Search Results - (Author, Cooperation:M. Mercken)

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  1. 1
    I. Tesseur ; A. C. Lo ; A. Roberfroid ; S. Dietvorst ; B. Van Broeck ; M. Borgers ; H. Gijsen ; D. Moechars ; M. Mercken ; J. Kemp ; R. D'Hooge ; B. De Strooper
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-05-25
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alzheimer Disease/*drug therapy/*metabolism ; Amyloid beta-Peptides/*metabolism ; Animals ; Apolipoproteins E/*metabolism ; Brain/*metabolism ; Male ; Tetrahydronaphthalenes/*pharmacology/*therapeutic use
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1432-0533
    Keywords:
    Microtubule-associated protein-2 ; Somatodendritic distribution ; Alzheimer's disease ; Senile plaque neurites ; Paired helical filaments
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary We have developed monoclonal antibodies that detect normal microtubule-associated protein-2 (MAP2) epitopes in routinely fixed, paraffin-embedded tissue. The somatodendritic distribution of MAP2 in bovine and human nervous tissue was confirmed with several of these antibodies. Furthermore, some of these antibodies immunohistochemically labeled certain pathological structures in Alzheimer brain, especially neurites in senile plaques. Electron microscopic observations, however, indicate that these MAP2 epitopes are not located in the Alzheimer paired helical filaments themselves, but in amorphous granular structures coexistent with them. While the pathological nature of these structures is undetermined, they may represent artefactual modifications of normal cytoskeletal components.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00308477

    Articles: DFG German National Licenses