Search Results - (Author, Cooperation:M. Herrmann)

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  1. 1
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  3. 3
    Hansen, K. G., Aviram, N., Laborenz, J., Bibi, C., Meyer, M., Spang, A., Schuldiner, M., Herrmann, J. M.
    American Association for the Advancement of Science (AAAS)
    Published 2018
    Staff View
    Publication Date:
    2018-09-14
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Biochemistry, Cell Biology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2012-03-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Conservation of Natural Resources ; Demography ; *Human Activities ; Humans ; *Policy Making
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    R. Beckmann ; J. M. Herrmann
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-04-18
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Humans ; Mitochondria/*ultrastructure ; Mitochondrial Proteins/*biosynthesis ; Ribosome Subunits, Large/*ultrastructure ; Ribosomes/*ultrastructure
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
    J. W. Ho ; Y. L. Jung ; T. Liu ; B. H. Alver ; S. Lee ; K. Ikegami ; K. A. Sohn ; A. Minoda ; M. Y. Tolstorukov ; A. Appert ; S. C. Parker ; T. Gu ; A. Kundaje ; N. C. Riddle ; E. Bishop ; T. A. Egelhofer ; S. S. Hu ; A. A. Alekseyenko ; A. Rechtsteiner ; D. Asker ; J. A. Belsky ; S. K. Bowman ; Q. B. Chen ; R. A. Chen ; D. S. Day ; Y. Dong ; A. C. Dose ; X. Duan ; C. B. Epstein ; S. Ercan ; E. A. Feingold ; F. Ferrari ; J. M. Garrigues ; N. Gehlenborg ; P. J. Good ; P. Haseley ; D. He ; M. Herrmann ; M. M. Hoffman ; T. E. Jeffers ; P. V. Kharchenko ; P. Kolasinska-Zwierz ; C. V. Kotwaliwale ; N. Kumar ; S. A. Langley ; E. N. Larschan ; I. Latorre ; M. W. Libbrecht ; X. Lin ; R. Park ; M. J. Pazin ; H. N. Pham ; A. Plachetka ; B. Qin ; Y. B. Schwartz ; N. Shoresh ; P. Stempor ; A. Vielle ; C. Wang ; C. M. Whittle ; H. Xue ; R. E. Kingston ; J. H. Kim ; B. E. Bernstein ; A. F. Dernburg ; V. Pirrotta ; M. I. Kuroda ; W. S. Noble ; T. D. Tullius ; M. Kellis ; D. M. MacAlpine ; S. Strome ; S. C. Elgin ; X. S. Liu ; J. D. Lieb ; J. Ahringer ; G. H. Karpen ; P. J. Park
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-08-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Caenorhabditis elegans/*cytology/*genetics ; Cell Line ; Centromere/genetics/metabolism ; Chromatin/chemistry/*genetics/*metabolism ; Chromatin Assembly and Disassembly/genetics ; DNA Replication/genetics ; Drosophila melanogaster/*cytology/*genetics ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic ; Heterochromatin/chemistry/genetics/metabolism ; Histones/chemistry/metabolism ; Humans ; Molecular Sequence Annotation ; Nuclear Lamina/metabolism ; Nucleosomes/chemistry/genetics/metabolism ; Promoter Regions, Genetic/genetics ; Species Specificity
    Published by:
    Latest Papers from Table of Contents or Articles in Press
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  8. 8
    M. Herrmann
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-02-14
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  9. 9
  10. 10
    Staff View
    Publication Date:
    2018-06-15
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1539-3755
    Electronic ISSN:
    1550-2376
    Topics:
    Physics
    Keywords:
    Plasma Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  11. 11
    Gut, G., Herrmann, M. D., Pelkmans, L.
    American Association for the Advancement of Science (AAAS)
    Published 2018
    Staff View
    Publication Date:
    2018-08-03
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Cell Biology, Techniques
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  12. 12
    Staff View
    Publication Date:
    2018-12-07
    Publisher:
    American Society of Hematology (ASH)
    Print ISSN:
    0006-4971
    Electronic ISSN:
    1528-0020
    Topics:
    Biology
    Medicine
    Keywords:
    Immunobiology and Immunotherapy, Myeloid Neoplasia
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  13. 13
    Staff View
    ISSN:
    1089-7674
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Because alpha particle losses can have a significant influence on tokamak reactor viability, the loss of deuterium–tritium alpha particles from the Tokamak Fusion Test Reactor (TFTR) [K. M. McGuire et al., Phys. Plasmas 2, 2176 (1995)] has been measured under a wide range of conditions. In TFTR, first orbit loss and stochastic toroidal field ripple diffusion are always present. Other losses can arise due to magnetohydrodynamic instabilities or due to waves in the ion cyclotron range of frequencies. No alpha particle losses have yet been seen due to collective instabilities driven by alphas. Ion Bernstein waves can drive large losses of fast ions from TFTR, and details of those losses support one element of the alpha energy channeling scenario. © 1996 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Herrmann, M. ; McVitie, S. ; Chapman, J. N.

    [S.l.] : American Institute of Physics (AIP)
    Published 2000
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Thin film elements of a soft magnetic nickel–iron alloy have been fabricated with structured edges in order to determine their effect on the magnetization reversal processes. Lorentz microscopy was used to study acicular elements with different edge structures and these were compared with standard elements with straight edges. The presence of the structured edges results in deviations of the magnetization along the length of the elements in the remanent state. Switching processes are described for a number of different elements and the effect of structuring the edges is discussed. © 2000 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Olivieri, G. ; Brack, Ch. ; Müller-Spahn, F. ; Stähelin, H. B. ; Herrmann, M. ; Renard, P. ; Brockhaus, M. ; Hock, C.

    Oxford UK : Blackwell Science Ltd
    Published 2000
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: Concentrations of heavy metals, including mercury, have been shown to be altered in the brain and body fluids of Alzheimer’s disease (AD) patients. To explore potential pathophysiological mechanisms we used an in vitro model system (SHSY5Y neuroblastoma cells) and investigated the effects of inorganic mercury (HgCl2) on oxidative stress, cell cytotoxicity, β-amyloid production, and tau phosphorylation. We demonstrated that exposure of cells to 50 μg/L (180 nM) HgCl2 for 30 min induces a 30% reduction in cellular glutathione (GSH) levels (n = 13, p 〈 0.001). Preincubation of cells for 30 min with 1 μM melatonin or premixing melatonin and HgCl2 appeared to protect cells from the mercury-induced GSH loss. Similarly, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assays revealed that 50 μg/L HgCl2 for 24 h produced a 50% inhibition of MTT reduction (n = 9, p 〈 0.001). Again, melatonin preincubation protected cells from the deleterious effects of mercury, resulting in MTT reduction equaling control levels. The release of β-amyloid peptide (Aβ) 1-40 and 1-42 into cell culture supernatants after exposure to HgCl2 was shown to be different: Aβ 1-40 showed maximal (15.3 ng/ml) release after 4 h, whereas Aβ 1-42 showed maximal (9.3 ng/ml) release after 6 h of exposure to mercury compared with untreated controls (n = 9, p 〈 0.001). Preincubation of cells with melatonin resulted in an attenuation of Aβ 1-40 and Aβ 1-42 release. Tau phosphorylation was significantly increased in the presence of mercury (n = 9, p 〈 0.001), whereas melatonin preincubation reduced the phosphorylation to control values. These results indicate that mercury may play a role in pathophysiological mechanisms of AD.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Herrmann, M. ; Schenk, A.

    [S.l.] : American Institute of Physics (AIP)
    Published 1995
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    High-temperature charge transport across an oxide-nitride-oxide sandwich of erasable programmable read only memories is mainly governed by the oxide conductivity as experimentally determined. It was verified in the examined devices that charge loss is not due to mobile ions. Since hole injection from the control gate into the nitride can be blocked by a 70-A(ring)-thick top oxide we conjecture that charge loss is due to leakage of electrons; however, the observed leakage current is too large to be explained by pure electrode-limited charge transport (Richardson emission and direct tunneling). It was also verified that field gain on asperities and along edges cannot increase the charge loss current to the required range. Numerical evaluation of trap tunneling and resonant tunneling indicated that both mechanisms are weakly temperature dependent while charge loss has a typical activation energy of 1.2 eV in the range of 250–350 °C. Consequently, a multiphonon-assisted tunneling mechanism is proposed where electrons stored on the floating gate tunnel to oxide traps, then are emitted into the nitride. The coupling of the trap level to oxide phonons results in virtual energy levels in the oxide which allow for more effective transition paths. As a consequence of the electron-phonon coupling, the emission occurs close to the oxide conduction-band edge at temperatures between 250 and 350 °C, producing a strong temperature dependence for the mechanism. © 1995 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Kräling, K. ; Röbbelen, G. ; Thies, W. ; Herrmann, M. ; Ahmadi, M. R.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1990
    Staff View
    ISSN:
    1439-0523
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes:
    The glucosinolate (GSL) pattern of 93 resynthesized (resyn) repeseed lines was examined over three years, and five stable genotypes with distinct GSL profiles were identified. Typically the resyn B. napus profile exhibited progoitrin as the main GSL, but contained sinigrin. The different GSL patterns of the four deviating lines are discussed with respect to the proposed biosynthetic pathway. Within the resyn and further extensive breeding materias, screening for low indolyl GSL contents resulted in finding one genotype with an extremely low 4-hydroxy-gluco-brassicin and glucobrassicin content. Furthermore, other lines were identified, over a wide range of indolyl GSL contents. The values were stable over two years.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Kolowos, W. ; Gaipl, U. S. ; Sheriff, A. ; Voll, R. E. ; Heyder, P. ; Kern, P. ; Kalden, J. R. ; Herrmann, M.

    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Various cells such as platelets, lymphocytes, endothelial cells, red blood cells and monocytes do release surface-derived microparticles (mps). We analysed mp isolated from supernatants of cultured antigen-presenting human cells (APCs) and human cell lines. Particle sizing by dynamic light scattering revealed a characteristic size of the particles ranging from 80 nm to 300 nm in viable cells and from 400 nm to 1200 nm in irradiated cells. Employing flow-cytometry, we observed partly an altered surface protein composition of the mp compared to their cellular source. Mp originating from dendritic cells (DCs) differed in their surface composition from those released from monocytes and monocyte-derived macrophages. In functional assays, these mp stimulated alloreactive T-cells. The treatment of the cells with either UV-B or lipopolysaccharide strongly influenced the quantity, the immunostimulatory features and the surface composition of the mp. Mp from apoptotic macrophages were able to reduce the stimulatory capacity of vital macrophages but not of DC. Apoptotic mps from DC, on the other hand, were always stimulatory. This is the first report regarding the study of mp released from DC and compared with those released from other APC.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    BEYER, T. D. ; KOLOWOS, W. ; DUMITRIU, I. E. ; VOLL, R. E. ; HEYDER, P. ; GAIPL, U. S. ; KALDEN, J. R. ; HERRMANN, M.

    Oxford, UK : Blackwell Science Ltd
    Published 2002
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Redistribution, post-translational modifications and coclustering with viral antigens contribute to the immunogenicity of apoptotic cell-derived autoantigens. Almost all known targets of the humoral autoimmune response in systemic lupus erythematosus (SLE) are cleaved by caspases or granzyme B during apoptosis. Antibodies against retroviral proteins can frequently be detected in the sera of SLE patients without overt retroviral infections. These antibodies may represent cross-reactive antibodies or may have been induced by proteins encoded by endogenous retroviral sequences. We used Tera-1 cells that abundantly express a group-specific antigen of human endogenous retroviruses, HERV-K10gag polyprotein, to investigate its processing during apoptosis. Tera-1 cells induced to undergo apoptosis showed an altered HERV-K10gag processing compared with viable cells. In addition, granzyme B was able to cleave HERV-K10gag isolated from viable Tera-1 cells.Similar to nuclear autoantigens, endogenous retroviral proteins are cleaved during the execution phase of apoptosis. These post-translational modifications may result in the generation of T-cell neoepitopes or a changed epitope hierarchy of retroviral proteins. Therefore, immunogenicity of retroviral antigens in SLE patients may result from a similar mechanism as described for nuclear autoantigens.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    0093-934X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Linguistics and Literary Studies
    Medicine
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses