Search Results - (Author, Cooperation:M. Shirouzu)
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1H. Tanabe ; Y. Fujii ; M. Okada-Iwabu ; M. Iwabu ; Y. Nakamura ; T. Hosaka ; K. Motoyama ; M. Ikeda ; M. Wakiyama ; T. Terada ; N. Ohsawa ; M. Hato ; S. Ogasawara ; T. Hino ; T. Murata ; S. Iwata ; K. Hirata ; Y. Kawano ; M. Yamamoto ; T. Kimura-Someya ; M. Shirouzu ; T. Yamauchi ; T. Kadowaki ; S. Yokoyama
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; Histidine/chemistry/metabolism ; Humans ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Receptors, Adiponectin/*chemistry/metabolism ; Structure-Activity Relationship ; Zinc/metabolismPublished by: -
2S. Arai ; S. Saijo ; K. Suzuki ; K. Mizutani ; Y. Kakinuma ; Y. Ishizuka-Katsura ; N. Ohsawa ; T. Terada ; M. Shirouzu ; S. Yokoyama ; S. Iwata ; I. Yamato ; T. Murata
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-01-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Binding Sites ; Crystallization ; Enterococcus/*enzymology/genetics ; *Models, Molecular ; Mutation ; Nucleotides/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Protein Subunits ; Rotation ; Vacuolar Proton-Translocating ATPases/*chemistry/geneticsPublished by: -
3M. Okada-Iwabu ; T. Yamauchi ; M. Iwabu ; T. Honma ; K. Hamagami ; K. Matsuda ; M. Yamaguchi ; H. Tanabe ; T. Kimura-Someya ; M. Shirouzu ; H. Ogata ; K. Tokuyama ; K. Ueki ; T. Nagano ; A. Tanaka ; S. Yokoyama ; T. Kadowaki
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenylate Kinase/metabolism ; Adiponectin/metabolism/pharmacology ; Adipose Tissue, White/drug effects/metabolism/pathology ; Administration, Oral ; Animals ; Diabetes Mellitus, Type 2/complications/*drug therapy/metabolism/prevention & ; control ; Diet, High-Fat ; Drug Evaluation, Preclinical ; Dyslipidemias/drug therapy ; Enzyme Activation/drug effects ; Glucose Intolerance/drug therapy ; Inflammation/drug therapy ; Insulin Resistance ; Liver/drug effects/metabolism/pathology ; Longevity/*drug effects ; Mice ; Mitochondria/drug effects/metabolism ; Muscle Fibers, Skeletal/cytology/drug effects ; Muscles/cytology ; Obesity/complications/drug therapy/genetics/*physiopathology ; Oxidative Stress/drug effects ; PPAR alpha/metabolism ; Piperidines/administration & dosage/metabolism/*pharmacology/therapeutic use ; Receptors, Adiponectin/*agonists/deficiency/genetics/metabolism ; Signal Transduction/drug effects ; Small Molecule Libraries/chemistry ; Transcription Factors/biosynthesis ; Triglycerides/metabolismPublished by: -
4Kujirai, T., Ehara, H., Fujino, Y., Shirouzu, M., Sekine, S.-i., Kurumizaka, H.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-11-02Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: BiochemistryPublished by: -
5Staff View
ISSN: 0014-5793Keywords: Effector region ; GTPase activating protein ; Krev-1 ; Mutagenesis ; c-Ha-rasSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1420-9071Keywords: Anti-dopamine serum ; rat ; spinal cord ; ventral horn ; electron microscopySource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary It has been thought that the ventral motor column in the rat spinal cord is virtually free of dopaminergic fibers. However, a new dopaminergic terminal plexus was visualized at all spinal levels in the ventral horn using electron as well as light microscopic immunohistochemistry.Type of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 1420-9071Keywords: TRH ; new antibody ; carbodiimide coupling method ; enzyme immunoassay ; immunohistochemistry ; rat ; hypothalamus ; magnocellular groupsSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary We produced a new type of antiserum to thyrotropin-releasing hormone (TRH) in rabbits. The immunogen is TRH-BSA, the production of which is based on the formation of an amide bond using carbodiimide (EDC). The specificity of the antiserum was assessed by enzyme immunoassay (EIA) and immunohistochemistry. When using the anti-TRH serum for immunohistochemistry in rat hypothalamus, new magnocellular groups were detected in the ventrolateral parts of the posterior hypothalamus and the dorsal parts of the third ventricle. Colchicine treatment was found not to be necessary to visualize perikarya containing TRH.Type of Medium: Electronic ResourceURL: