Search Results - (Author, Cooperation:N. Ferrara)
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1Latest Papers from Table of Contents or Articles in PressJ. A. Stefater, 3rd ; I. Lewkowich ; S. Rao ; G. Mariggi ; A. C. Carpenter ; A. R. Burr ; J. Fan ; R. Ajima ; J. D. Molkentin ; B. O. Williams ; M. Wills-Karp ; J. W. Pollard ; T. Yamaguchi ; N. Ferrara ; H. Gerhardt ; R. A. Lang
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-05-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Blood Vessels/growth & development ; Endothelial Cells/metabolism ; Fibroblasts ; Intracellular Signaling Peptides and Proteins/genetics/metabolism ; LDL-Receptor Related Proteins/genetics/metabolism ; Ligands ; Low Density Lipoprotein Receptor-Related Protein-5 ; Mice ; Myeloid Cells/*metabolism ; Neovascularization, Physiologic/*physiology ; Receptors, G-Protein-Coupled ; Retina/*cytology ; *Signal Transduction ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor ; Receptor-1/deficiency/genetics/*metabolism/secretion ; Wnt Proteins/deficiency/genetics/*metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressS. Rao ; C. Chun ; J. Fan ; J. M. Kofron ; M. B. Yang ; R. S. Hegde ; N. Ferrara ; D. R. Copenhagen ; R. A. Lang
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-01-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Count ; Cell Hypoxia/radiation effects ; Eye/*blood supply/*growth & development/metabolism/radiation effects ; Female ; Fetus/cytology/embryology/metabolism/*radiation effects ; *Light ; Light Signal Transduction/*radiation effects ; Mice ; Mice, Inbred C57BL ; Neovascularization, Pathologic ; Neovascularization, Physiologic/radiation effects ; Photons ; Retinal Ganglion Cells/cytology/metabolism/radiation effects ; Retinal Neurons/cytology/metabolism/*radiation effects ; Rod Opsins/deficiency/genetics/*metabolism ; Vascular Endothelial Growth Factor A/metabolismPublished by: -
3Articles: DFG German National LicensesAbete, P. ; Ferrara, N. ; Rengo, F. ; Vassalle, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. The actions of lidocaine on cardiac pacemaker rhythms were studied in anaesthetized dogs and in Purkinje fibres from hearts of the same animals.2. In vivo, lidocaine (1 mg/ kg, intravenously) slowed the sino-atrial (SA) node rhythm (– 5.0%), and (during vagal stimulation) prolonged ventricular standstill by + 25.1% and slowed the idioventricular rhythm (– 16.7%). A higher dose (4 mg/kg) had more pronounced effects.3. Propranolol also slowed sinus (– 26.2%) and idioventricular (– 27.2%) rhythms, and prolonged ventricular standstill (+ 36.8%). In the presence of propranolol, the effects of lidocaine on idioventricular rhythm were exaggerated.4. In Purkinje fibres driven in vitro, lidocaine (10 μmol/L) decreased contractile force (– 47.9%) and (during the interruption of drive) prolonged the suppression of (+ 53.2%) and slowed the escape rhythm (– 67.0%).5. In the presence of lidocaine the threshold potential was shifted to less negative values and diastolic depolarization slope was decreased (– 23.6%).6. Lidocaine slowed spontaneously active Purkinje fibres, abolished early afterdepolarizations in low [K]0 and slow responses in high [K]0 (by shifting the threshold to less negative values), and antagonized strophanthidin arrhythmias.7. TTX reduced the hyperpolarization by lidocaine in low [K]0 and vice versa.8. We conclude that lidocaine enhances vagally-induced ventricular standstill by depressing the idioventricular rhythm far more than the sinus rhythm, an action enhanced by beta-blockade. Furthermore, lidocaine depresses normal and different types of abnormal automaticity through direct and indirect effects of the blockade of the fast sodium channel.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0022-4731Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesRengo, F. ; Abete, P. ; Landino, P. ; Leosco, D. ; Covelluzzi, F. ; Vitale, D. ; Fedi, V. ; Ferrara, N.
Springer
Published 1993Staff ViewISSN: 1432-1440Keywords: Ubiquinone ; ATP ; Heart failureSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The pathophysiological basis for the use of metabolic therapy in the treatment of heart failure is analyzed. Bioenergetical processes related to ATP bioavailability play a central role in regulating myocardial contractility at rest and on effort. Furthermore, a significant correlation has been demonstrated in diseased heart between ATP content, revealed at endomyocardial biopsy, and systolic and diastolic left ventricular indexes evaluated with invasive and noninvasive methods. Several international investigations demonstrate the beneficial effects of ubiquinone (coenzyme Q10) in the treatment of heart failure. Here the results of a study are reported that was conducted on patients with heart failure treated with ubiquinone. After 7 months of oral drug administration (100 mg/day), a significant improvement was observed in echocardiographic indexes of systolic function, cardiothoracic ratio, and clinical signs and symptoms of congestive heart failure. In conclusion, the introduction of metabolic drugs, such as ubiquinone, in the treatment of heart failure opens new horizons in the therapeutic approach to an ailment that entails substantial human and social costs.Type of Medium: Electronic ResourceURL: