Search Results - (Author, Cooperation:M. Reichelt)
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1Latest Papers from Table of Contents or Articles in PressA. Murthy ; Y. Li ; I. Peng ; M. Reichelt ; A. K. Katakam ; R. Noubade ; M. Roose-Girma ; J. DeVoss ; L. Diehl ; R. R. Graham ; M. van Lookeren Campagne
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-02-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Motifs ; Animals ; Autophagy/genetics ; Carrier Proteins/chemistry/*genetics/*metabolism ; Caspase 3/deficiency/genetics/*metabolism ; Cell Line ; Cells, Cultured ; Crohn Disease/*genetics/pathology ; Cytokines/immunology ; Enzyme Activation ; Female ; Food Deprivation ; Humans ; Macrophages/immunology/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mutagenesis, Site-Directed ; Polymorphism, Single Nucleotide/*genetics ; *Proteolysis ; Stress, Physiological ; Yersinia enterocolitica/immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressD. Lafkas ; A. Shelton ; C. Chiu ; G. de Leon Boenig ; Y. Chen ; S. S. Stawicki ; C. Siltanen ; M. Reichelt ; M. Zhou ; X. Wu ; J. Eastham-Anderson ; H. Moore ; M. Roose-Girma ; Y. Chinn ; J. Q. Hang ; S. Warming ; J. Egen ; W. P. Lee ; C. Austin ; Y. Wu ; J. Payandeh ; J. B. Lowe ; C. W. Siebel
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-11-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies/immunology/pharmacology/*therapeutic use ; Asthma/drug therapy/metabolism/pathology ; Calcium-Binding Proteins/antagonists & inhibitors/immunology/metabolism ; Cell Death/drug effects ; Cell Division/drug effects ; Cell Lineage/drug effects ; Cell Tracking ; *Cell Transdifferentiation/drug effects ; Cilia/metabolism ; Disease Models, Animal ; Female ; Goblet Cells/cytology/drug effects/pathology ; Homeostasis/drug effects ; Humans ; Intercellular Signaling Peptides and Proteins/immunology/metabolism ; Ligands ; Lung/*cytology/drug effects/*metabolism ; Male ; Membrane Proteins/antagonists & inhibitors/immunology/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Receptors, Notch/*metabolism ; Signal Transduction/drug effectsPublished by: -
3Latest Papers from Table of Contents or Articles in PressK. V. Prasad ; B. H. Song ; C. Olson-Manning ; J. T. Anderson ; C. R. Lee ; M. E. Schranz ; A. J. Windsor ; M. J. Clauss ; A. J. Manzaneda ; I. Naqvi ; M. Reichelt ; J. Gershenzon ; S. G. Rupasinghe ; M. A. Schuler ; T. Mitchell-Olds
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-09-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Amino Acid Sequence ; Amino Acid Substitution ; Arabidopsis/genetics/metabolism/parasitology ; *Brassicaceae/genetics/metabolism/parasitology ; Cytochrome P-450 Enzyme System/*genetics ; Gene Dosage ; Gene-Environment Interaction ; Glucosinolates/biosynthesis/*genetics ; Herbivory/physiology ; Methionine/genetics/metabolism ; Molecular Sequence Data ; Plant Leaves/genetics/metabolism/parasitology ; Plants, Genetically Modified/genetics/metabolism/parasitology ; Polymorphism, Genetic ; *Quantitative Trait Loci ; *Quantitative Trait, Heritable ; *Selection, GeneticPublished by: -
4Latest Papers from Table of Contents or Articles in PressB. Bingol ; J. S. Tea ; L. Phu ; M. Reichelt ; C. E. Bakalarski ; Q. Song ; O. Foreman ; D. S. Kirkpatrick ; M. Sheng
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-06-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Line ; Cells, Cultured ; Drosophila melanogaster/genetics/metabolism ; Gene Knockdown Techniques ; HEK293 Cells ; HeLa Cells ; Humans ; Male ; Mitochondrial Degradation/*physiology ; Mitochondrial Proteins/genetics/*metabolism ; Neurons/metabolism ; Parkinson Disease/physiopathology ; Protein Kinases/metabolism ; Rats ; Thiolester Hydrolases/genetics/*metabolism ; Ubiquitin-Protein Ligases/genetics/*metabolism ; Ubiquitin-Specific Proteases/genetics/metabolism ; UbiquitinationPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-03-07Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
6Articles: DFG German National LicensesHummert, C. ; Dahlmann, J. ; Reichelt, M. ; Luckas, B.
Melbourne, Australia : Blackwell Science Asia Pty. Ltd.
Published 2001Staff ViewISSN: 1440-1770Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeographyNotes: The toxins of cyanobacteria include potent neurotoxins and hepatotoxins. Deaths after exposure by ingestion of cyanobacterial cells and toxins from freshwater sources have been reported. The hepatotoxins are cyclic peptides, which comprise microcystins (MC) and nodularin (NOD), and they cause poisonings with an established syndrome of human and animal illnesses. The identification and determination of these hepatotoxic peptides are challenges for analytical chemists. Methods based on solid phase extraction and size exclusion chromatography are available for the clean up of raw extracts. Both principles are also used for the enrichment of MC from low contaminated sample material. The separation of MC is achieved by high-pressure liquid chromatography methods with ultraviolet (UV) detection or mass spectrometric detection. The unambiguous identification of MC not available as standards is possible by mass spectrometry (MS) or, under optimal conditions, by UV spectrometry using diode array detection. To date, 60 different MC and four NOD have been described, but new compounds are frequently identified. Therefore, powerful tools for the elucidation of the structure of unknown MC are an important need. In addition to classical methods for structure elucidation (e.g. nuclear magnetic resonance spectrometry), microwave-assisted hydrolysis of cyclic peptides followed by enantio-selective determination of the amino acid profiles can be used. More recently, MS with collision-activated dissociation has become an important tool for obtaining structure information. The present paper discusses the advantages and disadvantages of the various analytical techniques used for monitoring of cyanobacteria in lakes, optimized or developed at the Institute of Nutrition, Jena, Germany. A pathway for handling MC-containing samples with regard to different analytical tasks (i.e. the identification and elucidation of structure followed by qualitative and quantitative determination) is proposed.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1060-3743Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Linguistics and Literary StudiesType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1060-3743Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Linguistics and Literary StudiesType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1060-3743Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Linguistics and Literary StudiesType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-1130Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract A new analytical strategy was established to improve the determination and identification performance during analyses of microcystins and diarrhetic shellfish poisoning (DSP) toxins in different matrices. Automated high performance size exclusion chromatography (gel permeation chromatography, SEC) was applied for the clean-up of raw extracts from algae and mussel tissue containing either microcystins or DSP toxins. The cleaned raw extracts are well suited for the direct determination of microcystins and DSP toxins by HPLC/MS. The analyses of cleaned raw extracts containing microcystin by HPLC and UV/diode array detection (DAD) revealed chromatograms without interfering peaks. Additionally, methods for the identification of unknown microcystins and those not available as standards were developed and established. The proposed strategy is exemplarily demonstrated for the analyses of a natural algae community from a lake in Slowakia and a naturally contaminated mussel from Portugal.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-1750Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary. SV40 and/ or DNA sequences indistinguishable from SV40 have been detected in several types of human tumours. The oncoprotein of Simian virus 40, SV40 large T-antigen (Tag), is known to bind and inactivate tumour suppressor proteins, such as members of the retinoblastoma family and p53, thereby promoting cell transformation. In this study, we used the yeast two-hybrid system to investigate whether the Simian virus 40 (SV40) large T-antigen is able to interact with p73, a noval discovered putative tumour suppressor, that is homologous both structurally and functionally to p53. The yeast two-hybrid system is a genetic method to detect protein-protein-interactions in vivo. Our results suggest that the SV40 large T-antigen is not able to bind p73 in yeast although both proteins are expressed in the transformed yeast strain as was shown by western blot analysis.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1612-1112Keywords: Column liquid chromatography ; Microwave hydrolysis ; Microcystin ; Nodularin ; D- and L-selective amino acid determinationSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Summary Microwave radiation has been successfully used for hydrolysis of the hepatotoxic cyclic peptides microcystins and nodularin. Set-up of the microwave device and the operating conditions for microwave hydrolysis were optimized. Results of the microwave hydrolysis were compared with results from conventional hydrolysis for 24 h at 110°C. Microwave hydrolysis of microcystins and nodularin for as little as 10 min at 160°C results in complete cleavage of peptide bonds and high recoveries of amino acids. Enantioselective determination of amino acids was achieved by use of a previously described HPLC method after pre-column derivatization withortho-phthaldialdehyde and the chiral thiolN-iso-butyryl-cysteine.Type of Medium: Electronic ResourceURL: