Search Results - (Author, Cooperation:M. T. Heneka)
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1Latest Papers from Table of Contents or Articles in PressS. Heilmann ; D. Drichel ; J. Clarimon ; V. Fernandez ; A. Lacour ; H. Wagner ; M. Thelen ; I. Hernandez ; J. Fortea ; M. Alegret ; R. Blesa ; A. Mauleon ; M. R. Roca ; J. Kornhuber ; O. Peters ; R. Heun ; L. Frolich ; M. Hull ; M. T. Heneka ; E. Ruther ; S. Riedel-Heller ; M. Scherer ; J. Wiltfang ; F. Jessen ; T. Becker ; L. Tarraga ; M. Boada ; W. Maier ; A. Lleo ; A. Ruiz ; M. M. Nothen ; A. Ramirez
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alzheimer Disease/*genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Humans ; Male ; Phospholipase D/*geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. T. Heneka ; M. P. Kummer ; A. Stutz ; A. Delekate ; S. Schwartz ; A. Vieira-Saecker ; A. Griep ; D. Axt ; A. Remus ; T. C. Tzeng ; E. Gelpi ; A. Halle ; M. Korte ; E. Latz ; D. T. Golenbock
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aged ; Aged, 80 and over ; Alzheimer Disease/enzymology/genetics/*pathology ; Amyloid beta-Peptides/metabolism ; Animals ; Behavior, Animal ; Brain/enzymology/*pathology ; Carrier Proteins/genetics/*metabolism ; Caspase 1/genetics/metabolism ; Gene Expression Regulation, Enzymologic ; Humans ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; Memory ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mild Cognitive Impairment/enzymology/physiopathology ; Nitric Oxide Synthase Type II/metabolism ; Phagocytosis/geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressM. Willem ; S. Tahirovic ; M. A. Busche ; S. V. Ovsepian ; M. Chafai ; S. Kootar ; D. Hornburg ; L. D. Evans ; S. Moore ; A. Daria ; H. Hampel ; V. Muller ; C. Giudici ; B. Nuscher ; A. Wenninger-Weinzierl ; E. Kremmer ; M. T. Heneka ; D. R. Thal ; V. Giedraitis ; L. Lannfelt ; U. Muller ; F. J. Livesey ; F. Meissner ; J. Herms ; A. Konnerth ; H. Marie ; C. Haass
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-09-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
4Articles: DFG German National LicensesBreidert, T. ; Callebert, J. ; Heneka, M. T. ; Landreth, G. ; Launay, J. M. ; Hirsch, E. C.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We examined the effect of pioglitazone, a peroxisome proliferator-activated receptor-γ (PPARγ)agonistofthethiazolidinedione class, on dopaminergic nerve cell death and glial activation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. The acute intoxication of C57BL/6 mice with MPTP led to nigrostriatal injury, as determined by tyrosine hydroxylase (TH) immunocytochemistry, and HPLC detection of striatal dopamine and metabolites. Damage to the nigrostriatal dopamine system was accompanied by a transient activation of microglia, as determined by macrophage antigen-1 (Mac-1) and inducible nitric oxide synthase (iNOS) immunoreactivity, and a prolonged astrocytic response. Orally administered pioglitazone (∼ 20 mg/kg/day) attenuated the MPTP-inducedglialactivation and prevented the dopaminergic cell loss in the substantia nigra pars compacta (SNpc). In contrast, there was little reduction of MPTP-induced dopamine depletion, with no detectable effect on loss of TH immunoreactivity and glial response in the striatum of pioglitazone-treated animals. Low levels of PPARγ expression were detected in the ventral mesencephalon and striatum, and were unaffected by MPTP or pioglitazone treatment. Since pioglitazone affects primarily the SNpc in our model, different PPARγ-independent mechanisms may regulate glial activation in the dopaminergic terminals compared with the dopaminergic cell bodies after acute MPTP intoxication.Type of Medium: Electronic ResourceURL: