Search Results - (Author, Cooperation:M. Humphries)

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  1. 1
    Staff View
    Publication Date:
    2018-03-16
    Publisher:
    Wiley-Blackwell
    Print ISSN:
    0012-9658
    Electronic ISSN:
    1939-9170
    Topics:
    Biology
    Published by:
    http://www.wiley.com/wiley-blackwell

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    K. Howe ; M. D. Clark ; C. F. Torroja ; J. Torrance ; C. Berthelot ; M. Muffato ; J. E. Collins ; S. Humphray ; K. McLaren ; L. Matthews ; S. McLaren ; I. Sealy ; M. Caccamo ; C. Churcher ; C. Scott ; J. C. Barrett ; R. Koch ; G. J. Rauch ; S. White ; W. Chow ; B. Kilian ; L. T. Quintais ; J. A. Guerra-Assuncao ; Y. Zhou ; Y. Gu ; J. Yen ; J. H. Vogel ; T. Eyre ; S. Redmond ; R. Banerjee ; J. Chi ; B. Fu ; E. Langley ; S. F. Maguire ; G. K. Laird ; D. Lloyd ; E. Kenyon ; S. Donaldson ; H. Sehra ; J. Almeida-King ; J. Loveland ; S. Trevanion ; M. Jones ; M. Quail ; D. Willey ; A. Hunt ; J. Burton ; S. Sims ; K. McLay ; B. Plumb ; J. Davis ; C. Clee ; K. Oliver ; R. Clark ; C. Riddle ; D. Elliot ; G. Threadgold ; G. Harden ; D. Ware ; S. Begum ; B. Mortimore ; G. Kerry ; P. Heath ; B. Phillimore ; A. Tracey ; N. Corby ; M. Dunn ; C. Johnson ; J. Wood ; S. Clark ; S. Pelan ; G. Griffiths ; M. Smith ; R. Glithero ; P. Howden ; N. Barker ; C. Lloyd ; C. Stevens ; J. Harley ; K. Holt ; G. Panagiotidis ; J. Lovell ; H. Beasley ; C. Henderson ; D. Gordon ; K. Auger ; D. Wright ; J. Collins ; C. Raisen ; L. Dyer ; K. Leung ; L. Robertson ; K. Ambridge ; D. Leongamornlert ; S. McGuire ; R. Gilderthorp ; C. Griffiths ; D. Manthravadi ; S. Nichol ; G. Barker ; S. Whitehead ; M. Kay ; J. Brown ; C. Murnane ; E. Gray ; M. Humphries ; N. Sycamore ; D. Barker ; D. Saunders ; J. Wallis ; A. Babbage ; S. Hammond ; M. Mashreghi-Mohammadi ; L. Barr ; S. Martin ; P. Wray ; A. Ellington ; N. Matthews ; M. Ellwood ; R. Woodmansey ; G. Clark ; J. Cooper ; A. Tromans ; D. Grafham ; C. Skuce ; R. Pandian ; R. Andrews ; E. Harrison ; A. Kimberley ; J. Garnett ; N. Fosker ; R. Hall ; P. Garner ; D. Kelly ; C. Bird ; S. Palmer ; I. Gehring ; A. Berger ; C. M. Dooley ; Z. Ersan-Urun ; C. Eser ; H. Geiger ; M. Geisler ; L. Karotki ; A. Kirn ; J. Konantz ; M. Konantz ; M. Oberlander ; S. Rudolph-Geiger ; M. Teucke ; C. Lanz ; G. Raddatz ; K. Osoegawa ; B. Zhu ; A. Rapp ; S. Widaa ; C. Langford ; F. Yang ; S. C. Schuster ; N. P. Carter ; J. Harrow ; Z. Ning ; J. Herrero ; S. M. Searle ; A. Enright ; R. Geisler ; R. H. Plasterk ; C. Lee ; M. Westerfield ; P. J. de Jong ; L. I. Zon ; J. H. Postlethwait ; C. Nusslein-Volhard ; T. J. Hubbard ; H. Roest Crollius ; J. Rogers ; D. L. Stemple
    Nature Publishing Group (NPG)
    Published 2013
    Staff View
    Publication Date:
    2013-04-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Chromosomes/genetics ; Conserved Sequence/*genetics ; Evolution, Molecular ; Female ; Genes/genetics ; Genome/*genetics ; Genome, Human/genetics ; Genomics ; Humans ; Male ; Meiosis/genetics ; Molecular Sequence Annotation ; Pseudogenes/genetics ; Reference Standards ; Sex Determination Processes/genetics ; Zebrafish/*genetics ; Zebrafish Proteins/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    B. Dantzer ; A. E. Newman ; R. Boonstra ; R. Palme ; S. Boutin ; M. M. Humphries ; A. G. McAdam
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-04-20
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Adaptation, Physiological ; Animals ; Cues ; Female ; Glucocorticoids/*metabolism ; *Growth and Development ; Hydrocortisone/blood ; Litter Size/*physiology ; Maternal Behavior/*physiology ; Population Density ; Sciuridae/*physiology ; Selection, Genetic ; Vocalization, Animal
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    A. M. M. Sequeira, J. P. Rodriguez, V. M. Eguiluz, R. Harcourt, M. Hindell, D. W. Sims, C. M. Duarte, D. P. Costa, J. Fernandez–Gracia, L. C. Ferreira, G. C. Hays, M. R. Heupel, M. G. Meekan, A. Aven, F. Bailleul, A. M. M. Baylis, M. L. Berumen, C. D. Braun, J. Burns, M. J. Caley, R. Campbell, R. H. Carmichael, E. Clua, L. D. Einoder, Ari Friedlaender, M. E. Goebel, S. D. Goldsworthy, C. Guinet, J. Gunn, D. Hamer, N. Hammerschlag, M. Hammill, L. A. Huckstadt, N. E. Humphries, M.–A. Lea, A. Lowther, A. Mackay, E. McHuron, J. McKenzie, L. McLeay, C. R. McMahon, K. Mengersen, M. M. C. Muelbert, A. M. Pagano, B. Page, N. Queiroz, P. W. Robinson, S. A. Shaffer, M. Shivȷi, G. B. Skomal, S. R. Thorrold, S. Villegas–Amtmann, M. Weise, R. Wells, B. Wetherbee, A. Wiebkin, B. Wienecke, M. Thums
    National Academy of Sciences
    Published 2018
    Staff View
    Publication Date:
    2018-03-21
    Publisher:
    National Academy of Sciences
    Print ISSN:
    0027-8424
    Electronic ISSN:
    1091-6490
    Topics:
    Biology
    Medicine
    Natural Sciences in General
    Published by:
    http://www.nasonline.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Hackett, P. A. ; Humphries, M. R. ; Mitchell, S. A. ; Rayner, D. M.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1986
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    An accurate value for the first ionization potential of zirconium of 53 506.0(3) cm−1 has been obtained from convergence limits of high lying Rydberg series observed using two laser, field- ionization spectroscopy of an atomic beam of zirconium. The new value is consistent with analysis of s-electron binding energies of other second transition series elements.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.450986

    Articles: DFG German National Licenses
  6. 6
    Mitchell, S. A. ; Hackett, P. A. ; Rayner, D. M. ; Humphries, M. R.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1985
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    UV and visible multiphoton dissociation (MPD) processes of Ga(CH3)3 have been investigated by time-resolved detection of Ga(4 2PJ ) (J=1/2, 3/2) and Ga(5 2S1/2) following pulsed laser photolysis in a low pressure gas cell, and by mass spectrometric detection of ionic photofragments in a molecular beam. The relative abundances of neutral and ionic fragments were monitored as a function of photolysis wavelength and flux. Measurements of the anisotropy of the velocity distribution and the average kinetic energy of nascent Ga(4 2PJ ) are also reported. Under conditions of moderate photolysis flux ((approximately-equal-to)108 W cm−2), MPD of Ga(CH3)3 in the wavelength range 420–520 nm produced mainly neutral fragments, including Ga(4 2PJ ) and a metastable molecular fragment which is identified as GaCH3. Photolysis at 222 nm produced GaCH3 to the exclusion of Ga(4 2PJ ), or primarily ionic fragments at relatively high flux. At 308 nm, ionic Ga(CH3)+n species were produced in relatively high yield even in the limit of low photolysis flux. The mechanisms of MPD and MPI of Ga(CH3)3 are discussed with reference to simple rate equations models.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.449769

    Articles: DFG German National Licenses
  7. 7
    O'leary, C. ; McCarthy, J. ; Humphries, M. ; Shanahan, F. ; Quigley, E.

    Oxford, UK : Blackwell Science Ltd
    Published 2003
    Staff View
    ISSN:
    1365-2036
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background : Patients report that the prophylactic consumption of a proton pump inhibitor minimizes gastrointestinal symptoms expected to be provoked by late-night food and alcohol consumption. The efficacy of this practice has not been studied formally.Aim : To perform a randomized, double-blind, placebo-controlled trial of a single dose of lansoprazole (30 mg) taken prior to a large meal and alcohol consumption.Methods : Study subjects were recruited randomly from local primary care and hospital physicians. Each participant (n = 56; 37 male, 19 female; mean age, 38 years) completed questionnaires before and after the meal. Approximately 90 min prior to the provocative meal, participants were witnessed taking either placebo or 30 mg lansoprazole. Bar tokens were dispensed to permit the accurate quantification of alcohol consumption (mean, 15 units).Results : Forty per cent of subjects reported significant reflux symptoms. For the entire group, there was no significant difference between lansoprazole and placebo. Post-prandial reflux was more frequent in those consuming 〉 15 units of alcohol (13/26, 50%) compared with those consuming 〈 15 units (7/30, 24%; P 〈 0.05). In the group who consumed 〉 15 units of alcohol, lansoprazole was associated with a lower rate of heartburn (5/15, 33%) compared with placebo (8/11, 73%; P 〈 0.05).Conclusion : A single dose of a proton pump inhibitor prior to indulgence was only associated with reduced heartburn in those consuming 〉 15 units of alcohol.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2036.2003.01483.x

    Articles: DFG German National Licenses
  8. 8
    Humphries, M. ; Stuart Thompson, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-2697
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-2697(80)90464-9

    Articles: DFG German National Licenses
  9. 9
    Humphries, M. ; Thompson, J.S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-2697
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-2697(81)90094-4

    Articles: DFG German National Licenses
  10. 10
    Au, Mei-Kuen ; Hackett, P. A. ; Humphries, M. ; John, P.
    Springer
    Published 1984
    Staff View
    ISSN:
    1432-0649
    Keywords:
    82.50
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Physics
    Notes:
    Abstract A frequency-doubled carbon dioxide laser of modest output energy (1 mJ) has been used to study, for the first time, the infrared multiphoton absorption by, and dissociation of, the unsubstituted carbonyls of vanadium, chromium, iron, nickel, molybdenum, and tungsten. The multiphoton absorption cross-sections measured for Ni(CO)4, Fe(CO)5, Cr(CO)6, Mo(CO)6, and V(CO)6 are high (σ∼2×10−17) and ensure facile multiphoton dissociation. In focussed beams a pressure independent reaction yield proportional to the 1.5 power of the beam energy is observed for Fe(CO)5, Cr(CO)6, and Mo(CO)6 implying threshold fluences of only 32, 25, and 26 mJ cm−2, respectively. The stoichiometry of the reaction, observed by a pressure measurement technique, is consistent with production of metal atoms and carbon monoxide as final products for Ni(CO)4, Fe(CO)5, Cr(CO)6, and Mo(CO)6. This extensive decarbonylation along the ground state surface is consistent with recent studies of the photochemistry of these molecules from excited electronic states.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00690024

    Articles: DFG German National Licenses
  11. 11
    Curley, G. P. ; Blum, H. ; Humphries, M. J.
    Springer
    Published 1999
    Staff View
    ISSN:
    1420-9071
    Keywords:
    Key words. Integrins; cell adhesion; antagonists; inflammation; cancer; arthritis; therapeutics.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract. Integrins are a family of cell surface glycoproteins that mediate numerous cell-cell and cell-matrix interactions and are involved in biological processes such as tissue morphogenesis, leukocyte recirculation and migration, wound healing, blood clotting and immune response. Aberrant cell adhesion has been implicated in the pathogenesis of several diseases, including a number of inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease and asthma, as well as cancer and coronary heart disease. As such integrins are seen as excellent targets for the development of therapeutic agents. This report begins with an examination of the structure of integrin molecules and their ligands and then goes on to review the current state of development of antiintegrin antagonists.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s000180050443

    Articles: DFG German National Licenses
  12. 12
    Teoh, R. ; Poon, W. ; Humphries, M. J. ; O'Mahony, G.
    Springer
    Published 1988
    Staff View
    ISSN:
    1432-1459
    Keywords:
    Tuberculous meningitis ; Tuberculoma ; Visual failure
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary An adult patient on treatment for tuberculous meningitis developed visual failure due to a tuberculoma compressing both optic nerves and chiasm. Although continued anti-tuberculous chemotherapy is the treatment of choice for intracranial tuberculoma, the rapid deterioration in vision necessitated urgent surgical decompression, which resulted in complete recovery of vision.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00314183

    Articles: DFG German National Licenses
  13. 13
    Teoh, R. ; Humphries, M. J. ; Hoare, R. D. ; O'Mahony, G.
    Springer
    Published 1989
    Staff View
    ISSN:
    1432-1459
    Keywords:
    TB meningitis ; Clinical features ; Computed tomography
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary CT changes in 64 Chinese patients with proven tuberculous meningitis were compared with the clinical features at diagnosis. In patients presenting with advanced disease, hydrocephalus and cerebral infarction were common, and the hydrocephalus in these patients was more likely to require surgery at a later date for control of raised intracranial pressure. New infarctions were only seen in follow-up scans of patients who had presented with disturbed consciousness. Meningeal enhancement, the commonest finding, and intracranial tuberculomata were not related to the severity of disease at presentation. A normal scan in a drowsy patient virtually excludes the diagnosis of tuberculous meningitis.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00314218

    Articles: DFG German National Licenses
  14. 14
    Tang, E. S. C. ; Chau, A. ; Fong, D. ; Humphries, M. J.
    Springer
    Published 1991
    Staff View
    ISSN:
    1432-1459
    Keywords:
    Tuberculosis ; Meningitis ; Intracranial abscess ; Neurosurgery
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary A Chinese female aged 2 years 8 months with tuberculous meningitis developed hydrocephalus requiring insertion of a ventriculoperitoneal shunt. After adequate anti-tuberculosis chemotherapy for 14 weeks, multiple intracranial tuberculous abscesses developed. The lesions increased in size and number accompanied by clinical deterioration. Repeated drainage operations were performed in view of the increased intracranial pressure. The child made a remarkable recovery after an initial stormy course.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00319688

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1617-4623
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Summary DNA isolated from a rodent-human hybrid cell line containing human chromosomes 3, 7, 9, 10, 14 and 22 was cloned in the plasmid vector pAT153. Recombinant plasmids containing inserts of human origin were identified by colony hybridization to 32P-labelled human DNA under conditions in which only repetitive sequences interact. Single- and low-copy sequences were liberated from these plasmids by restriction endonuclease digestion and used as hybridization probes against human DNA and DNA isolated from a panel of Chinese hamster-human hybrids. One single-copy probe was shown to react with a genomic sequence unique to human chromosome 7 and to recognize an apparent restriction fragment size polymorphism in human DNA.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00330337

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1573-7276
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We investigated the adhesion of three morphologically distinct human neuroblastoma cell lines (NCG, GOTO and SK-N-DZ) to intact fibronectin, central cell binding domain fragment (CBF) and CS peptide-IgG conjugates in the fibronectin molecule. Each cell line was found to express different integrin fibronectin receptors (α 3 β 1,α 4 β 1 and α5β1), although similarly attached on intact fibronectin. To CBF, NCG attached well, while GOTO moderately and SK-N-DZ poorly attached. Only GOTO adhered to CS1-IgG. RGDS inhibited the spreading of NCG and SK-N-DZ on intact fibronectin, but it barely inhibited that of GOTO. The analysis by fluorescence-activated cell sorting (FACS) revealed that NCG expressed abundant α3β1 and α5β1, but little α4β1, while GOTO expressed a large amount of α4β1 as well as α5β1. SK-N-DZ was undetectable in any of these molecules, but expressed αvβ1, which was identified by immunoprecipitation and immunoblotting. Polyclonal antibody to αvβ3 inhibited the adhesion of SK-N-DZ but not that of NCG or GOTO on intact fibronectin. These results suggest the existence of a distinct mechanism of cell adhesion to fibronectin among human neuroblastoma cell lines. It remains to be determined if such heterogeneous adhesion properties are related to the unique metastatic character of human neuroblastoma.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01769356

    Articles: DFG German National Licenses