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1Latest Papers from Table of Contents or Articles in PressS. Sawcer ; G. Hellenthal ; M. Pirinen ; C. C. Spencer ; N. A. Patsopoulos ; L. Moutsianas ; A. Dilthey ; Z. Su ; C. Freeman ; S. E. Hunt ; S. Edkins ; E. Gray ; D. R. Booth ; S. C. Potter ; A. Goris ; G. Band ; A. B. Oturai ; A. Strange ; J. Saarela ; C. Bellenguez ; B. Fontaine ; M. Gillman ; B. Hemmer ; R. Gwilliam ; F. Zipp ; A. Jayakumar ; R. Martin ; S. Leslie ; S. Hawkins ; E. Giannoulatou ; S. D'Alfonso ; H. Blackburn ; F. Martinelli Boneschi ; J. Liddle ; H. F. Harbo ; M. L. Perez ; A. Spurkland ; M. J. Waller ; M. P. Mycko ; M. Ricketts ; M. Comabella ; N. Hammond ; I. Kockum ; O. T. McCann ; M. Ban ; P. Whittaker ; A. Kemppinen ; P. Weston ; C. Hawkins ; S. Widaa ; J. Zajicek ; S. Dronov ; N. Robertson ; S. J. Bumpstead ; L. F. Barcellos ; R. Ravindrarajah ; R. Abraham ; L. Alfredsson ; K. Ardlie ; C. Aubin ; A. Baker ; K. Baker ; S. E. Baranzini ; L. Bergamaschi ; R. Bergamaschi ; A. Bernstein ; A. Berthele ; M. Boggild ; J. P. Bradfield ; D. Brassat ; S. A. Broadley ; D. Buck ; H. Butzkueven ; R. Capra ; W. M. Carroll ; P. Cavalla ; E. G. Celius ; S. Cepok ; R. Chiavacci ; F. Clerget-Darpoux ; K. Clysters ; G. Comi ; M. Cossburn ; I. Cournu-Rebeix ; M. B. Cox ; W. Cozen ; B. A. Cree ; A. H. Cross ; D. Cusi ; M. J. Daly ; E. Davis ; P. I. de Bakker ; M. Debouverie ; B. D'Hooghe M ; K. Dixon ; R. Dobosi ; B. Dubois ; D. Ellinghaus ; I. Elovaara ; F. Esposito ; C. Fontenille ; S. Foote ; A. Franke ; D. Galimberti ; A. Ghezzi ; J. Glessner ; R. Gomez ; O. Gout ; C. Graham ; S. F. Grant ; F. R. Guerini ; H. Hakonarson ; P. Hall ; A. Hamsten ; H. P. Hartung ; R. N. Heard ; S. Heath ; J. Hobart ; M. Hoshi ; C. Infante-Duarte ; G. Ingram ; W. Ingram ; T. Islam ; M. Jagodic ; M. Kabesch ; A. G. Kermode ; T. J. Kilpatrick ; C. Kim ; N. Klopp ; K. Koivisto ; M. Larsson ; M. Lathrop ; J. S. Lechner-Scott ; M. A. Leone ; V. Leppa ; U. Liljedahl ; I. L. Bomfim ; R. R. Lincoln ; J. Link ; J. Liu ; A. R. Lorentzen ; S. Lupoli ; F. Macciardi ; T. Mack ; M. Marriott ; V. Martinelli ; D. Mason ; J. L. McCauley ; F. Mentch ; I. L. Mero ; T. Mihalova ; X. Montalban ; J. Mottershead ; K. M. Myhr ; P. Naldi ; W. Ollier ; A. Page ; A. Palotie ; J. Pelletier ; L. Piccio ; T. Pickersgill ; F. Piehl ; S. Pobywajlo ; H. L. Quach ; P. P. Ramsay ; M. Reunanen ; R. Reynolds ; J. D. Rioux ; M. Rodegher ; S. Roesner ; J. P. Rubio ; I. M. Ruckert ; M. Salvetti ; E. Salvi ; A. Santaniello ; C. A. Schaefer ; S. Schreiber ; C. Schulze ; R. J. Scott ; F. Sellebjerg ; K. W. Selmaj ; D. Sexton ; L. Shen ; B. Simms-Acuna ; S. Skidmore ; P. M. Sleiman ; C. Smestad ; P. S. Sorensen ; H. B. Sondergaard ; J. Stankovich ; R. C. Strange ; A. M. Sulonen ; E. Sundqvist ; A. C. Syvanen ; F. Taddeo ; B. Taylor ; J. M. Blackwell ; P. Tienari ; E. Bramon ; A. Tourbah ; M. A. Brown ; E. Tronczynska ; J. P. Casas ; N. Tubridy ; A. Corvin ; J. Vickery ; J. Jankowski ; P. Villoslada ; H. S. Markus ; K. Wang ; C. G. Mathew ; J. Wason ; C. N. Palmer ; H. E. Wichmann ; R. Plomin ; E. Willoughby ; A. Rautanen ; J. Winkelmann ; M. Wittig ; R. C. Trembath ; J. Yaouanq ; A. C. Viswanathan ; H. Zhang ; N. W. Wood ; R. Zuvich ; P. Deloukas ; C. Langford ; A. Duncanson ; J. R. Oksenberg ; M. A. Pericak-Vance ; J. L. Haines ; T. Olsson ; J. Hillert ; A. J. Ivinson ; P. L. De Jager ; L. Peltonen ; G. J. Stewart ; D. A. Hafler ; S. L. Hauser ; G. McVean ; P. Donnelly ; A. Compston
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Cell Differentiation/immunology ; Europe/ethnology ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; Genome-Wide Association Study ; HLA-A Antigens/genetics ; HLA-DR Antigens/genetics ; HLA-DRB1 Chains ; Humans ; Immunity, Cellular/genetics/*immunology ; Major Histocompatibility Complex/genetics ; Multiple Sclerosis/*genetics/*immunology ; Polymorphism, Single Nucleotide/genetics ; Sample Size ; T-Lymphocytes, Helper-Inducer/cytology/immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. Zhong ; M. P. Hedges ; R. L. Ahlefeldt ; J. G. Bartholomew ; S. E. Beavan ; S. M. Wittig ; J. J. Longdell ; M. J. Sellars
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-01-09Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressM. L. Wilson ; C. Boesch ; B. Fruth ; T. Furuichi ; I. C. Gilby ; C. Hashimoto ; C. L. Hobaiter ; G. Hohmann ; N. Itoh ; K. Koops ; J. N. Lloyd ; T. Matsuzawa ; J. C. Mitani ; D. C. Mjungu ; D. Morgan ; M. N. Muller ; R. Mundry ; M. Nakamura ; J. Pruetz ; A. E. Pusey ; J. Riedel ; C. Sanz ; A. M. Schel ; N. Simmons ; M. Waller ; D. P. Watts ; F. White ; R. M. Wittig ; K. Zuberbuhler ; R. W. Wrangham
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-09-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Africa ; Aggression/*physiology/*psychology ; Animals ; Animals, Wild/physiology/psychology ; Behavior, Animal/*physiology ; Female ; Food ; *Human Activities ; Humans ; Male ; *Models, Biological ; *Pan paniscus/physiology/psychology ; *Pan troglodytes/physiology/psychology ; Population Density ; Sexual Behavior, Animal/physiologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-18Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 0167-4781Keywords: Captan ; DNA polymerase I ; ExonucleaseSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1435-1536Keywords: surface structure ; electron microscopy ; transferred multilayer systemSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract The substance-specific stability properties of transferred multilayer systems on germanium and quartz supports have been examined in the electron microscope. Typical micrographs with magnifications between 8 000 x and 40 000 x show that the surface structure of cadmium octadecanoate and octadecylammonium phosphate layer systems is dependent on the investigated parameters: type of substance, material of support, number of layers. Lateral structure rearrangement processes have been observed in the octadecanoate systems forming crystallites on both support materials and all layer numbers. Similar irreversible transformations did not occur in transferred octadecylamine layer systems. The influence of the support material on the surface structure is interpreted as interaction differences between the support and the polar group of the first layer.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1435-1536Keywords: transferred multilayer system ; FTIR spectroscopy ; ATR technique ; octadecanoic acid ; octadecylamineSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract An ATR attachment was adapted to a FTIR spectrometer. The increased sensitivity makes it possible to measure spectra of transferred monolayers. The characteristic vibrational frequencies of the transferred multilayer systems of two different substance types (octadecanoic acid, octadecylamine) were investigated in dependence on the layer number. A direct correlation between the absorbance and the transferred substance quantity was found. The absence of interaction between the first layer and the germanium surface was evidenced by the lack of a difference between multilayer spectra divided by the layer number, and the measured spectrum of one layer.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-055XKeywords: Schlüsselwörter: Autologe Transfusion – Spendeintervalle – Erythropoese ; Key words: Autologous transfusion – Intervals between donation sessions – ErythropoiesisSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Abstract. Homologous transfusion is associated with infectious and immunological risks. Preoperative autologous deposit reduces homologous transfusion requirements considerably. Usually donations are carried out at weekly intervals. In this study we investigated the effect of shorter donation intervals on erythropoiesis and perioperative transfusion requirements. Methods. A total of 40 consecutive patients scheduled for hip arthroplasty and taking part in an autologous donation programme were randomly assigned to two groups: group I gave blood on day 0, 3, 7 (and 14), group II at weekly intervals. The aim was deposit of three blood units of 450 ml. A patient was deferred if hemoglobin concentration prior to donation fell below 11 g/dl, and in this case 100 mg Fe2+ three times daily was prescribed. Blood was stored with CPDA-1 anticoagulant. Surgery was performed between day 28 and 35. A perioperative hemoglobin concentration lower than 9 g/dl was considered a transfusion trigger. Results. Group I was made up of 21 patients (10 women, 11 men, aged 39 – 69 years) who gave blood at short intervals, and group II of 19 patients (10 women, 9 men, aged 37 – 77 years) who gave blood at weekly intervals. General data, calculated blood volume and erythrocyte mass prior to donation were comparable. Each patient donated three units. Four patients had to be deferred once, one in group I, three in group II. The hemoglobin concentration in group I decreased from 13.9±1.2 g/dl (x±SD) to 13.3±1.0 g/dl prior the operation, in group II from 13.5±1.3 g/dl to 12.5±1.1 g/dl. Preoperatively the hemoglobin concentrations differed significantly (P〈0.05), as did calculated erythrocyte mass (1633 versus 1474 ml, P〈0.05). Reticulocytes increased from 46×103/µl (median) to a maximum of 94×103/µl on day 7 in group I, and from 44×103/µl to 108×103/µl in group II on day 14. Serum ferritin decreased from 122 µg/l (median) to 82 µg/l in group I, and from 140 µg/l to 77 µg/l in group II. These parameters did not differ statistically between the two groups. Intra- and postoperative blood loss amounted to 2175 ml (median) in group I versus 1430 ml in group II (P〈0.05). The perioperative hemoglobin concentration was similar in the two groups. Homologous transfusion requirements were similar in the two groups (1 unit in group I, vs 3 units in one patient and 1 unit in two patients in group II). Conclusions. Short donation intervals resulted in a higher preoperative erythrocyte mass after similar preoperative deposit, and significantly higher blood loss was tolerated with similar homologous transfusion volume.Notes: Zusammenfassung. In einer prospektiven, randomisierten Studie wurde untersucht, ob kürzere Spendeintervalle im Vergleich zu wöchentlichen bei gleichem zeitlichen Beginn vor dem Operationstermin zu einer ausgeprägteren Steigerung der Erythropoese während der Eigenblutspende und damit zu einem geringeren intra- und postoperativen Transfusionsbedarf führen. An der Untersuchung nahmen 40 Patienten teil, die zur Implantation einer Hüftgelenkendoprothese vorgesehen waren. Mit der Eigenblutspende wurde 4 Wochen vor der Woche begonnen, in der die Operation geplant war. Angestrebt wurde die Abnahme von 3 Vollblutkonserven zu 450 ml. Als Stabilisator wurde CPD-A 1 verwandt. Lag die Hämoglobinkonzentration vor der Spende unter 11 g/dl, wurde die Spende auf den nächsten Termin bzw. um eine Woche verschoben. Die Patienten erhielten vom Beginn der Spende bis zum Operationstag 3⋅100 mg zweiwertiges Eisen pro Tag. 19 Patienten (Gruppe II: 10 Frauen, 9 Männer) spendeten in wöchentlichen Intervallen, 21 Patienten (Gruppe I: 10 Frauen, 11 Männer) an den Tagen 0, 3 und 7. Die allgemeinen Daten und das errechnete Blutvolumen der beiden Gruppen waren vergleichbar. In beiden Untersuchungsgruppen fiel die Hämoglobinkonzentration vom Wert vor der ersten Spende (13,9±1,17 g/dl Gruppe 1; 13,5±1,29 g/dl Gruppe 2; x±s) bis zum Operationstermin signifikant ab (13,3±1,05 g/dl bzw. 12,5±1,14 g/dl). Der Unterschied zwischen den beiden Gruppen zum Operationszeitpunkt ist signifikant (p〈0,05). Der Abfall der Serumeisen- und Serumferritinkonzentrationen in beiden Gruppen war vergleichbar. Der erfaßte Gesamtblutverlust lag in Gruppe I (Median 2175 ml) signifikant höher als in Gruppe II (1430 ml). Da sich trotz des signifikant höheren Blutverlusts in Gruppe I (kurzes Spendeintervall) ein niedrigerer, allerdings nicht signifikant niedrigerer, homologer Transfusionsbedarf ergab (20 von 21 Patienten in Gruppe I ohne homologe Transfusion, gegenüber 16 von 19 Patienten in Gruppe II), erscheint die Eigenblutspende in kurzen Intervallen vorteilhaft.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1573-4919Keywords: reverse transcriptase ; captan ; RNA dependent-DNA polymerase ; RNase H activitySource: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyMedicineNotes: Summary The inhibitor captan (N-trichloromethylthio-4-cyclohexen-1,2-dicarboximide) was used to explore the ribonuclease H (RNase H) active site of avian myeloblastosis virus (AMV) reverse transcriptase. Gel permeation chromatography of purified enzyme showed that [l4C]captan bound to the a subunit in a ratio of 10:1 and to a 32,000 d polypeptide in a ratio of 4:1. Neither the αβ nor the β subunit bound [l4C]captan. The binding of 5 of the captan molecules was prevented by preincubating enzyme with polynucleotide. Deoxyguanosine triphosphate (dGTP) protected the enzyme against the binding of 4 captan molecules. Each holoenzyme bound 2 molecules of [3H]dGTP in the absence of, and 1 molecule of [3H]dGTP in the presence of 1 mM captan. Ribonuclease H activity was inhibited when AMV reverse transcriptase was preincubated with 1 mM captan before the degradative reaction was initiated. Preincubation of enzyme with polynucleotide before exposure to captan could partially protect the RNase H activity (61 ± 2% activity remained). Deoxyguanosine triphosphate also partially protected the RNase H activity from inhibition by captan (75 ± 9% activity remained). Inhibition of the RNase H activity was completely prevented by preincubating enzyme simultaneously with polynucleotide and dGTP. When separated by glycerol gradients the α subunit and αβ dimer both exhibited RNase H activity, but only the RNase H activity of the α subunit was inhibited by captan. Activity and binding studies revealed that the RNase H and polymerase activities of the α subunit are not susceptible to the interaction of captan when this subunit is in the αβ dimer form. Thus, either β subunit, upon association with a physically blocks the captan binding sites, or the interaction of β subunit with α subunit causes a conformational change in the α subunit making it incapable of binding captan.Type of Medium: Electronic ResourceURL: