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1Latest Papers from Table of Contents or Articles in PressA. Ichimura ; A. Hirasawa ; O. Poulain-Godefroy ; A. Bonnefond ; T. Hara ; L. Yengo ; I. Kimura ; A. Leloire ; N. Liu ; K. Iida ; H. Choquet ; P. Besnard ; C. Lecoeur ; S. Vivequin ; K. Ayukawa ; M. Takeuchi ; K. Ozawa ; M. Tauber ; C. Maffeis ; A. Morandi ; R. Buzzetti ; P. Elliott ; A. Pouta ; M. R. Jarvelin ; A. Korner ; W. Kiess ; M. Pigeyre ; R. Caiazzo ; W. Van Hul ; L. Van Gaal ; F. Horber ; B. Balkau ; C. Levy-Marchal ; K. Rouskas ; A. Kouvatsi ; J. Hebebrand ; A. Hinney ; A. Scherag ; F. Pattou ; D. Meyre ; T. A. Koshimizu ; I. Wolowczuk ; G. Tsujimoto ; P. Froguel
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-02-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipocytes/metabolism/pathology ; Adipogenesis ; Adipose Tissue/metabolism/pathology ; Animals ; Calcium Signaling ; Cell Differentiation ; DNA Mutational Analysis ; Diet, High-Fat ; Energy Metabolism ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Exons/genetics ; Fatty Liver/complications/genetics ; Gene Expression Regulation ; Glucagon-Like Peptide 1/secretion ; Glucose/metabolism ; Glucose Intolerance/complications ; Humans ; Insulin/metabolism ; Insulin Resistance ; Lipogenesis ; Liver/metabolism ; Macrophages/metabolism ; Mice ; Mutation/genetics ; Obesity/complications/genetics/*metabolism/pathology ; Receptors, G-Protein-Coupled/deficiency/genetics/*metabolism ; Signal Transduction/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-12-13Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 0029-554XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1434-601XSource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract α-particle and proton spectra in coincidence with the 4.44 MeVγ-ray from the12C first excited state have been taken atE τ MeV. Several states in13N and16O are seen to contribute to the decay sequenceα−p andp−α respectively. Estimates are given for the branching of these two decay modes and for a possible simultaneous break-up.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1434-601XSource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract The nucleus16O has been investigated within the excitation range of 25–32 MeV by means of the reaction13C(τ, α)12C* 15.1(γ)12C. Excitation functions for the 15.1 MeVγ-rays, taken for bombarding energiesE τ=2.6–12 MeV at 0Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-1254Source: Springer Online Journal Archives 1860-2000Topics: GeographyPhysicsNotes: Abstract Temperate zone insect species have evolved three general strategies for synchronizing the end of hibernation with the return of favorable conditions. Recent eco-physiological studies of insect dormancy and development indicate that the prevailing concepts of the adaptations regulating hibernation and the resumption of spring activity, need revision. In particular, experimental evidence shows that despite implications in the term, dormancy is a dynamic state; the organism, by constantly monitoring the constantly-changing environmental parameters, is kept in phase with the seasons at its particular locality. Furthermore, the insect's ability to respond to environmental factors generally changes as the season progresses. Therefore, the construction of realistic predictive models of insect seasonality should be based on investigations of natural populations undergoing hibernation in the field, combined with ecologically and physiologically meaningful laboratory studies.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0029-554XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesHanaire-Broutin, H. ; Sallerin-Caute, B. ; Poncet, M. F. ; Tauber, M. ; Bastide, R. ; Chalé, J. J. ; Rosenfeld, R. ; Tauber, J. P.
Springer
Published 1996Staff ViewISSN: 1432-0428Keywords: Keywords Insulin-dependent diabetes mellitus ; implantable pumps ; insulin-like growth factor I ; growth hormone binding protein ; IGF binding proteins.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Low plasma insulin-like growth factor (IGF)-I despite high circulating growth hormone (GH) in insulin-dependent diabetes mellitus (IDDM) indicate a hepatic GH resistance. This state may be reflected by the reduction of the circulating GH binding protein (GHBP), corresponding to the extracellular domain of the GH receptor, and the reduction of insulin-like growth factor binding protein (IGFBP)-3, major IGF-I binding protein, upregulated by GH. We carried out two studies. In the first, plasma GHBP activity was compared in patients with IDDM on continuous subcutaneous insulin infusion (CSII) or on conventional therapy and in healthy subjects. In the second study, the 18 patients on CSII at baseline were then treated by continuous intraperitoneal insulin infusion with an implantable pump (CPII) and prospectively studied for GH-IGF-I axis. Although HbA1 c was lower in patients on CSII than in those on conventional therapy, GHBP was similarly reduced in both when compared to control subjects (10.2 ± 0.8 and 11.6 ± 0.9 % vs 21.0 ± 1.3, p 〈 0.01). CPII for 12 months resulted in: a slight and transient improvement in HbA1 c (Time (T)0: 7.6 ± 0.2 %, T3:7.1 ± 0.2 %, T12: 7.5 ± 0.2 %, p 〈 0.02), improvement in GHBP (T0: 10.2 ± 0.8 %, T12: 15.5 ± 1.5, p 〈 0.0001), near-normalization of IGF-I (T0: 89.4 ± 8.8 ng/ml, T12: 146.9 ± 15.6, p 〈 0.002) and normalization of IGFBP-3 (T0: 1974 ± 121 ng/ml, T12: 3534 ± 305, p 〈 0.0001). The hepatic GH resistance profile in IDDM does not seem to be related to glycaemic control, but partly to insufficient portal insulinization. Intraperitoneal insulin delivery, allowing primary portal venous absorption, may influence GH sensitivity, and improve hepatic IGF-I and IGFBP-3 generation. [Diabetologia (1996) 39: 1498–1504]Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesTauber, M. J. ; Tauber, C. A. ; Ruberson, J. R. ; Milbrath, L. R. ; Albuquerque, G. S.
Springer
Published 1993Staff ViewISSN: 1420-9071Keywords: Chrysopa ; prey specificity ; general predator ; speciation ; behavioural plasticity ; individual repeatability ; reproductive isolation ; geographic variationSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Comparative experiments with two extant sister-species ofChrysopa provide the first demonstration of mechanisms whereby a general predator (e.g., aC. quadripunctata-like ancestor) may have given rise to a specialist (C. slossonae). First, the generalist expresses characteristics (e.g., phenotypic plasticity in larval and adult behaviour, defence-related morphology) that promote establishment on the specialist's ant-tended prey. Second, the patterns of variation among populations of the generalist suggest heritability and repeatability in traits that influence survival and reproduction on the specialist's prey — a requirement for evolutionary adaptation to the specific prey. Third, sympatric populations of the generalist and specialist have ovolved reproductive isolation, thus maintaining prey fidelity. This descriptive model appears broadly applicable to predacious as well as herbacious insects.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-1076Keywords: Octreotide ; Long acting somatostatin analog ; Indications in gastroenterology ; Treatment of tall stature ; NesidioblastosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Preliminary data of the use of the long-acting somatostatin analog octreotide (Sandostatin) in pediatrics are reported. In nesidioblastosis and other hyperinsulinemic conditions, timely treatment with octreotide can protect cerebral function and may reduce mortality. The acure use of octreotide produces prompt elevation of blood glucose, even in patients who fail to respond to diazoxide. In addition, it may be possible to avoid the need for partial or subtotal pancreatectomy by the long-term use of octreotide. As in adults, octreotide should find a place in the symptomatic treatment of secretory diarrhea, notably the watery diarrheahypokalemia-achlorhydria complex and pancreatic cholera syndrome. Octreotide has been shown to be effective in the treatment of familial tall stature by reducing height velocity and final height. Responses to octreotide therapy vary and the individual responsiveness must be extensively studied.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-1076Keywords: Key words: Tall stature – Growth hormone secretionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. Sixty-five patients (22 boys and 43 girls) presenting with familial tall stature were investigated with regard to growth hormone (GH) secretion, both physiological and after stimulation with thyrotropin releasing hormone (TRH) and growth hormone releasing hormone (GHRH). Plasma insulin-like growth factor-I (IGF-I) was also measured. Two groups of patients were distinguished according to their physiological secretion of GH: a high secretory group (n=49) with a mean 24 h integrated concentration of GH (IC-GH) of 5.4±2.3 µg/l per minute and a large number of peaks (5.1±1.6 in 24 h), and a low secretory group (n=16) with a mean 24 h IC-GH of 2.1±0.5 µg/l per minute and few peaks (3.3±1.3 in 24 h). Plasma IGF-I levels and GH peak values after the TRH test were significantly higher in the high secretory group. These results indicate that familial tall stature is the consequence either of hypersecretion of GH or of hypersensitivity to this hormone (IGF-I levels being normal in spite of low GH levels).Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-1076Keywords: Key words: Octreotide – Long acting somatostatin analog – Indications in gastroenterology – Treatment of tall stature – NesidioblastosisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. Preliminary data of the use of the long-acting somatostatin analog octreotide (Sandostatin) in pediatrics are reported. In nesidioblastosis and other hyperinsulinemic conditions, timely treatment with octreotide can protect cerebral function and may reduce mortality. The acute use of octreotide produces prompt elevation of blood glucose, even in patients who fail to respond to diazoxide. In addition, it may be possible to avoid the need for partial or subtotal pancreatectomy by the long-term use of octreotide. As in adults, octreotide should find a place in the symptomatic treatment of secretory treatment of secretory diarrhea, notably the watery diarrheahypokalemia-achlorhydria complex and pancreatic cholera syndrome. Octreotide has been shown to be effective in the treatment of familial tall stature by reducing height velocity and final height. Responses to octreotide therapy vary and the individual responsiveness must be extensively studied.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1573-0875Source: Springer Online Journal Archives 1860-2000Topics: BiologyGeosciencesNotes: Abstract A theoretical study of the gas dynamics and chemistry of lightning-produced shock waves in a postulated primordial reducing atmosphere was conducted. It was shown that the conditions are similar to those encountered in a previously performed shock-tube experiment which resulted in 36% of the ammonia in the original mixture being converted into amino acids. The calculations gave the (very large) energy rate of about 0.4 cal/cm2/yr available for amino produproduction, supporting previous hypotheses that ‘thunder’ could have been responsible for efficient large scale production of organic molecules serving as precursors of life.Type of Medium: Electronic ResourceURL: