Search Results - (Author, Cooperation:M. Okun)
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1M. Okun ; N. A. Steinmetz ; L. Cossell ; M. F. Iacaruso ; H. Ko ; P. Bartho ; T. Moore ; S. B. Hofer ; T. D. Mrsic-Flogel ; M. Carandini ; K. D. Harris
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Female ; Macaca mulatta ; Male ; Mice ; Models, Neurological ; Neurons/*cytology/*physiology ; Optogenetics ; Synapses/physiology ; Visual Cortex/*cytology/*physiologyPublished by: -
2Staff View
Publication Date: 2018-06-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Genetics, Medicine, Diseases, Online OnlyPublished by: -
3Staff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The differential diagnosis of melanocytic lesions is fraught with difficulty and a common source of litigation either if a lesion misreported as ‘benign’ recurs locally or re-presents with nodal metastases or if an atypical naevus is called ‘malignant’ leading to a cosmetically unsatisfactory wider resection, unwarranted anxiety about prognosis and adverse life insurance prospects. Several authors have claimed that there are valid morphological criteria which, alone or in combination, enable reliable distinction between benign and malignant melanocytic lesions. Others question these criteria and, doubting the extent to which unequivocal diagnoses can be rendered in all cases, believe that the diagnosis is purely subjective and that most diagnostic errors are non-negligent. To address these issues, expert opinions were commissioned from three sets of authors.Okun, Edelstein & Kasznica emphasize that a significant minority of melanocytic lesions are so borderline morphologically that diagnostic uncertainty is allowable and that such uncertainty can be handled responsibly. Kirkham, in favouring the methodical use of criteria, concedes that they are ‘largely opinion-based rather than evidence-based, but do go beyond mere subjective pattern analysis’. In agreement with Okun and his colleagues, Slater emphasises that no single feature is reliable by itself and that all aspects, including clinical details, should be interpreted together; he has no hesitation in reporting the diagnosis as ‘uncertain’ in doubtful cases.In the absence of a specific marker pathognomonic of melanocytic malignancy, the diagnosis will continue to rely on the judicious application of morphological criteria with a small proportion of elusive cases in which diagnostic uncertainty should not be concealed.Type of Medium: Electronic ResourceURL: -
4Staff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The objective of this study was to determine the validity of sharpness of lateral margins (an important component of the pattern analysis method) as a criterion for the histological distinction of naevi from malignant melanoma.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsThe sharpness of lateral borders in a series of histologically unequivocal malignant melanomas, Spitz naevi and compound naevi, chosen at random from dermatopathology slide archives, was determined. The incidence of poor demarcation of lateral borders in malignant melanomas was about equal to that of Spitz naevi and was significantly less than in compound naevi. The sharpness of lateral borders frequently varies with level of sectioning.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsThe proposal that malignant melanomas have a significantly greater incidence of poor demarcation of lateral borders than benign melanocytic neoplasms (Spitz naevi and compound naevi) was shown to be without validity on cited empirical grounds as well as theoretical grounds (the lack of constancy of pattern from a 3-dimensional standpoint).Type of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 0022-1031Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1439-6327Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 1439-6327Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung Bei Arbeit in heißer Umgebung (mechanisierte Schmiede des Charkower Traktorenwerks) ist der an Stirn und zwischen den Schulterblättern gewonnene Schweiß mitp H 7,8–8,0 (über 50 Versuche an 8 Vpn.) ohne Ausnahme deutlich alkalisch. Die Milchsäurekonzentration im Schweiß ist dabei beträchtlich (bis über 200 mg%). Die Konzentration an Ammoniak ist wesentlich geringer und nicht ausreichend, die Milchsäure im Schweiß zu neutralisieren. Untersuchungen des Harns ergaben eine deutliche Verschiebung derp H bei der Arbeit nach der sauren Seite, auch die Quotienten NH3-N: Gesamt-N liegen sehr hoch.Type of Medium: Electronic ResourceURL: