Search Results - (Author, Cooperation:N. Kayagaki)
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1Latest Papers from Table of Contents or Articles in PressN. Kayagaki ; M. T. Wong ; I. B. Stowe ; S. R. Ramani ; L. C. Gonzalez ; S. Akashi-Takamura ; K. Miyake ; J. Zhang ; W. P. Lee ; A. Muszynski ; L. S. Forsberg ; R. W. Carlson ; V. M. Dixit
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-07-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Caspases/biosynthesis ; Cholera Toxin/immunology ; Disease Models, Animal ; Escherichia coli/immunology ; Escherichia coli Infections/genetics/immunology ; *Immunity, Innate ; Inflammasomes/*immunology ; Lipid A/genetics/*immunology ; Macrophages/*immunology ; Mice ; Mice, Mutant Strains ; Mutation ; Salmonella Infections/immunology ; Salmonella typhimurium/immunology ; Sepsis/immunology ; Toll-Like Receptor 4/*immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressP. Broz ; T. Ruby ; K. Belhocine ; D. M. Bouley ; N. Kayagaki ; V. M. Dixit ; D. M. Monack
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-08-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adjuvants, Immunologic/pharmacology ; Animals ; Caspases/*metabolism ; Cell Death ; Cells, Cultured ; Disease Susceptibility/*enzymology ; Gene Expression Regulation ; Inflammasomes/immunology ; Interferon-gamma/pharmacology ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects/enzymology/microbiology ; Mice ; Mice, Knockout ; Salmonella Infections, Animal/*enzymology/genetics ; Salmonella typhimurium/physiology ; Signal TransductionPublished by: -
3Latest Papers from Table of Contents or Articles in PressS. Rutz ; N. Kayagaki ; Q. T. Phung ; C. Eidenschenk ; R. Noubade ; X. Wang ; J. Lesch ; R. Lu ; K. Newton ; O. W. Huang ; A. G. Cochran ; M. Vasser ; B. P. Fauber ; J. DeVoss ; J. Webster ; L. Diehl ; Z. Modrusan ; D. S. Kirkpatrick ; J. R. Lill ; W. Ouyang ; V. M. Dixit
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-12-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Enzyme Stability ; Female ; Inflammation/genetics/pathology ; Interleukin-17/*biosynthesis ; Intestine, Small/metabolism/pathology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; *Protein Biosynthesis ; Signal Transduction ; Substrate Specificity ; Th17 Cells/*metabolism ; Transforming Growth Factor beta/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Specific Proteases/biosynthesis/deficiency/genetics/*metabolism ; UbiquitinationPublished by: -
4Latest Papers from Table of Contents or Articles in PressN. Kayagaki ; I. B. Stowe ; B. L. Lee ; K. O'Rourke ; K. Anderson ; S. Warming ; T. Cuellar ; B. Haley ; M. Roose-Girma ; Q. T. Phung ; P. S. Liu ; J. R. Lill ; H. Li ; J. Wu ; S. Kummerfeld ; J. Zhang ; W. P. Lee ; S. J. Snipas ; G. S. Salvesen ; L. X. Morris ; L. Fitzgerald ; Y. Zhang ; E. M. Bertram ; C. C. Goodnow ; V. M. Dixit
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-09-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressE. Meunier ; M. S. Dick ; R. F. Dreier ; N. Schurmann ; D. Kenzelmann Broz ; S. Warming ; M. Roose-Girma ; D. Bumann ; N. Kayagaki ; K. Takeda ; M. Yamamoto ; P. Broz
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-04-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Autophagy/immunology ; Caspases/*metabolism ; Cytosol/microbiology ; Enzyme Activation ; GTP Phosphohydrolases/*metabolism ; Galectins/immunology ; Gram-Negative Bacteria/growth & development/*immunology/pathogenicity ; Immunity, Innate/immunology ; Inflammasomes/immunology/*metabolism ; Interferon Type I/*immunology ; Lipopolysaccharides/immunology ; Mice ; Phagosomes/immunology/microbiology ; Salmonella typhimurium/growth & development/immunology ; Vacuoles/*microbiologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressN. Kayagaki ; S. Warming ; M. Lamkanfi ; L. Vande Walle ; S. Louie ; J. Dong ; K. Newton ; Y. Qu ; J. Liu ; S. Heldens ; J. Zhang ; W. P. Lee ; M. Roose-Girma ; V. M. Dixit
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Caspase 1/metabolism ; Caspases/genetics/*metabolism ; Citrobacter rodentium/immunology ; Enzyme Activation ; Escherichia coli/immunology ; Immunity, Innate/immunology ; Inflammasomes/*metabolism ; Interleukin-1beta/biosynthesis/secretion ; Lipopolysaccharides/adverse effects/immunology ; Macrophages/immunology/secretion ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Vibrio cholerae/immunologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressY. Qu ; S. Misaghi ; A. Izrael-Tomasevic ; K. Newton ; L. L. Gilmour ; M. Lamkanfi ; S. Louie ; N. Kayagaki ; J. Liu ; L. Komuves ; J. E. Cupp ; D. Arnott ; D. Monack ; V. M. Dixit
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-08-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; CARD Signaling Adaptor Proteins/chemistry/deficiency/genetics/*metabolism ; Calcium-Binding Proteins/chemistry/deficiency/genetics/*metabolism ; Caspase 1/metabolism ; Enzyme Activation ; Gene Knock-In Techniques ; Humans ; Immunity, Innate/immunology ; Inflammasomes/*metabolism ; Interleukin-1beta/immunology/secretion ; Macrophages/immunology ; Mice ; Molecular Sequence Data ; Phosphorylation ; Protein Conformation ; Protein Kinase C-delta/deficiency/genetics/metabolism ; Salmonella typhimurium/immunology ; Sequence AlignmentPublished by: -
8Articles: DFG German National LicensesTakeda, Y. ; Gotoh, M. ; Dono, K. ; Nishihara, M. ; Grochowiecki, T. ; Kimura, F. ; Yoshida, T. ; Ohta, Y. ; Ota, H. ; Ohzato, H. ; Umeshita, K. ; Takeda, T. ; Matsuura, N. ; Sakon, M. ; Kayagaki, N. ; Yagita, H. ; Okumura, K. ; Miyasaka, M. ; Monden, M.
Springer
Published 1998Staff ViewISSN: 1432-0428Keywords: Keywords Fas ; Fas ligand ; islet transplantation ; testicular tissue ; apoptosis ; composite graft.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Fas ligand (FasL) is highly expressed in testicular tissues and thought to be responsible for protection from allograft rejection by inducing apoptosis of anti-graft activated T cells. FasL-expressing islets have been shown to induce a granulocyte-mediated inflammatory reaction. We investigated whether a graft can be protected from alloimmune responses by manipulating the Fas/FasL-system. We transplanted allogeneic islets under the kidney capsule of streptozotocin-induced diabetic mice together with testicular tissue. Significant prolongation of survival of C3H islet allograft was observed in C57BL/6 (B6) recipients transplanted with C3H testicular tissue, but not in those transplanted with C3H-gld testicular tissue expressing non-functional FasL. No significant prolongation was observed in B6-lpr recipients expressing non-functional Fas. Immunohistochemical staining of C3H testicular tissue in the composite graft showed a high expression of FasL, but not that of the C3H-gld testicular tissue. In situ terminal deoxynucleotidyl transferase-mediated dUDP-biotin catalysed DNA nick-end labelling (TUNEL) staining of a composite graft of C3H islet and testicular tissue in B6 recipients demonstrated extensive apoptosis of infiltrating mononuclear cells around the graft. The protective effect of C3H testicular tissue was abrogated when anti-FasL monoclonal antibody was administered i. p. postoperatively. Our results suggest that FasL-positive testicular allografts protect composite islet allografts and indicate that manipulation of Fas/FasL mediated apoptosis is a suitable strategy for controlling rejection of islet allografts. [Diabetologia (1998) 41: 315–321]Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesFujihara, T. ; Takeuchi, T. ; Tsubota, K. ; Kayagaki, N. ; Yagita, H. ; Okumura, K. ; Abe, T.
Springer
Published 1998Staff ViewISSN: 1434-9949Keywords: Autoimmune disease ; Enzyme-linked immunosorbent assay ; Sjögren's syndrome ; Soluble Fas/APO-1 proteinSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The aim of the study was to elucidate the involvement of Fas antigen in human autoimmune disease, by analysing serum levels of soluble Fas/APO-1 protein in patients with various autoimmune diseases, including system lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), polymyositis/dermatomyositis (PM/DM), Behçet's syndrome and Sjögren's syndrome (SjS). The levels of soluble Fas/APO-1 in sera were quantitated by a sandwich enzymelinked immunosorbent assay. Soluble Fas/APO-1 levels were significantly increased in serum from patients with primary Sjögren's syndrome (1° SjS) compared with control subjects. However, no significant differences in soluble Fas/APO-1 levels were noted in patients with secondary Sjögren's syndrome (2° SjS) nor in patients with any of the other autoimmune diseases. The soluble Fas/APO-1 level in 1° SjS patients with extraglandular diseases was significantly higher than that in patients without extraglandular diseases. These results suggest that soluble Fas/APO-1 protein may play an important role in the pathogenesis of 1° SS.Type of Medium: Electronic ResourceURL: -
10Latest Papers from Table of Contents or Articles in PressLee, B. L., Stowe, I. B., Gupta, A., Kornfeld, O. S., Roose-Girma, M., Anderson, K., Warming, S., Zhang, J., Lee, W. P., Kayagaki, N.
Rockefeller University Press
Published 2018Staff ViewPublication Date: 2018-09-04Publisher: Rockefeller University PressPrint ISSN: 0022-1007Electronic ISSN: 1540-9538Topics: MedicineKeywords: Innate Immunity and Inflammation, Infectious Disease and Host DefensePublished by: -
11Latest Papers from Table of Contents or Articles in PressOrning, P., Weng, D., Starheim, K., Ratner, D., Best, Z., Lee, B., Brooks, A., Xia, S., Wu, H., Kelliher, M. A., Berger, S. B., Gough, P. J., Bertin, J., Proulx, M. M., Goguen, J. D., Kayagaki, N., Fitzgerald, K. A., Lien, E.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-11-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: ImmunologyPublished by: