Search Results - (Author, Cooperation:O. Shalem)
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1Latest Papers from Table of Contents or Articles in PressM. C. Canver ; E. C. Smith ; F. Sher ; L. Pinello ; N. E. Sanjana ; O. Shalem ; D. D. Chen ; P. G. Schupp ; D. S. Vinjamur ; S. P. Garcia ; S. Luc ; R. Kurita ; Y. Nakamura ; Y. Fujiwara ; T. Maeda ; G. C. Yuan ; F. Zhang ; S. H. Orkin ; D. E. Bauer
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-09-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Base Sequence ; CRISPR-Associated Proteins/*metabolism ; CRISPR-Cas Systems/genetics ; Carrier Proteins/*genetics ; Cells, Cultured ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Enhancer Elements, Genetic/*genetics ; Erythroblasts/metabolism ; Fetal Hemoglobin/genetics ; *Genetic Engineering ; Genome/genetics ; Humans ; Mice ; Molecular Sequence Data ; Mutagenesis/*genetics ; Nuclear Proteins/*genetics ; Organ Specificity ; RNA, Guide/genetics ; Reproducibility of Results ; Species SpecificityPublished by: -
2Latest Papers from Table of Contents or Articles in PressI. H. Jain ; L. Zazzeron ; R. Goli ; K. Alexa ; S. Schatzman-Bone ; H. Dhillon ; O. Goldberger ; J. Peng ; O. Shalem ; N. E. Sanjana ; F. Zhang ; W. Goessling ; W. M. Zapol ; V. K. Mootha
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-02-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Anaerobiosis ; Animals ; Antimycin A/analogs & derivatives/pharmacology ; Bacterial Proteins ; Biomarkers/blood ; Body Temperature ; Body Weight ; Disease Models, Animal ; Electron Transport/drug effects ; Electron Transport Complex I/genetics ; Endonucleases ; Energy Metabolism/drug effects/genetics ; Gene Knockout Techniques ; Genome-Wide Association Study ; Glycine/analogs & derivatives/pharmacology/therapeutic use ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Isoquinolines/pharmacology/therapeutic use ; K562 Cells ; Leigh Disease/*genetics/pathology/*therapy ; Mice ; Mice, Knockout ; Mitochondria/drug effects/*metabolism ; Oxygen/*metabolism ; Respiration ; Suppression, Genetic ; Von Hippel-Lindau Tumor Suppressor Protein/antagonists & inhibitors/*genetics ; ZebrafishPublished by: -
3Latest Papers from Table of Contents or Articles in PressO. Shalem ; N. E. Sanjana ; E. Hartenian ; X. Shi ; D. A. Scott ; T. S. Mikkelsen ; D. Heckl ; B. L. Ebert ; D. E. Root ; J. G. Doench ; F. Zhang
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-12-18Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/genetics ; Caspase 9/*genetics ; Cell Survival/*genetics ; *Clustered Regularly Interspaced Short Palindromic Repeats ; Cullin Proteins/genetics ; Drug Resistance, Neoplasm/*genetics ; Gene Knockout Techniques ; Gene Library ; Genes, Neurofibromatosis 1 ; Genes, Neurofibromatosis 2 ; Genetic Loci ; Genetic Testing/*methods ; Genome-Wide Association Study ; Humans ; Indoles/therapeutic use ; Lentivirus ; Mediator Complex/genetics ; Melanoma/drug therapy/*genetics ; Pluripotent Stem Cells/*metabolism ; Protein Kinase Inhibitors/therapeutic use ; Selection, Genetic ; Sulfonamides/therapeutic use ; Transcription Factors/genetics ; raf Kinases/antagonists & inhibitorsPublished by: -
4Latest Papers from Table of Contents or Articles in PressF. A. Ran ; L. Cong ; W. X. Yan ; D. A. Scott ; J. S. Gootenberg ; A. J. Kriz ; B. Zetsche ; O. Shalem ; X. Wu ; K. S. Makarova ; E. V. Koonin ; P. A. Sharp ; F. Zhang
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Base Sequence ; CRISPR-Associated Proteins/genetics/*metabolism ; Cholesterol/blood/metabolism ; Gene Targeting ; Genetic Engineering/*methods ; Genome/*genetics ; Liver/metabolism/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Proprotein Convertases/biosynthesis/blood/deficiency/genetics ; Serine Endopeptidases/biosynthesis/blood/deficiency/genetics ; Staphylococcus aureus/*enzymology/genetics ; Substrate SpecificityPublished by: