Search Results - (Author, Cooperation:N. Sinclair)
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1Latest Papers from Table of Contents or Articles in PressSamantha N. Sinclair, Joseph M. Licciardi, Seth W. Campbell, Brian M. Madore
Wiley-Blackwell
Published 2018Staff ViewPublication Date: 2018-02-10Publisher: Wiley-BlackwellPrint ISSN: 0267-8179Electronic ISSN: 1099-1417Topics: GeographyGeosciencesPublished by: -
2Latest Papers from Table of Contents or Articles in PressE. Saglamyurek ; N. Sinclair ; J. Jin ; J. A. Slater ; D. Oblak ; F. Bussieres ; M. George ; R. Ricken ; W. Sohler ; W. Tittel
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-01-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Articles: DFG German National LicensesSINCLAIR, N. R. StC. ; ANDERSON, C. C.
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1996Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Specific immune responses are controlled by two counterbalancing mechanisms—co-stimulation and co-inhibition. Antigen receptors determine specificity, activate co-stimulation and/or co-inhibition, and interact with these co-stimulatory/co-inhibitory mechanisms to dictate the direction of the immune response, either positive or negative. Co-stimulatory or co-inhibitory ligands interact with their specific receptors and may indicate the context in which antigen is perceived by lymphocytes. Ligation of antigen receptors may activate only co-stimulatory or co-inhibitory mechanisms, and thus may influence secondarily the direction of the immune response. Furthermore, the activity of a given co-stimulator or co-inhibitory receptor is modified depending on signalling via the antigen receptor. If neither co-stimulators nor co-inhibitors are present, lymphocytes, activated in response to antigen receptor signalling, produce low levels of effector elements and then revert to inactivity. Co-inhibitors are defective in autoimmune disease.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 〈blockFixed type="quotation"〉Hie therefore, Robin, overcast the night; The starry welkin cover thou anon With drooping fog as black as Acheron; And lead these testy rivals so astray, As one come not within another's way. William Shakespeare, A Midsummer Night's Dream Act III, Scene IIType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Conditions under which one searches for Fc-signalling determine the success in finding it. A major condition is that one must have enough T cells to drive a T-cell-dependent response, but not enough T-cell activity to obscure the Fc-signalling. Antigen-masking and destructive phagocytosis of antigen occur. Under conditions and in areas of the body where T-cell activities are limiting and Fc-signalling can not be blocked, Fc-signalling may be observed. The balance between costimulation and coinhibition is a major determinant in immune responsiveness, because costimulation and coinhibition interfere with each other.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Passive antibody can both suppress and augment immune responses. Until recently, there was virtual unanimity on the importance of the interaction of the Fc portion of modulating antibody with Fc-receptors (Fc-signalling), especially in experiments involving the suppression by antibody. Experiments reported in the last few years, that do not demonstrate the range of Fc-portion/Fc-receptor influences on the suppression of immune responses by passive antibody, have introduced new uncertainty into this field. The purpose of this paper is to review how the initial controversy on the influence of Fc-signalling in inhibition by passive antibody was resolved. Old and new approaches are suggested that may help in resolving the current uncertainty engendered by recent experimental results that were interpreted to mean that passive suppressive antibody does not utilize the inhibitory FcγRIIB receptor. An understanding of the factors that influence negative Fc-signalling is needed in order to optimize clinical therapies whose action depends on the suppressive property of antibody.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The mice used in these experiments were derived from the CFW strain obtained from Carworth Farms, New City, and have been maintained in this laboratory by brother?sister mating for 16 generations. The back of each mouse was shaved and 0.15 ml. of 0.05 per cent DMBA in acetone was applied to an ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0731-7085Keywords: Automation ; Milli-lab ; complexation with diethylthiobarbituric acid ; instability. ; liquid chromatography ; nicotine and urinary metabolitesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0041-624XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1573-0832Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The obligately psychrophilic yeast, Leucosporidium stokesii increased in size, produced irregular wall growth and formed atypical buds when incubated within one to three degrees above 20 °C, the maximum growth temperature. Incubation of cells anaerobically or aerobically in the presence of 2,4-dinitrophenol at the elevated temperatures prevented the development of atypical buds. An investigation of subcellular morphology revealed that the atypical bud was anucleate, did not form a septum between bud and parent cell and produced numerous cytoplasmic vesicles. On shift-down to 15 °C, the optimum growth temperature, nuclear division, migration and septum formation resumed.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Teams in two laboratories have demonstrated the optimal effect with regard to immunosuppression by antibody 1,11,13,14. In both cases, optimal immunosuppression was achieved by certain doses of antibody; if more antibody was added, the degree of immunosuppression became less. In Diener and ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesSINCLAIR, N. R. STC. ; LEES, ROSEMARY K. ; ELLIOTT, E. V.
[s.l.] : Nature Publishing Group
Published 1968Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Sera containing IS anti-sheep erythrocyte haemolysin was obtained from inbred Swiss mice 40 to 60 days after a second injection of 108 sheep erythrocytes. After three precipitations with 40 per cent ammonium sulphate, pepsin digestion was carried out in a 0-07 M acetate and 0-05 M chloride buffer ...Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-119XSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Using serum from human atopic individuals with a sufficiently high titre of IgE and IgG antibodies to birchor hazel-pollen allergens and antigens, the localization of IgE binding sites in birch- and hazel-pollen grain was determined by pre- and post-embedding electron microscopic immunoautoradiography with 125J-anti-IgE, whereas the IgG binding sites were localized in ultrathin sections of birch-pollen grains by the protein-A/gold technique. Concerning the distribution patterns of both IgE/IgG binding sites within the pollen grains, no difference could be observed in the dormant pollen grain: Labelling was found in the exine part of the pollen wall and throughout the highly condensed cytoplasm except for starch grains and lipid droplets. The intine part and the germination pores were almost completely unlabelled. In pollen grains which had been soaked in a hypotonic buffer for 15 min, however, IgE binding sites were predominantly localized within the intine and the germination pores. The specificity of the labelling reactions and the observed differences in the localization patterns are discused.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-119XSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary In electron micrographs it could be shown that hazelnut (Corylus avellana) pollen grains are covered on their surface by a diffusible 10 nm thick lamellar layer. On pollen surface as well as in pollen extract this layer could be precipitated and stained by the polycationic dye Cuprolinic blue. By subsequent application of both immunogold labeling with serum from a hay-fever patient allergic to tree pollen grains and histochemical detection with Cuprolinic blue this pollen surface layer proved to be an effective antigen.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1573-0832Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Penicillium corylophilum Dierckx was isolated from sludge collected at the interface of an aqueous, copper-bearing leachate and an organic, kerosene based, ion exchange solvent. The organism assimilated kerosene and various straight chain and cyclic hydrocarbons including dodecane, hexadecane, octadecane, toluene, benzene, and cyclohexane. Assimilation of kerosene and hexadecane was optimal at pH 2 and was stimulated by yeast extract.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1573-0832Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Induction of cytoplasmic pyruvate decarboxylase (PDC) in Candida utilis increases with culture age throughout aerobic logarithmic phase growth on glucose and is due to oxygen depletion. Resting cells, grown on ethanol or acetate, fail to initiate PDC synthesis for two to three hours following anaerobic suspension in glucose although these cells are capable of glucose uptake. PDC induction occurs only at permissive growth temperatures, i.e., 5 ° C to 35 ° C. A preliminary characterization of the enzyme indicates an activity optimum of 35 ° C and a lack of any regulatory properties.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1573-0832Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The induction of fermentation was studied in Candida utilis, a Crabtree-negative, respiratory yeast. This process occurs under oxygen-limiting conditions in the presence of a fermentable substrate and is the result of de novo enzyme synthesis. Induction occurs at permissive growth temperatures and its inhibition at 45 ° C is accompanied by loss of ability to take up glucose. The ability to be induced to an increased fermentative state is characteristic of all Crabtree-negative yeasts observed with the exception of an obligate aerobe, Hansenula wingei. No similar process occurs in the Crabtree-positive yeasts.Type of Medium: Electronic ResourceURL: