Search Results - (Author, Cooperation:N. Giri)
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1N. Giri ; M. G. Del Popolo ; G. Melaugh ; R. L. Greenaway ; K. Ratzke ; T. Koschine ; L. Pison ; M. F. Gomes ; A. I. Cooper ; S. L. James
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-11-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2L. F. Batista ; M. F. Pech ; F. L. Zhong ; H. N. Nguyen ; K. T. Xie ; A. J. Zaug ; S. M. Crary ; J. Choi ; V. Sebastiano ; A. Cherry ; N. Giri ; M. Wernig ; B. P. Alter ; T. R. Cech ; S. A. Savage ; R. A. Reijo Pera ; S. E. Artandi
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-05-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Cycle Proteins/genetics/metabolism ; Cell Division ; Cellular Reprogramming ; Dyskeratosis Congenita/*genetics/*pathology ; Fibroblasts ; Gene Expression Regulation ; Humans ; Induced Pluripotent Stem Cells/*metabolism/*pathology ; Nuclear Proteins/genetics/metabolism ; RNA/genetics ; Telomerase/genetics/metabolism ; Telomere/enzymology/genetics/metabolism/*pathologyPublished by: -
3Staff View
ISSN: 1572-9052Keywords: Locally best invariant tests ; locally minimax tests ; type D critical regionSource: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract Let X: p × 1, Y: p × 1 be independently and normally distributed p-vectors with unknown means ξ1, ξ2 and unknown covariance matrices Σ1, Σ2 (〉0) respectively. We shall show that Pillai's test, which is locally best invariant, is locally minimax for testing H 0: Σ1=Σ2 against the alternative H 1: % MathType!MTEF!2!1!+-% feaafeart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXafv3ySLgzGmvETj2BSbqefm0B1jxALjhiov2D% aebbfv3ySLgzGueE0jxyaibaiiYdd9qrFfea0dXdf9vqai-hEir8Ve% ea0de9qq-hbrpepeea0db9q8as0-LqLs-Jirpepeea0-as0Fb9pgea% 0lrP0xe9Fve9Fve9qapdbaqaaeGacaGaaiaabeqaamaabaabcaGcba% GaaeiDaiaabkhacaqGOaWaaabmaeaadaaeqaqaaiabgkHiTiaadMea% caGGPaGaaiiiaiabg2da9iaacccacqaHdpWCcaGGGaGaeyOpa4Jaai% iiaiaaicdaaSqaaiaaigdaaeqaniabggHiLdaaleaacaqGYaaabaGa% aeylaiaabgdaa0GaeyyeIuoaaaa!4E3F!\[{\rm{tr(}}\sum\nolimits_{\rm{2}}^{{\rm{ - 1}}} {\sum\nolimits_1 { - I) = \sigma 〉 0} }\]as σ→0. However this test is not of type D among G-invariant tests.Type of Medium: Electronic ResourceURL: -
4Staff View
ISSN: 1420-8938Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 1420-8938Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1420-8938Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 1420-8938Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1420-8938Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 1420-8938Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 1432-2064Source: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Summary A non-commutative analogue of the central limit theorem and the weak law of large numbers has been derived, the analogues of integrable functions being non-commutative polynomials. Without the assumption of positivity higher central limit theorems hold which have no analogy in the classical probabilistic case. The treatment includes this classical case and the convergence to so-called “quasi-free states” in the quantum mechanics of bosons [3, 4].Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 1435-926XSource: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract LetX be ap-normal random vector with unknown mean μ and unknown covariance matrix Σ and letX be partitioned asX=(X (1) ′ ,X (2) ′ , ...,X (r) ′ )′ whereX (j) is a subvector of dimensionp j such that ∑ j=1 r p j =p. We show that the tests, obtained by Dahel (1988), are locally minimax. These tests have been derived to confront Ho: μ=0 versusH 1: μ≠0 on the basis of sample of sizeN, X 1, ..., XN, drawn fromX andr additional samples of sizeN j, U i (j) , i=1, ..., Nj, drawn fromX (1), ...X (r) respectively. We assume that the (r+1) samples are independent and thatN j〉p j forj=0, 1, ..., r (N o≡N andp o≡p). Whenr=2 andp=2, a Monte Carlo study is performed to compare these tests with the likelihood ratio test (LRT) given by Srivastava (1985). We also show that no locally most powerful invariant test exists for this problem.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1435-4373Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Pradimicins are a new class of antifungal compounds currently undergoing preclinical and early phase I clinical trials. The pradimicin structure is characterized by an aglycone of dihydrobenzo (alpha) naphthacenequinone with substitutions by a D-amino acid and hexose sugar. Pradimicins prossess a novel mechanism of action consisting of a specific binding recognition to terminal D-mannosides of the cell wall ofCandida albicans, resulting in the formation of a ternary complex consisting of D-mannoside, pradimicin, and calcium that leads to disruption of the integrity of the fungal cell membrane. Pradimicin in the form of BMS-181184 has broad-spectrum in vitro antifungal activity againstCandida spp.,Cryptococcus neoformans, Aspergillus spp., dematiaceous molds, and the Zygomycetes.Fusarium spp. are comparatively resistant to high concentrations of pradimicin. Initial in vivo studies indicate that pradimicins have antifungal activity against experimental murine disseminated candidiasis and disseminated aspergillosis. Early studies indicate an excellent therapeutic index with no major end-organ toxicity. Pradimicins warrant further investigation for treatment of opportunistic mycoses in immunocompromised hosts.Type of Medium: Electronic ResourceURL: