Search Results - (Author, Cooperation:M. Ryden)

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  1. 1
    Staff View
    Publication Date:
    2011-09-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adipocytes/chemistry/metabolism ; Adipose Tissue/cytology/*metabolism ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carbon Radioisotopes/analysis ; Cell Aging ; Cell Size ; Child ; Child, Preschool ; Cohort Studies ; DNA/chemistry ; Dyslipidemias/metabolism/pathology ; *Health ; Humans ; Hyperlipidemia, Familial Combined/genetics/metabolism/pathology ; *Lipid Metabolism ; Lipolysis ; Metabolic Diseases/*metabolism ; Middle Aged ; Nuclear Weapons ; Obesity/metabolism ; Subcutaneous Fat/metabolism ; Time Factors ; Triglycerides/analysis/metabolism ; Young Adult
    Published by:
    http://www.nature.com/

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  2. 2
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Keywords Adipose tissue, BMI, obesity, polymorphism, TNFα gene.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Aims/hypothesis. Tumour necrosis factor alpha (TNFα) is a candidate gene for the development of obesity, which in turn is a major risk factor for diabetes mellitus. The aim of our study was to investigate whether a previously known NcoI-sensitive polymorphism (–308 G/A) in the promoter region of the TNFα gene was related to body weight.¶Methods. Genotyping was done in 239 male and 342 female non-diabetic subjects with a marked variation in body mass index (BMI).¶Results. We found three genotypes; AA (n = 13), AG (n = 158) and GG (n = 410). When the material was divided according to sex, allele specific phenotypic differences were confined to women. The female subjects carrying the AA genotype were markedly more obese than both the AG and GG carriers (mean BMI = 41.4 vs 32.3 and 31.7 kg/m2, respectively, p = 0.02). The body fat content of female AA carriers was increased by one-third compared with AG/GG carriers (p = 0.02). We found no differences between genotypes with respect to waist-to-hip ratio, blood pressure or metabolic variables. Among obese female subjects (BMI 〉 27 kg/m2), we also found that the BMI and body fat content of AA carriers (n = 7) were also higher than for AG/GG carriers.¶Conclusion/interpretation. The AA-variant at position –308 in the promoter region of the TNFα gene could be an important genetic factor behind excessive fat accumulation in women. [Diabetologia (2000) 43: 117–120]
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001250050015

    Articles: DFG German National Licenses