Search Results - (Author, Cooperation:M. Turunen)

2012-11-03

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Adenomatous Polyposis Coli/genetics/pathology ; Animals ; Cell Transformation, Neoplastic/*genetics ; Colon/metabolism/pathology ; Enhancer Elements, Genetic/*genetics ; Humans ; Ileum/metabolism/pathology ; Intestinal Neoplasms/*genetics/pathology ; Mice ; Mice, Mutant Strains ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins c-myc/*genetics

0250-6874

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Electrical Engineering, Measurement and Control Technology

Electronic Resource

0093-691X

DNA ; PCR ; bovine ; embryo ; sexing

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Medicine

Electronic Resource

1433-9285

Springer Online Journal Archives 1860-2000

Medicine

Abstract This register study includes all patients under 18 years in Finland discharged from psychiatric inpatient treatment in 1990 (n = 818) and 1993 (n = 958). The prevalence of children and adolescents in the population who had previously been treated was about 7–8 per 10,000. The incidence of new cases of children and adolescents who had previously been inpatients within the last year was about 5–6 per 10,000 in this age group. The prevalence was lowest in the preschool group (about 1:10,000) and highest in the adolescent group (about 12–14:10,000). About two-thirds of inpatients were boys. Adjustment disorders (DSM-III-R) were the most common diagnosis both in 1990 and 1993 (about 30%). Mood and anxiety disorders were the second most frequent (19–23%) and disruptive behaviour disorders the third most frequent (13–15%) diagnostic category. The diagnostic profiles differed largely according to sex and age.

Electronic Resource

0942-0940

Keywords: Gene therapy; glioma; packaging cells; thymidine kinase.

Springer Online Journal Archives 1860-2000

Medicine

Summary  Background. The purpose of this study was to test the use of Herpes Simplex virus thymidine kinase (HSVtk) retrovirus packaging cell injections in the treatment of malignant brain tumours.  Methods. Therapeutic effect and tissue responses were examined in vivo in a syngeneic BT4C rat glioma model after HSVtk-producing PA317 packaging cell injections and intraperitoneal ganciclovir (GCV) medication. MRI was used to visualise the tumours before and after the treatment. Immunohistochemical stainings were performed to study astroglia and microglia responses and apoptosis-mediated cell death.  Results. The results suggest that only a limited treatment effect can be achieved with HSVtk packaging cell injections with no prolonged survival rates. Histological examination showed a strong astroglia response but only a modest microglia response after the treatment. HSVtk and GCV-induced cell death was at least partially mediated by apoptosis. It is concluded that HSVtk packaging cell injections and GCV treatment do not lead to eradication of malignant cells in a syngeneic BT4C rat glioma model. The lack of efficacy is most likely due to low gene transfer efficiency and limited life span of the injected packaging cells inside the tumours.  Conclusions. Improvements in gene transfer efficiency, and stimulation of immunoresponse against tumour cells might lead to a more effective therapeutic response in vivo.

Electronic Resource

1573-4803

Springer Online Journal Archives 1860-2000

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Abstract A general theoretical model for plastic deformation is presented, which is based on considerations of the variation of internal stored energy during deformation. It is proposed that the deformation rate will always be such that the rate of energy dissipation in the deforming material is minimal. The physical justification of this principle is discussed. The model is applied to dislocation deformation in metals and the result is then compared with experimental observations in aluminium.

Electronic Resource

1435-2451

Springer Online Journal Archives 1860-2000

Medicine

Zusammenfassung An der Klinik der Autoren wird diese Operation seit 8 Jahren ausgeführt. Die hier vorgetragenen Ergebnisse beruhen auf den ersten 400 Fällen aus den Jahren 1965–1969. Die Papillenplastik wurde in ca. 10% aller Gallenblasenoperationen und ca. einem Drittel aller Gallengangsoperationen durchgeführt. Drei Viertel aller Papillenplastiken wurden anläßlich einer Erstoperation an den Gallenwegen durchgeführt, ein Viertel als Zweitoperation. Die wichtigsten Indikationen waren Prophylaxe des Pankreatitis-Rezidivs, multiple Gallensteine und Papillenstenose. Bei der Gesamtzahl der Operationen sahen wir Komplikationen in 9% (35 Fälle). Diese waren meistens zu beherrschen, so daß die Mortalität 2,5% (10 Fälle) betrug. Bei der Auswertung der in 80% durchgeführten Nachunter suchungen ergibt sich folgendes Ergebnis: ca. 60% beschwerdefrei, 35% leichte Beschwerden, 5% keine Besserung.

Summary This operation has been practiced in the authors' hospital since 1965. The results discussed are based on the first 400 operations performed between 1965–1969. About 10% of all gallbladder operations and about one third of all operations on the choledochus were combined with a papilloplastic. In three-quarters of all cases, papilloplastic was performed during a primary operation on the choledochus, and in one quarter during a second operation. The most important indications were prophylaxis of a relapse of pancreatitis, multiple gallstones, and stenosis of the papilla. In these 400 cases the frequency of complications was 9% (35 cases). These complications were controllable in most cases; the mortality was 2.5% (10 cases). 80% of all cases were later examined; 60% were free of pain, 35% had minor symptoms, and in 5% there had been no improvement.

Electronic Resource

1435-2451

Stomach, postoperative ; Cancer, gastric ; Operierte Magen ; Magencarcinom

Springer Online Journal Archives 1860-2000

Medicine

Zusammenfassung 42 von 200 konsekutiven Patienten, die 1956-1957 eine Operation wegen gutartigem peptischem Geschwür durchgemacht hatten, wurden mittels Endoskopie und histologisch nachuntersucht. Die mittlere Beobachtungsdauer betrug 18 Jahre. Veränderungen wurden in vier Gruppen eingeteilt: I. Weder Atrophie noch Gastritis (1), II. Gastritis ohne prominente Schleimhautatrophie (7), III. Prominente atrophische Veränderungen mit merklicher Gastritis (20),IV. Atrophische Schleimhaut ohne Gastritis (14). Die Atrophie wurde histologisch als „selektive Parietalzellatrophie” klassifiziert. Nur 1 Magencarcinom wurde entdeckt statt der erwarteten Frequenz (= 2,27).

Summary Of 200 consecutive patients operated on for benign peptic ulcer in 1956-57, 42 were reexamined endoscopically and histologically in 1974 (20 had had gastric and 22 duodenal ulcers). The mean age was 44 years and the mean follow-up time 18 years. The stump mucosa was normal in one case. Gastritis without mucosal atrophy was found in 7 and prominent atrophy with gastritis in 20 patients. Gastric carcinoma was found in only one of the initial 200 patients; this is a lower incidence than is expected in the general Finnish population (2.27). Fourteen patients had atrophicstump mucosa without gastritis. Histologically this atrophy was classified as “dselective parietal cell atrophy”.

Electronic Resource

1435-2451

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1435-2451

Springer Online Journal Archives 1860-2000

Medicine

Zusammenfassung Zusammenfassend können wir auf Grund unserer Versuche sagen, daß magnesiumoxydhaltiges Stärkehandschuhpulver in der Bauchhöhle von Kaninchen noch nach mindestens 6 Monaten ein Reizfaktor ist, denn nach dieser Zeit konnten wir dort noch Stärkekristalle nachweisen, ein Faktum, das noch nicht allgemein anerkannt ist. Geringe Mengen von Magnesiumoxyd verursachten in der Bauchhöhle nur minimale Veränderungen, und wir sind der Meinung, daß dieses als Bestandteil des Stärkepulvers keine praktische Bedeutung als Reizfaktor hat. Verglichen mit dem Talkpulver ist der Reiz des Stärkepulvers schwächer und kürzer, aber nichtsdestoweniger in Betracht zu ziehen. Ein ideales Operationshandschuhpulver, d. h. ein solches, das keine Fremdkörperreaktion hervorruft, müßte leicht wasserlöslich sowie chemisch und physikalisch reizlos seim. Bis jetzt ist es noch nicht erfunden worden und bis dahin müssen wir eben im klinischen Gebrauch weiterhin Vorsicht üben.

Electronic Resource

1435-2451

Gastrectomy ; Carcinoma, gastric ; Esophagitis ; Magenresektion ; Magen-Carcinom ; Oesophagitis

Springer Online Journal Archives 1860-2000

Medicine

ZusammenfaBung Oesophagitis und OesophaguBtriktur nach totaler Gastrektomie sind recht allgemeine Komplikationen, die den Hauptanteil der postoperativen Beschwerden dieser Patienten verursachen. Da diese Patienten oft in schlechtem Zustand sind, ist das Risiko operativer Eingriffe groB und wir sind deshalb mit recht guten Resultaten zur Anwendung von Eder-Puestow-Dilatatoren übergegangen. Das Perforationsrisiko ist gering und ebenso anschlieBend die Möglichkeit einer Ruptur, falls genügende Vorsicht gewahrt wird.

Summary Of 189 patients operated on for gastric cancer from 1970 to 1975, total gastrectomy was performed in 22% (41) with a mortality of 12%. At follow-up of 2.5 years 56% of patients did not have esophageal symptoms, 25% had chronic, severe esophagitis, 36% developed stenosis. Malignant recidivations caused half of them and in the others the benign scar strictures were often combined with esophagitis. To decrease these late complications, emphasis was placed on preventing alkaline reflux by operative methods. The patients were examined endoscopically and when neceBary, Eder-Puestow dilators were used without complications. Strictures at anastomoses yielded best results. When stenosis and esophagitis were compined, it was in some cases neceBary to repeat dilatations, and in malignant strictures the complaints were relieved transiently.

Electronic Resource