Search Results - (Author, Cooperation:N. T. Nguyen)
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1Latest Papers from Table of Contents or Articles in PressB. P. Kleinstiver ; M. S. Prew ; S. Q. Tsai ; V. V. Topkar ; N. T. Nguyen ; Z. Zheng ; A. P. Gonzales ; Z. Li ; R. T. Peterson ; J. R. Yeh ; M. J. Aryee ; J. K. Joung
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Substitution/genetics ; Animals ; CRISPR-Associated Proteins/*genetics/*metabolism ; CRISPR-Cas Systems ; Cell Line ; Clustered Regularly Interspaced Short Palindromic Repeats/*genetics ; Directed Molecular Evolution ; Genome/genetics ; Humans ; Mutation/genetics ; *Nucleotide Motifs ; Protein Engineering/*methods ; Staphylococcus aureus/enzymology ; Streptococcus pyogenes/*enzymology ; Streptococcus thermophilus/enzymology ; Substrate Specificity/genetics ; Zebrafish/embryology/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressB. P. Kleinstiver ; V. Pattanayak ; M. S. Prew ; S. Q. Tsai ; N. T. Nguyen ; Z. Zheng ; J. K. Joung
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-01-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Base Sequence ; CRISPR-Associated Proteins/*genetics/*metabolism ; CRISPR-Cas Systems/*physiology ; Clustered Regularly Interspaced Short Palindromic Repeats/*genetics ; DNA/genetics/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Endonucleases/genetics/*metabolism ; *Genetic Engineering ; Genome, Human/*genetics ; Humans ; Mutation ; Protein Binding ; RNA/genetics ; Reproducibility of Results ; Sequence Analysis, DNA ; Streptococcus pyogenes/enzymology/genetics ; Substrate SpecificityPublished by: -
3Latest Papers from Table of Contents or Articles in PressLuigi Aurelio, Jo-Anne Baltos, Leigh Ford, Anh T. N. Nguyen, Manuela Jörg, Shane M. Devine, Celine Valant, Paul J. White, Arthur Christopoulos, Lauren T. May and Peter J. Scammells
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-02-24Publisher: American Chemical Society (ACS)Topics: Chemistry and PharmacologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressS. W. Oh ; J. A. Harris ; L. Ng ; B. Winslow ; N. Cain ; S. Mihalas ; Q. Wang ; C. Lau ; L. Kuan ; A. M. Henry ; M. T. Mortrud ; B. Ouellette ; T. N. Nguyen ; S. A. Sorensen ; C. R. Slaughterbeck ; W. Wakeman ; Y. Li ; D. Feng ; A. Ho ; E. Nicholas ; K. E. Hirokawa ; P. Bohn ; K. M. Joines ; H. Peng ; M. J. Hawrylycz ; J. W. Phillips ; J. G. Hohmann ; P. Wohnoutka ; C. R. Gerfen ; C. Koch ; A. Bernard ; C. Dang ; A. R. Jones ; H. Zeng
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-04-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Atlases as Topic ; Axons/physiology ; Brain/*anatomy & histology/*cytology ; Cerebral Cortex/cytology ; *Connectome ; Corpus Striatum/cytology ; Male ; Mice ; Mice, Inbred C57BL ; Models, Neurological ; Neuroanatomical Tract-Tracing Techniques ; Thalamus/cytologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressDagmar E. Ehrnhoefer, Dale D. O. Martin, Mandi E. Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S. Caron, Niels H. Skotte, Yen T. N. Nguyen, Kuljeet Vaid, Amber L. Southwell, Sabine Engemann, Sonia Franciosi and Michael R. Hayden
BioMed Central
Published 2018Staff ViewPublication Date: 2018-03-09Publisher: BioMed CentralElectronic ISSN: 2051-5960Topics: MedicinePublished by: -
6Latest Papers from Table of Contents or Articles in PressMinh T. N. Nguyen, Gerta Shema, René P. Zahedi, Steven H. L. Verhelst
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-04-22Publisher: American Chemical Society (ACS)Print ISSN: 1535-3893Electronic ISSN: 1535-3907Topics: Chemistry and PharmacologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressS. M. Mohseni ; S. R. Sani ; J. Persson ; T. N. Nguyen ; S. Chung ; Y. Pogoryelov ; P. K. Muduli ; E. Iacocca ; A. Eklund ; R. K. Dumas ; S. Bonetti ; A. Deac ; M. A. Hoefer ; J. Akerman
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-03-16Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
8Articles: DFG German National LicensesStaff View
ISSN: 1460-2695Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract— A mathematical model is developed to predict the effect of weld toe undercut, misalignment and residual stresses on the fatigue behaviour of butt welded joints subjected to zero-to-tensile loading. Linear Elastic Fracture Mechanics (LEFM), Finite Element Analysis (FEA) and superposition approaches have been used for the modelling. It has been found that an undercut at the toes of welded joints is one of the most important weld geometry parameters. The reduction of fatigue strength of welded joints with a weld toe undercut is at least twice that of joints without an undercut in comparison with flush-ground welded plate. A misalignment of 5% of plate thickness and an undercut of 2% of plate thickness are fairly representative for the lower boundary of S-N curves of butt joints. The improvement of fatigue limits by means of surface treatments is shown to be effective for both undercut and misaligned joints. This approach is practical for a “Fitness-for-Purpose” assessment of welded joints subject to fatigue conditions.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1572-9486Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Conclusions Table VIII summarizes the computed binding energy of He4-nucleus which includes the zeroth order contribution and the correction up to the third order for three different potentials. The binding energy does not contain the C.M. energy, which has been calculated up to the second order. The r.m.s. radii corrected for the C.M. motion and for not-point-like nucleons are calculated up to the second order for potential RHEL 1 and up to the first order for Reid and RHEL 2 potentials. The binding energy and r.m.s. radii are computed for two different self-consistent conditions, the first of which is the usual classical condition (2.16), the second reads ΔE (1) = 0. In all cases the absolute value of the binding energy of the He4-nucleus is lower than the experimental value. It has been shown that the perturbation series built up on the Goldstone reaction matrix diverges, when a self-consistent technique is not used. This represents certain danger also for the self-consistent formulation, although it gives plausible results up to the third order. The result obtained seems to indicate that the discrepancy between the experimental and theoretical values for the binding energy may be caused by neglect of some fundamental facts (relativistic effects, many-body forces etc.) in the present many-body theory.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesLuketich, J. D. ; Meehan, M. ; Nguyen, N. T. ; Christie, N. ; Weigel, T. ; Yousem, S. ; Keenan, R. J. ; Schauer, P. R.
Springer
Published 2000Staff ViewISSN: 1432-2218Keywords: Key words: Esophageal cancer — Laparoscopy — Minimally invasive surgery — Staging — ThoracoscopySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background: The incidence of esophageal adenocarcinoma is increasing in the United States, and the 5-year survival rate is dismal. Preliminary data suggest that conventional imaging is inaccurate in staging esophageal cancer and could limit accurate assessment of new treatments. The objective of this study was to compare minimally invasive surgical staging (MIS) with conventional imaging for staging esophageal cancer. Methods: Patients with potentially resectable esophageal cancer were eligible. Staging by conventional methods used computed tomography (CT) scan of the chest and abdomen, and endoscopic ultrasound (EUS), whereas MIS used laparoscopy and videothoracoscopy. Conventional staging results were compared to those from MIS. Results: In 53 patients, the following stages were assigned by CT scan and EUS: carcinoma in situ (CIS; n= 1), I (n= 1), II (n= 23), III (n= 20), IV (n= 8). In 17 patients (32.1%), MIS demonstrated inaccuracies in the conventional imaging, reassigning a lower stage in 10 patients and a more advanced stage in 7 patients. Conclusions: In 32.1% of patients with esophageal cancer, MIS changed the stage originally assigned by CT scan and EUS. Therefore, MIS should be applied to evaluate the accuracy of new noninvasive imaging methods and to assess new therapies for esophageal cancer.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesNguyen, N. T. ; Luketich, J. D. ; Shurin, M. R. ; Schatz, S. ; Tran, Q. ; Ravid, J. ; Schauer, P. R.
Springer
Published 1998Staff ViewISSN: 1432-2218Keywords: Key words: Laparoscopic cholecystectomy — Hypercoagulable state — Hypercoagulation — Thromboelastography — PigSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background: The stress response to surgical trauma precipitates a state of transient hypercoagulation. Studies have demonstrated that laparoscopic surgery results in a diminished stress response compared to open surgery. The aim of this study was to determine the extent of postoperative hypercoagulability following laparoscopic cholecystectomy (LC) compared to open cholecystectomy (OC). Methods: Twenty-one pigs were randomly selected to undergo LC (N= 10) or OC (N= 11). Whole blood was collected preoperatively and on postoperative days (PODs) 1, 2, and 3 for determination of viscoelastic changes using a thromboelastography (TEG) coagulation analyzer. Four parameters were calculated from the TEG: R (reaction time), K (coagulation time), α (rate of clot formation), and MA (maximal amplitude). Antithrombin III (AT III) level was measured preoperatively and on POD 1. Results: After OC, three of four TEG parameters changed to reflect a state of hypercoagulation. Only MA values were significantly changed after LC. Comparison between OC and LC showed no difference in the TEG parameter. There was no significant change in AT III levels after LC or OC. Conclusions: OC results in postoperative hypercoagulation typically encountered in open abdominal surgery. Although there were no differences in TEG or AT III between the two groups, after the laparoscopic approach all but one TEG parameter remained unchanged, suggesting a diminished hypercoagulable state. By reducing postoperative hypercoagulation, laparoscopic surgery may reduce the risk of developing postoperative venous thrombosis.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1572-9486Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract A new model Hamiltonian and a new type of the Goldstone expansion is used for calculation of binding energies, r. m. s. radii and densities of4He,8Be,12C and16O nuclei. The model Hamiltonian suggested depends on few parameters, the Goldstone equation for the reaction matrix can be solved exactly, quickly and without computational difficulties. The results are promising.Type of Medium: Electronic ResourceURL: