Search Results - (Author, Cooperation:M. W. Kirschner)
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1Latest Papers from Table of Contents or Articles in PressY. Lu ; B. H. Lee ; R. W. King ; D. Finley ; M. W. Kirschner
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-04-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Cyclin B/metabolism ; Geminin/metabolism ; Humans ; Kinetics ; Proteasome Endopeptidase Complex/chemistry/*metabolism ; Protein Binding ; Protein Transport ; *Proteolysis ; Securin/metabolism ; Stochastic Processes ; Ubiquitin/chemistry/*metabolism ; Ubiquitinated Proteins/chemistry/*metabolism ; UbiquitinationPublished by: -
2Latest Papers from Table of Contents or Articles in PressY. Lu ; W. Wang ; M. W. Kirschner
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-04-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Anaphase-Promoting Complex-Cyclosome/antagonists & ; inhibitors/chemistry/*metabolism ; Cell Cycle ; Cyclin A/metabolism ; Cyclin B/metabolism ; Feedback, Physiological ; Fluorescence ; Fluorescent Dyes ; HeLa Cells ; Humans ; Kinetics ; Protein Binding ; Protein Interaction Domains and Motifs ; SMN Complex Proteins/metabolism ; Substrate Specificity ; Ubiquitin/metabolism ; UbiquitinationPublished by: -
3Latest Papers from Table of Contents or Articles in PressJ. M. Berg ; N. Bhalla ; P. E. Bourne ; M. Chalfie ; D. G. Drubin ; J. S. Fraser ; C. W. Greider ; M. Hendricks ; C. Jones ; R. Kiley ; S. King ; M. W. Kirschner ; H. M. Krumholz ; R. Lehmann ; M. Leptin ; B. Pulverer ; B. Rosenzweig ; J. E. Spiro ; M. Stebbins ; C. Strasser ; S. Swaminathan ; P. Turner ; R. D. Vale ; K. VijayRaghavan ; C. Wolberger
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressO. Simakov ; T. Kawashima ; F. Marletaz ; J. Jenkins ; R. Koyanagi ; T. Mitros ; K. Hisata ; J. Bredeson ; E. Shoguchi ; F. Gyoja ; J. X. Yue ; Y. C. Chen ; R. M. Freeman, Jr. ; A. Sasaki ; T. Hikosaka-Katayama ; A. Sato ; M. Fujie ; K. W. Baughman ; J. Levine ; P. Gonzalez ; C. Cameron ; J. H. Fritzenwanker ; A. M. Pani ; H. Goto ; M. Kanda ; N. Arakaki ; S. Yamasaki ; J. Qu ; A. Cree ; Y. Ding ; H. H. Dinh ; S. Dugan ; M. Holder ; S. N. Jhangiani ; C. L. Kovar ; S. L. Lee ; L. R. Lewis ; D. Morton ; L. V. Nazareth ; G. Okwuonu ; J. Santibanez ; R. Chen ; S. Richards ; D. M. Muzny ; A. Gillis ; L. Peshkin ; M. Wu ; T. Humphreys ; Y. H. Su ; N. H. Putnam ; J. Schmutz ; A. Fujiyama ; J. K. Yu ; K. Tagawa ; K. C. Worley ; R. A. Gibbs ; M. W. Kirschner ; C. J. Lowe ; N. Satoh ; D. S. Rokhsar ; J. Gerhart
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-11-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chordata, Nonvertebrate/classification/*genetics ; Conserved Sequence/genetics ; Echinodermata/classification/genetics ; *Evolution, Molecular ; Genome/*genetics ; Multigene Family/genetics ; Phylogeny ; Signal Transduction ; Synteny/genetics ; Transforming Growth Factor betaPublished by: -
5Latest Papers from Table of Contents or Articles in PressM. Jain ; R. Nilsson ; S. Sharma ; N. Madhusudhan ; T. Kitami ; A. L. Souza ; R. Kafri ; M. W. Kirschner ; C. B. Clish ; V. K. Mootha
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-05-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Breast Neoplasms/genetics/metabolism/pathology ; Cell Cycle ; Cell Line ; Cell Line, Tumor ; *Cell Proliferation ; Cell Transformation, Neoplastic ; Chromatography, Liquid ; Culture Media ; Gene Expression ; Gene Expression Profiling ; Glycine/biosynthesis/*metabolism ; Humans ; Metabolic Networks and Pathways/genetics ; Metabolome ; Mitochondria/enzymology/metabolism ; Neoplasms/genetics/*metabolism/*pathology ; Purines/biosynthesis ; Tandem Mass SpectrometryPublished by: -
6Latest Papers from Table of Contents or Articles in PressH. X. Hao ; Y. Xie ; Y. Zhang ; O. Charlat ; E. Oster ; M. Avello ; H. Lei ; C. Mickanin ; D. Liu ; H. Ruffner ; X. Mao ; Q. Ma ; R. Zamponi ; T. Bouwmeester ; P. M. Finan ; M. W. Kirschner ; J. A. Porter ; F. C. Serluca ; F. Cong
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-05-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Polarity/physiology ; Colorectal Neoplasms/genetics ; DNA-Binding Proteins/deficiency/genetics/metabolism ; Feedback, Physiological ; Female ; Frizzled Receptors/metabolism ; HEK293 Cells ; Humans ; Low Density Lipoprotein Receptor-Related Protein-6/metabolism ; Male ; Mice ; Mice, Knockout ; Oncogene Proteins/deficiency/genetics/metabolism ; Protein Stability ; Protein Structure, Tertiary ; Receptors, G-Protein-Coupled/deficiency/genetics/metabolism ; Receptors, Wnt/*metabolism ; Thrombospondins/*metabolism ; Ubiquitin-Protein Ligases/chemistry/*deficiency/genetics/*metabolism ; Ubiquitination ; Wnt Signaling Pathway ; Xenopus ; Zebrafish ; beta Catenin/metabolismPublished by: -
7Latest Papers from Table of Contents or Articles in PressR. Kafri ; J. Levy ; M. B. Ginzberg ; S. Oh ; G. Lahav ; M. W. Kirschner
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Count ; Cell Cycle/drug effects/*physiology ; Cell Line ; Cell Proliferation ; *Cell Size/drug effects ; Cycloheximide ; Dimethyl Sulfoxide ; *Feedback, Physiological ; G1 Phase/drug effects/physiology ; HeLa Cells ; Humans ; Leupeptins ; Phosphoproteins ; S Phase/physiology ; Single-Cell Analysis/*methods ; SirolimusPublished by: -
8Latest Papers from Table of Contents or Articles in PressP. Liu ; M. Begley ; W. Michowski ; H. Inuzuka ; M. Ginzberg ; D. Gao ; P. Tsou ; W. Gan ; A. Papa ; B. M. Kim ; L. Wan ; A. Singh ; B. Zhai ; M. Yuan ; Z. Wang ; S. P. Gygi ; T. H. Lee ; K. P. Lu ; A. Toker ; P. P. Pandolfi ; J. M. Asara ; M. W. Kirschner ; P. Sicinski ; L. Cantley ; W. Wei
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Apoptosis/genetics ; Cell Cycle/*physiology ; Cell Proliferation ; Cyclin A2/metabolism ; Cyclin-Dependent Kinase 2/metabolism ; Embryonic Stem Cells/cytology/metabolism ; Enzyme Activation ; Male ; Mice ; Multiprotein Complexes/metabolism ; Neoplasms/enzymology/pathology ; Olfactory Bulb/cytology/enzymology/metabolism ; Oncogene Protein v-akt/chemistry/metabolism ; Phosphorylation ; Phosphoserine/metabolism ; Phosphothreonine/metabolism ; Proto-Oncogene Proteins c-akt/*chemistry/*metabolism ; TOR Serine-Threonine Kinases/metabolismPublished by: -
9Latest Papers from Table of Contents or Articles in PressA. R. Hernandez ; A. M. Klein ; M. W. Kirschner
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-11-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Casein Kinase I/chemistry/metabolism ; Cell Line, Tumor ; Cysteine Proteinase Inhibitors/pharmacology ; Glycogen Synthase Kinase 3/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Leupeptins/pharmacology ; Phosphorylation ; *Signal Transduction ; Wnt Proteins/*metabolism ; Wnt3A Protein/metabolism ; beta Catenin/*metabolismPublished by: -
10Latest Papers from Table of Contents or Articles in PressK. L. Cooper ; S. Oh ; Y. Sung ; R. R. Dasari ; M. W. Kirschner ; C. J. Tabin
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bone and Bones/*cytology ; Cell Size ; Cells, Cultured ; Chondrocytes/*cytology ; Growth Plate/*cytology/*growth & development ; Insulin-Like Growth Factor I/metabolism ; Metatarsal Bones/cytology ; Mice ; Tibia/cytologyPublished by: -
11Latest Papers from Table of Contents or Articles in PressZhang, J., Wu, T., Simon, J., Takada, M., Saito, R., Fan, C., Liu, X.-D., Jonasch, E., Xie, L., Chen, X., Yao, X., Teh, B. T., Tan, P., Zheng, X., Li, M., Lawrence, C., Fan, J., Geng, J., Liu, X., Hu, L., Wang, J., Liao, C., Hong, K., Zurlo, G., Parker, J. S., Auman, J. T., Perou, C. M., Rathmell, W. K., Kim, W. Y., Kirschner, M. W., Kaelin, W. G., Baldwin, A. S., Zhang, Q.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-07-20Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Biology, Medicine, DiseasesPublished by: -
12Latest Papers from Table of Contents or Articles in PressBriggs, J. A., Weinreb, C., Wagner, D. E., Megason, S., Peshkin, L., Kirschner, M. W., Klein, A. M.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-06-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Biology, Online OnlyPublished by: -
13Articles: DFG German National LicensesReddy, S. K. ; Rape, M. ; Margansky, W. A. ; Kirschner, M. W.
[s.l.] : Nature Publishing Group
Published 2007Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Eukaryotic cells rely on a surveillance mechanism known as the spindle checkpoint to ensure accurate chromosome segregation. The spindle checkpoint prevents sister chromatids from separating until all kinetochores achieve bipolar attachments to the mitotic spindle. Checkpoint proteins tightly ...Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesValenzuela, P. ; Quiroga, M. ; Zaldivar, J. ; Rutter, W. J. ; Kirschner, M. W. ; Cleveland, D. W.
[s.l.] : Nature Publishing Group
Published 1981Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Most of the mRNA sequences coding for α and β tubulin in embryonic chick brain have been determined by sequencing of cloned cDNA copies of these mRNAs. From a 1,682-base pair cDNA sequence we have deduced the entire protein sequence for β tubulin. For α tubulin, all but about ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesCaron, Joan M. ; Jones, Albert L. ; Rall, Leslie B. ; Kirschner, M. W.
[s.l.] : Nature Publishing Group
Published 1985Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We first examined the effect of anti-microtubule drugs on the cytoplast cytoskeleton. Cytoplasts were prepared as described previously9 from mouse L929 cells and found to be 98 2% free of nuclei, retaining the extensive microtubule arrays found in whole cells (Fig. I A). Microtubules in cytoplasts ...Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1058-8388Keywords: Xenopus laevis ; Tyrosine kinases ; Embryonic development ; Neural crest ; Eph ; Csk ; FGFR ; PDGFR ; Tyk2 ; Klg ; Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: MedicineNotes: Growth factors and their receptors play an important role in controlling cellular proliferation, migration, and differentiation during vertebrate embryogenesis. We have used the reverse transcription-polymerase chain reaction to survey the repertoire of receptor tyrosine kinases (TK) expressed during early embryogenesis of Xenopus laevis. Twelve distinct Xenopus TK cDNA classes were identified among a total of 352 cDNAs screened. A single TK cDNA class has been described previously and encodes the fibroblast growth factor receptor FGFR-A1. The remaining 11 TK cDNA classes appear to encode novel genes of the FGFR, platelet-derived growth factor receptor (PDGFR), Eph, Csk, Tyk2, and Klg subfamilies. By RNase protection assays, Xenopus TK mRNAs are rare transcripts (≤107 mRNA mol-ecules/embryo), and are usually found to be expressed also maternally in the embryo. Most Xenopus TK genes examined by whole-mount in situ hybridization were expressed widely in tissues derived from multiple germ layers. Two Eck-related genes, however, were found to be restricted in their expression to neural crest of the second (hyoid) arch. Our findings are consistent with the proposed function of TKs in the regulation of specification and differentiation of embryonic tissues. ©1995 Wiley-Liss, Inc.Additional Material: 8 Ill.Type of Medium: Electronic ResourceURL: