Search Results - (Author, Cooperation:O. Takeuchi)
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1Latest Papers from Table of Contents or Articles in PressT. Satoh ; H. Kidoya ; H. Naito ; M. Yamamoto ; N. Takemura ; K. Nakagawa ; Y. Yoshioka ; E. Morii ; N. Takakura ; O. Takeuchi ; S. Akira
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipose Tissue/*cytology/metabolism/pathology ; Animals ; Bone Marrow Cells/cytology/metabolism ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; Cell Count ; Cell Cycle Proteins/deficiency/genetics/metabolism ; *Cell Differentiation ; Cytokines/genetics ; Diet, High-Fat/adverse effects ; Eosinophils/cytology/metabolism ; Female ; Hypertriglyceridemia/chemically induced/genetics ; Inflammation Mediators/metabolism ; Insulin Resistance/genetics ; Intracellular Signaling Peptides and ; Proteins/chemistry/deficiency/genetics/*metabolism ; Lipodystrophy/chemically induced/metabolism/pathology ; Lipolysis ; Lung/cytology ; Macrophages/classification/*cytology/*metabolism ; Male ; Mice ; Neutrophils/cytology/metabolism ; Organ Specificity ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases/*antagonists & ; inhibitors/chemistry/deficiency/genetics/metabolism ; Spleen/cytology ; Ubiquitin/metabolismPublished by: -
2Articles: DFG German National LicensesIiyama, R. ; Kanai, T. ; Uraushihara, K. ; Ishikura, T. ; Makita, S. ; Totsuka, T. ; Yamazaki, M. ; Nakamura, T. ; Miyata, T. ; Yoshida, H. ; Takeuchi, O. ; Hoshino, K. ; Takeda, K. ; Ishikawa, H. ; Akira, S. ; Watanabe, M.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: MyD88 is a key adaptor molecule for signalling via Toll-like receptors (TLRs) and the response to gut commensal microbes. To investigate the role of TLRs/MyD88 pathway in the development of the gut-associated lymphoid tissue (GALT), we examined the development of Peyer's patches (PPs) and cryptopatch (CP), and also one of effector compartment, intraepithelial lymphocyte (IEL) in MyD88–/–, TLR2–/– and TLR4–/– mice. In MyD88–/– mice, the organogenesis of PPs was not disturbed. However, PPs in 2-week-old MyD88–/– mice were significantly smaller than those in MyD88+/– mice. Also, in 2-week-old TLR4–/–, but not TLR2–/– mice, PPs did not develop rapidly. The development of PPs in MyD88–/– and TLR4–/– mice was completely recovered in 10 weeks. PP cells from MyD88–/– mice showed significant decrease in proliferation when stimulated with lipopolysaccharide. The development of CP and IEL was also normal in 10-week-old MyD88–/– mice. These results suggest that the TLRs/MyD88 pathway might be involved in the development of PPs only at early postnatal stage, and TLRs/MyD88-independent signalling is critically involved in the development of GALT in adult mice.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0040-4020Keywords: N-monosubsituted carboxamides ; NO acyl migration. ; hydrolysisSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: