Search Results - (Author, Cooperation:N. Syed)
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1Latest Papers from Table of Contents or Articles in PressNosheen Akhtar, Deeba N. Syed, Rahul K. Lall, Bushra Mirza, Hasan Mukhtar
Wiley-Blackwell
Published 2018Staff ViewPublication Date: 2018-02-14Publisher: Wiley-BlackwellPrint ISSN: 0899-1987Electronic ISSN: 1098-2744Topics: MedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressM. S. Kim ; S. M. Pinto ; D. Getnet ; R. S. Nirujogi ; S. S. Manda ; R. Chaerkady ; A. K. Madugundu ; D. S. Kelkar ; R. Isserlin ; S. Jain ; J. K. Thomas ; B. Muthusamy ; P. Leal-Rojas ; P. Kumar ; N. A. Sahasrabuddhe ; L. Balakrishnan ; J. Advani ; B. George ; S. Renuse ; L. D. Selvan ; A. H. Patil ; V. Nanjappa ; A. Radhakrishnan ; S. Prasad ; T. Subbannayya ; R. Raju ; M. Kumar ; S. K. Sreenivasamurthy ; A. Marimuthu ; G. J. Sathe ; S. Chavan ; K. K. Datta ; Y. Subbannayya ; A. Sahu ; S. D. Yelamanchi ; S. Jayaram ; P. Rajagopalan ; J. Sharma ; K. R. Murthy ; N. Syed ; R. Goel ; A. A. Khan ; S. Ahmad ; G. Dey ; K. Mudgal ; A. Chatterjee ; T. C. Huang ; J. Zhong ; X. Wu ; P. G. Shaw ; D. Freed ; M. S. Zahari ; K. K. Mukherjee ; S. Shankar ; A. Mahadevan ; H. Lam ; C. J. Mitchell ; S. K. Shankar ; P. Satishchandra ; J. T. Schroeder ; R. Sirdeshmukh ; A. Maitra ; S. D. Leach ; C. G. Drake ; M. K. Halushka ; T. S. Prasad ; R. H. Hruban ; C. L. Kerr ; G. D. Bader ; C. A. Iacobuzio-Donahue ; H. Gowda ; A. Pandey
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Cells, Cultured ; Databases, Protein ; Fetus/metabolism ; Fourier Analysis ; Gene Expression Profiling ; Genome, Human/genetics ; Hematopoietic Stem Cells/cytology/metabolism ; Humans ; Internet ; Mass Spectrometry ; Molecular Sequence Annotation ; Open Reading Frames/genetics ; Organ Specificity ; Protein Biosynthesis ; Protein Isoforms/analysis/genetics/metabolism ; Protein Sorting Signals ; Protein Transport ; Proteome/analysis/chemistry/genetics/*metabolism ; *Proteomics ; Pseudogenes/genetics ; RNA, Untranslated/genetics ; Reproducibility of Results ; Untranslated Regions/geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressKannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-10-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 0928-4257Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesCohen, Michael B. ; Alam, Syed N. ; Medina, Edith B. ; Bernal, Carmencita C.
Springer
Published 1997Staff ViewISSN: 1570-7458Keywords: Nilaparvata lugens ; host plant resistance ; tolerance ; IR64 ; riceSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract We investigated the mechanism of brown planthopper, Nilaparvata lugens (Stål), resistance in the popular rice cultivar IR64, and the current level of resistance of IR64 to N. lugens in a large rice growing area with low brown planthopper populations (Central Luzon, Philippines). In greenhouse experiments with N. lugens populations collected from Central Luzon, IR64 showed slight to moderate levels of antibiosis, antixenosis, and tolerance relative to the cultivars IR22 and Azucena, which contain no major genes for N. lugens resistance. IR64 was also more resistant than IR26 in most experiments, despite the fact that both varieties have the same major gene for N. lugens resistance, Bph1. This confirms that IR64 contains one or more additional, apparently minor, genes for brown planthopper resistance. Our findings also demonstrate that, in an area with low insecticide use, it is not necessary to have high levels of N. lugens resistance, even in a rice cultivar grown by the majority of farmers, to maintain low and stable N. lugens populations.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1570-7458Keywords: Nilaparvata lugens ; host plant resistance ; durability ; rice ; IR64Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Colonies of brown planthopper, Nilaparvata lugens (Stål), established from three locations on Luzon Island, Philippines, were selected for adaptation to four rice varieties: IR22 (no major resistance genes), IR26 (Bph1 gene), IR64 (Bph1 and additional moderate resistance from minor genes), and IR72 (Bph3). In each of the first eleven generations, and the fifteenth generation, the fitness of N. lugens from subcolonies reared on each of the varieties was measured with four tests: survival to adult, feeding rate, female weight, and developmental time. In three of the four tests, insects from all three locations showed slower adaptation to IR64 than to IR22, IR26, and IR72. In the fourth test, developmental time, the rate of adaptation on IR64 and IR72 was similar, and both varieties retained a significant level of resistance after 15 generations of selection. However, as measured by survival to adult, feeding rate, and female weight, after 15 generations the fitness on IR64 of N. lugens from two locations no longer differed from those on other varieties. In these two locations, Central Luzon and IRRI, IR64 has been widely grown for 10 years. After 15 generations of selection IR64 remained resistant to insects from Banaue, an isolated location where modern resistant varieties are not grown, as measured by all four tests. Our results demonstrate that the relatively greater durability of brown planthopper resistance in IR64, which has been suspected on the basis of its performance in the field, is also evident under greenhouse conditions in the absence of natural enemies and other mortality factors.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-1351Keywords: Respiration ; Interneurons ; Neural circuitry ; Semi-intact-preparation ; Peripheral feedbackSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Previously (Syed et al. 1991) we described the ventilatory behavior of the pond snail Lymnaea stagnalis and identified motor neurons that innervate various muscles involved in this behavior. In the present study we describe an interneuronal network that controls ventilatory behavior in Lymnaea. An identified interneuron, termed the input 3 interneuron (Ip.3.I), was found to be involved in the opening movement of the pneumostome (expiration), whereas another identified interneuron known as visceral dorsal 4 (V.D.4) caused its closure (inspiration). These cells have reciprocal inhibitory connections with each other, which accounts for their opposing effects on common follower motor neurons. In isolated brain preparations a third identified interneuron, right pedal dorsal 1 (R.Pe.D.1) initiated the respiratory cycle by the excitation of Ip.3.I. Whereas Ip.3.I in turn excited R.Pe.D.1, the connections between R.Pe.D.1 and V.D.4 were mutually inhibitory. Both Ip.3.I and V.D.4 were active during spontaneously occurring respiratory behavior as recorded from semi-intact preparations, and selective hyperpolarization of V.D.4 during such spontaneous activity disrupted the respiratory behavior. Regarding peripheral feedback, the mechanical stimulation of the pneumostome during its opening movements not only caused closure but also inhibited Ip.3.I in the middle of its discharge. Ip.3.I and V.D.4 were also found to be multifunctional, inhibiting both locomotor and whole body withdrawal neural networks. We conclude from these results that the rhythmic patterned activity underlying respiratory behavior in Lymnaea is generated centrally, and that the network described here therefore comprises a central pattern generator.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-1351Keywords: Central pattern generator ; Motor neurons ; Mollusc ; Respiratory behavior ; Neuronal circuits ; Peripheral feedbackSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary This study describes the neural basis of respiratory behavior in a pulmonate mollusc, Lymnaea stagnalis. We describe and identify muscles of the respiratory orifice (pneumostome) and mantle cavity as well as relevant motor neurons innervating these muscles. All of these identified motor neurons are active during spontaneously occurring respiratory behavior and a sporadically occurring synaptic input, termed Input 3, controls the activities of these motor neurons. This spontaneous input can also be recorded from isolated brain preparations, suggesting that the respiratory motor program is generated centrally. However, evidence is also presented that in semi-intact preparations the role of peripheral feedback is important for the initiation and termination of respiratory behavior in Lymnaea.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesBrandt, C. R. ; Imesch, P. ; Spencer, B. ; Eliassi-Rad, B. ; Syed, N. A. ; Untawale, S. ; Robinson, N. L. ; Albert, D. M.
Springer
Published 1997Staff ViewISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary. We have used a herpes simplex virus type 1 (HSV-1) ribonucleotide reductase (RR) null mutant (ICP6Δ) to determine if the HSV-1 RR is required for acute retinal disease. Injection of the ICP6Δ mutant into the vitreous induced mild transient signs of infection (vitreal infiltrate, retinal inflammation, and changes in retinal cytology). In contrast, the parental KOS and a revertant virus (ICP6Δ + 3.1) in which the RR gene had been restored, caused severe retinitis. Injection of media alone also induced mild transient signs of disease. Two months after infection, ICP6Δ injected eyes could not be distinguished from normal eyes. Repeated injection of ICP6Δ (3 times, 2 weeks apart) resulted in vitreal infiltrate near the site of injection but the retina did not appear damaged. The mutant, ICP6Δ, grew to peak titers to -fold lower and cleared faster than KOS or ICP6Δ + 3.1 in the injected eyes suggesting that the reduced virulence was due to reduced ability of the virus to grow. These results show that the viral RR is required for acute retinal disease.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-2242Keywords: Key words Arabidopsis ; Microsatellites ; DNA markers ; PCRSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract In this paper we show how rogue genotypes in the parental stocks or contaminants among the crossed progeny of Arabidopsis thaliana can be readily identified and excluded from the breeding process using microsatellite markers derived from a small quantity of intact leaf tissue which has been alkali-treated. This method is fast and cost effective as it does not require DNA extraction, is highly reliable, and is less damaging to small plants where only limited quantities of plant tissue are available. Furthermore, a large number of samples can be processed in 1 day, facilitating the identification process prior to selfing or crossing the plants. In addition, the procedure could potentially be automated since no centrifugation is required.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1573-6830Keywords: dopamine ; neurite outgrowth ; molluscs ; neurotransmitters ; in vitro ; synapse formation ; developmentSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary 1. An identified dopaminergic interneuron (RPeD1) of the snailLymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neuronsin vivo. When culturedin vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. 2. To test whether exogenous dopamine exerts effects on the neurite outgrowth of both target and non-target neurons respectively, these cells were cultured in conditioned media (CM) in the presence of dopamine (10−5M). The growth of the non-target cells was severely restricted and retarded in the presence of dopamine. These data suggest that dopamine may regulate neurite outgrowth of non-target cells in culture. 3. The growth regulatory effects of dopamine on the non-target cells were blocked in the presence of a dopamine receptor antagonist (R(+) SCH-23390, 10−4M). These results indicate that dopamine-induced growth regulation of the non-target cells is mediated via dopamine receptors on these cells. 4. In the absence of conditioned media, dopamine was not sufficient to exert growth promoting effects on either target or non-target cells. 5. Taken together, our data show that dopamine differentially regulates growth of identifiedLymnaea neurons in culture. Dopamine alone, however, is not sufficient to initiate and support neurite outgrowth from these cells. Rather, it functions to suppress the neurite outgrowth of the non-target cells, initiated by the conditioned media.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1573-7330Keywords: in vitro fertilization ; gonadotropin releasing hormone agonist (GnRH-a) receptor down regulation ; aberrant response to GnRH-aSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Purpose: Our purpose was to evaluate the IVF-ET outcome in patients who did not achieve timely pituitary-ovarian suppression following “long”-protocol GnRH agonist (GnRH-a) administration. Methods: A retrospective analysis was done on 96 IVF treatment cycles characterized by a delayed response (DR) to long-protocol GnRH-a treatment. The study included those patients who either achieved ovarian suppression (E2 ≤ 110 pM) despite an elevated LH level (group DR-A) or had pituitary desensitization (LH ≤ 1.5 IU/L) without ovarian suppression (group DR-B) on day 12 of GnRH-a treatment but needed an extended course of GnRH-a treatment to achieve complete suppression. These patients had gonadotropin stimulation either from day 12, despite an elevated level of LH (subgroup DR-A1; n=13) or elevated E2 levels (subgroup DR-B1; n=9), or after achieving a complete hypogonadotropic-hypopgonadal state following an extended course of GnRH-a treatment [subgroups DR-A2 (n=46) and DR-B2 (n=28)]. The outcome was compared with that of 88 cycles of normal responders (group NR) who had pituitary-ovarian suppression by day 12 of GnRH-a administration. Results: Ovarian response and pregnancy rates in subgroups DR-A1 and DR-A2 were statistically not different and comparable to those in the NR group. In subgroups DR-B1 and DR-B2, E2 response and rates of oocyte retrieval and pregnancy were significantly lower than those in the other groups, but fertilization and cleavage rates were similar. The requirement of gonadotropin for ovarian stimulation was comparatively higher in subgroup DR-A2 and both DR-B subgroups. Conclusions: There was no treatment cancellation in group NR and both DR-A subgroups, but 22% of the cycles in DR-B1 and 14% of the cycles in DR-B2 were canceled due to poor ovarian response. It therefore appears that during long-protocol pituitary desensitization, the post-GnRH-a level of serum E2, rather than LH, better predicts IVF-ET outcome.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesSteffensen, I. ; Syed, N. I. ; Lukowiak, K. ; Bulloch, A. G. M. ; Morris, C. E.
Springer
Published 1995Staff ViewISSN: 1439-1104Keywords: mollusc ; neuropeptide ; AplysiaSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract The pond snailLymnaea stagnalis is a useful model system for studying the neural basis of behaviour but the mechanosensory inputs that impact on behaviours such as respiration, locomotion, reproduction and feeding are not known. InAplysia, the peptide sensorin-A appears to be specific to a class of central mechanosensory neurons. We show that in theLymnaea central nervous system sensorin-A immunocytochemistry reveals a discrete pattern of staining involving well over 100 neurons. Identifiable sensorin positive clusters of neurons are located in the buccal and cerebral ganglia, and a single large neuron is immunopositive in each pedal ganglion. These putative mechanosensory neurons are not in the same locations as previously identified motoneurons, interneurons or neurosecretory cells. As would be expected for a mechanoafferent, sensorin positive fibres were found in nerve tracts innervating the body wall. This study lays the foundation for future electrophysiological and behavioural analysis of these putative mechanosensory neurons.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesHusain, Sajid ; Narsimha, Ramaran ; Alvi, Syed N. ; Rao, Ramisetti Nageswara
Weinheim : Wiley-Blackwell
Published 1993Staff ViewISSN: 0935-6304Keywords: Reversed phase LC ; Industrial contaminants ; Chloroacetic acids ; Chemistry ; Analytical Chemistry and SpectroscopySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyAdditional Material: 2 Ill.Type of Medium: Electronic ResourceURL: