Search Results - (Author, Cooperation:N. Papadopoulos)

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  1. 1
    B. Vogelstein ; N. Papadopoulos ; V. E. Velculescu ; S. Zhou ; L. A. Diaz, Jr. ; K. W. Kinzler
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-03-30
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Cell Transformation, Neoplastic/*genetics ; *Genes, Neoplasm ; Genetic Heterogeneity ; *Genome, Human ; Humans ; *Mutagenesis ; Mutation ; Neoplasms/*genetics ; Signal Transduction/genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    C. G. Joseph ; E. Darrah ; A. A. Shah ; A. D. Skora ; L. A. Casciola-Rosen ; F. M. Wigley ; F. Boin ; A. Fava ; C. Thoburn ; I. Kinde ; Y. Jiao ; N. Papadopoulos ; K. W. Kinzler ; B. Vogelstein ; A. Rosen
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-12-07
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Autoantibodies/blood/immunology ; Autoantigens/genetics/*immunology ; Autoimmune Diseases/*complications/genetics ; Autoimmunity/genetics ; CD4-Positive T-Lymphocytes/immunology ; Genetic Loci ; Humans ; Mutation, Missense ; Neoplasms/complications/genetics/*immunology ; Polymorphism, Single Nucleotide ; RNA Polymerase III/genetics/*immunology ; Scleroderma, Systemic/*complications/genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    J. Yun ; E. Mullarky ; C. Lu ; K. N. Bosch ; A. Kavalier ; K. Rivera ; J. Roper ; Chio, II ; E. G. Giannopoulou ; C. Rago ; A. Muley ; J. M. Asara ; J. Paik ; O. Elemento ; Z. Chen ; D. J. Pappin ; L. E. Dow ; N. Papadopoulos ; S. S. Gross ; L. C. Cantley
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-11-07
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adenomatous Polyposis Coli Protein/genetics ; Animals ; Ascorbic Acid/administration & dosage/pharmacology/*therapeutic use ; Cell Line, Tumor ; Colorectal Neoplasms/*drug therapy/*genetics ; Dehydroascorbic Acid/metabolism ; Female ; Glucose Transporter Type 1/metabolism ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/metabolism ; Glycolysis/drug effects ; Humans ; Mice ; Mice, Mutant Strains ; Mice, Nude ; Proto-Oncogene Proteins/*genetics ; Proto-Oncogene Proteins B-raf/*genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Reactive Oxygen Species/metabolism ; Xenograft Model Antitumor Assays ; ras Proteins/*genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2010-12-18
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adult ; Cerebellar Neoplasms/*genetics/metabolism ; Child ; DNA Copy Number Variations ; DNA-Binding Proteins/genetics/metabolism ; *Genes, Neoplasm ; Genes, Tumor Suppressor ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Histones/metabolism ; Humans ; Medulloblastoma/*genetics/metabolism ; Methylation ; MicroRNAs/genetics ; *Mutation ; Neoplasm Proteins/genetics/metabolism ; Oligonucleotide Array Sequence Analysis ; Point Mutation ; Sequence Analysis, DNA ; Signal Transduction
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2011-08-06
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Brain Neoplasms/*genetics ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 19/genetics ; DNA Helicases/chemistry/*genetics/metabolism ; DNA-Binding Proteins/chemistry/*genetics/metabolism ; Exons ; Female ; Genes, Tumor Suppressor ; Genetic Predisposition to Disease ; Humans ; Loss of Heterozygosity ; Male ; *Mutation ; Mutation, Missense ; Oligodendroglioma/*genetics ; Receptor, Notch2/genetics ; Repressor Proteins/chemistry/*genetics/metabolism ; Sequence Analysis, DNA
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2011-01-22
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptor Proteins, Signal Transducing/*genetics ; Carcinoma, Pancreatic Ductal/genetics ; Chromatin Assembly and Disassembly/genetics ; DNA Helicases/*genetics ; Genes, Tumor Suppressor ; Humans ; *Mutation ; Neuroendocrine Tumors/*genetics/metabolism ; Nuclear Proteins/*genetics ; PTEN Phosphohydrolase/genetics ; Pancreatic Neoplasms/*genetics/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Prognosis ; Proto-Oncogene Proteins/*genetics ; Sequence Analysis, DNA ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/genetics/*metabolism ; Tumor Suppressor Proteins/genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Staff View
    Publication Date:
    2011-07-30
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Carcinoma/drug therapy/*genetics/virology ; Carcinoma, Squamous Cell ; Cell Cycle Proteins/*genetics ; Codon, Nonsense ; Exons ; F-Box Proteins/*genetics ; Gene Dosage ; *Genes, Tumor Suppressor ; Genes, p53 ; Head and Neck Neoplasms/drug therapy/*genetics/virology ; Humans ; INDEL Mutation ; *Mutation ; Mutation, Missense ; Neoplasms, Squamous Cell/drug therapy/*genetics/virology ; Oligonucleotide Array Sequence Analysis ; Oncogenes ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/virology ; Receptor, Notch1/chemistry/*genetics ; Sequence Analysis, DNA ; Smoking ; Tobacco ; Ubiquitin-Protein Ligases/*genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    D. Psaltis ; I. N. Papadopoulos
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-11-09
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Tomography, Optical/*methods
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  9. 9
    Staff View
    Publication Date:
    2011-07-02
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptor Proteins, Signal Transducing/*genetics/metabolism ; Carcinoma, Neuroendocrine/*genetics/pathology/physiopathology ; Cell Nucleus/metabolism ; Central Nervous System Neoplasms/*genetics/pathology/physiopathology ; Chromatin Assembly and Disassembly ; DNA Helicases/*genetics/metabolism ; Humans ; In Situ Hybridization, Fluorescence ; Mutant Proteins/genetics/metabolism ; Mutation ; Nuclear Proteins/*genetics/metabolism ; Pancreatic Neoplasms/*genetics/pathology/physiopathology ; Phenotype ; Telomere/*physiology/ultrastructure
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  10. 10
    Staff View
    Publication Date:
    2018-02-23
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Medicine, Diseases
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  11. 11
    S Fatouros, P Papadopoulos, N L Matiadou and S Vassiliadis
    Institute of Physics (IOP)
    Published 2018
    Staff View
    Publication Date:
    2018-12-08
    Publisher:
    Institute of Physics (IOP)
    Print ISSN:
    1757-8981
    Electronic ISSN:
    1757-899X
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by:
    http://www.iop.org/

    Latest Papers from Table of Contents or Articles in Press
  12. 12
    Tamiolakis, D. ; Venizelos, J. ; Karamanidis, D. ; Prassopoulos, P. ; Papadopoulos, N.

    Oxford, UK : Blackwell Science Ltd
    Published 2003
    Staff View
    ISSN:
    1365-2303
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2303.2003.00069.x

    Articles: DFG German National Licenses
  13. 13
    Papadopoulos, N. ; Cevallos, W. ; Hess, W. C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1959
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-4159.1959.tb13196.x

    Articles: DFG German National Licenses
  14. 14
    Tamiolakis, D. ; Venizelos, I. ; Nikolaidou, S. ; Kostopoulou, A. ; Georgiou, G. ; Boglou, P. ; Papadopoulos, N.

    Oxford, UK : Blackwell Science Ltd
    Published 2004
    Staff View
    ISSN:
    1365-2303
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2303.2004.00115.x

    Articles: DFG German National Licenses
  15. 15
    PAPADOPOULOS, N.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The most common procedure for isolating genes that predispose to a certain disease is positional cloning. This process is initiated by mapping the responsible gene to its location on a chromosome linked to the disease. Successive cloning of the region results in the isolation of candidate genes. Finally, identification of mutations by mutational analysis points to the correct gene.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2222.1995.tb00438.x

    Articles: DFG German National Licenses
  16. 16
    Papadopoulos, N. G. ; Stanciu, L. A. ; Papi, A. ; Holgate, S. T. ; Johnston, S. L.

    Oxford, UK : Blackwell Science Ltd
    Published 2002
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background Rhinovirus (RV) infection is the commonest trigger of acute asthma exacerbations; however, the immune response to these viruses and any potential implications in the mechanisms leading to asthma exacerbations are not well understood.Objective To assess the effects of in vitro RV infection on the phenotype and expression of costimulatory molecules on peripheral blood mononuclear cells (PBMC) from normal and atopic asthmatic subjects, as a model for RV antigen presentation.Methods PBMC from seven normal and seven asthmatic subjects were exposed to one infectious unit/cell of RV16 for 48 h. Surface expression of CD25, CD28, CD40, CD54, CD80, CD86 and CTLA-4 was evaluated on CD3, CD4, CD8, CD14 and CD19 PBMC subpopulations by three-colour flow cytometry.Results No changes in the percentage of CD3, CD4, CD8 or CD19 were observed. CD14 was significantly reduced by the infection and this was more pronounced in normal subjects. On Th cells CTLA-4 was increased after RV infection only in the asthmatic group. Levels of CD80 and CD86 in the control cultures were lower in the asthmatic group. RV infection induced a significant increase of CD80 on monocytes and of CD86 on B cells, which occurred in both groups but were less marked in atopic asthmatic subjects.Conclusion Exposure of PBMC to RV is able to activate the antigen presentation machinery. Differences between normal and atopic asthmatic individuals are compatible with the hypothesis that an aberrant immune response to RV may be involved in the development of acute exacerbations in atopic asthmatic subjects.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.0954-7894.2002.01313.x

    Articles: DFG German National Licenses
  17. 17
    Papadopoulos, N. G. ; Papi, A. ; Meyer, J. ; Stanciu, L. A. ; Salvi, S. ; Holgate, S. T. ; Johnston, S. L.

    Oxford, UK : Blackwell Science, Ltd
    Published 2001
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background Human rhinoviruses (RVs) are the most common precipitants of asthma exacerbations. RV infection of bronchial epithelium results in local airway inflammation inducing eosinophil recruitment and activation. Induction of eosinophil chemoattractants could represent a central mechanism, as well as a prime target for intervention.Objective To assess the effect of RV infection on mRNA expression and production of eosinophil chemoattractants by bronchial epithelial cells in-vitro.Methods BEAS-2B cells were infected with major and minor RVs and the mRNA expression of IL-8, RANTES, MIP-1α, eotaxin, eotaxin-2, MCP-2, MCP-3 and MCP-4 was assessed by reverse transcription PCR. In cases where mRNA induction was observed, a fluoroimmunoassay was used to confirm protein production. To assess the virus-specificity of the observed reactions, cells were also exposed to inactivated RVs.Results RV infection was able to up-regulate mRNA expression of IL-8, RANTES, MIP-1α, eotaxin and eotaxin-2, did not affect MCP-4, while MCP-2 and MCP-3 were not expressed either at baseline or after virus infection. Protein production was confirmed for IL-8, RANTES and eotaxin, but not for MIP-1α. When RVs were inactivated cytokine up-regulation was almost completely lost.Conclusion Infection of bronchial epithelial cells with RVs results in the production of a wide array of mediators that are able to chemoattract eosinophils. These include the eosinophil-specific molecules eotaxin and eotaxin-2, in addition to IL-8 and RANTES, which are the most abundant. Eosinophil recruitment after RV infection of bronchial epithelium could represent a central event in the pathogenesis of virus-induced asthma exacerbations.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2222.2001.01112.x

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    0393-0440
    Keywords:
    Space of reducible connections ; Yang-Mills theories ; [Mathematical Subject Codes] 53 C 05 ; [Mathematical Subject Codes] 81 E 13
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Mathematics
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0393-0440(90)90003-L

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1398-9995
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Skin prick testing (SPT) is the standard method for diagnosing allergic sensitization but is to some extent performed differently in clinical centres across Europe. There would be advantages in harmonizing the standard panels of allergens used in different European countries, both for clinical purposes and for research, especially with increasing mobility within Europe and current trends in botany and agriculture. As well as improving diagnostic accuracy, this would allow better comparison of research findings in European allergy centres. We have compared the different SPT procedures operating in 29 allergy centres within the Global Allergy and Asthma European Network (GA2LEN). Standard SPT is performed similarly in all centres, e.g. using commercial extracts, evaluation after 15–20 min exposure with positive results defined as a wheal 〉3 mm diameter. The perennial allergens included in the standard SPT panel of inhalant allergens are largely similar (e.g. cat: pricked in all centres; dog: 26 of 29 centres and Dermatophagoides pteronyssinus: 28 of 29 centres) but the choice of pollen allergens vary considerably, reflecting different exposure and sensitization rates for regional inhalant allergens. This overview may serve as reference for the practising doctor and suggests a GA2LEN Pan-European core SPT panel.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1398-9995.2005.00895.x

    Articles: DFG German National Licenses
  20. 20
    Kakagia, D. ; Tamiolakis, D. ; Alexiadis, G. ; Lambropoulou, M. ; Manavis, J. ; Grekou, A. ; Papadopoulos, N.

    Oxford, UK : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1365-2230
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2230.2004.01666.x

    Articles: DFG German National Licenses