Search Results - (Author, Cooperation:M. Taniguchi)

2018-01-26

Wiley-Blackwell

0008-543X

1097-0142

Biology

Medicine

2018-03-24

American Physical Society (APS)

1098-0121

1095-3795

Physics

Electronic structure and strongly correlated systems

2011-04-02

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0028-0836

1476-4687

Biology

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Animals ; CD40 Ligand/metabolism ; Carrier Proteins/metabolism ; Cells, Cultured ; HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Multiprotein Complexes/*chemistry/*metabolism ; NF-kappa B/*metabolism ; Nerve Tissue Proteins/deficiency/genetics/*metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Ubiquitin/*metabolism ; Ubiquitin-Protein Ligase Complexes/chemistry/metabolism ; Ubiquitin-Protein Ligases/metabolism

2018-11-03

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1755-1307

1755-1315

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2011-04-09

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

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2018-04-21

American Physical Society (APS)

1098-0121

1095-3795

Physics

Surface physics, nanoscale physics, low-dimensional systems

2018-05-11

American Physical Society (APS)

1098-0121

1095-3795

Physics

Electronic structure and strongly correlated systems

2012-04-24

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Adipocytes/cytology/drug effects ; Animals ; Bone Marrow Cells/cytology/metabolism ; *Bone Resorption/drug therapy ; Cell Differentiation/drug effects ; Cells, Cultured ; Coculture Techniques ; *Cytoprotection/drug effects ; Female ; Male ; Mice ; Neuropilin-1/metabolism ; Osteoblasts/*cytology/drug effects ; Osteoclasts/*cytology/drug effects ; *Osteogenesis/drug effects ; Semaphorin-3A/deficiency/genetics/*metabolism/pharmacology ; Skull/cytology ; Wnt Signaling Pathway/drug effects

2011-10-08

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

3' Untranslated Regions/genetics ; Alternative Splicing/drug effects/*genetics ; Animals ; Disease Models, Animal ; Dystroglycans/metabolism ; Exons/*genetics ; Gene Knock-In Techniques ; Glycosylation ; Humans ; Introns/genetics ; Japan ; Laminin/metabolism ; Membrane Proteins/genetics/metabolism ; Mice ; Molecular Sequence Data ; Mutagenesis, Insertional/drug effects/genetics ; Oligonucleotides, Antisense/genetics/pharmacology/therapeutic use ; RNA Isoforms/genetics ; RNA Splice Sites/genetics ; Retroelements/*genetics ; Walker-Warburg Syndrome/*genetics/*pathology/therapy

1089-7550

AIP Digital Archive

Physics

Photoemission spectra were measured for the I–III–IV2 chalcopyrite semiconductors CuInSe2, CuInS2, CuInTe2, and CuGaS2 with various photon energies (32 to 140, and 1253 eV). The partial density-of-states (DOS) of Cu 3d orbital is selectively observed at the photon energies beyond 100 eV. The DOS of Cu 3d spreads from the top of valence band (VB) to 5 or 6 eV below. Three dominant peaks are labeled as A, B, and C, the structures of which are interpreted as antibonding, nonbonding, and bonding states. Reflection spectra were also measured for CuInSe2 from 2 to 100 eV at room temperature and 98.5 K. The In 4d core reflection is observed at 17.5, 18.9, 19.8, and 21.2 eV at 98.5 K; very similar characteristics are also observed at 5.28, 6.21, 7.35, and 8.67 eV. These contributions are due to the Cu 3d nonbonding electrons. Photoemission and reflection experiments thus confirm conclusively the existence of nonbonding Cu 3d states in I–III–VI2 chalcopyrites. This result proves the theoretical model that attributes the upper VB to the antibonding state, in contrast with the bonding state of sp3-hybridized semiconductors.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

An automatic microwave stub tuner (AST) has been developed and used to characterize and stabilize an electron-cyclotron resonance (ECR) plasma source. The tuner provides a new method for measuring plasma impedance dynamically without disturbing the plasma. The Ar ECR plasmas were excited by a 2.45 GHz microwave (〈800 W) in the presence of the static axial magnetic fields ranging from 875 to 2000 G, and the characteristics were investigated using a double probe and the AST. Results of these measurements indicated that the Ar ECR plasma had discrete stable modes where the plasma parameters and impedance varied continuously. For certain operating conditions, slight shifts of microwave power and/or magnetic-field strength brought about discontinuous mode transitions. In the transition regions, the drastic changes of plasma characteristics were observed, resulting in the instability of the plasma. It was quite effective for stabilizing the unstable plasmas to control the reflection coefficient of the microwave transmission line.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

The performance of the bandpass photon detector for inverse photoemission spectroscopy has been significantly improved. The detector basically consists of a simple combination of a SrF2 entrance window and a commercial Cu–BeO photomultiplier. RbCl (KBr) evaporation onto the SrF2 window realizes a FWHM of 0.51 eV (0.58 eV), at the sacrifice of sensitivity. On the other hand, KCl evaporation onto the first dynode of the photomultiplier provides good characteristics for the photon detector not only with respect to the FWHM but also in terms of the sensitivity. The new detector has a FWHM of 0.47 eV with a maximum response at a photon energy of 9.4 eV. The sensitivity is improved by about one order of magnitude.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

Intense negative ion source producing multimegawatt hydrogen/deuterium negative ion beams has been developed for the neutral beam injector (NBI) in TOKAMAK thermonuclear fusion machines. Negative ions are produced in a cesium seeded multi-cusp plasma generator via volume and surface processes, and accelerated with a multistage electrostatic accelerator. The negative ion source for JT-60U has produced 18.5 A/360 keV (6.7 MW) H− and 14.3 A/380 keV (5.4 MW) D− ion beams at average current densities of 11 mA/cm2 (H−) and 8.5 mA/cm2 (D−). A high energy negative ion source has been developed for the next generation TOKAMAK such as the International Thermonuclear Experimental Reactor (ITER). The source has demonstrated to accelerate negative ions up to 1 MeV, the energy required for ITER. Higher negative ion current density of more than 20 mA/cm2 was obtained in the ITER concept sources. It was confirmed that the consumption rate of cesium is small enough to operate the source for a half year in ITER-NBI without maintenance. © 2000 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

To develop a high power negative ion source/accelerator for 1 MeV class neutral beam injector, hydrogen negative ion beam acceleration has been studied using a five-stage, multiaperture electrostatic accelerator. After conditioning each accelerator stage, the negative ions are accelerated to 1 MeV successfully with a drain current of 25 mA for 1 s. Cs was introduced into the ion source to produce higher current density. The highenst acceleration current density of 15 mA/cm2 was successfully accelerated up to an energy of 700 keV for 1 s, keeping the optimum perveance. The total acceleration current of 200 mA was extracted from nine central apertures 14 mm diameter each. A preliminary measurement of the heat load in the accelerator showed that the direct interception of the beam for the first grid and the third grid was negligibly small. The highest heat load was 4.5% of the input power at the second grid. © 2000 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

We have designed a 1.5-GeV storage-ring system for a new synchrotron-radiation project at Hiroshima. The storage ring has an achromatic structure with six dispersion-free straight sections for insertion devices. Superconducting horizontal wigglers are used to generate hard x ray. The multipole field of the wiggler causes no problem on beam dynamics. In spite of its small size, 100 m in circumference, the ring can generate excellent synchrotron radiation in a wide wavelength region from VUV up to hard x rays.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

Angular distributions of radiation from a three-pole superconducting horizontal wiggler operated on a 1.5-GeV storage ring have been calculated in detail. The horizontal distribution of vertically integrated power exhibits a remarkable asymmetry when the radiation is observed at distances close to the center of the wiggler. The distribution exhibits a prominent dip in the forward direction, at a position where the radiation stems primarily from the main magnet, which is set at a maximum field of 4.40 T. The spectral flux at around 1–2 A(ring) exhibits an effective angular spread of ±37 mrad. The central brilliance at 1 A(ring) is 7×1012 photons/s mrad2 mm2 0.1% bandwidth for a current of 300 mA.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

A new VUV beamline at the Photon Factory ring that is designed to accept radiation emitted from an undulator is described. The characteristics of the undulator and all parts of the beamline; a front end, a mirror system, and two monochromators, are described in detail. The characteristics of optical elements in the beamline are also shown.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

The optical design and mechanical solution for a soft x-ray beamline BL-7A in PF-KEK for the energy range 10–1000 eV with a PGM are described. The optical characteristics of the beamline are tested with gas phase absorption and photoelectron spectroscopy.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

In cesium-seeded hydrogen negative-ion sources, surface production on the plasma grid plays an important role in negative ion production. To enhance the surface, it is required to use material that would give a lower work function when Cs is absorbed on the surface. In a semicylindrical and cesium-seeded volume negative-ion source, eight materials (W, Cu, Mo, V, Cr, Ni, Ag, and Au) were tested as candidates for the plasma grid material. To avoid deposition of the cathode material on these materials, a filament-free plasma source was used, to fire the microwave (2.45 GHz) discharge in the Kamaboko source. The material surface was examined by measuring the photoelectron current by laser irradiation. It was observed that the discharge enhanced the photoelectron current when the material was biased negatively to the plasma potential during discharge. In the present experiment, Ni, Au, and Ag surfaces with a Cs layer showed a higher photoelectron current than the others. This was 1.5 times larger than that of Cu and W used as a plasma grid and filament in conventional high current negative ion sources. It is expected that higher negative-ion production efficiency would be obtained by using Ni, Ag, and Au as the plasma grid material, if deposition of filament materials is avoided on the surface. © 2002 American Institute of Physics.

Electronic Resource

1365-2222

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background Eosinophil peroxidase and myeloperoxidase halogenate tyrosine residues in plasma proteins and generate 3-bromotyrosine (BY) and 3-chlorotyrosine (CY), respectively.Objectives (1) To estimate urinary concentrations of BY and CY in asthmatic patients. (2) To investigate BY concentration in relation to urinary leukotriene E4 (LTE4) concentration in order to evaluate the activation of eosinophils in patients with aspirin-induced asthma (AIA).Methods BY and CY were quantified with a gas chromatograph-mass spectrometer using 13C-labelled compounds as internal standards.Results (1) Activation of eosinophils and neutrophils by immobilized IgG1 induced preferential formation of BY and CY, respectively. (2) A significantly higher concentration of BY was observed in the urine from asthmatic patients than in that from healthy control subjects (45±21.7 vs. 22.6±10.8 ng/mg-creatinine, P〈0.01). CY concentration was also elevated in the urine from asthmatic patients (4.4±3.2 vs. 1.5±1.0 ng/mg-creatinine, P〈0.01). (3) After intravenous aspirin challenge of aspirin-induced asthmatic patients, the concentration of BY in urine did not significantly change. No significant change was also observed in the ratio of BY concentration to total tyrosine concentration in plasma proteins. In contrast, the concentration of urinary LTE4 significantly increased after the intravenous aspirin challenge.Conclusion Determination of BY and CY concentrations may be useful for monitoring the activation of eosinophils and neutrophils in asthmatic patients, respectively. After aspirin challenge of AIA patients, the increased concentration of urinary LTE4 did not accompany changes in BY concentration in both urine and plasma proteins. These results may preclude the activation of eosinophils after aspirin challenge in patients with AIA.

Electronic Resource