Search Results - (Author, Cooperation:M. Voorhorst)
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1Latest Papers from Table of Contents or Articles in PressC. A. Diebolder ; F. J. Beurskens ; R. N. de Jong ; R. I. Koning ; K. Strumane ; M. A. Lindorfer ; M. Voorhorst ; D. Ugurlar ; S. Rosati ; A. J. Heck ; J. G. van de Winkel ; I. A. Wilson ; A. J. Koster ; R. P. Taylor ; E. O. Saphire ; D. R. Burton ; J. Schuurman ; P. Gros ; P. W. Parren
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-03-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Membrane/*immunology ; *Complement Activation ; Complement C1/*immunology ; Humans ; Immunoglobulin Fab Fragments/chemistry/immunology ; Immunoglobulin G/*chemistry/immunology ; Liposomes ; Protein Conformation ; Protein MultimerizationPublished by: -
2Articles: DFG German National LicensesBrinkmann, A. O. ; Klaasen, P. ; Kuiper, G. G. J. M. ; Korput, J. A. G. M. ; Bolt, J. ; Boer, W. ; Smit, A. ; Faber, P. W. ; Rooij, H. C. J. ; Geurts van Kessel, A. ; Voorhorst, M. M. ; Mulder, E. ; Trapman, J.
Springer
Published 1989Staff ViewISSN: 1434-0879Keywords: Androgen ; Receptor ; cDNA ; Structure ; HumanSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The androgen receptor in several species (human, rat, calf) is a monomeric protein with a molecular mass of 100–110kDa. The steroid binding domain is confined to a region of 30 kDa, while the DNA-binding domain has the size of approx. 10 kDa. A 40 kDa fragment containing both the DNA and steroid binding domain displayed a higher DNA binding activity than did the intact 100 kDa molecule. cDNA encoding the major part of the human androgen receptor was isolated. The cDNA contains an open reading frame of 2,277 bp but still lacks part of the 5′-coding sequence. Homology with the progesterone and glucocorticoid receptor was about 80% in the DNA binding domain and 50% in the steroid binding domain. The present data provide evidence that the androgen receptor belongs to the superfamily of ligand responsive transcriptional regulators and consists of three distinct domains each with a specialized function.Type of Medium: Electronic ResourceURL: