Search Results - (Author, Cooperation:M. M. Chan)

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  1. 1
    Z. D. Smith ; M. M. Chan ; T. S. Mikkelsen ; H. Gu ; A. Gnirke ; A. Regev ; A. Meissner
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-03-30
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; CpG Islands/genetics ; *DNA Methylation/genetics ; Embryo, Mammalian/*embryology/*metabolism ; Embryonic Development/*genetics ; Female ; Fertilization/genetics ; Genome/genetics ; Long Interspersed Nucleotide Elements/genetics ; Male ; Mice ; Oocytes/metabolism ; Spermatozoa/metabolism ; Terminal Repeat Sequences/genetics ; Zygote/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Z. D. Smith ; M. M. Chan ; K. C. Humm ; R. Karnik ; S. Mekhoubad ; A. Regev ; K. Eggan ; A. Meissner
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-08-01
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Blastocyst/*metabolism ; Cell Line ; CpG Islands/physiology ; DNA/metabolism ; *DNA Methylation ; Embryonic Stem Cells ; Female ; Gene Expression Regulation, Developmental ; Humans ; Male ; Mice ; Mice, Inbred C57BL
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Chan, M. M. ; Kano, K. ; Dorman, B. ; Ruddle, F. H. ; Milgrom, F.
    Springer
    Published 1979
    Staff View
    ISSN:
    1432-1211
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract Clones of man-mouse hybrids derived from four different crosses which retained a very limited number of human chromosomes were studied for the expression of human cell surface antigens. In testing a variety of rabbit antisera to human cells and tissues, it was found that an antiserum to Daudi cells recognizes human species-specific antigen(s) on three ‘WA’ clones, all of which carried human chromosome 21. Absorption of the antiserum with any of the clones abolished its activity against all clones, indicating that the antiserum recognized the same antigen(s) on these clones. The antigen(s) was shown to be present on normal human lymphocytes, more on B than on T cells, but apparently absent from erythrocytes. C3H mice, from which the murine parent originated, were immunized with the WA clones carrying human chromosome 21. The resultant antisera reacted with clones carrying chromosome 21 but not with clones which did not retain this chromosome, even though some of these clones possessed many other human chromosomes. The murine antisera reacted with some, but not all, human peripheral blood lymphocytes tested. Absorption studies clearly showed the multiple nature of the antigens recognized by these antisera. Studies on cells of identical twins provided evidence that these antigens are inheritable.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01561436

    Articles: DFG German National Licenses