Search Results - (Author, Cooperation:M. Umlauf)

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  1. 1
    F. Hellal ; A. Hurtado ; J. Ruschel ; K. C. Flynn ; C. J. Laskowski ; M. Umlauf ; L. C. Kapitein ; D. Strikis ; V. Lemmon ; J. Bixby ; C. C. Hoogenraad ; F. Bradke
    American Association for the Advancement of Science (AAAS)
    Published 2011
    Staff View
    Publication Date:
    2011-01-29
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Axons/*physiology ; Cells, Cultured ; Chondroitin Sulfate Proteoglycans/metabolism ; Cicatrix/pathology/*prevention & control ; Female ; Ganglia, Spinal/cytology ; Kinesin/metabolism ; Microtubules/drug effects/*metabolism ; Paclitaxel/*administration & dosage/pharmacology ; Protein Transport ; Rats ; Rats, Sprague-Dawley ; Sensory Receptor Cells/physiology ; Signal Transduction ; Smad2 Protein/metabolism ; Spinal Cord/cytology/drug effects ; Spinal Cord Injuries/*drug therapy/pathology/*physiopathology ; *Spinal Cord Regeneration ; Transforming Growth Factor beta/metabolism
    Published by:
    http://www.aaas.org/

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  2. 2
    Eggli, K. D. ; Close, P. ; Dillon, P. W. ; Umlauf, M. ; Hopper, K. D.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-1998
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract In pediatric oncology, therapeutic decisions are made based on tumor response to chemotherapeutic agents. Sequential measurement of tumor bulk and its percent change on therapy must be accurately assessed. Will 3-dimensional (3-D) volumetric determination improve our ability to assess tumor response to therapy? Forty-five CT scans of pediatric patients with unresectable thoracic or abdominal neoplasia were assessed for tumor bulk by the standard “2-dimensional (2-D)” volume formula (cross-sectional areaxlength) and by 3-D volumetric analysis. Thirty-two examinations were performed in follow-up, and percent change in tumor size was calculated. The 2-D volume calculation overestimated tumor volume by more than 50% on all but two examinations when the 2-D volume was compared with the 3-D volume. In 28% of follow-up examinations, the 2-D calculation of percent change differed by more than 10% from the 3-D volume. Fifteen percent differed by over 25%. This changed the response category of one patient from “no response” to “partial response”. 3-D volumetric analysis, easily performed by a trained technologist, will give more accurate assessment of the actual tumor bulk and its subsequent changes in size in response to therapy. An additional, unexpected benefit of volumetric determination and its accompanying 3-D images was their use and enthusiastic acceptance by clinicians. Pediatric oncologists and surgeons used the sequential images in conferences with parents. In the future, graphic representations of tumor response to therapy might be used in determining the best time for second-look surgery or for other therapeutic manipulations.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02020828

    Articles: DFG German National Licenses