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1Latest Papers from Table of Contents or Articles in PressC. Gieger ; A. Radhakrishnan ; A. Cvejic ; W. Tang ; E. Porcu ; G. Pistis ; J. Serbanovic-Canic ; U. Elling ; A. H. Goodall ; Y. Labrune ; L. M. Lopez ; R. Magi ; S. Meacham ; Y. Okada ; N. Pirastu ; R. Sorice ; A. Teumer ; K. Voss ; W. Zhang ; R. Ramirez-Solis ; J. C. Bis ; D. Ellinghaus ; M. Gogele ; J. J. Hottenga ; C. Langenberg ; P. Kovacs ; P. F. O'Reilly ; S. Y. Shin ; T. Esko ; J. Hartiala ; S. Kanoni ; F. Murgia ; A. Parsa ; J. Stephens ; P. van der Harst ; C. Ellen van der Schoot ; H. Allayee ; A. Attwood ; B. Balkau ; F. Bastardot ; S. Basu ; S. E. Baumeister ; G. Biino ; L. Bomba ; A. Bonnefond ; F. Cambien ; J. C. Chambers ; F. Cucca ; P. D'Adamo ; G. Davies ; R. A. de Boer ; E. J. de Geus ; A. Doring ; P. Elliott ; J. Erdmann ; D. M. Evans ; M. Falchi ; W. Feng ; A. R. Folsom ; I. H. Frazer ; Q. D. Gibson ; N. L. Glazer ; C. Hammond ; A. L. Hartikainen ; S. R. Heckbert ; C. Hengstenberg ; M. Hersch ; T. Illig ; R. J. Loos ; J. Jolley ; K. T. Khaw ; B. Kuhnel ; M. C. Kyrtsonis ; V. Lagou ; H. Lloyd-Jones ; T. Lumley ; M. Mangino ; A. Maschio ; I. Mateo Leach ; B. McKnight ; Y. Memari ; B. D. Mitchell ; G. W. Montgomery ; Y. Nakamura ; M. Nauck ; G. Navis ; U. Nothlings ; I. M. Nolte ; D. J. Porteous ; A. Pouta ; P. P. Pramstaller ; J. Pullat ; S. M. Ring ; J. I. Rotter ; D. Ruggiero ; A. Ruokonen ; C. Sala ; N. J. Samani ; J. Sambrook ; D. Schlessinger ; S. Schreiber ; H. Schunkert ; J. Scott ; N. L. Smith ; H. Snieder ; J. M. Starr ; M. Stumvoll ; A. Takahashi ; W. H. Tang ; K. Taylor ; A. Tenesa ; S. Lay Thein ; A. Tonjes ; M. Uda ; S. Ulivi ; D. J. van Veldhuisen ; P. M. Visscher ; U. Volker ; H. E. Wichmann ; K. L. Wiggins ; G. Willemsen ; T. P. Yang ; J. Hua Zhao ; P. Zitting ; J. R. Bradley ; G. V. Dedoussis ; P. Gasparini ; S. L. Hazen ; A. Metspalu ; M. Pirastu ; A. R. Shuldiner ; L. Joost van Pelt ; J. J. Zwaginga ; D. I. Boomsma ; I. J. Deary ; A. Franke ; P. Froguel ; S. K. Ganesh ; M. R. Jarvelin ; N. G. Martin ; C. Meisinger ; B. M. Psaty ; T. D. Spector ; N. J. Wareham ; J. W. Akkerman ; M. Ciullo ; P. Deloukas ; A. Greinacher ; S. Jupe ; N. Kamatani ; J. Khadake ; J. S. Kooner ; J. Penninger ; I. Prokopenko ; D. Stemple ; D. Toniolo ; L. Wernisch ; S. Sanna ; A. A. Hicks ; A. Rendon ; M. A. Ferreira ; W. H. Ouwehand ; N. Soranzo
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-12-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Blood Platelets/*cytology/metabolism ; Cell Size ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Europe ; Gene Expression Profiling ; Gene Silencing ; Genome, Human/genetics ; Genome-Wide Association Study ; Hematopoiesis/*genetics ; Humans ; Megakaryocytes/*cytology/metabolism ; Platelet Count ; Protein Interaction Maps ; Transcription, Genetic/genetics ; Zebrafish/genetics ; Zebrafish Proteins/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressP. van der Harst ; W. Zhang ; I. Mateo Leach ; A. Rendon ; N. Verweij ; J. Sehmi ; D. S. Paul ; U. Elling ; H. Allayee ; X. Li ; A. Radhakrishnan ; S. T. Tan ; K. Voss ; C. X. Weichenberger ; C. A. Albers ; A. Al-Hussani ; F. W. Asselbergs ; M. Ciullo ; F. Danjou ; C. Dina ; T. Esko ; D. M. Evans ; L. Franke ; M. Gogele ; J. Hartiala ; M. Hersch ; H. Holm ; J. J. Hottenga ; S. Kanoni ; M. E. Kleber ; V. Lagou ; C. Langenberg ; L. M. Lopez ; L. P. Lyytikainen ; O. Melander ; F. Murgia ; I. M. Nolte ; P. F. O'Reilly ; S. Padmanabhan ; A. Parsa ; N. Pirastu ; E. Porcu ; L. Portas ; I. Prokopenko ; J. S. Ried ; S. Y. Shin ; C. S. Tang ; A. Teumer ; M. Traglia ; S. Ulivi ; H. J. Westra ; J. Yang ; J. H. Zhao ; F. Anni ; A. Abdellaoui ; A. Attwood ; B. Balkau ; S. Bandinelli ; F. Bastardot ; B. Benyamin ; B. O. Boehm ; W. O. Cookson ; D. Das ; P. I. de Bakker ; R. A. de Boer ; E. J. de Geus ; M. H. de Moor ; M. Dimitriou ; F. S. Domingues ; A. Doring ; G. Engstrom ; G. I. Eyjolfsson ; L. Ferrucci ; K. Fischer ; R. Galanello ; S. F. Garner ; B. Genser ; Q. D. Gibson ; G. Girotto ; D. F. Gudbjartsson ; S. E. Harris ; A. L. Hartikainen ; C. E. Hastie ; B. Hedblad ; T. Illig ; J. Jolley ; M. Kahonen ; I. P. Kema ; J. P. Kemp ; L. Liang ; H. Lloyd-Jones ; R. J. Loos ; S. Meacham ; S. E. Medland ; C. Meisinger ; Y. Memari ; E. Mihailov ; K. Miller ; M. F. Moffatt ; M. Nauck ; M. Novatchkova ; T. Nutile ; I. Olafsson ; P. T. Onundarson ; D. Parracciani ; B. W. Penninx ; L. Perseu ; A. Piga ; G. Pistis ; A. Pouta ; U. Puc ; O. Raitakari ; S. M. Ring ; A. Robino ; D. Ruggiero ; A. Ruokonen ; A. Saint-Pierre ; C. Sala ; A. Salumets ; J. Sambrook ; H. Schepers ; C. O. Schmidt ; H. H. Sillje ; R. Sladek ; J. H. Smit ; J. M. Starr ; J. Stephens ; P. Sulem ; T. Tanaka ; U. Thorsteinsdottir ; V. Tragante ; W. H. van Gilst ; L. J. van Pelt ; D. J. van Veldhuisen ; U. Volker ; J. B. Whitfield ; G. Willemsen ; B. R. Winkelmann ; G. Wirnsberger ; A. Algra ; F. Cucca ; A. P. d'Adamo ; J. Danesh ; I. J. Deary ; A. F. Dominiczak ; P. Elliott ; P. Fortina ; P. Froguel ; P. Gasparini ; A. Greinacher ; S. L. Hazen ; M. R. Jarvelin ; K. T. Khaw ; T. Lehtimaki ; W. Maerz ; N. G. Martin ; A. Metspalu ; B. D. Mitchell ; G. W. Montgomery ; C. Moore ; G. Navis ; M. Pirastu ; P. P. Pramstaller ; R. Ramirez-Solis ; E. Schadt ; J. Scott ; A. R. Shuldiner ; G. D. Smith ; J. G. Smith ; H. Snieder ; R. Sorice ; T. D. Spector ; K. Stefansson ; M. Stumvoll ; W. H. Tang ; D. Toniolo ; A. Tonjes ; P. M. Visscher ; P. Vollenweider ; N. J. Wareham ; B. H. Wolffenbuttel ; D. I. Boomsma ; J. S. Beckmann ; G. V. Dedoussis ; P. Deloukas ; M. A. Ferreira ; S. Sanna ; M. Uda ; A. A. Hicks ; J. M. Penninger ; C. Gieger ; J. S. Kooner ; W. H. Ouwehand ; N. Soranzo ; J. C. Chambers
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Cycle/genetics ; Cytokines/metabolism ; Drosophila melanogaster/genetics ; Erythrocytes/cytology/*metabolism ; Female ; Gene Expression Regulation/genetics ; *Genetic Loci ; *Genome-Wide Association Study ; Hematopoiesis/genetics ; Hemoglobins/genetics ; Humans ; Male ; Mice ; Organ Specificity ; *Phenotype ; Polymorphism, Single Nucleotide/genetics ; RNA Interference ; Signal Transduction/geneticsPublished by: -
3Articles: DFG German National LicensesDeterre, Philippe ; Paupardin-Tritsch, Danièle ; Bockaert, Joël ; Gerschenfeld, Hersch M.
[s.l.] : Nature Publishing Group
Published 1981Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The experiments were carried out on identified neurones of the viscero-abdominal ganglionic mass of Helix aspersa (cells F5, F6, E1, E2, E15, E17 of Kerkut et al.5). The ganglia were isolated in a chamber and continuously bathed in circulating saline of the following composition in mM: NaCl 120, ...Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesPiccolino, Marco ; Neyton, Jacques ; Gerschenfeld, Hersch M.
[s.l.] : Nature Publishing Group
Published 1980Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The experiments were carried out on eyecup retina preparations from the turtle Pseudemys scripta elegans placed on a suitable chamber and continuously superfused with a bicarbonate saline solution9 bubbled with a mixture of 95% O2 + 5% CO2. SrCl2 was added to the saline without molarity ...Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesFAIN, GORDON L. ; QUANDT, FRED N. ; GERSCHENFELD, HERSCH M.
[s.l.] : Nature Publishing Group
Published 1977Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Retinas were removed from the eyes of dark-adapted toads under dim red illumination and were secured with receptors upwards in a perfusion chamber. Oxygenated Ringer flowed from a gravity-controlled perfusion system into a 0.03-ml pool above the retina at a rate of 0.5-1.0 ml min'1. Silver-silver ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesPaupardin-Tritsch, Danièle ; Hammond, Constance ; Gerschenfeld, Hersch M. ; Nairn, Angus C. ; Greengard, P.
[s.l.] : Nature Publishing Group
Published 1986Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We first examined the effect of cGMP-PK on the serotonin-induced broadening of the Ca2+-dependent plateau of the somatic action potential of identified snail ventral neurones (cells D6, D7). The neurones (n = 6) were impaled with two microelectrodes connected both to a current/voltage clamp device ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] SIR-We have recently received distressing news from colleagues at the University of Chile, Santiago. Over the past ten years, both the university budget and student numbers have been reduced by half and no positions have been opened for the recruitment of young scientists and teachers. Last ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesHammond, Constance ; Paupardin-Tritsch, Danièle ; Nairn, Angus C. ; Greengard, Paul ; Gerschenfeld, Hersch M.
[s.l.] : Nature Publishing Group
Published 1987Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The effect of CCK8 on the somatic Ca2+-dependent action potential was measured in the identified snail neurons F77 (Fig. la) and D2 (not shown) bathed in tetraethylammonium (TEA)/Cs+-saline. CCK8 (5 nM) reduced the duration of the Ca2+-dependent action potential, a maximum decrease being ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-1238Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Conclusions Acute respiratory acidosis may be an early ominous sign of a diseased and “starved” bowel perforation in heavily sedated totally ventilator dependant MVE patient. Further attention of intensivists to validate this pilot observation is needed.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-0878Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Submicroscopic structure of synapses of Vaginula solea, Helix pomatia, and Cryptomphallus aspersa was studied. Synaptic junctions in these nervous tissues are always of the axo-axonal type. Perikarya are located at the periphery of the ganglion and never show synaptic contacts. These appear beyond the axon hillock, at the neuropile situated in the core of the ganglion. The postsynaptic membranes are mainly located on finger-like axonal branches. The presynaptic endings may be either “en passant” or of the terminal type, the latter being much more abundant than the former. The general structure of these synapses does not differ in their submicroscopic features from those described in vertebrate synapses, but they may contain, apart from mitochondria, different types of vesicular material: 1) Clear synaptic vesicles (CSV) (450–600 Å in methacrylate, 600–800 Å in epon) similar in structure to classical synaptic vesicles, 2) dense synaptic vesicles (DSV) (600 to 750 Å in methacrylate, 800–1,100 Å in epon) containing a very dense granule. DSV highly resemble vesicles observed in vertebrate adrenergic nerve endings, and 3) “neurosecretory” synaptic vesicles (NSV) (800–1,300 Å in methacrylate, 1,200–1,400 Å in epon) similar to elementary neurosecretory granules observed in “neurosecretory” neurons of both Vertebrates and Invertebrates. Other contents of synapses are: a dense granular ribosome-like material which appears mixed with CSV; clear empty vesicles of 800–900 Å and multivesicular bodies that are observed accompanying NSV. According to the distribution of this vesicular material, synaptic endings are classified as: Type I: contain only CSV; Type II: contain DSV and clear vesicles similar to CSV (proper CSV or empty forms of DSV) and Type III: contain NSV, clear vesicles of 800–900 Å, clear vesicles resembling CSV and multivesicular bodies (Table 2). These findings are discussed on the bases of available biochemical and physiological data. Microphysiological and biochemical work has demonstrated in these ganglia the existence of cholinergic and non-cholinergic synaptic transmitters. As CSV are analogous to classical synaptic vesicles present in cholinergic synapses, endings of the type I are postulated as possibly cholinergic. Non-cholinergic synaptic input is hypothetically related to DSV, therefore to synapses of the type II and the possible nature of the involved transmitters is considered. The “neurosecretory” character of NSV is discussed and its possible participation in nervous activity is postulated. Main facts and hypothesis are also summarized in Table 1, 2 and 3.Type of Medium: Electronic ResourceURL: