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1Latest Papers from Table of Contents or Articles in PressK. Forslund ; F. Hildebrand ; T. Nielsen ; G. Falony ; E. Le Chatelier ; S. Sunagawa ; E. Prifti ; S. Vieira-Silva ; V. Gudmundsdottir ; H. Krogh Pedersen ; M. Arumugam ; K. Kristiansen ; A. Y. Voigt ; H. Vestergaard ; R. Hercog ; P. Igor Costea ; J. R. Kultima ; J. Li ; T. Jorgensen ; F. Levenez ; J. Dore ; H. B. Nielsen ; S. Brunak ; J. Raes ; T. Hansen ; J. Wang ; S. D. Ehrlich ; P. Bork ; O. Pedersen
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-12-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Biodiversity ; Diabetes Mellitus, Type 2/drug therapy/*microbiology ; Female ; Gastrointestinal Microbiome/*drug effects/genetics/*physiology ; Humans ; Hypoglycemic Agents/pharmacology/therapeutic use ; Male ; Metagenome/drug effects/physiology ; Metformin/*pharmacology/therapeutic use ; RNA, Ribosomal, 16S/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2015-05-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Embryo Research/*ethics ; Genetic Engineering/*ethics ; Genome, Human/*genetics ; Germ Cells/*metabolism ; Germ-Line Mutation/*genetics ; Humans ; Patient Safety/*standardsPublished by: -
3Latest Papers from Table of Contents or Articles in PressE. Le Chatelier ; T. Nielsen ; J. Qin ; E. Prifti ; F. Hildebrand ; G. Falony ; M. Almeida ; M. Arumugam ; J. M. Batto ; S. Kennedy ; P. Leonard ; J. Li ; K. Burgdorf ; N. Grarup ; T. Jorgensen ; I. Brandslund ; H. B. Nielsen ; A. S. Juncker ; M. Bertalan ; F. Levenez ; N. Pons ; S. Rasmussen ; S. Sunagawa ; J. Tap ; S. Tims ; E. G. Zoetendal ; S. Brunak ; K. Clement ; J. Dore ; M. Kleerebezem ; K. Kristiansen ; P. Renault ; T. Sicheritz-Ponten ; W. M. de Vos ; J. D. Zucker ; J. Raes ; T. Hansen ; P. Bork ; J. Wang ; S. D. Ehrlich ; O. Pedersen
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-08-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adiposity ; Adult ; Bacteria/classification/genetics/*isolation & purification ; Biomarkers/*metabolism ; Body Mass Index ; Case-Control Studies ; Diet ; Dyslipidemias/microbiology ; Energy Metabolism ; Europe/ethnology ; European Continental Ancestry Group ; Female ; Gastrointestinal Tract/*microbiology ; Genes, Bacterial ; Humans ; Inflammation/microbiology ; Insulin Resistance ; Male ; *Metagenome/genetics ; Obesity/metabolism/microbiology ; Overweight/metabolism/microbiology ; Phylogeny ; Thinness/microbiology ; Weight Gain ; Weight LossPublished by: -
4Latest Papers from Table of Contents or Articles in PressM. Fumagalli ; I. Moltke ; N. Grarup ; F. Racimo ; P. Bjerregaard ; M. E. Jorgensen ; T. S. Korneliussen ; P. Gerbault ; L. Skotte ; A. Linneberg ; C. Christensen ; I. Brandslund ; T. Jorgensen ; E. Huerta-Sanchez ; E. B. Schmidt ; O. Pedersen ; T. Hansen ; A. Albrechtsen ; R. Nielsen
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Acclimatization/*genetics ; Alleles ; Arctic Regions ; Body Height/genetics ; Body Weight/genetics ; Chromosomes, Human, Pair 11/genetics ; Climate ; *Diet, High-Fat ; Fatty Acids, Omega-3/*administration & dosage/analysis ; Female ; Genetic Loci ; Genome, Human/genetics ; Genome-Wide Association Study ; Greenland ; Humans ; Inuits/*genetics ; Linkage Disequilibrium ; Male ; Membrane Lipids/analysis/genetics ; Polymorphism, Single Nucleotide ; Selection, GeneticPublished by: -
5Latest Papers from Table of Contents or Articles in PressB. B. Hansen ; V. Grotan ; R. Aanes ; B. E. Saether ; A. Stien ; E. Fuglei ; R. A. Ims ; N. G. Yoccoz ; A. O. Pedersen
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-01-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arctic Regions ; Arvicolinae/*physiology ; *Climate Change ; Foxes/*physiology ; Galliformes/*physiology ; Herbivory ; Ice Cover ; Population Dynamics ; Rain ; Reindeer/*physiology ; SnowPublished by: -
6Latest Papers from Table of Contents or Articles in PressI. Moltke ; N. Grarup ; M. E. Jorgensen ; P. Bjerregaard ; J. T. Treebak ; M. Fumagalli ; T. S. Korneliussen ; M. A. Andersen ; T. S. Nielsen ; N. T. Krarup ; A. P. Gjesing ; J. R. Zierath ; A. Linneberg ; X. Wu ; G. Sun ; X. Jin ; J. Al-Aama ; J. Wang ; K. Borch-Johnsen ; O. Pedersen ; R. Nielsen ; A. Albrechtsen ; T. Hansen
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Blood Glucose/analysis ; Codon, Nonsense/genetics ; Diabetes Mellitus, Type 2/*genetics ; GTPase-Activating Proteins/*genetics ; Gene Frequency ; *Genetic Variation ; Genome-Wide Association Study ; Genotype ; Greenland ; Humans ; Insulin/blood ; Insulin Resistance/*genetics ; Middle Aged ; Muscle, Skeletal/metabolismPublished by: -
7Latest Papers from Table of Contents or Articles in PressM. Arumugam ; J. Raes ; E. Pelletier ; D. Le Paslier ; T. Yamada ; D. R. Mende ; G. R. Fernandes ; J. Tap ; T. Bruls ; J. M. Batto ; M. Bertalan ; N. Borruel ; F. Casellas ; L. Fernandez ; L. Gautier ; T. Hansen ; M. Hattori ; T. Hayashi ; M. Kleerebezem ; K. Kurokawa ; M. Leclerc ; F. Levenez ; C. Manichanh ; H. B. Nielsen ; T. Nielsen ; N. Pons ; J. Poulain ; J. Qin ; T. Sicheritz-Ponten ; S. Tims ; D. Torrents ; E. Ugarte ; E. G. Zoetendal ; J. Wang ; F. Guarner ; O. Pedersen ; W. M. de Vos ; S. Brunak ; J. Dore ; M. Antolin ; F. Artiguenave ; H. M. Blottiere ; M. Almeida ; C. Brechot ; C. Cara ; C. Chervaux ; A. Cultrone ; C. Delorme ; G. Denariaz ; R. Dervyn ; K. U. Foerstner ; C. Friss ; M. van de Guchte ; E. Guedon ; F. Haimet ; W. Huber ; J. van Hylckama-Vlieg ; A. Jamet ; C. Juste ; G. Kaci ; J. Knol ; O. Lakhdari ; S. Layec ; K. Le Roux ; E. Maguin ; A. Merieux ; R. Melo Minardi ; C. M'Rini ; J. Muller ; R. Oozeer ; J. Parkhill ; P. Renault ; M. Rescigno ; N. Sanchez ; S. Sunagawa ; A. Torrejon ; K. Turner ; G. Vandemeulebrouck ; E. Varela ; Y. Winogradsky ; G. Zeller ; J. Weissenbach ; S. D. Ehrlich ; P. Bork
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-04-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Bacteria/*classification/genetics ; Bacterial Typing Techniques ; Biodiversity ; Biomarkers/analysis ; Europe ; Feces/microbiology ; Female ; Humans ; Intestines/*microbiology ; Male ; *Metagenome ; Metagenomics ; PhylogenyPublished by: -
8Latest Papers from Table of Contents or Articles in PressJ. Qin ; Y. Li ; Z. Cai ; S. Li ; J. Zhu ; F. Zhang ; S. Liang ; W. Zhang ; Y. Guan ; D. Shen ; Y. Peng ; D. Zhang ; Z. Jie ; W. Wu ; Y. Qin ; W. Xue ; J. Li ; L. Han ; D. Lu ; P. Wu ; Y. Dai ; X. Sun ; Z. Li ; A. Tang ; S. Zhong ; X. Li ; W. Chen ; R. Xu ; M. Wang ; Q. Feng ; M. Gong ; J. Yu ; Y. Zhang ; M. Zhang ; T. Hansen ; G. Sanchez ; J. Raes ; G. Falony ; S. Okuda ; M. Almeida ; E. LeChatelier ; P. Renault ; N. Pons ; J. M. Batto ; Z. Zhang ; H. Chen ; R. Yang ; W. Zheng ; H. Yang ; J. Wang ; S. D. Ehrlich ; R. Nielsen ; O. Pedersen ; K. Kristiansen
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Asian Continental Ancestry Group ; Butyrates/metabolism ; China/ethnology ; Cohort Studies ; Diabetes Mellitus, Type ; 2/classification/complications/*microbiology/physiopathology ; Feces/microbiology ; Genetic Linkage/genetics ; Genetic Markers ; Genome-Wide Association Study/*methods ; High-Throughput Nucleotide Sequencing ; Humans ; Intestines/*microbiology ; Metabolic Networks and Pathways/genetics ; Metagenome/*genetics ; Metagenomics/*methods ; Opportunistic Infections/complications/microbiology ; Reference Standards ; Sulfates/metabolismPublished by: -
9Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-01-12Publisher: American Heart Association (AHA)Print ISSN: 1942-325XElectronic ISSN: 1942-3268Topics: MedicineKeywords: Electrophysiology, Genetic, Association StudiesPublished by: -
10Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-11Publisher: American Heart Association (AHA)Print ISSN: 1942-325XElectronic ISSN: 1942-3268Topics: MedicineKeywords: Electrophysiology, Epidemiology, Genetic, Association StudiesPublished by: -
11Articles: DFG German National LicensesStaff View
ISSN: 1398-9995Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Nasal patency shows spontaneous variations but is influenced by a number of factors like exercise and allergic conditions. Nasal histamine challenge has been used to define nasal hypersensitivity. We have applied acoustic rhinometry as a new objective method to study the spontaneous variations of the nasal mucosa and its response to histamine challenge in 12 nonallergic subjects and 12 subjects with nasal allergy to pollen, but out of the pollen season. Measurements of the minimum cross-sectional area and the volume of the nasal cavities were done every 15 min for 6 h. More pronounced spontaneous variations, defined by the coefficient of variation of the measurements, were encountered in the allergic than in the nonallergic subjects, especially with regard to the minimum cross-sectional areas in the nasal cavities (P 〈 0.02). Allergic subjects showed increased sensitivity to histamine, as compared with nonallergic subjects, during low-concentration (0.1%) challenge (P 〈 0.05) and a prolonged effect of histamine challenge (P = 0.01). Antihistamine (cetirizine) had a significant effect on the histamine-induced symptoms and decrease of nasal dimensions during histamine challenge, but no significant effect on pollen-induced changes. In the allergic group, the decrease in minimum area during allergen provocation correlated with the level of specific IgE (r = 0.81; P = 0.0015).Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1365-3040Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Mentha aquatica L. was grown at different nutrient availabilities in water and in air at 60% RH. The plants were kept at 600 mmol m−3 free CO2 dissolved in water (40 times air equilibrium) and at 30 mmol m−3 CO2 in air to ensure CO2 saturation of growth in both environments. We quantified the transpiration-independent water transport from root to shoot in submerged plants relative to the transpiration stream in emergent plants and tested the importance of transpiration in sustaining nutrient flux and shoot growth. The acropetal water flow was substantial in submerged Mentha aquatica, reaching 14% of the transpiration stream in emergent plants. The transpiration-independent mass flow of water from the roots, measured by means of tritiated water, was diverted to leaves and adventitious shoots in active growth. The plants grew well and at the same rates in water and air, but nutrient fluxes to the shoot were greater in plants grown in air than in those that were submerged when they were rooted in fertile sediments. Restricted O2 supply to the roots of submerged plants may account for the smaller nutrient concentrations, though these exceeded the levels required to saturate growth. In hydroponics, the root medium was aerated and circulated between submerged and emergent plants to minimize differences in medium chemistry, and here the two growth forms behaved similarly and could fully exploit nutrient enrichment. It is concluded that the lack of transpiration from leaf surfaces in a vapour-saturated atmosphere, or under water, is not likely to constrain the transfer of nutrients from root to shoot in herbaceous plants. Nutrient deficiency under these environmental conditions is more likely to derive from restricted development and function of the roots in waterlogged anoxic soils or from low porewater concentrations of nutrients.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-3040Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Sudden events of seagrass die-off have been suggested to be induced by invasion of the phytotoxin sulphide under environmental stress generating low oxygen supply in seagrass tissues. Laboratory experiments were conducted with eelgrass (Zostera marina L.) to measure intra-plant changes in oxygen and sulphide by means of microelectrodes at different oxygen concentrations in the water column. The objectives were to examine whether sulphide intrusion into seagrass tissues can be induced, to determine the role of plant oxygen status for sulphide intrusion and to determine how fast internal sulphide pools are depleted after internal oxygen supplies have been restored. Under conditions with oxygen partial pressures (pO2) above 7.4 kPa (〉 35% of air saturation) within eelgrass rhizomes or meristematic tissues no intrusion of sulphide occurred in spite of high sediment concentrations of gaseous sulphide (〉 1000 µm). Lack of sulphide intrusion at high internal pO2 suggested that oxygen release from the roots ensured complete re-oxidation of sulphide in the rhizosphere. Under oxygen stress, however, the experiments clearly demonstrated intrusion of sulphide in eelgrass rhizomes and meristematic tissues. Rates of sulphide intrusion were controlled by internal pO2, which in turn was controlled by water column oxygen concentrations. Maximum internal sulphide content reached 325 µm which by far exceeded the 1–10 µm known to inhibit mitochondrial activity in eukaryotic cells. Sulphide and low levels of oxygen could coexist in the eelgrass tissues reflecting fast internal transport of sulphide and slow rates of sulphide re-oxidation. Upon re-establishment of high internal oxygen concentrations the depletion of the sulphide pool was slow (half-life = 20–30 min) indicating, that sulphide re-oxidation within the eelgrass tissue was not bacterially or enzymatically facilitated but occurred by simple chemical oxidation. The results of this study are consistent with the proposed detrimental role of sulphide intrusion in events of sudden seagrass die-off.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1365-3040Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Flooding imposes stress upon terrestrial plants since it severely hampers gas exchange rates between the shoot and the environment. The resulting oxygen deficiency is considered to be the major problem for submerged plants. Oxygen microelectrode studies have, however, shown that aquatic plants maintain relatively high internal oxygen pressures under water, and even may release oxygen via the roots into the sediment, also in dark. Based on these results, we challenge the dogma that oxygen pressures in submerged terrestrial plants immediately drop to levels at which aerobic respiration is impaired. The present study demonstrates that the internal oxygen pressure in the petioles of Rumex palustris plants under water is indeed well above the critical oxygen pressure for aerobic respiration, provided that the air-saturated water is not completely stagnant. The beneficial effect of shoot acclimation of this terrestrial plant species to submergence for gas exchange capacity is also shown. Shoot acclimation to submergence involved a reduction of the diffusion resistance to gases, which was not only functional by increasing diffusion of oxygen into the plant, but also by increasing influx of CO2, which enhances underwater photosynthesis.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0005-2736Keywords: (Human adipocyte) ; Glucose metabolism ; Insulin effect ; d-Glucose transportSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: ATB-BMPA ; Exofacial photolabelling ; Glucose transporter ; Skeletal muscle ; Subcellular fractionationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesBak, J. ; Ellison, J.A. ; Marsh, B. ; Meyer, F.E. ; Pedersen, O. ; Petersen, J.B.B. ; Uggerhoj, E. ; Ostergaard, K. ; Sorensen, A.H. ; Suffert, M. ; Moller, S.P.
Amsterdam : ElsevierStaff ViewISSN: 0550-3213Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesBak, J.F. ; Ellison, J.A. ; Marsh, B. ; Meyer, F.E. ; Pedersen, O. ; Petersen, J.B.B. ; Uggerhoj, E. ; Moller, S.P. ; Sorensen, H. ; Suffert, M.
Amsterdam : ElsevierStaff ViewISSN: 0550-3213Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0167-4889Keywords: (Human adipocyte) ; Adenosine deaminase ; Glucose metabolism ; Indomethacin ; Insulin stimulation ; Prostaglandin E"2Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0167-4889Keywords: (Human skeletal muscle) ; Insulin receptor kinase ; Kinetic analysis ; Skeletal muscleSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: