Search Results - (Author, Cooperation:M. J. Sheehan)
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1Latest Papers from Table of Contents or Articles in PressZhang, Y., Paikari, A., Sumazin, P., Ginter Summarell, C. C., Crosby, J. R., Boerwinkle, E., Weiss, M. J., Sheehan, V. A.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-07-20Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Red Cells, Iron, and ErythropoiesisPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. J. Sheehan ; E. A. Tibbetts
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-12-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptation, Biological ; Animals ; *Biological Evolution ; Cognition ; *Face ; Female ; *Learning ; Pattern Recognition, Visual ; Recognition (Psychology) ; Species Specificity ; *WaspsPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 0007-1269Topics: PsychologyURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0007-1269Topics: PsychologyURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesDexter, E. J. ; Butchers, P. R. ; Reeves, J. J. ; Sheehan, M. J. ; Pearce 〈!-RID="h1"--〉 〈!-ID="h1" Correspondence to: F.L. Pearce--〉, F. L.
Springer
Published 1999Staff ViewISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesReeves, J. J. ; Jones, C. A. ; Sheehan, M. J. ; Vardey, C. J. ; Whelan, C. J.
Springer
Published 1997Staff ViewISSN: 1420-908XKeywords: Key words: Rat mast cells — Degranulation — Adenosine A3 receptorsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. Objective: To investigate the effects of adenosine receptor agonists and antagonists on 5-HT release from rat isolated pleural mast cells and on plasma protein extravasation in the skin of conscious rats.¶In vitro Methods: Rat isolated pleural mast cells were loaded with [14C] 5-HT, sensitised with mouse monoclonal anti-DNP and then challenged with human serum albumin-DNP. DNP-stimulated 5-HT release from mast cells was determined.¶In vivo Methods: Rats, loaded intravenously with [125I] human serum albumin, were injected intradermally with adenosine agonists at sites on the back. 30 min later plasma protein extravasation at each injection site was determined.¶Results: In isolated mast cells, each adenosine agonist enhanced DNP-induced 5-HT release, N6-(3-iodobenzyl)-5-(N-methyl-carboxamidoadenosine), (IB-MECA), being the most potent agonist. The adenosine A1/A2 antagonist, 8-phenyltheophylline (8-PT), had no effect on the response to IB-MECA. In contrast, 3-(4-amino-iodobenzyl)-8-[4-[[[carboxy]methyl]oxy]phenyl]-1-propylxanthine, (I-ABOPX), inhibited (pA2 6.2) the IB-MECA responses. In the skin of conscious rats, intradermal IB-MECA produced a marked plasma protein extravasation (PPE) which was mimicked by N6-2-(4-aminophenyl)-ethyladenosine (APNEA). The PPE produced by IB-MECA was not affected by either 8-PT or CGS15943A, but was virtually abolished by cyproheptadine and in rats pre-treated with Compound 48/80.¶Conclusions: These results indicate that stimulation of adenosine A3 receptors both enhances degranulation in vitro and directly produces degranulation of rat mast cells in vivo.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-2072Keywords: Mesolimbic ; Nigro-striatal ; Atypical neuroleptics ; Typical neuroleptics ; Muscimol ; BehaviourSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Direct injections of muscimol into the ventral tegmental area (VTA) or substantia nigra zona reticulata (SNR) have been used to selectively stimulate the mesolimbic and nigro-striatal dopamine pathways respectively. Such injections induced locomotor activity, rearing, sniffing and in some animals an intermittent grooming response. These responses were rapid in onset, dose-related and relatively short lasting (〈40 min). Selective increases in dopamine turnover were seen in the nucleus accumbens and in the striatum following VTA and SNR injections of muscimol (100 ng) respectively. Haloperidol inhibited the behavioural consequences of VTA and SNR injections of muscimol with similar potency (ED50s 0.01–0.03 mg/kg IP), and fluphenazine did likewise (ED50s 0.05–0.16 mg/kg IP). However, thioridazine (ED50s VTA: 1.45–2.04 mg/kg IP, SNR 8.50–9.20 mg/kg IP) and in particular clozapine (ED50s VTA: 0.24–0.58 mg/kg IP, SNR: 6.10–9.70 mg/kg IP) were more potent at inhibiting the locomotor activity and sniffing responses due to VTA rather than SNR administered muscimol. Since dopamine D2 antagonists are believed to exert their anti-psychotic effects via an action on mesolimbic dopaminergic systems, and their ability to induce extrapyramidal side effects (EPS) is thought to be due to an action on nigro-striatal dopamine systems, these results suggest that the behavioural models described can be used to predict efficacy and side-effect liability of potential neuroleptic drugs.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-1912Keywords: Voltammetry ; Brain slice ; Dopamine release ; D2-receptors ; Nucleus accumbensSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Fast cyclic voltammetry has been used to measure electrically evoked dopamine overflow from slices of rat nucleus accumbens in vitro. The substance detected was shown voltammetrically and biochemically to be dopamine of neuronal origin. Enough dopamine was released by a single electrical pulse to be easily detectable, and under these conditions there was no auto-inhibition by the endogenous transmitter (as demonstrated by the failure of dopamine antagonists to increase the amount released). There was no significant inhibition, or enhancement, of release by agonists at the following receptor types: dopamine D1, 5-hydroxytryptamine, cholinoceptors, α1-, α2-, β-adrenoceptors, cholecystokinin or neurotensin receptors. However, the dopamine D2 receptor agonist, quinpirole, was capable of totally inhibiting the release; this effect was concentration-dependently antagonized by the D2 antagonists haloperidol, sulpiride, metoclopramide and clozapine, with potencies which corresponded to their affinities for D2 receptors in striatal tissue. The results show that the presynaptic receptors on dopaminergic nerve terminals are of the D2 type and apparently identical to those in the corpus striatum.Type of Medium: Electronic ResourceURL: