Search Results - (Author, Cooperation:N. Howe)
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1Latest Papers from Table of Contents or Articles in PressKunadian, V., Chan, D., Ali, H., Wilkinson, N., Howe, N., McColl, E., Thornton, J., von Wilamowitz-Moellendorff, A., Holstein, E.-M., Burns, G., Fisher, A., Stocken, D., De Soyza, A., On behalf of APPLE COPD-ICON2 Trial Investigators
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-05-27Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Cardiovascular medicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressY. Kang ; X. E. Zhou ; X. Gao ; Y. He ; W. Liu ; A. Ishchenko ; A. Barty ; T. A. White ; O. Yefanov ; G. W. Han ; Q. Xu ; P. W. de Waal ; J. Ke ; M. H. Tan ; C. Zhang ; A. Moeller ; G. M. West ; B. D. Pascal ; N. Van Eps ; L. N. Caro ; S. A. Vishnivetskiy ; R. J. Lee ; K. M. Suino-Powell ; X. Gu ; K. Pal ; J. Ma ; X. Zhi ; S. Boutet ; G. J. Williams ; M. Messerschmidt ; C. Gati ; N. A. Zatsepin ; D. Wang ; D. James ; S. Basu ; S. Roy-Chowdhury ; C. E. Conrad ; J. Coe ; H. Liu ; S. Lisova ; C. Kupitz ; I. Grotjohann ; R. Fromme ; Y. Jiang ; M. Tan ; H. Yang ; J. Li ; M. Wang ; Z. Zheng ; D. Li ; N. Howe ; Y. Zhao ; J. Standfuss ; K. Diederichs ; Y. Dong ; C. S. Potter ; B. Carragher ; M. Caffrey ; H. Jiang ; H. N. Chapman ; J. C. Spence ; P. Fromme ; U. Weierstall ; O. P. Ernst ; V. Katritch ; V. V. Gurevich ; P. R. Griffin ; W. L. Hubbell ; R. C. Stevens ; V. Cherezov ; K. Melcher ; H. E. Xu
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-07-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arrestin/*chemistry/*metabolism ; Binding Sites ; Crystallography, X-Ray ; Disulfides/chemistry/metabolism ; Humans ; Lasers ; Mice ; Models, Molecular ; Multiprotein Complexes/biosynthesis/chemistry/metabolism ; Protein Binding ; Reproducibility of Results ; Rhodopsin/*chemistry/*metabolism ; Signal Transduction ; X-RaysPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1365-2214Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: Background The therapeutic function of play has been investigated in relation to recognized stressors such as hospitalization, illness and medical treatments for ill children. While medical treatments in the past 30 years have improved survival rates, children's psychological experiences and quality of life during and after their illness have received limited attention.Objective The present study investigated the therapeutic effects of play on 3- to 5-year-old children with leukaemia compared with a control group of healthy children.Method The participants with leukaemia (n = 11) were from the external oncology clinic of an urban children's hospital; control children (n = 11) attended a day care centre. Measures included children's experience of stress, social and cognitive play behaviours, and daily mood.Results A series of manova revealed that the children with leukaemia, compared with the control children, engaged in (a) significantly fewer total play behaviours, and in particular less (b) parallel, (c) group and (d) dramatic play. Pearson correlations revealed significant relationships between reports of ‘being happy’ and play only for children with leukaemia. Quantitative and qualitative analyses revealed a pattern of repetitive play activities week after week for children with leukaemia, but not controls.Discussion Findings are discussed in light of the theoretical and practical implications for children undergoing treatment for leukaemia.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesScheffer, J. W. ; Howe, N. ; Gunning, P. W. ; Austin, L.
Oxford, UK : Blackwell Publishing Ltd
Published 1984Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: It has previously been shown that 4S RNA is transported in the optic nerve of the chick, but that no movement of rRNA can be detected. The 4S component behaved as though it were composed mainly of transfer RNA (tRNA), but the possibility remained that it could contain significant amounts of material resulting from RNA degradation. The transport of this 4S component has been examined in more detail to determine its nature. In addition, the transported material was examined to establish whether the transport of tRNA is a general phenomenon or that there are only a limited number of species involved. This was done using the same principles applied in the previous study; i.e., the specific activities of separated 4S RNA species appearing in the optic tectum 4 days after intraocular injection of [3H]uridine were compared with that of 5S RNA, a nontransported species. The separation was accomplished using 2.8-5-10-17% slab polyacrylamide gels, and 18 separate regions of 4S species could be identified. The results show that at least most, if not all 4S RNA species are transported. In a separate series of experiments the 4S RNA was aminoacylated and again separated on slab gels. In this instance, the RNA was labelled with [3H]uridine and the aminoacyl component with [14C]amino acids. Gel profiles of these dual-labelled components showed excellent correspondence between the two labels, demonstrating that 4S RNA species could be aminoacylated and were therefore tRNA species. In contrast to tRNA, the small-molecular-weight RNA (smwRNA), species L (7S RNA) is not transported. This smwRNA is largely cytoplasmic in location, as is tRNA. If the transport system were nonspecific it would be expected that smw-L would also be transported. A number of potential roles for axonal tRNA are considered.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0885-2006Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: EducationPsychologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesKirchner, R.M. ; Mealli, C. ; Bailey, M. ; Howe, N. ; Torre, L.P. ; Wilson, L.J. ; Andrews, L.C. ; Rose, N.J. ; Lingafelter, E.C.
Amsterdam : ElsevierStaff ViewISSN: 0010-8545Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0885-2006Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: EducationPsychologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-1793Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Lethal and certain sublethal effects of salt brines on adults and subadults of two species of penaeid shrimps, Penaeus setiferus and P. aztecus, were examined to evaluate the potential impact of ocean disposal of brine from solution mining of salt domes. Brines, prepared from dome salt or synthetic sea salt diluted with Brazos River (Texas, USA) water or deionized water, were mixed with seawater and dalivered from a proportional diluter to shrimp held (usually) at 25°C. For each combination of species, salt, and diluent, 90-individual trials were conducted in the fall and spring. The effects of temperature were evaluated separately. Median lethal time was strongly dose-dependent: Median lethal concentrations at 48 and 96 h were 654±42 (95% confidence interval) and 540±41 mOsm kg-1 above ambient seawater, respectively, well above the worst-case predictions for the brine-disposal area. Salt type, diluent type, season or species did not significantly affect brine lethality. Mortality was higher for both species at 30°C and lower for P. setiferus and higher for P. aztecus below 25°C. Lethal brine doses produced tachycardia after 6 (P. setiferus) or 12 h (P. aztecus) of brine exposure. Opacity of abdominal muscles increased with brine concentration. Lethal brine concentrations evoked hyperactivity after 0.75–1.5 h of exposure, significant failure to orient after 6 h and a reduction in general activity after 12 h. Behavior and osmoregulation suggest higher sensitivities to brines made with dome salt or river water and in shrimp tested during the cool seasons.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0001-1541Keywords: Chemistry ; Chemical EngineeringSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyProcess Engineering, Biotechnology, Nutrition TechnologyAdditional Material: 8 Ill.Type of Medium: Electronic ResourceURL: