Search Results - (Author, Cooperation:M. Pyrski)

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  1. 1
    Staff View
    Publication Date:
    2011-03-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Action Potentials ; Animals ; Behavior, Animal ; Disease Models, Animal ; Female ; Gene Expression Profiling ; Humans ; Male ; Mice ; Mutant Proteins/*genetics/*metabolism ; Mutation/*genetics ; NAV1.7 Voltage-Gated Sodium Channel ; Odors/analysis ; Olfaction Disorders/congenital/*genetics/pathology/*physiopathology ; Olfactory Mucosa/cytology/pathology ; Olfactory Pathways/metabolism/pathology/physiopathology ; Olfactory Perception/genetics/physiology ; Olfactory Receptor Neurons/metabolism/pathology ; Pain/genetics/physiopathology ; Phenotype ; Smell/genetics/physiology ; Sodium Channels/deficiency/*genetics/metabolism ; Synapses/metabolism/pathology ; Urine/chemistry
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Stepanyan, Z. ; Kocharyan, A. ; Pyrski, M. ; Hübschle, T. ; Watson, A. M. D. ; Schulz, S. ; Meyerhof, W.

    Oxford, UK : Blackwell Science, Ltd
    Published 2003
    Staff View
    ISSN:
    1365-2826
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Hypothalamic leptinoceptive neurones can be visualized by histochemical demonstration of leptin-induced nuclear translocation of the signalling molecule STAT3. We investigated the relationship of the leptinoceptive neurones to the somatostatin signalling system. With double-labelling immunohistochemistry, we studied the colocalization of leptin-activated transcription factor, STAT3, with somatostatin receptor subtypes, sst1, sst2A, sst2B, sst3 and sst4, or the neuropeptide itself, in the rat hypothalamus. Immunoreactivity for all the entities was widely distributed throughout the entire hypothalamus. Despite the wide distribution, only few cases of colocalization of somatostatin with leptin-activated STAT3 were detected in the paraventricular, arcuate and dorsomedial nuclei. A moderate to high degree of colocalization of nuclear STAT3 and all investigated subtypes of somatostatin receptors was found in the lateral and dorsal hypothalamic areas and in the dorsomedial hypothalamic nucleus. Immunoreactivity for sst1, sst2B and sst4 was present in STAT3-containing nuclei of the paraventricular, periventricular, arcuate and ventromedial hypothalamic neurones, as well as in the retrochiasmatic and posterior hypothalamic areas. Despite the wide distribution of sst2A in the rat hypothalamus, few events of colocalization with leptin-activated STAT3 were observed in the dorsomedial nucleus and in the lateral and dorsal hypothalamic areas only. Many leptin-responsive neurones of the dorsal, lateral, periarcuate, perifornical and posterior hypothalamic areas, as well as in the ventromedial and dorsomedial hypothalamic nuclei, displayed sst3 immunoreactivity at their neuronal cilia. These results provide strong anatomical evidence for the direct interaction of leptin and the somatostatin systems in neuroendocrine control loops such as the energy homeostasis, growth or stress response.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses