Search Results - (Author, Cooperation:M. Weksler)
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1Latest Papers from Table of Contents or Articles in PressM. A. O'Leary ; J. I. Bloch ; J. J. Flynn ; T. J. Gaudin ; A. Giallombardo ; N. P. Giannini ; S. L. Goldberg ; B. P. Kraatz ; Z. X. Luo ; J. Meng ; X. Ni ; M. J. Novacek ; F. A. Perini ; Z. Randall ; G. W. Rougier ; E. J. Sargis ; M. T. Silcox ; N. B. Simmons ; M. Spaulding ; P. M. Velazco ; M. Weksler ; J. R. Wible ; A. L. Cirranello
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-08-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Biological Evolution ; Female ; *Fossils ; *Mammals ; *Phylogeny ; PregnancyPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. A. O'Leary ; J. I. Bloch ; J. J. Flynn ; T. J. Gaudin ; A. Giallombardo ; N. P. Giannini ; S. L. Goldberg ; B. P. Kraatz ; Z. X. Luo ; J. Meng ; X. Ni ; M. J. Novacek ; F. A. Perini ; Z. S. Randall ; G. W. Rougier ; E. J. Sargis ; M. T. Silcox ; N. B. Simmons ; M. Spaulding ; P. M. Velazco ; M. Weksler ; J. R. Wible ; A. L. Cirranello
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-02-09Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Base Sequence ; *Biological Evolution ; Dentition ; Ecosystem ; Extinction, Biological ; Female ; *Fossils ; *Mammals/anatomy & histology/classification/genetics ; Paleodontology ; *Phylogeny ; Phylogeography ; Placenta ; Pregnancy ; Sequence Alignment ; Time ; Xenarthra/anatomy & histology/classification/geneticsPublished by: -
3Articles: DFG German National LicensesNOBREGA, A. ; HAURY, M. ; GUERET, R. ; COUTINHO, A. ; WEKSLER, M. E.
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1996Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Serum immunoglobulins reactive with several autoantigens have been reported to increase with age. The authors have studied the reactivity of serum immunoglobulins from mice between 2 and 24 months of age with antigens present in lysates of syngeneic tissue extracts from young mice. The profile of immunoglobulin binding with the immunoblots of spleen and brain tissue increased progressively with age, showing only minor differences from mouse to mouse and, with one exception, revealing that the age-associated increase in binding of immunoglobulins occurred with antigens with the same migratory position in the immunoblots detectable, at lower concentration, in sera from young mice. Not all sera from older mice had increased immunoglobulin binding when tested with extracts of skin, muscle and liver but those that did expressed increased binding with antigens in all three lysates and with the same profile shown by sera from young mice. These results are consistent with the hypothesis that the age-associated increase in autoreactive immunoglobulins represents a selective increase in autoreactive specificities expressed by serum immunoglobulins from young animals at lower levels.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesVIALE, A.-C. ; CHIES, J. A. B. ; HUETZ, F. ; MALENCHERE, E. ; WEKSLER, M. ; FREITAS, A. A. ; COUTINHO, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The cellular composition and Vn-gene family repertoire were compared in different B-cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the Vh J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesBOVBJERG, D. ; KIM, Y. T. ; SISKIND, G. W. ; WEKSLER, M. E.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: Ageing ; Dehydroepiandrosterone ; immunitySource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary Immune senescence is characterized by dysregulation of the immune system. The disorder occurs during old age and is manifested by an increased production of autoantibodies and a decreased production of antibodies to most foreign antigens. These events seem to reflect an altered ratio of activity between the CD5 + and CD5 - B cell subsets. Likewise, there is dysregulation of cytokine production with an increased production of IL-4, IL-5 and IL-6 associated with a decreased production of IL-2. This appears to reflect an altered ratio of activity between the Thl and Th2 cell subsets. Dehydroepiandrosterone (DHEA) is one of the three principal adrenal steroids; its serum concentration declines with age. Recent results suggest that in vitro culture of lymphocytes, from aged donors, with DHEA or in vivo treatment of old mice with DHA sulphate results in the augmentation of the antibody response to foreign antigens and a reversal in the dysregulated cytokine production by T cells. Thus, a decline in one of the three principal adrenal steroids is associated with age-associated changes in the immune system. Some of these changes can be reversed by exposure to DHEA.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesSchleimer, R. P. ; Canonica, G. W. ; Karina, M. ; Indiveri, F. ; Marone, G. ; Weksler, M. E.
Springer
Published 1993Staff ViewISSN: 1432-1041Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: