronic Resource

1432-1459

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-1459

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-1459

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-1459

Springer Online Journal Archives 1860-2000

Medicine

Zusammenfassung Es wird der Fall eines 50jährigen bis dahin gesunden Mannes beschrieben, bei dem etwa 20 Std nach einem Bagatelltrauma neurologische Ausfallserscheinungen in den Armen auftraten, die sich in den folgenden Tagen weitgehend zurückbildeten. Akute Verschlechterung 7 Tage nach dem Unfall. Seitdem bestand eine schwere, schlaffe Tetraparese. 4 Tage später Exitus an interkurrenter Erkrankung (Perforationsperitonitis). Im Rückenmark fand sich ein kompletter thrombotischer Verschluß der Arteria spinalis anterior im oberen Halsmark, dessen Entstehung zeitlich etwa mit dem Unfallereignis zusammenfällt. Gefäßbedingte nekrotische Veränderungen von typischer Ausdehnung vom oberen bis mittleren Halsmark. Vergleich mit den wenigen ähnlichen Fällen der Literatur, besonders den Mitteilungen von Grinker u. Guy, Foerster, Henneaux und Hultsch. Die Bedeutung sog. Bagatelltraumen für die Entstehung von Rückenmarksschäden wird unter besonderem Hinweis auf die Auffassungen von Bodechtel und Foerster diskutiert. Als wesentlicher pathogenetischer Faktor für das Zustandekommen der Gefäß- und Rückenmarksveränderungen werden unter Verwertung der Ansichten Rickers funktionelle Kreislaufstörungen angenommen.

Electronic Resource

1432-1459

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-1459

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-1351

Spatial learning and memory ; Sex differences ; Magnetic fields ; Meadow voles ; Protein kinase C

Springer Online Journal Archives 1860-2000

Biology

Medicine

Abstract 1. This study examined spatial learning and memory in breeding adult male and female meadow voles, Microtus pennsylvanicus, and the effects of brief exposure to weak (0.1 mT or 1.0 Gauss rms) 60 Hz magnetic fields on their spatial performance. 2. There were significant sex differences in the spatial performance of the polygynous meadow voles. Reproductive male voles displayed significantly better spatial learning and retention than reproductive females in a Morris water maze task, whereby individual voles had to learn and remember the location of a submerged hidden platform using extramaze visual cues. Males showed over 9 days of daily blocks of 4 trials both a faster rate and greater overall level of acquisition (shorter latency to find hidden platform) of the spatial task than did the females. 3. Brief (maximum 5 min) exposure to 60 Hz magnetic fields during acquisition of the water maze task significantly enhanced the spatial performance of both the male and female meadow voles. Females showed a relatively greater facilitation of spatial acquisition and retention than did the males, resulting by day 9 in the elimination of sex differences in water maze performance. 4. The time-varying magnetic fields may be : (i) functioning as orientation cues and providing directional cues, and/or (ii) affecting neuromodulatory systems that are involved in the mediation of spatial learning and memory. Exposure to weak time-varying magnetic fields has been shown to attenuate the activity of endogenous opioid systems, enhance protein kinase C (PKC) activity, and alter calcium ion flux. These effects have been shown to affect spatial learning and memory and are consistent with an enhancement of water maze performance.

Electronic Resource

1432-1351

spatial learning ; sex differences ; opioids ; 60 Hz magnetic fields

Springer Online Journal Archives 1860-2000

Biology

Medicine

Abstract We examined the effects of brief exposure to weak 60 Hz extremely low frequency (ELF) magnetic fields and opioid systems on spatial behavior and learning in reproductive adult male and female deer mice, Peromyscus maniculatus. Sex differences were evident in spatial performance, with male deer mice displaying significantly better performance than female mice in the Morris water maze, whereby animals had to acquire and retain the location of a submerged hidden platform. Brief (maximum 5 min) exposure to weak (100 μT) 60 Hz magnetic fields during task acquisition significantly improved female performance, eliminating the sex differences in acquisition. The opiate antagonist, naltrexone, also improved female acquisition, though significantly less than the magnetic fields. These facilitatory effects involved alterations of “non-spatial” (task familiarization and reduction of related anxiety/aversive related behaviors) and possibly “spatial” aspects of the task. Enhancement of enkephalin activity with the enkephalinase inhibitor, SCH 34826, significantly reduced task performance by male deer mice. Both naltrexone and the 60 Hz magnetic fields attenuated the enkephalin mediated reductions of spatial performance. These findings indicate that brief exposure to 60 Hz magnetic fields can enhance water maze task acquisition by deer mice and suggest that these facilitatory effects on spatial performance involve alterations in opioid activity.

Electronic Resource

1432-1254

Springer Online Journal Archives 1860-2000

Geography

Physics

Electronic Resource

0091-3057

Meadow voles ; Morris water-maze ; Naloxone ; Opiates ; Sex differences ; Spatial acquisition ; Stress

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Medicine

Electronic Resource

0091-3057

Area postrema ; Behavioral toxicology ; Conditioned taste aversion ; Deoxynivalenol ; Rats ; Trichothecene mycotoxin ; Vomitoxin

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Medicine

Electronic Resource

0196-9781

Analgesia ; Magnetic fields ; Mu ; delta ; kappa ; sigma opiates

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource