Search Results - (Author, Cooperation:N. Ferrand)
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1Latest Papers from Table of Contents or Articles in PressM. Carneiro ; C. J. Rubin ; F. Di Palma ; F. W. Albert ; J. Alfoldi ; A. M. Barrio ; G. Pielberg ; N. Rafati ; S. Sayyab ; J. Turner-Maier ; S. Younis ; S. Afonso ; B. Aken ; J. M. Alves ; D. Barrell ; G. Bolet ; S. Boucher ; H. A. Burbano ; R. Campos ; J. L. Chang ; V. Duranthon ; L. Fontanesi ; H. Garreau ; D. Heiman ; J. Johnson ; R. G. Mage ; Z. Peng ; G. Queney ; C. Rogel-Gaillard ; M. Ruffier ; S. Searle ; R. Villafuerte ; A. Xiong ; S. Young ; K. Forsberg-Nilsson ; J. M. Good ; E. S. Lander ; N. Ferrand ; K. Lindblad-Toh ; L. Andersson
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-08-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Animals, Domestic/anatomy & histology/*genetics/psychology ; Animals, Wild/anatomy & histology/*genetics/psychology ; Base Sequence ; Behavior, Animal ; Breeding ; Evolution, Molecular ; Gene Frequency ; Genetic Loci ; Genome/genetics ; Molecular Sequence Data ; Phenotype ; Polymorphism, Single Nucleotide ; Rabbits/anatomy & histology/*genetics/psychology ; Selection, Genetic ; Sequence Analysis, DNAPublished by: -
2Latest Papers from Table of Contents or Articles in PressMesange, P., Bouygues, A., Ferrand, N., Sabbah, M., Escargueil, A. E., Savina, A., Chibaudel, B., Tournigand, C., Andre, T., de Gramont, A., Larsen, A. K.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-06-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
3Articles: DFG German National LicensesTosetti, P. ; Bakels, R. ; Colin-Le Brun, I. ; Ferrand, N. ; Gaiarsa, J. L. ; Caillard, O.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The consequences of sustained activation of GABAB receptors on GABAB-mediated inhibition and network activity were investigated in the neonatal rat hippocampus using whole-cell and extracellular field recordings. GABAB-mediated presynaptic control of γ-aminobutyric acid (GABA) release progressively diminished with time in spite of the continued presence of the agonist (100 µm baclofen, 15 min), indicating acute desensitization of presynaptic GABAB-mediated inhibition on GABAergic terminals. By contrast, neither GABAB-mediated inhibition of glutamate release nor postsynaptic GABAB-mediated inhibition seemed to produce this desensitization. Efficacy of presynaptic GABAB receptors was still reduced by 49% 30 min after baclofen washout, suggesting a long timeframe for recovery from desensitization. The 15-min baclofen application was followed by a dramatic modification of the spontaneous network activity, with the occurrence of epileptiform events called ictal-like discharges (ILDs). Extracellular field recordings confirmed the epileptic nature of the discharges that could be recorded up to 4 h after baclofen washout. ILDs did not occur when the GABAB receptor antagonist CGP35348 was coapplied with baclofen. This indicates that ILD induction is a consequence of the sustained activation of GABAB receptors and the correlated changes in GABAB-mediated inhibition. Furthermore, ILDs were also induced when blocking with CGP35348 an amount of GABAB receptors that exactly mimicked the loss of inhibition obtained with desensitization. These results show that presynaptic GABAB-mediated inhibition of GABA release acutely and specifically desensitizes following a sustained application of the GABAB receptor agonist baclofen. Conditions that induce desensitization of the GABAB-mediated responses also trigger persistent epileptiform discharges in the neonatal rat hippocampus.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesAlexandrino, P. J. ; Sousa, C. ; Pereira, A. ; Ferrand, N.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: A genetic polymorphism of adenosine deaminase (ADA), is described for the first time in European shad species, Alosa alosa and Alosa fallax. Significant heterogeneity in gene frequencies was found, both between species and within species.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: The degree of genetic differentiation between European shads, Alosa alosa and A. fallax, was studied in populations from different Portuguese hydrographic basins. Using isoelectric focusing, polymorphic variation was detected in a haemoglobin (HB) chain and in adenosine deaminase (ADA). These polymorphisms are shared by the two species but show significant differences in their gene frequency distributions. Individuals with intermediate morphological characteristics were found to exhibit intermediate allele frequencies. While not completely excluding introgression, our results strongly support the existence of two distinct species that can hybridize.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1600-0633Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyAgriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Abstract– Allozyme and other protein loci were examined to study the genetic structure of Portuguese brown trout (Salmo trutta) populations. A total of 247 individuals from three tributaries of the Lima hydrological basin and a hatchery, all located in northern Portugal, were analyzed. Four of 22 protein coding loci were found to be polymorphic: CK-A1*, GPI-A2*, MPI-2* and TF*. A new allelc at the latter locus was found in Atlantic populations. The data obtained for Portuguese brown trout were compared with published data for 14 European populations and three hatchery stocks. Six polymorphic loci (CK-A1*, GPI-A2*, GPI-B2*, LDH-C*, ME* and MPI-2*) were used in a cluster analysis. This showed the similarity of Portuguese natural populations and northern Iberian populations and that Portuguese hatchery fish have an autochthonous origin, distinct from that of other Atlantic hatchery stocks.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesASTESANO, A. ; FERRAND, N. ; BENDAYAN, M. ; ROSSELIN, G.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesA Highly Polymorphic Plasma Protein Locus in Brown Trout (Salmo trutta L.) Populations from PortugalStaff View
ISSN: 1573-4927Keywords: plasma protein ; polymorphism ; isoelectric focusing ; brown trout; Salmo trutta ; salmonids.Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNotes: Abstract Genetic polymorphism of an unidentified plasma protein (PX) is described for the first time in Salmo trutta (L.) by means of isoelectric focusing. The analysis of 414 individuals from different geographic origins in Portugal allowed the identification of nine alleles. Heterozygosity in natural populations is generally above 0.60, thus giving similar values to those reported for brown trout microsatellite loci. Substructuring of Portuguese brown trout is evident between northern and southern basins. Genetic affinities between the southernmost rivers and the hatchery stock were detected, suggesting the existence of recent stocking influences.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1573-4927Keywords: PEPTIDASES ; RABBIT ; ELECTROPHORESIS ; GENETIC POLYMORPHISM ; HETEROZYGOSITY ; CLINAL ; VARIATIONSource: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNotes: Abstract Genetic polymorphism of peptidases A, B, C, andD in the wild rabbit (Oryctolagus cuniculus)was assessed by horizontal starch gel electrophoresis,in a total of 1003 individuals comprising 16 Iberian and 2 French populations and 1 domestic stock.Twenty-five different alleles were detected: 6 in PEPA,4 in PEPB, 8 in PEPC, and 7 in PEPD. The highest valuesof observed heterozygosity averaged over the four loci were obtained for the southwestern Iberianpopulations and a clinal loss of variability in anortheastern direction was detected. A clear separationbetween the two putative subspecies O. c.cuniculus and O. c. algirus was notobtained.Type of Medium: Electronic ResourceURL: