Search Results - (Author, Cooperation:M. Platten)
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1Latest Papers from Table of Contents or Articles in PressT. Schumacher ; L. Bunse ; S. Pusch ; F. Sahm ; B. Wiestler ; J. Quandt ; O. Menn ; M. Osswald ; I. Oezen ; M. Ott ; M. Keil ; J. Balss ; K. Rauschenbach ; A. K. Grabowska ; I. Vogler ; J. Diekmann ; N. Trautwein ; S. B. Eichmuller ; J. Okun ; S. Stevanovic ; A. B. Riemer ; U. Sahin ; M. A. Friese ; P. Beckhove ; A. von Deimling ; W. Wick ; M. Platten
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibody Specificity ; Antigens, Neoplasm/genetics/immunology ; Cancer Vaccines/*immunology/*therapeutic use ; Female ; Glioma/enzymology/genetics/*immunology/*therapy ; Histocompatibility Antigens Class II/immunology ; Humans ; Immunity, Humoral ; Immunotherapy/methods ; Isocitrate Dehydrogenase/*genetics/*immunology ; Male ; Mice ; Mutant Proteins/genetics/*immunology ; Mutation ; T-Lymphocytes, Helper-Inducer/immunology ; Xenograft Model Antitumor AssaysPublished by: -
2Latest Papers from Table of Contents or Articles in PressC. A. Opitz ; U. M. Litzenburger ; F. Sahm ; M. Ott ; I. Tritschler ; S. Trump ; T. Schumacher ; L. Jestaedt ; D. Schrenk ; M. Weller ; M. Jugold ; G. J. Guillemin ; C. L. Miller ; C. Lutz ; B. Radlwimmer ; I. Lehmann ; A. von Deimling ; W. Wick ; M. Platten
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Autocrine Communication ; Brain Neoplasms/genetics/immunology/*metabolism/*pathology ; Cell Line, Tumor ; Cell Survival ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Glioma/genetics/immunology/*metabolism/*pathology ; Humans ; Kynurenine/immunology/*metabolism/pharmacology/secretion ; Ligands ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Neoplasm Transplantation ; Paracrine Communication ; Receptors, Aryl Hydrocarbon/immunology/*metabolism ; Tryptophan/metabolism ; Tryptophan Oxygenase/deficiency/genetics/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressA. Bessede ; M. Gargaro ; M. T. Pallotta ; D. Matino ; G. Servillo ; C. Brunacci ; S. Bicciato ; E. M. Mazza ; A. Macchiarulo ; C. Vacca ; R. Iannitti ; L. Tissi ; C. Volpi ; M. L. Belladonna ; C. Orabona ; R. Bianchi ; T. V. Lanz ; M. Platten ; M. A. Della Fazia ; D. Piobbico ; T. Zelante ; H. Funakoshi ; T. Nakamura ; D. Gilot ; M. S. Denison ; G. J. Guillemin ; J. B. DuHadaway ; G. C. Prendergast ; R. Metz ; M. Geffard ; L. Boon ; M. Pirro ; A. Iorio ; B. Veyret ; L. Romani ; U. Grohmann ; F. Fallarino ; P. Puccetti
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-06-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacterial Infections/immunology/metabolism ; Disease Resistance/drug effects/*genetics/*immunology ; Endotoxemia/genetics/immunology/metabolism ; Enzyme Activation/drug effects ; Gene Expression Regulation/drug effects ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Inflammation/enzymology/genetics/metabolism ; Kynurenine/metabolism ; Lipopolysaccharides/pharmacology ; Mice ; Phosphorylation ; Receptors, Aryl Hydrocarbon/genetics/*metabolism ; Signal Transduction ; Tryptophan Oxygenase/metabolism ; src-Family Kinases/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressM. Osswald ; E. Jung ; F. Sahm ; G. Solecki ; V. Venkataramani ; J. Blaes ; S. Weil ; H. Horstmann ; B. Wiestler ; M. Syed ; L. Huang ; M. Ratliff ; K. Karimian Jazi ; F. T. Kurz ; T. Schmenger ; D. Lemke ; M. Gommel ; M. Pauli ; Y. Liao ; P. Haring ; S. Pusch ; V. Herl ; C. Steinhauser ; D. Krunic ; M. Jarahian ; H. Miletic ; A. S. Berghoff ; O. Griesbeck ; G. Kalamakis ; O. Garaschuk ; M. Preusser ; S. Weiss ; H. Liu ; S. Heiland ; M. Platten ; P. E. Huber ; T. Kuner ; A. von Deimling ; W. Wick ; F. Winkler
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Astrocytoma/metabolism/*pathology/radiotherapy ; Brain Neoplasms/metabolism/*pathology/radiotherapy ; Cell Communication/radiation effects ; Cell Death/radiation effects ; Cell Proliferation/radiation effects ; Cell Surface Extensions/metabolism/radiation effects ; Cell Survival/radiation effects ; Connexin 43/metabolism ; Disease Progression ; GAP-43 Protein/metabolism ; Gap Junctions/*metabolism/radiation effects ; Glioma/metabolism/pathology/radiotherapy ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Radiation Tolerance/drug effectsPublished by: -
5Latest Papers from Table of Contents or Articles in PressM. Caskey ; F. Klein ; J. C. Lorenzi ; M. S. Seaman ; A. P. West ; N. Buckley ; G. Kremer ; L. Nogueira ; M. Braunschweig ; J. F. Scheid ; J. A. Horwitz ; I. Shimeliovich ; S. Ben-Avraham ; M. Witmer-Pack ; M. Platten ; C. Lehmann ; L. A. Burke ; T. Hawthorne ; R. J. Gorelick ; B. D. Walker ; T. Keler ; R. M. Gulick ; G. Fatkenheuer ; S. J. Schlesinger ; M. C. Nussenzweig
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
6Latest Papers from Table of Contents or Articles in PressM. Caskey ; F. Klein ; J. C. Lorenzi ; M. S. Seaman ; A. P. West, Jr. ; N. Buckley ; G. Kremer ; L. Nogueira ; M. Braunschweig ; J. F. Scheid ; J. A. Horwitz ; I. Shimeliovich ; S. Ben-Avraham ; M. Witmer-Pack ; M. Platten ; C. Lehmann ; L. A. Burke ; T. Hawthorne ; R. J. Gorelick ; B. D. Walker ; T. Keler ; R. M. Gulick ; G. Fatkenheuer ; S. J. Schlesinger ; M. C. Nussenzweig
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Amino Acid Sequence ; Antibodies, Monoclonal/administration & ; dosage/immunology/pharmacokinetics/therapeutic use ; Antibodies, Neutralizing/administration & dosage/adverse ; effects/*immunology/pharmacology/therapeutic use ; Antigens, CD4/metabolism ; Binding Sites ; Case-Control Studies ; Evolution, Molecular ; Female ; HIV Antibodies/administration & dosage/adverse ; HIV Envelope Protein gp120/chemistry/immunology ; HIV Infections/immunology/*therapy/virology ; HIV-1/chemistry/drug effects/*immunology ; Humans ; Immunization, Passive/methods ; Male ; Middle Aged ; Molecular Sequence Data ; Time Factors ; Viral Load/drug effects/*immunology ; Viremia/immunology/*therapy/virology ; Young AdultPublished by: -
7Articles: DFG German National LicensesGoh, Y-W ; Spagnolo, D V ; Platten, M ; Caterina, P ; Fisher, C ; Oliveira, A M ; Nascimento, A G
Oxford UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation Aims: Extraskeletal myxoid chondrosarcoma is a rare low-grade soft-tissue sarcoma with locally aggressive and metastasizing potential. Extraskeletal myxoid chondrosarcoma has distinctive clinical, light microscopic, immunophenotypic, cytogenetic and ultrastructural features. Evidence that extraskeletal myxoid chondrosarcoma often shows neuroendocrine features was first provided by Chhieng et al.9 on the basis of an immunohistochemical and ultrastructural study of seven cases. Our study aims to further confirm by immunohistochemistry and ultrastructural studies, including immunoelectron microscopy, that extraskeletal myxoid chondrosarcoma indeed may show neuroendocrine differentiation. Methods and results: Fifteen cases of extraskeletal myxoid chondrosarcoma and seven control cases of skeletal chondrosarcomas were studied. Extensive immunohistochemical analysis was performed in all cases and ultrastructural studies were done in 11 extraskeletal myxoid chondrosarcomas and three skeletal chondrosarcomas. Immunoelectron microscopy was performed on one case each of extraskeletal myxoid chondrosarcoma and skeletal chondrosarcoma. Extraskeletal myxoid chondrosarcomas expressed neuron-specific enolase (100%), synaptophysin (87%), S100 (50%), PGP 9.5 (40%), and epithelial membrane antigen (25%). Co-expression of synaptophysin and PGP 9.5 was observed in six tumours. Skeletal chondrosarcomas showed expression of S100 protein, vimentin and neuron-specific enolase in all cases. Synaptophysin, chromogranin and PGP 9.5 were not expressed in any skeletal chondrosarcoma case. Ultrastructurally, extraskeletal myxoid chondrosarcoma was characterized by distinct cords of cells immersed in a glycosaminoglycan-rich matrix. The cells were rich in mitochondria, had well-developed Golgi apparatus and there were numerous smooth vesicles. In three cases there were easily found 140–180 nm diameter membrane-bound dense-core granules in cell bodies and in processes, unrelated to the Golgi, compatible with neurosecretory granules. Fewer such granules were present in the remaining extraskeletal myxoid chondrosarcoma cases, three of which also contained intracisternal tubules typical of extraskeletal myxoid chondrosarcoma. The skeletal chondrosarcomas had scalloped cell surfaces, prominent rough endoplasmic reticulum focally distended with secretory product, and lacked neurosecretory granules. Intermediate filaments were prominent in both extraskeletal myxoid chondrosarcoma and skeletal chondrosarcomas. Immunoelectron microscopy showed synaptophysin expression in the extraskeletal myxoid chondrosarcoma but not in the skeletal chondrosarcoma case. Conclusions: This study confirms that a substantial proportion of extraskeletal myxoid chondrosarcomas show immunophenotypic and/or ultrastructural evidence of neuroendocrine differentiation, and are unlikely to be related to conventional skeletal chondrosarcomas.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesBatchelor, T.T. ; Platten, M. ; Palmer-Toy, D.E. ; Hunter, G.J. ; Lev, M.H. ; Dalmau, J. ; Hochberg, F.H.
Springer
Published 1998Staff ViewISSN: 1573-7373Keywords: chorea ; Hodgkin's disease ; paraneoplasticSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Neurologic complications of Hodgkin's disease (HD) include both metastatic and non-metastatic involvement of the nervous system. There are at least five paraneoplastic syndromes associated with HD but chorea has not been described. We report the first choreiform disorder as a paraneoplastic complication of HD and only the second case of paraneoplastic chorea in the literature.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1573-7373Keywords: immunoadsorption ; cancer ; paraneoplasticSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Paraneoplastic neurologic syndromes associated with systemic cancer are being increasingly recognized. Although these syndromes are thought to be immunologically mediated treatment with steroids, immunoglobulin and plasmapharesis has been disappointing. Based on our preliminary experience with the treatment of 6 cases of paraneoplastic neurologic syndromes with protein A immunoadsorption, an institutional, open-arm treatment protocol was established. Since our original report we have treated an additional 7 patients with this method. The 13 cases were accrued over a 2 year period and included 10 women and 3 men with an average age of 63. The paraneoplastic syndromes included 6 cases of cerebellar degeneration, 3 cases of opsoclonus/myoclonus, 3 cases of encephalomyelitis and 1 case of Lambert Eaton myasthenic syndrome. Primary cancers included 4 cases of small cell lung cancer, 2 cases of breast cancer, 2 cases of lymphoma and 1 each of acinic cell cancer, cholangiocarcinoma, Merkel cell cancer, pancreatic adenocarcinoma and rectal cancer. Anti-neuronal antibody status, cerebrospinal fluid and neuroimaging studies as well as cancer staging and treatment protocols were reviewed. Neurologic syndromes were clinically separated into component symptoms and signs for assessment of treatment effect. The treatment goal was a total of 6 sessions of protein A immunoadsorption given twice weekly. Twelve of 13 patients completed therapy and one patient developed cutaneous vasculitis during the second session with termination of treatment. Of the remaining patients 3/12 had a complete response of the primary clinical symptom/sign while 6/12 had a partial response for a total response rate of 9/12 (75%). Toxicity was limited to cutaneous vasculitis in 1 patient and an episode of hemisensory changes in another patient. Current treatment of paraneoplastic neurologic syndromes remains unsatisfactory. Despite the small number of patients in this report, protein A immunoadsorption is a promising therapy which deserves further study in a larger population of patients with paraneoplastic syndromes.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0030-4921Keywords: Chemistry ; Analytical Chemistry and SpectroscopySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: The CH3-proton resonances for the 2,4- and 2,6-isomers of toluene di-isocyanate separate when hexafluorobenzene is used as a solvent. Integration of these absorptions over an expanded sweep scale gives the isomer ratio with an accuracy of ±0.5% over the range normally encountered with commercial samples.Additional Material: 1 Ill.Type of Medium: Electronic ResourceURL: