Search Results - (Author, Cooperation:N. M. Cohen)

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  1. 1
    Z. Shipony ; Z. Mukamel ; N. M. Cohen ; G. Landan ; E. Chomsky ; S. R. Zeliger ; Y. C. Fried ; E. Ainbinder ; N. Friedman ; A. Tanay
    Nature Publishing Group (NPG)
    Published 2014
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    Publication Date:
    2014-07-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Cell Line ; Cell Line, Tumor ; Clone Cells/cytology/metabolism ; *DNA Methylation ; Embryonic Stem Cells/cytology/metabolism ; *Epigenesis, Genetic ; Fibroblasts/cytology/*metabolism ; Genome, Human/genetics ; Humans ; Induced Pluripotent Stem Cells/cytology/*metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    LEDERER, W. J. ; BERLIN, J. R. ; COHEN, N. M. ; HADLEY, R. W. ; BERS, D. M. ; CANNELL, M. B.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1990
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    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1990.tb13210.x

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1432-0428
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01219441

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1573-4919
    Keywords:
    excitation-contraction coupling ; mammalian heart muscle ; calcium current ; fura-2 ; intracellular calcium ; sodium-calcium exchange
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Notes:
    Abstract We have investigated the links between electrical excitation and contraction in mammalian heart muscle. Using isolated single cells from adult rat ventricle, a whole-cell voltage-clamp technique and quantitative fluorescence microscopy, we have measured simultaneously calcium current (Ica) and [Ca2+]i (with fura-2). We find that the voltage-dependence of Ica and the [Ca 2+]i-transient and the dependence of [Ca2+]i-transient on depolarization-duration cannot both be readily explained by a simple calcium-induced Ca-release (‘CICR’) mechanism. Additionally, we find that when [Ca2+]i and [Na+]i are at their diastolic levels, activation of the Na-Ca exchange mechanism by depolarization does not measurably trigger the release of Ca2+i. Finally, measuring Ica in adult and neonatal rat heart cells and using the alkaloid ryanodine, we have carried out complementary experiments. These experiments show that there may be an action of ryanodine on Ica that is independent of [Ca2+]i and independent of a direct action of the alkaloid on the calcium channel itself. Along with experiments of others showing that ryanodine binds to the sarcoplasmic reticulum calcium-release channel/spanning protein complex, our data suggests a model to explain our findings. The model links the calcium channels responsible for Ica to the sarcoplasmic reticulum by means of one or more of the spanning protein(s). Information from the calcium channel can be communitated to the sarcoplasmic reticulum by this route and, presumably, information can move in the opposite direction from the sarcoplasmic reticulum to the calcium channel.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00220762

    Articles: DFG German National Licenses