Search Results - (Author, Cooperation:M. Slaoui)

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  1. 1
    K. Famm ; B. Litt ; K. J. Tracey ; E. S. Boyden ; M. Slaoui
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-04-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Action Potentials/physiology ; Animals ; Drug Discovery ; Electric Stimulation Therapy/*methods/*trends ; Humans ; Interdisciplinary Communication ; *Neural Pathways/physiology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Slaoui, M. ; Urbain-Vansanten, G. ; Demeur, C. ; Leo, O. ; Marvel, J. ; Moser, M. ; Tassignon, J. ; Greene, M. I. ; Urbain, J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1986
    Staff View
    ISSN:
    1600-065X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-065X.1986.tb01478.x

    Articles: DFG German National Licenses
  3. 3
    URBAIN, J. ; FRANCOTTE, M. ; FRANSSEN, J. D. ; HIERNAUX, J. ; LEO, O. ; MOSER, M. ; SLAOUI, M. ; URBAIN-VANSANTEN, G. ; ACKER, A. ; WIKLER, M.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1983
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1983.tb18048.x

    Articles: DFG German National Licenses
  4. 4
    HIERNAUX, J. ; SLAOUI, M. ; LEO, O. ; MOSER, M. ; FRANSSEN, J.D. ; URBAIN, J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1983
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1983.tb18049.x

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1432-1076
    Keywords:
    Key words Haemophilus influenzae type b  ;   Combination vaccine  ;  Immunological memory
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  The lack of an adequate immune response to the major polysaccharide of the Haemophilus influenzae type b (Hib) capsule (polyribosyl ribitol phosphate) (PRP) in very young infants (〈 18 months) can be overcome by conjugating PRP to a T-cell dependent carrier protein. We studied whether administration of a tetanus-PRP conjugate vaccine reconstituted with a diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine as a three dose primary course at 3, 4 and 5 months of age induced PRP-specific immunological memory, by examining the anti-PRP response to a dose of unconjugated PRP given with the DTPa-HBV booster approximately 1 year later. The unconjugated PRP elicited protective anti-PRP antibody levels (≥ 0.15 μg/ml) in all but 3 of the 369 vaccinees, including 13 infants who failed to demonstrate a measurable immune response after the primary course. In a sub-cohort of 54 subjects all had anti-PRP levels ≥ 0.5 μg/ml within 7–14 days of the booster showing a rapid anamnestic type response. Both primary and booster responses were predominantly IgG1 indicating a T-cell dependent response. The DTPa-HBV components elicited protective anti-diphtheria, anti-tetanus and anti-HBs antibody levels in ≥ 98.5% of vaccinees, and immune responses to each of the acellular pertussis vaccine components in 92.3%–97.3% of subjects. Conclusion The tetanus-PRP conjugate vaccine not only elicited a good primary humoral response, but also induced immunological memory so that the infants were able to mount a large and rapid immune response to subsequent exposure to plain PRP, indicating that protection against circulating wild-type Hib had been generated. Successful induction of immunological memory occurred even when there was no measurable humoral anti-PRP response to the primary course. Tetanus-PRP conjugate vaccine can be used in combination with DTPa-HBV vaccine, when administered separately or as a single injection in the same syringe, in primary immunisation schedules at 3, 4 and 5 months of age.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004310050544

    Articles: DFG German National Licenses