Search Results - (Author, Cooperation:O. Witt)

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  1. 1
    S. C. Mack ; H. Witt ; R. M. Piro ; L. Gu ; S. Zuyderduyn ; A. M. Stutz ; X. Wang ; M. Gallo ; L. Garzia ; K. Zayne ; X. Zhang ; V. Ramaswamy ; N. Jager ; D. T. Jones ; M. Sill ; T. J. Pugh ; M. Ryzhova ; K. M. Wani ; D. J. Shih ; R. Head ; M. Remke ; S. D. Bailey ; T. Zichner ; C. C. Faria ; M. Barszczyk ; S. Stark ; H. Seker-Cin ; S. Hutter ; P. Johann ; S. Bender ; V. Hovestadt ; T. Tzaridis ; A. M. Dubuc ; P. A. Northcott ; J. Peacock ; K. C. Bertrand ; S. Agnihotri ; F. M. Cavalli ; I. Clarke ; K. Nethery-Brokx ; C. L. Creasy ; S. K. Verma ; J. Koster ; X. Wu ; Y. Yao ; T. Milde ; P. Sin-Chan ; J. Zuccaro ; L. Lau ; S. Pereira ; P. Castelo-Branco ; M. Hirst ; M. A. Marra ; S. S. Roberts ; D. Fults ; L. Massimi ; Y. J. Cho ; T. Van Meter ; W. Grajkowska ; B. Lach ; A. E. Kulozik ; A. von Deimling ; O. Witt ; S. W. Scherer ; X. Fan ; K. M. Muraszko ; M. Kool ; S. L. Pomeroy ; N. Gupta ; J. Phillips ; A. Huang ; U. Tabori ; C. Hawkins ; D. Malkin ; P. N. Kongkham ; W. A. Weiss ; N. Jabado ; J. T. Rutka ; E. Bouffet ; J. O. Korbel ; M. Lupien ; K. D. Aldape ; G. D. Bader ; R. Eils ; P. Lichter ; P. B. Dirks ; S. M. Pfister ; A. Korshunov ; M. D. Taylor
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-02-21
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Brain Neoplasms/drug therapy/genetics ; CpG Islands/*genetics ; DNA Methylation/drug effects ; Embryonic Stem Cells/metabolism ; Ependymoma/drug therapy/*genetics ; Epigenesis, Genetic/*genetics ; Epigenomics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing/drug effects ; Histones/drug effects/metabolism ; Humans ; Infant ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Phenotype ; Polycomb Repressive Complex 2/metabolism ; Prognosis ; Rhombencephalon/pathology ; Xenograft Model Antitumor Assays
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    J. Schwartzentruber ; A. Korshunov ; X. Y. Liu ; D. T. Jones ; E. Pfaff ; K. Jacob ; D. Sturm ; A. M. Fontebasso ; D. A. Quang ; M. Tonjes ; V. Hovestadt ; S. Albrecht ; M. Kool ; A. Nantel ; C. Konermann ; A. Lindroth ; N. Jager ; T. Rausch ; M. Ryzhova ; J. O. Korbel ; T. Hielscher ; P. Hauser ; M. Garami ; A. Klekner ; L. Bognar ; M. Ebinger ; M. U. Schuhmann ; W. Scheurlen ; A. Pekrun ; M. C. Fruhwald ; W. Roggendorf ; C. Kramm ; M. Durken ; J. Atkinson ; P. Lepage ; A. Montpetit ; M. Zakrzewska ; K. Zakrzewski ; P. P. Liberski ; Z. Dong ; P. Siegel ; A. E. Kulozik ; M. Zapatka ; A. Guha ; D. Malkin ; J. Felsberg ; G. Reifenberger ; A. von Deimling ; K. Ichimura ; V. P. Collins ; H. Witt ; T. Milde ; O. Witt ; C. Zhang ; P. Castelo-Branco ; P. Lichter ; D. Faury ; U. Tabori ; C. Plass ; J. Majewski ; S. M. Pfister ; N. Jabado
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-01-31
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptor Proteins, Signal Transducing/genetics ; Base Sequence ; Child ; Chromatin/*genetics/metabolism ; Chromatin Assembly and Disassembly/*genetics ; DNA Helicases/genetics ; DNA Mutational Analysis ; Exome/genetics ; Gene Expression Profiling ; Glioblastoma/*genetics ; Histones/*genetics/metabolism ; Humans ; Molecular Sequence Data ; Mutation/*genetics ; Nuclear Proteins/genetics ; Telomere/genetics ; Tumor Suppressor Protein p53/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    D. T. Jones ; N. Jager ; M. Kool ; T. Zichner ; B. Hutter ; M. Sultan ; Y. J. Cho ; T. J. Pugh ; V. Hovestadt ; A. M. Stutz ; T. Rausch ; H. J. Warnatz ; M. Ryzhova ; S. Bender ; D. Sturm ; S. Pleier ; H. Cin ; E. Pfaff ; L. Sieber ; A. Wittmann ; M. Remke ; H. Witt ; S. Hutter ; T. Tzaridis ; J. Weischenfeldt ; B. Raeder ; M. Avci ; V. Amstislavskiy ; M. Zapatka ; U. D. Weber ; Q. Wang ; B. Lasitschka ; C. C. Bartholomae ; M. Schmidt ; C. von Kalle ; V. Ast ; C. Lawerenz ; J. Eils ; R. Kabbe ; V. Benes ; P. van Sluis ; J. Koster ; R. Volckmann ; D. Shih ; M. J. Betts ; R. B. Russell ; S. Coco ; G. P. Tonini ; U. Schuller ; V. Hans ; N. Graf ; Y. J. Kim ; C. Monoranu ; W. Roggendorf ; A. Unterberg ; C. Herold-Mende ; T. Milde ; A. E. Kulozik ; A. von Deimling ; O. Witt ; E. Maass ; J. Rossler ; M. Ebinger ; M. U. Schuhmann ; M. C. Fruhwald ; M. Hasselblatt ; N. Jabado ; S. Rutkowski ; A. O. von Bueren ; D. Williamson ; S. C. Clifford ; M. G. McCabe ; V. P. Collins ; S. Wolf ; S. Wiemann ; H. Lehrach ; B. Brors ; W. Scheurlen ; J. Felsberg ; G. Reifenberger ; P. A. Northcott ; M. D. Taylor ; M. Meyerson ; S. L. Pomeroy ; M. L. Yaspo ; J. O. Korbel ; A. Korshunov ; R. Eils ; S. M. Pfister ; P. Lichter
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-07-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Aging/genetics ; Amino Acid Sequence ; Cell Transformation, Neoplastic ; Cerebellar Neoplasms/classification/diagnosis/*genetics/pathology ; Child ; Chromatin/metabolism ; Chromosomes, Human/genetics ; DEAD-box RNA Helicases/genetics ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Genome, Human/*genetics ; Genomics ; Hedgehog Proteins/metabolism ; High-Throughput Nucleotide Sequencing ; Histone Demethylases/genetics ; Humans ; Medulloblastoma/classification/diagnosis/*genetics/pathology ; Methylation ; Mutation/genetics ; Mutation Rate ; Neoplasm Proteins/genetics ; Nuclear Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Phosphoprotein Phosphatases/genetics ; Polyploidy ; Receptors, Cell Surface/genetics ; Sequence Analysis, RNA ; Signal Transduction ; T-Box Domain Proteins/genetics ; Transcription Factors/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2014-05-23
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Binding Sites ; Cell Line, Tumor ; Chromatin/genetics/metabolism ; Chromatin Immunoprecipitation ; DNA Methylation/*genetics ; Female ; *Gene Expression Regulation, Neoplastic ; *Gene Silencing ; Genome/genetics ; Histones/metabolism ; Humans ; Medulloblastoma/*genetics/pathology ; Mice ; Promoter Regions, Genetic/genetics ; RNA-Binding Proteins/genetics ; Sequence Analysis, DNA/*methods ; Transcription Factors/metabolism ; Transcription, Genetic
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    P. A. Northcott ; C. Lee ; T. Zichner ; A. M. Stutz ; S. Erkek ; D. Kawauchi ; D. J. Shih ; V. Hovestadt ; M. Zapatka ; D. Sturm ; D. T. Jones ; M. Kool ; M. Remke ; F. M. Cavalli ; S. Zuyderduyn ; G. D. Bader ; S. VandenBerg ; L. A. Esparza ; M. Ryzhova ; W. Wang ; A. Wittmann ; S. Stark ; L. Sieber ; H. Seker-Cin ; L. Linke ; F. Kratochwil ; N. Jager ; I. Buchhalter ; C. D. Imbusch ; G. Zipprich ; B. Raeder ; S. Schmidt ; N. Diessl ; S. Wolf ; S. Wiemann ; B. Brors ; C. Lawerenz ; J. Eils ; H. J. Warnatz ; T. Risch ; M. L. Yaspo ; U. D. Weber ; C. C. Bartholomae ; C. von Kalle ; E. Turanyi ; P. Hauser ; E. Sanden ; A. Darabi ; P. Siesjo ; J. Sterba ; K. Zitterbart ; D. Sumerauer ; P. van Sluis ; R. Versteeg ; R. Volckmann ; J. Koster ; M. U. Schuhmann ; M. Ebinger ; H. L. Grimes ; G. W. Robinson ; A. Gajjar ; M. Mynarek ; K. von Hoff ; S. Rutkowski ; T. Pietsch ; W. Scheurlen ; J. Felsberg ; G. Reifenberger ; A. E. Kulozik ; A. von Deimling ; O. Witt ; R. Eils ; R. J. Gilbertson ; A. Korshunov ; M. D. Taylor ; P. Lichter ; J. O. Korbel ; R. J. Wechsler-Reya ; S. M. Pfister
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-07-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Child ; Chromosomes, Human, Pair 9/genetics ; DNA-Binding Proteins/*genetics/metabolism ; Enhancer Elements, Genetic/*genetics ; Genomic Structural Variation/*genetics ; Humans ; Medulloblastoma/classification/*genetics/pathology ; Mice ; Oncogenes/*genetics ; Proto-Oncogene Proteins/*genetics/metabolism ; Repressor Proteins/*genetics/metabolism ; Transcription Factors/*genetics/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Hausser, H. ; Witt, O. ; Kresse, H.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-4827
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/excr.1993.1261

    Articles: DFG German National Licenses
  7. 7
    Eranian, A. ; Dezauzier, P. ; de Witt, O.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0030-4018
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0030-4018(73)90088-6

    Articles: DFG German National Licenses
  8. 8
    Witt, O. ; Jäckel, M. ; Eiffert, H. ; Laskawi, R. ; Eber, S.
    Springer
    Published 1999
    Staff View
    ISSN:
    1433-0474
    Keywords:
    Schlüsselwörter Lymphadenitis colli ; Atypische Mykobakterien ; Antibiotische Therapie ; Inkomplette Operation ; Key words Lymphadenitis colli ; Atypical mycobacterial infection ; Antibiotic treatment ; Incomplete excision
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Summary The treatment of choice of atypical mycobacterial cervical lymphadenitis is complete surgical excision of all involved lymph nodes. However, a high recurrence rate of infection following incomplete surgery has been described. We report on 3 children with atypical mycobacterial cervical lymphadenitis who underwent incomplete surgery of lymph nodes in order to preserve cranial nerves and blood vessels. After surgery, the patients were treated with clarithromycin alone or in combination with protionamid and rifabutin over a period of 6 weeks to 3 months. All 3 patients were completely cured with no recurrence of lymphadenitis. Discussion: In case of an infiltrative character of a cervical lymphadenitis caused by atypical mycobacteria, surgical resection is often incomplete. A postoperative antibiotic treatment might prevent recurrence of lymphadenitis in these cases.
    Notes:
    Zusammenfassung Die Therapie der Wahl der Lymphadenitis colli durch atypische Mykobakterien ist die komplette chirurgische Sanierung von entzündlich verändertem Lymphknotengewebe. Eine Therapieempfehlung für Patienten nach inkompletter chirurgischer Sanierung der Lymphadenitis colli, bei denen eine hohes Rezidivrisiko besteht, existiert derzeit nicht. Wir berichten über 3 Kinder mit Lymphadenitis colli infolge atypischer Mykobakterieninfektion, bei denen die befallenen Halslymphknoten nur teilweise entfernt wurden, um Läsionen wichtiger Nerven und Gefäße zu vermeiden. Postoperativ wurden die Patienten über 6 Wochen bis zu 3 Monaten mit Clarithromycin allein bzw. einer Dreifachkombination aus Clarithromycin, Protionamid und Rifabutin behandelt. In allen Fällen heilte die Lymphadenitis rezidivfrei aus. Diskussion: Bei einer infiltrierenden Lymphadenitis colli durch atypische Mykobakterien ist oft nur eine teilweise Lymphknotenentfernung möglich. Eine postoperative antibiotische Therapie könnte in diesen Fällen ein Rezidiv der Lymphadenitis verhindern.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001120050475

    Articles: DFG German National Licenses
  9. 9
    Witt, O. ; Iglauer, A. ; Riggert, J. ; Bommer, W. ; Eber, S.
    Springer
    Published 1998
    Staff View
    ISSN:
    1433-0474
    Keywords:
    Schlüsselwörter Bluttransfusion ; Malaria ; Fieber unklarer Genese ; Malariatherapie ; Key words Blood-transfusion ; Fever of unknown origin ; Malaria therapy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Summary An 18 month old boy developed septic fever 14 days after surgery not responding to antibiotic treatment. The cause was found to be a transfusion transmitted infection with plasmodium falciparum. The patient completely recovered after anti-malaria treatment with quinine and halofantrine. Discussion: In cases of unclear septic illness up to 3 month after a blood transfusion, a transfusion malaria should be included in the differential diagnosis. The mortality rate is 15%. Early treatment can prevent a lethal outcome.
    Notes:
    Zusammenfassung Wir berichten über einen 18 Monate alten Jungen, der 14 Tage nach einer Operation ein Antibiotika-refraktäres, septisches Krankheitsbild entwickelte. Als Ursache fand sich eine durch Bluttransfusion übertragene Infektion mit Plasmodium falciparum. Nach Therapie dieser Transfusionsmalaria mit Chinin und Halofantrin kam es zur vollständigen Heilung. Diskussion: Bei unklarem septischen Krankheitsbild bis zu 3 Monate nach einer Transfusion muß auch an eine transfusionsbedingte Malaria gedacht werden. Die Mortalität beträgt bis zu 15%. Durch die rechtzeitige Therapie kann ein letaler Ausgang verhindert werden.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001120050363

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1432-119X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract  Histones are the major protein constituents of the chromatin of eukaryotic cell nuclei. This group of basic proteins is extremely conserved throughout evolution and includes five classes termed H1, H2A, H2B, H3and H4. In mammals, each of these classes except H4 is subdivided into several subtypes. The most divergent class of histones is the H1 protein family, which consists of seven different subtypes, termed H1.1–H1.5, H1°, and H1t. The subtypes H1.2 and H1.4 are found in most somatic cell nuclei, whereas H1° is found in several differentiated tissues, and H1t is restricted to mammalian testicular cells. Similarly, core histone subtypes replacing the major forms of H2A, H2B or H3 have been described. Biochemical analysis of protein and RNA from different tissues and cell lines demonstrates varied patterns of expression of individual histone subtype genes. Moreover, antibodies against specific histone subtypes and in situ hybridization with subtype-specific probes indicate that the expression of histone subtype genes is in several cases modulated in a tissue-specific manner. This is particularly evident at the different stages of spermatogenesis when chromatin undergoes substantial reorganization, which finally results in the highly condensed state of chromatin of the mature sperm head.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004180050083

    Articles: DFG German National Licenses
  11. 11
    Witt, O. ; Pereira, P. L. ; Tillmann, W.
    Springer
    Published 1999
    Staff View
    ISSN:
    1433-0350
    Keywords:
    Key words Venous sinus thrombosis ; Dural arteriovenous fistula ; Protein S deficiency
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract A 12-month-old infant presented with cerebral seizures and neurological deficits. MRI scan of the brain and angiography showed massive cerebral venous sinus thrombosis complicated by a dural arteriovenous fistula. Subsequent clotting analysis revealed a protein S deficiency. Screening for inherited coagulation inhibitor deficiency is recommended in children with unexplained or atypical thrombotic events.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s003810050349

    Articles: DFG German National Licenses
  12. 12
    Witt, O. N. ; Jäger, F.
    Springer
    Published 1903
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01302748

    Articles: DFG German National Licenses
  13. 13
    Lombard, M. ; Griess, P. ; Witt, O. N.
    Springer
    Published 1914
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01561880

    Articles: DFG German National Licenses
  14. 14
    Euwes, P. C. J. ; Witt, O. N. ; Krafft ; Ross
    Springer
    Published 1917
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01767796

    Articles: DFG German National Licenses
  15. 15
    Witt, O. N.
    Springer
    Published 1895
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01595799

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01369156

    Articles: DFG German National Licenses
  17. 17
    Witt, O. N. ; Law, Robert ; Pflüger, E.
    Springer
    Published 1888
    Staff View
    ISSN:
    1618-2650
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01369322

    Articles: DFG German National Licenses
  18. 18
    Apel, M. ; Witt, O.

    Weinheim : Wiley-Blackwell
    Published 1896
    Staff View
    ISSN:
    0075-4617
    Keywords:
    Chemistry ; Organic Chemistry
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/jlac.18962900203

    Articles: DFG German National Licenses
  19. 19
    Witt, O. N.

    Weinheim : Wiley-Blackwell
    Published 1906
    Staff View
    ISSN:
    0365-9496
    Keywords:
    Chemistry ; Inorganic Chemistry
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/cber.19060390102

    Articles: DFG German National Licenses
  20. 20
    Witt, O. N.

    Weinheim : Wiley-Blackwell
    Published 1909
    Staff View
    ISSN:
    0365-9496
    Keywords:
    Chemistry ; Inorganic Chemistry
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/cber.19090420102

    Articles: DFG German National Licenses