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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-08-01Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
2Latest Papers from Table of Contents or Articles in PressF. F. Soon ; L. M. Ng ; X. E. Zhou ; G. M. West ; A. Kovach ; M. H. Tan ; K. M. Suino-Powell ; Y. He ; Y. Xu ; M. J. Chalmers ; J. S. Brunzelle ; H. Zhang ; H. Yang ; H. Jiang ; J. Li ; E. L. Yong ; S. Cutler ; J. K. Zhu ; P. R. Griffin ; K. Melcher ; H. E. Xu
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-11-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Abscisic Acid/chemistry/*metabolism ; Amino Acid Sequence ; Arabidopsis/chemistry/*metabolism ; Arabidopsis Proteins/antagonists & inhibitors/*chemistry/*metabolism ; Catalytic Domain ; Crystallography, X-Ray ; Enzyme Activation ; Models, Molecular ; *Molecular Mimicry ; Molecular Sequence Data ; Phosphoprotein Phosphatases/*chemistry/*metabolism ; Phosphorylation ; Protein Binding ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/*chemistry/*metabolism ; Recombinant Fusion Proteins/chemistry/metabolism ; Signal TransductionPublished by: -
3Latest Papers from Table of Contents or Articles in PressJ. R. Friedman ; L. L. Lackner ; M. West ; J. R. DiBenedetto ; J. Nunnari ; G. K. Voeltz
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-09-03Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; COS Cells ; Cercopithecus aethiops ; Endoplasmic Reticulum/*physiology/*ultrastructure ; GTP Phosphohydrolases/genetics/metabolism ; Humans ; Membrane Proteins/genetics/metabolism ; Microscopy, Electron ; Microscopy, Fluorescence ; Microtubule-Associated Proteins/genetics/metabolism ; Mitochondria/*physiology/ultrastructure ; Mitochondrial Proteins/genetics/metabolism ; Saccharomyces cerevisiae/*ultrastructure ; Saccharomyces cerevisiae Proteins/genetics/metabolism ; TransfectionPublished by: -
4Latest Papers from Table of Contents or Articles in PressY. Kang ; X. E. Zhou ; X. Gao ; Y. He ; W. Liu ; A. Ishchenko ; A. Barty ; T. A. White ; O. Yefanov ; G. W. Han ; Q. Xu ; P. W. de Waal ; J. Ke ; M. H. Tan ; C. Zhang ; A. Moeller ; G. M. West ; B. D. Pascal ; N. Van Eps ; L. N. Caro ; S. A. Vishnivetskiy ; R. J. Lee ; K. M. Suino-Powell ; X. Gu ; K. Pal ; J. Ma ; X. Zhi ; S. Boutet ; G. J. Williams ; M. Messerschmidt ; C. Gati ; N. A. Zatsepin ; D. Wang ; D. James ; S. Basu ; S. Roy-Chowdhury ; C. E. Conrad ; J. Coe ; H. Liu ; S. Lisova ; C. Kupitz ; I. Grotjohann ; R. Fromme ; Y. Jiang ; M. Tan ; H. Yang ; J. Li ; M. Wang ; Z. Zheng ; D. Li ; N. Howe ; Y. Zhao ; J. Standfuss ; K. Diederichs ; Y. Dong ; C. S. Potter ; B. Carragher ; M. Caffrey ; H. Jiang ; H. N. Chapman ; J. C. Spence ; P. Fromme ; U. Weierstall ; O. P. Ernst ; V. Katritch ; V. V. Gurevich ; P. R. Griffin ; W. L. Hubbell ; R. C. Stevens ; V. Cherezov ; K. Melcher ; H. E. Xu
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-07-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arrestin/*chemistry/*metabolism ; Binding Sites ; Crystallography, X-Ray ; Disulfides/chemistry/metabolism ; Humans ; Lasers ; Mice ; Models, Molecular ; Multiprotein Complexes/biosynthesis/chemistry/metabolism ; Protein Binding ; Reproducibility of Results ; Rhodopsin/*chemistry/*metabolism ; Signal Transduction ; X-RaysPublished by: -
5Latest Papers from Table of Contents or Articles in PressJ. A. Morgan ; D. R. LeCain ; E. Pendall ; D. M. Blumenthal ; B. A. Kimball ; Y. Carrillo ; D. G. Williams ; J. Heisler-White ; F. A. Dijkstra ; M. West
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Atmosphere/chemistry ; Biomass ; Carbon Dioxide/metabolism/*pharmacology ; Desert Climate ; *Desiccation ; *Ecosystem ; *Global Warming ; Photosynthesis/*drug effects/physiology ; Plant Stomata/metabolism ; Plant Transpiration ; Poaceae/*drug effects/*growth & development/metabolism ; Seasons ; Soil/chemistry ; Volatilization ; Water/analysis ; WyomingPublished by: -
6Articles: DFG German National LicensesMeyer, Edwin M. ; M. West, Christopher ; Stevens, Bruce R. ; Chau, Vincent ; Nguyen, Minh-thanh ; Judkins, Jennifer H.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Affinity-purified antibodies specific for ubiquitin were found to inhibit the sodium-dependent uptake of [3H]choline, r-[3H]aminobutyric acid ([3H]GABA), [3H]-glutamate, [3H]norepinephrine, [3H]aspartate, and [3H]scrotonin in rat cerebral cortical synaptosomes at a low concentration (10 μg/ml). These antibodies (termed anti-Uh) had no effect on the sodium-independent uptake of these substances or their calcium-dependent efflux. Synaptosomal [3H]deoxyglucose uptake was not affected in normal Krebs Ringer buffer containing 10 mM glucose, but was inhibited in glucose-free medium. Other nonneuronal sodium-dependent transport processes were found to be unaffected by 10 μg/ml anti-Ub, suggesting that anti-Ub does not bind indiscriminantly to sodium-binding sites on sodium-dependent organic solute transporters. Finally, anti-Ub inhibited sodium-dependent [3H]GABA and [3H]glutamate uptake in plasma membrane ghosts, devoid of membrane potential, which were derived from rat cerebral cortical synaptosomes. These results suggest that neuronal transporters or sites proximal to them may be ubiquitinylated on the plasma membrane surface.Type of Medium: Electronic ResourceURL: -
7Latest Papers from Table of Contents or Articles in PressArends, M., Biegstraaten, M., Wanner, C., Sirrs, S., Mehta, A., Elliott, P. M., Oder, D., Watkinson, O. T., Bichet, D. G., Khan, A., Iwanochko, M., Vaz, F. M., van Kuilenburg, A. B. P., West, M. L., Hughes, D. A., Hollak, C. E. M.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-04-28Publisher: BMJ Publishing GroupPrint ISSN: 0022-2593Electronic ISSN: 1468-6244Topics: MedicineKeywords: Open accessPublished by: -
8Articles: DFG German National LicensesBiegon, A. ; Alvarado, M. ; Budinger, T. F. ; Grossman, R. ; Hensley, K. ; West, M. S. ; Kotake, Y. ; Ono, M. ; Floyd, R. A.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Following induction of acute neuroinflammation by intracisternal injection of endotoxin (lipopolysaccharide) in rats, quantitative autoradiography was used to assess the regional level of microglial activation and glutamate (NMDA) receptor binding. The possible protective action of the antioxidant phenyl-tert-butyl nitrone in this model was tested by administering the drug in the drinking water for 6 days starting 24 hafter endotoxin injection. Animals were killed 7 days post-injection and consecutive cryostat brain sections labeled with [3H]PK11195 as a marker of activated microglia and [125I]iodoMK801 as a marker of the open-channel, activated state of NMDA receptors. Lipopolysaccharide increased [3H]PK11195 binding in the brain, with the largest increases (two- to threefold) in temporal and entorhinal cortex, hippocampus, and substantia innominata. A significant (〉 50%) decrease in [125I]iodoMK801 binding was found in the same brain regions. Phenyl-tert-butyl nitrone treatment resulted in a partial inhibition (approx. 25% decrease) of the lipopolysaccharide-induced increase in [3H]PK11195 binding but completely reversed the lipopolysaccharide-induced decrease in [125I]iodoMK80 binding in the entorhinal cortex, hippocampus, and substantia innominata. Loss of NMDA receptor function in cortical and hippocampal regions may contribute to the cognitive deficits observed in diseases with a neuroinflammatory component, such as meningitis or Alzheimer's disease.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesKern, S. ; Lander, G. H. ; Soderholm, L. ; Loong, C.-K. ; Trouw, F. ; West, M. ; Hoisington, D. ; Cort, B. ; Welp, U.
College Park, Md. : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Neutron inelastic scattering experiments have been performed on UF4 and NpF4. We had anticipated observing a number of sharp magnetic transitions in these experiments because the tetravalent metal ions are expected to have localized f states. However, very few transitions were observed, three and two in UF4 and NpF4, respectively. Except for the lowest-lying level (at 1.5 meV) in UF4 the transitions are wider than the instrumental resolution, suggesting a strong interaction between the electronic states and lattice vibrations. The levels observed do not correspond to those predicted by a crystal-field scheme recently proposed from optical spectroscopy. However, the paucity of observed levels in our experiments excludes us proposing an alternative scheme. The 1.5 meV energy level in UF4 is in good agreement with that deduced from specific heat and magnetic susceptibility data. © 1994 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesKern, S. ; Hayward, J. ; Roberts, S. ; Richardson, J. W. ; Rotella, F. J. ; Soderholm, L. ; Cort, B. ; Tinkle, M. ; West, M. ; Hoisington, D. ; Lander, G. H.
College Park, Md. : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We have used neutron diffraction on polycrystalline samples of AnF4 (An=Th, U, and Np) to examine the structures. All are isostructural with monoclinic space group C2/c. The structure of UF4 has been examined in some detail as a function of temperature. The volume of the unit cell has a minimum not at lowest temperature (15 K) examined, but rather at ∼350 K. ThF4 also has a larger volume at low rather than room temperature; suggesting that this effect is caused by structural rather than electronic (as ThF4 has no 5f electrons) interactions. An examination of the coordination around the two independent An sites in UF4 shows that the fluorine configuration changes appreciably around An2 as a function of temperature. At low temperatures the distorted cubic antiprism structure is considerably more "puckered'' than at higher temperatures. This puckering requires more volume for the molecule, thus causing the volume to expand as the temperature is lowered. The temperature factors and the interatomic distances vary smoothly with temperature and show no unusual behavior. © 1994 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesGovoni, J. J. ; West, M. A. ; Bonaventura, J. ; Goddette, G. ; Jenkins, T. E.
Oxford, UK; Malden, USA : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: The ontogeny of haematopoiesis in the perciform fish, spot Leiostomus xanthurus, differed from that reported as the norm for fishes, as exemplified by the cypriniform zebrafish Danio rerio, and observed in the batrachoidiform oyster toadfish Opsanus tau. Erythropoiesis in spot was first evident in the head kidney of yolk-sac larvae 3 days after hatching (DAH). No embryonic intermediate cell mass (ICM) of primitive stem cells or blood islands on the yolk were apparent within embryos. Erythrocytes were first evident in circulation near the completion of yolk absorption, c. 5 DAH, when larvae were c. 2·0 mm notochord length (LN). Erythrocyte abundance increased rapidly with larval development for c. 14 to 16 DAH, then became highly variable following changes in cardiac chamber morphology and volume. Erythrocytic haemoglobin (Hb) was not detected within whole larvae until they were 12 DAH or c. 3·1 mm LN, well after yolk and oil-globule absorption. The Hb was not quantified until larvae were 〉47 DAH or 〉7 mm standard length. The delayed appearance of erythrocytes and Hb in spot was similar to that reported for other marine fishes with small embryos and larvae. In oyster toadfish, a marine teleost that exhibits large embryos and larvae, the ICM and Hb were first evident in two bilateral slips of erythropoietic tissue in the embryos, c. 5 days after fertilization. Soon thereafter, erythrocytes were evident in the heart, and peripheral and vitelline circulation. Initial haematopoiesis in oyster toadfish conformed with that described for zebrafish. While the genes that code for the development of haematopoiesis are conserved among vertebrates, gene expression lacks phylogenetic pattern among fishes and appears to conform more closely with phenotypic expression related to physiological and ecological influences of overall body size and environmental oxygen availability.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesWest, M. J. ; Summers, K. M. ; Burstow, D. J. ; Wong, K. K. ; Huggard, P. R.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. The associations between left ventricular hypertrophy (LVH) and specific alleles of the renin and angiotensin-converting enzyme (ACE) genes were studied in patients with essential hypertension and normal blood pressure.2. LVH was present in 42% of those with essential hypertension (n= 72) and 17% of those with normal blood pressure (n= 44).3. The frequency of each renin allele was the same in hypertensive and in normotensive patients. Renin allele frequencies were also the same for those with LVH and those with normal cardiac mass. When only hypertensives were considered, renin alleles were in the same proportion for the groups with and without LVH. Similarly, ACE alleles were not associated with essential hypertension nor with elevated cardiac mass.4. We conclude that, in this population, variations in the renin or ACE genes do not contribute significantly to the development of LVH or to essential hypertension.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. Family and population studies have reported that blood pressure has a heritability of 30–50%, but simple genetic models do not readily explain the patterns of inheritance of hypertension.2. Restriction fragment length polymorphisms were used to study allele frequencies of a selection of candidate genes that may be important in determining the genetic component of hypertension. These included the genes for renin, haptoglobin, neuropeptide Y and cardiac myosin β heavy chain.3. There was no significant association between alleles at any of these loci and the presence of hypertension in this population, suggesting that the contribution of variation at these loci to the genetic component of the variance in hypertension may be quite small.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesMorris, M. J. ; Pilowsky, P. M. ; Minson, J. B. ; West, M. J. ; Chalmers, J. P.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY1. Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline-containing neurons.2. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y-like immunoreactivity into the spinal subarachnoid space.3. These data provide evidence for a functional bulbospinal neuropeptide Y-containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesMorris, M. J. ; Elliott, J. M. ; Cain, M. D. ; Kapoor, V. ; West, M. J. ; Chalmers, J. P.
Oxford, UK : Blackwell Publishing Ltd
Published 1986Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. Neuropeptide Y (NPY) is colocalised with noradrenaline in post-ganglionic sympathetic neurons. In order to examine the possibility that activation of the sympathetic nervous system might cause release of NPY into the plasma NPY levels were measured in 16 patients undergoing exercise tests for investigation of chest pain.2. Plasma NPY concentrations rose in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (s.e.m. = 37) to 455 (s.e.m. = 41) pg/ml.3. Plasma noradrenaline and adrenaline levels increased four- and two-fold respectively.4. The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesWing, L. M. H. ; Bune, A. J. C. ; Chalmers, J. P. ; Graham, J. R. ; West, M. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1981Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. Twelve treated hypertensive patients (ages 58–71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period.2. Blood pressure was increased in all patients throughout the indomethacin treatment period (P〈0.001) - average mean blood pressure increases were 9 mmHg (casual), 8 mmHg (supine), 10 mmHg (standing).3. The blood pressure increase during indomethacin treatment was independent of the particular antihypertensive regimen in use.4. Plasma aldosterone concentration was reduced by 50% (P〈0.01), plasma renin activity was reduced by 43% (P= 0.102) and plasma urea concentration was increased by 17% (P〈0.001) during indomethacin treatment.5. The findings confirm that indomethacin impairs the blood pressure lowering effect of antihypertensive regimens.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesWong, K. K. ; Summers, K. M. ; Burstow, D. J. ; West, M. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. The association of different patterns of left ventricular hypertrophy and diastolic dysfunction with angiotensin converting enzyme (ACE) genotypes or angiotensinogen dinucleotide repeat alleles were studied in human subjects.2. Three abnormal patterns of hypertrophy (remodelled, eccentric and concentric) were associated with a history of hypertension. The presence of remodelled or concentric hypertrophy was associated with diastolic dysfunction.3. There was no difference between the frequencies of the ACE genotypes in normotensive and hypertensive subjects, in subjects with normal ventricles and those with different patterns of left ventricular hypertrophy, nor in subjects with normal and abnormal diastolic function. Similarly, there was no difference between the relative frequencies of AGT alleles in the same clinical subgroups.4. We conclude that in this population of hospital patients, variants of the ACE and AGT genes do not contribute to the presence of different patterns of hypertrophy or to diastolic dysfunction.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesKorner, P. I. ; West, M. J. ; Shaw, J. ; Uther, J. B.
Oxford, UK : Blackwell Publishing Ltd
Published 1974Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY 1. Rises and falls in mean arterial (MAP) and pulse (PP) pressures from the resting value were evoked by intravenous injections of phenylephrine and glyceryl trinitrate, and were related to the reflexly evoked changes in heart period (HP; pulse interval).2. The steady-state properties of the baroreceptor-heart rate reflex were examined by deriving MAP-HP curves in a group of twenty-three healthy normotensive subjects, and in two groups of sixteen and eight subjects with essential hypertension of different severity. Each group was subdivided into two subgroups according to age: (i) 18–30 years; (ii) 33–57 years. The MAP-HP curves are sigmoid and each is characterized by its median blood pressure (BP50), average gain (Ḡ1) and heart period range (HPR).3. In a given age group, the curves are ‘reset’ about a higher BP50 with increasing severity of hypertension. There is progressive reduction in HPR (to 80–55% of normotensive HPR) due to lowering of the upper HP plateau, which probably indicates impairment of function of the vagal component of the reflex. In three out of four hypertensive groups, Ḡ is also significantly reduced to between 60 and 30% of Ḡ of normotensive subjects of the same age.4. The effect of age on the curve parameters is independent of the effects due to hypertension. For a given MAP, Ḡ and HPR are lower in older than in younger subjects.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. The storage of noradrenaline (NA) in hearts of DOCA-salt hypertensive rats was examined after in vivo administration of labelled NA.2. The cardiac N A concentration and the neuronal NA storage capacity were reduced in these rats compared with normotensive controls. The extent of reduction was dependent on the duration of hypertension.3. These findings are similar to observations on spontaneously hypertensive rats and support the hypothesis that storage of the cardiac sympathetic transmitter is impaired in DOCA-salt hypertension.Type of Medium: Electronic ResourceURL: