Search Results - (Author, Cooperation:M. Lai)
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1Latest Papers from Table of Contents or Articles in PressRaman, G., Balk, E. M., Lai, L., Shi, J., Chan, J., Lutz, J. S., Dubois, R. W., Kravitz, R. L., Kent, D. M.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-05-27Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Patient-centred medicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressKong, Y., Cao, X.-N., Zhang, X.-H., Shi, M.-M., Lai, Y.-Y., Wang, Y., Xu, L.-P., Chang, Y.-J., Huang, X.-J.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-03-16Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Thrombocytopenia, Platelets and ThrombopoiesisPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-07-21Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressL. Dou ; A. B. Wong ; Y. Yu ; M. Lai ; N. Kornienko ; S. W. Eaton ; A. Fu ; C. G. Bischak ; J. Ma ; T. Ding ; N. S. Ginsberg ; L. W. Wang ; A. P. Alivisatos ; P. Yang
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressL. Arranz ; A. Sanchez-Aguilera ; D. Martin-Perez ; J. Isern ; X. Langa ; A. Tzankov ; P. Lundberg ; S. Muntion ; Y. S. Tzeng ; D. M. Lai ; J. Schwaller ; R. C. Skoda ; S. Mendez-Ferrer
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adrenergic beta-3 Receptor Agonists/pharmacology/therapeutic use ; Animals ; Apoptosis/drug effects ; Disease Progression ; Female ; Hematopoietic Stem Cells/drug effects/*pathology ; Humans ; Interleukin-1beta/metabolism ; Janus Kinase 2/genetics ; Mesenchymal Stromal Cells/drug effects/pathology ; Mice ; Myeloproliferative Disorders/drug therapy/*pathology ; Neoplasms/drug therapy/*pathology ; Neoplastic Stem Cells/drug effects/pathology ; Nerve Fibers/drug effects/*pathology ; Nestin/metabolism ; Neuroprotective Agents/pharmacology/therapeutic use ; Receptors, Adrenergic, beta-3/metabolism ; Schwann Cells/drug effects/pathology ; *Stem Cell Niche ; Sympathetic Nervous System/drug effects/*pathology/physiopathologyPublished by: -
6Articles: DFG German National LicensesZeegelaar, Jim E. ; De Feijter, Annemieke ; De Vries, Henry J. C. ; Fat, Rudy F. M. Lai A ; Neumann, Martino A. M. ; Faber, William R.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-4632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Travelers to tropical areas seem to be affected by nonhealing leg ulcers more frequently. One of the factors that can affect wound healing in a negative manner is leg edema. This study was performed to determine whether there is increased leg edema in travelers to tropical areas.Method In this study, we measured the capillary filtration rate (CFR) of the lower leg by strain gauge plethysmography, as a measure of leg edema, on location in Surinam. Three groups were included: A, travelers in the first few weeks after arrival; B, travelers who had stayed in the tropics for a minimum of 2 months; C, native inhabitants.Results The mean CFR (mL/100 mL tissue/min) was significantly higher in group A than in groups B and C; the difference between groups B and C was not significant (group A 0.05 mL/100 mL tissue/min (standard deviation (SD), 0.03) vs. group B 0.02 mL/100 mL tissue/min (SD, 0.02), P = 0.01, and vs. group C 0.02 mL/100 mL tissue/min (SD, 0.02), P = 0.01).Conclusions Travelers to tropical areas are affected by increased CFR in the first few weeks after arrival. A prolonged stay leads to the normalization of the CFR. Compression therapy is recommended for travelers to the tropics.Type of Medium: Electronic ResourceURL: -
7Latest Papers from Table of Contents or Articles in PressSu, W.-C., Yu, W.-Y., Huang, S.-H., Lai, M. M. C.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-01-31Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
8Latest Papers from Table of Contents or Articles in PressSilver, D., Hubert, T., Schrittwieser, J., Antonoglou, I., Lai, M., Guez, A., Lanctot, M., Sifre, L., Kumaran, D., Graepel, T., Lillicrap, T., Simonyan, K., Hassabis, D.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-12-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Computers, MathematicsPublished by: -
9Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Praseodymium (Pr) is added to the InGaP growth melt during liquid phase epitaxy (LPE). The epilayers are grown, by using a supercooling method, on (100) Cr-doped semi-insulating GaAs substrates at a growth temperature of 790 °C. An examination of the structural properties of the InGaP-grown layers reveals that its lattice constant increases slightly with increasing Pr concentration in the growth melts. Similarly, an examination of the electrical properties reveals that, depending on the amount of Pr in the growth melt, n-type InGaP epilayers with room-temperature electron concentrations in the range of 3.4×1016 cm−3 to 5.2×1015 cm−3 and electron mobilities from 730 to 1310 cm2/V s can be prepared. The photoluminescence spectral results show that by increasing the amount of Pr in the growth melt, smaller full-width at half-maximum values and better band-edge emission intensities result. The experimental results support the fact that Pr exhibits a gettering effect in the InGaP LPE process, as no characteristic Pr intra-4f-shell transitions are observed in the luminescence spectra of the InGaP-grown layers.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesQUARTU, M. ; DIAZ, G. ; LAI, M. L. ; FIACCO, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesFIACCO, M. ; FLORIS, A. ; LAI, M. L. ; MONTISCI, R. ; QUARTU, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: We implement a linear stability analysis for the mush under rocking motion. Owing to the rocking motion, the shifted gravity induces a parallel flow. Without rocking, all the instability modes propagating in different directions are of equal stability criteria. With rocking, except for the longitudinal mode propagating in the direction perpendicular to the induced flow, all modes are to various extents inhibited by the induced flow. More precisely, all these modes are inhibited by the periodical buoyancy reduction in the direction of density gradient, which essentially stabilizes the system without preferred direction. © 2002 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims: To determine the clinicopathological and molecular features of gastric medullary cancer.Methods and results: Clinicopathological review and microsatellite instability (MSI) analysis were carried out on 17 gastric medullary and 64 non-medullary cancers. In addition to characteristic histopathology, gastric medullary cancers had certain prominent features: (i) the average survival time was longer in medullary and low-grade non-medullary cancers than in high-grade (P = 0.004); (ii) serosal involvement was less common in medullary cancers (29.4%, 5/17) than in non-medullary cancers (9.4%, 6/64) (P 〈 0.05) while pushing borders were more common in medullary cancers (70.6%, 12/17 versus 17.2%, 11/64, P = 0); (iii) the presence of intraepithelial lymphocytes (IELs) in medullary and non-medullary cancers was 2380/10 high-power field (HPF) and 147/10 HPF (P = 0), respectively. Both peritumoural infiltrating lymphocytes (pTIL) and a Crohn's-like reaction were more common in medullary cancers than in non-medullary (pTIL 35.3%, 6/17 versus 3.1%, 2/64; a Crohn's-like reaction 70.6%, 12/17 versus 32.8%, 21/64; P 〈 0.05); (iv) medullary and high-grade non-medullary cancers were more associated with reduced ECD expression in comparison with low-grade cancers (P 〈 0.05); (v) higher MSI-H (Bat26+) rate was observed in medullary cancers (41.2%, 7/17) than in non-medullary (1.6%, 1/64) (P = 0).Conclusions: Gastric medullary cancer has distinct clinicopathological features and genetic alterations. Two subtypes of gastric medullary cancers, Bat26+ and Bat26–, might have prognostic implications, thus analysis of Bat26 may be of clinical value.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesLai, M L ; Rizzo, N ; Liguori, C ; Zucca, G ; Faa, G
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1998Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Papillary thyroid carcinoma (PTC) is the most common malignant tumour of the thyroid gland. The immunohistochemical profile of PTC is characterized by immunoreactivity of tumour cells for cytokeratins, thyroglobulin, vimentin, EMA and S100 protein. Recently, the presence of a serum protease inhibitor, alpha-1-antitrypsin (A1AT), has been demonstrated in tumour cells of PTC. The aim of our study was to test immunoreactivity of PTC for another inhibitor of proteases, alpha-1-antichymotrypsin (A1ACT).〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsSerial paraffin sections of nine consecutive cases of PTC were tested with anti-A1AT and anti-A1ACT antibodies. No immunoreactivity for A1AT and A1ACT was found in the normal thyroid tissue surrounding each tumour. In seven out of nine cases, tumour cells of PTC showed cytoplasmic immunoreactivity for A1ACT. In two cases, A1ACT was detected even in the nuclei. Immunoreactivity for A1AT was found only in three cases. Two cases of PTC showed no staining for both A1ACT and A1AT. No significant correlation of A1ACT staining was found with various prognostic indices (age of patients, histological pattern, tumour size, presence of regional lymph node metastases). The two cases showing a lack of staining for both A1ACT and A1AT showed a more aggressive clinical behaviour.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsOur preliminary study shows that A1ACT is expressed by tumour cells in a large proportion of papillary carcinomas of the thyroid gland. Its significance remains, to the best of our knowledge, still unknown. The observation of a more aggressive behaviour in the two cases characterized by the absence of immunoreactivity for both A1ACT and A1AT suggests that the presence or absence of protease inhibitors could play a role in controlling tumour progression in PTC.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesChang, C. H. ; Chen, K. Y. ; Lai, M. Y. ; Chan, K. A.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aim : To use meta-analysis to study the risk of anaemiarelated to ribavirin therapy for chronic hepatitisC.Methods : The MEDLINE database up to January 2001 was searched for randomized controlled trials of ribavirin (monotherapy or combined with interferon) for chronic hepatitis C. The outcomes evaluated were withdrawal from the study due to anaemia, ribavirin dosage reduction due to a decrease in haemoglobin and haemoglobin levels below 10 g/dL.Results : Based on 17 studies, the overall risk difference (ribavirin vs. no ribavirin) for anaemia was 0.09 [95% confidence interval (CI), 0.04–0.13]. Two Asian studies reported risk differences of 0.29 and 0.22, greater than the pooled risk difference of 0.07 (95% CI, 0.03–0.12) for 15 non-Asian studies. The risk associated with 1 g or more of ribavirin per day was higher (risk difference, 0.09; 95% CI, 0.04–0.14) than that for 0.8 g of ribavirin per day (risk difference, 0.01; 95% CI, − 0.04–0.06).Conclusions : Chronic hepatitis C patients treated with 1 g or more of ribavirin per day were at a higher risk of developing anaemia. Reported risks were higher among Asian studies, which may be due to differences in study entrance criteria, dosage titration strategy or ethnic vulnerability.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0003-9861Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesManetta, J.V. ; Lai, M.-H.T. ; Edward Osborne, H. ; Dee, A. ; Margolin, N. ; Richard Sportsman, J. ; Vlahos, C.J. ; Betty Yan, S. ; Heath, W.F.
Amsterdam : ElsevierStaff ViewISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Glucocorticoid ; Jun ; OncogeneSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: