Search Results - (Author, Cooperation:O. Simon)
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1Latest Papers from Table of Contents or Articles in PressC. W. McNamara ; M. C. Lee ; C. S. Lim ; S. H. Lim ; J. Roland ; A. Nagle ; O. Simon ; B. K. Yeung ; A. K. Chatterjee ; S. L. McCormack ; M. J. Manary ; A. M. Zeeman ; K. J. Dechering ; T. R. Kumar ; P. P. Henrich ; K. Gagaring ; M. Ibanez ; N. Kato ; K. L. Kuhen ; C. Fischli ; M. Rottmann ; D. M. Plouffe ; B. Bursulaya ; S. Meister ; L. Rameh ; J. Trappe ; D. Haasen ; M. Timmerman ; R. W. Sauerwein ; R. Suwanarusk ; B. Russell ; L. Renia ; F. Nosten ; D. C. Tully ; C. H. Kocken ; R. J. Glynne ; C. Bodenreider ; D. A. Fidock ; T. T. Diagana ; E. A. Winzeler
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: 1-Phosphatidylinositol 4-Kinase/*antagonists & ; inhibitors/chemistry/genetics/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Binding Sites ; Cytokinesis/drug effects ; Drug Resistance/drug effects/genetics ; Fatty Acids/metabolism ; Female ; Hepatocytes/parasitology ; Humans ; Imidazoles/metabolism/pharmacology ; Life Cycle Stages/drug effects ; Macaca mulatta ; Malaria/*drug therapy/*parasitology ; Male ; Models, Biological ; Models, Molecular ; Phosphatidylinositol Phosphates/metabolism ; Plasmodium/classification/*drug effects/*enzymology/growth & development ; Pyrazoles/metabolism/pharmacology ; Quinoxalines/metabolism/pharmacology ; Reproducibility of Results ; Schizonts/cytology/drug effects ; rab GTP-Binding Proteins/genetics/metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: : A 3-dimensional conjugate heat-transfer model for the analysis of freezing food products has been developed. The food-freezing process is a multi-medium, multi-phase, and transient heat-exchange phenomenon in connection with the cooling flow around the food items. The developed numerical model couples the energy equation with the Navier-Stokes equations outside the food items to simulate the velocity distribution around the food items and the heat flux across the food surfaces. The conjugate heat-transfer methodology and enthalpy method was used to solve the energy equation across the fluid-solid interface into the food item. The heat convection in the fluid and conduction in the foods are implicitly coupled to predict the heat-transfer rate and the enthalpy change during its freezing process. The conjugate heat-transfer model presented here is applicable to perform various heat-transfer calculations involved in the design of storage and refrigeration equipment and to estimate the process time required for freezing of foods. The article presents the mathematical model used, the outline of the numerical scheme, and the results of computations. The model-predicted results are compared with the experimental data available in the literature. Overall good agreement was obtained.Type of Medium: Electronic ResourceURL: -
3FIS Bildung LiteraturdatenbankTaranto, Susanne E. [Verfasser] ; Johnson, Simon O. [Verfasser]
Springfield, Ill. : Thomas
Published 1984Staff ViewType of Medium: bookPublication Date: 1984Keywords: Schule ; Freiwilliger MitarbeiterLanguage: EnglishNote: Literaturangaben S. 123 - 124 -
4FIS Bildung LiteraturdatenbankJohnson, Simon O. [Verfasser] ; Johnson, Verna J. [Verfasser]
Springfield, Ill. : Thomas
Published 1988Staff ViewType of Medium: bookPublication Date: 1988Keywords: Lernmotivation ; MinderheitLanguage: English -
5FIS Bildung LiteraturdatenbankJohnson, Simon O. [Verfasser] ; Johnson, Verna J. [Verfasser]
Springfield, Ill. : Thomas
Published 1990Staff ViewType of Medium: bookPublication Date: 1990Keywords: Disziplin (Ordnung) ; UnterrichtLanguage: English -
6Articles: DFG German National LicensesStaff View
ISSN: 1467-9310Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1439-0264Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The intestinal morphology of 7-week-old pigs was investigated by light (LM) and scanning electron microscopy (SEM). The piglets were fed either a semisynthetic or a cereal-based diet. The shapes of the intestinal villi and crypts of the duodenum, jejunum and ileum were examined. The villi were predominantly tongue-shaped. In the duodenum they were also ridged, branched and folded, and in the jejunum they were also leaf-like and ridged. At places with lymph follicles, the surface of the ileum was rugged with meandering fold-like villi. The crypts of the three segments of the small intestine were mainly coiled and sometimes branched. A novel morphometric evaluation method was introduced using the enlargement factors of each villus and crypt surface. The enlargement factor for the villus surface of the duodenum, jejunum and ileum was 3.13, 3.72 and 2.71, respectively. The factor for the crypt surface of the duodenum, jejunum and ileum was 9.07, 8.94 and 6.53, respectively. Furthermore, the relative proliferation rate and the epithelial renewal index were calculated for the first time. The relative proliferation rate of the duodenum, jejunum and ileum was 32.88, 34.78 and 50.77 proliferations per mm crypt perimeter, respectively. The diets consumed had an influence on the epithelial renewal index being higher for piglets fed the cereal-based diets.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0042-675XTopics: English, American StudiesURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0026-7724Topics: Linguistics and Literary StudiesNotes: DOSTOEVSKY NUMBERURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0026-7724Topics: Linguistics and Literary StudiesNotes: FRANZ KAFKA NUMBERURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0026-7724Topics: Linguistics and Literary StudiesDescription / Table of Contents: THEN AND NOWNotes: ANNIVERSARY ISSUEURL: -
12Articles: DFG German National LicensesReddin, Karen M ; Crowley-Luke, Annette ; Clark, Simon O ; Vincent, Philip J ; Gorringe, Andrew R ; Hudson, Michael J ; Robinson, Andrew
Oxford, UK : Blackwell Publishing Ltd
Published 2001Staff ViewISSN: 1574-695XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Serogroup C meningococcal conjugate vaccines generally use diphtheria or tetanus toxoids as the protein carriers. The use of alternative carrier proteins may allow multivalent conjugate vaccines to be formulated into a single injection and circumvent potential problems of immune suppression in primed individuals. Bordetella pertussis fimbriae were assessed as carrier proteins for Neisseria meningitidis serogroup C polysaccharide. Fimbriae were conjugated to the polysaccharide using modifications of published methods and characterised by size exclusion chromatography; co-elution of protein and polysaccharide moieties confirmed conjugation. The conjugates elicited boostable IgG responses to fimbriae and serogroup C polysaccharide in mice, and IgG:IgM ratios indicated that the responses were thymus-dependent. High bactericidal antibody titres against a serogroup C strain of N. meningitidis were also observed. In a mouse infection model, the conjugate vaccine protected against lethal infection with N. meningitidis. Therefore, B. pertussis fimbriae are effective carrier proteins for meningococcal serogroup C polysaccharide and could produce a vaccine to protect against meningococcal disease and to augment protection against pertussis.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesKutzler, David P. ; Warrick, John M. ; Wuttke, Mark S. ; Okewole, Simon O. ; Tompkins, Laurie
Springer
Published 1998Staff ViewISSN: 1572-8889Keywords: Drosophila melanogaster ; larvae ; vision ; mutantsSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Foraging-stage third-instar larvae from most wild-type (normal) Drosophila melanogaster stocks are generally repelled by light. To identify factors that affect the larval photoresponse, we elucidated the effects of age, temperature, and time on the photoresponse of larvae from a wild-type Canton-S stock. In addition, we analyzed the larvae from the LI2 isofemale line, which are unresponsive to light in a photoassay. To determine whether LI2 larvae behave abnormally on other behavioral paradigms, in comparison to Canton-S controls, we tested larvae in taste and olfactory assays and observed them to determine whether they dispersed in a food source. Like Canton-S larvae, LI2 larvae and other isofemale lines whose progenitors were collected from the same natural population are responsive to taste and olfactory stimuli. Moreover, LI2 larvae disperse in the food source, as do Canton-S larvae tested in the dark. Larvae expressing parasbl mutations, which respond normally to light but not to chemical stimuli, do not disperse normally in the food source, suggesting that dispersal may be mediated by perception of chemical cues.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-0703Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Abstract. Cadmium (Cd) and methylmercury (MeHg) trophic transfers were analyzed between the Asiatic clam Corbicula fluminea and the crayfish Astacus astacus. Metal bioaccumulation in crayfish was quantified after 5, 10, and 15 days of exposure via daily ingestion of soft bodies of C. fluminea, previously exposed during 7 days to Cd (20 μg · L−1) and MeHg (4 μg · L−1). Bioaccumulation kinetics in the predator were investigated at organ and tissue levels: hemolymph, tail muscle, hepatopancreas, gills, stomach/mesenteron, intestine, green gland, carapace. Trophic transfer rates were estimated at the whole organism level. Results showed marked differences (1) in assimilation efficiencies, mean transfer rates being 5% for Cd and 16% for MeHg; and (2) in the metal distribution within the different tissue compartments of the crayfish: for Cd, the trophic uptake leads to high concentrations in the hepatopancreas and small accumulation in the muscle tissue; for MeHg, the highest levels of bioaccumulation occur in the green gland and in the tail muscle. From an ecotoxicological point of view, these experimental data suggest a small risk of Cd transfer between the crayfish and predators, humans included; on the other hand, Hg distribution in the muscle and accumulation trends in this tissue represent an obvious risk of transfer.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1439-0574Source: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionDescription / Table of Contents: Summary Between 1995 – 1997 the method of line taxation was used to survey 124 samples of bark stripping damage incurred in the red deer districts of North and Ruhreifel, Northrhine Westfalia (Tab.3). On the basis of 150000 counted trunks this investigation showed an optimal method for the determination of bark stripping. Of paramount importance here is a sufficiently large sample size of trunks in bark stripping prone stands (Tab.1). The inclusion of 1000 trunks in 10 100 trunk rows per sample plot suffices (Fig.1) The average sampling time including driving time from stand to stand and brief preparation time before and after sampling is about 3 hours, maximally 4 hours for one person. In order to determine the amount of bark stripping as completely as possible, beech stands were sampled in August and spruce in mid-September. The data were statistically tested using a binomial distribution to provide sufficient accuracy in the determination of percent stripping (Tabs. 4 and 5). In comparing the present various methods for the determination of bark stripping damage to line taxation, this method has the clear advantage of a high degree of precision in determining percent bark stripping and large sample size in comparison to spot sampling. In addition the time consuming search for the individual sample plots in the selected sample areas can be circumvented.Abstract: Résumé De 1995 à 1997, 124 relevés d'écorcement ont été effectués dans les territoires à Cerf du Nordeifel et du Rureifel en Rhénanie-Westphalie au moyen de la méthode d'estimation linéaire (Tabl. 3). L'étude montre, sur base d'environ 150.000 arbres dénombrés, une optimisation de la méthode d'estimation des écorcements. Il est déterminant de disposer d'un échantillon suffisamment important d'arbres susceptibles d'être écorcés (Tabl. 1). Il s'est avéré suffisant de relever 1.000 pieds sur 100 rangées d'arbres par parcelle (Fig. 1). La durée moyenne du relevé pour une personne, en tenant compte des déplacements de parcelle à parcelle et d'un temps nécessaire avant et après le relevé, est de 3 à maximum 4 heures. Afin de procéder à un relevé aussi exhaustif que possible, les relevés d'écorcement du Hêtre ont lieu en août et ceux de l'Epicéa mi-septembre. Les séries de données ont été statistiquement vérifiées, en ce qui concerne la précision des relevés, au moyen d'une répartition binomiale (Tabl. 4 et 5). Comparée aux 6 différentes méthodes appliquées dans les différents Länder pour le relevé des dégâts d'écorcement, la méthode d'estimation linéaire présente l'avantage important, par rapport à la méthode par échantillonnage par blocs aléatoires, d'un échantillonnage important auquel correspond une précision élevée de la proportion des arbres écorcés. En outre, on fait l'économie de la recherche et de l'identification, exigeantes en temps, des différents points d'intersection du maillage où se situent les placettes de référence.Notes: Zusammenfassung Zwischen 1995–1997 wurden im Rotwildgebiet „Nord- und Rureifel“, Nordrhein-Westfalen, 124 Schälaufnahmen nach der Methode der Linientaxation durchgeführt (Tab. 3). Die Untersuchung zeigt anhand von ca. 150.000 ausgezählten Stämmen eine Methodenoptimierung zur Schälerhebung auf. Von wesentlicher Bedeutung ist eine ausreichend große Stichprobenzahl an Stämmen im schälgefährdeten Bestand (Tab. 1). Es hat sich als hinreichend erwiesen, je Aufnahmefläche 1.000 Stämme in zehn 100-Stamm-Reihen auszuzählen (Abb. 1). Die durchschnittliche Zeitdauer einer Schälaufnahme mit Anfahrtsweg von Bestand zu Bestand und kurzer Vor- und Nachbereitung der Aufnahme, von einer Person durchgeführt, beträgt etwa 3 Stunden, maximal 4 Stunden. Um das Schälereignis möglichst vollständig zu erfassen, erfolgte die Schälaufnahme der Buche im August und die der Fichte Mitte September. Die Datenreihen wurden mittels Binomialverteilung auf eine ausreichende Genauigkeit in der Ermittlung des Schälprozentes statistisch überprüft (Tab. 4 und 5). Im Vergleich der bundesweit aktuell sieben verschiedenen Länder-Verfahren der forstwirtschaftlichen Schälschadenserhebung bringt die Linientaxation gegenüber den Stichprobenverfahren nach dem System der Klumpenstichproben den wesentlichen Vorteil eines hohen Stichprobenumfanges mit einer entsprechend hohen Genauigkeit des ermittelten Schälprozentes. Zudem entfällt die zeitaufwendige Suche und Identifizierung der einzelnen Anlaufpunkte in den Probekreisen.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesTerjung, Werner H. ; Kickert, Ronald N. ; Kochevar, Ronald J. ; Mrowka, Jack P. ; Ojo, Simon O. ; Potter, Gerald L. ; Tuller, Stanton E.
Springer
Published 1969Staff ViewISSN: 1434-4483Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesPhysicsDescription / Table of Contents: Zusammenfassung Zur Bestimmung der monatlichen Verteilung der Strahlungsbilanz in Südkalifornien unter Berücksichtigung des Geländeverlaufs wurde ein vorgängig entwickeltes Modell [9] benützt, das auf der theoretischen Kenntnis der physikalischen Beeinflussung der Sonnenenergie durch die Atmosphäre und ihrer Umwandlung am Erdboden beruht. Die in den Gleichungen verwendeten Parameter sind Wolkenbedeckung, Wolkenform, Erdbodenalbedo, Gesamtwasserdampfgehalt, Erdoberflächentemperatur, Neigung und Orientierung des Geländes, Höhe über Meer und Stadtdunst. Es wurde ein bemerkenswerter Unterschied zwischen relativ hohen Strahlungsbilanzwerten für die Küste und die Küstenberge und niedrigeren Werten für die östlichen Teile Südkaliforniens gefunden.Abstract: Résumé Pour déterminer la répartition mensuelle du bilan de radiation dans le sud de la Californie en tenant compte des conditions topographiques, on utilise un modèle développé récemment [9]. Ce dernier repose sur la connaissance théorique des modifications physiques que subit l'énergie solaire en traversant l'atmosphère et de sa transformation au sol. Les paramètres utilisés dans ces équations sont: la nébulosité, la forme des nuages, l'albédo du sol, le contenu total de l'air en vapeur d'eau, la température à la surface du sol, la pente et l'orientation du sol, l'altitude et la brume urbaine. On a ainsi trouvé une différence marquée entre les valeurs relativement élevées du bilan de radiation valables sur la côte et les régions montagneuses côtières et les faibles valeurs que l'on rencontre dans les parties orientales de la Californie du sud.Notes: Summary A previously determined model [9], based on the theoretical knowledge of the physical modifications of solar energy by the atmosphere and its transformation at the surface, has been used to determine the monthly distribution of net radiation in southern California at a topoclimatic scale. Parameters utilized in the equations were cloud cover, cloud type, surface albedo, precipitable water vapor, surface temperature, slope angle, slope orientation, elevation, and urban sinog. A remarkable contrast was found between relatively high net radiation values for the littoral and coastal mountains and those of the lower values of the arid eastern parts of southern California.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1618-2650Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesDilthey, Walther ; Bauriedel, G. ; Burger, B. ; Geisselbrecht, G. ; von Ibach, F. ; Kiefer, F. ; Seeger, A. ; Simon, O. ; Taucher, R. ; Winkler, J.
New York, NY : Wiley-Blackwell
Published 1921Staff ViewISSN: 0021-8383Keywords: Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0075-4617Keywords: Chemistry ; Organic ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: