Search Results - (Author, Cooperation:M. Halliday)
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1Staff View Availability
Person(s): Boakes, R. A.; Halliday, M. S.Type of Medium: UnknownPages: 568 S. : graph. Darst.ISBN: 0121080501Language: English -
2J. A. Moreno ; H. Radford ; D. Peretti ; J. R. Steinert ; N. Verity ; M. G. Martin ; M. Halliday ; J. Morgan ; D. Dinsdale ; C. A. Ortori ; D. A. Barrett ; P. Tsaytler ; A. Bertolotti ; A. E. Willis ; M. Bushell ; G. R. Mallucci
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-05-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Death/drug effects ; Cinnamates/pharmacology ; Eukaryotic Initiation Factor-2/analysis/*chemistry/*metabolism ; Hippocampus/cytology/metabolism/pathology ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred C57BL ; Neurodegenerative Diseases/etiology/*metabolism/pathology ; Neurons/drug effects/pathology ; Neuroprotective Agents ; Phosphoproteins/analysis/*metabolism ; Phosphorylation ; PrPSc Proteins/analysis/metabolism/toxicity ; Prion Diseases/pathology ; Prions/biosynthesis/genetics/*metabolism ; *Protein Biosynthesis/drug effects ; Protein Folding/drug effects ; Protein Phosphatase 1/genetics/metabolism ; Repressor Proteins/analysis/chemistry/*metabolism ; Synapses/drug effects/metabolism/pathology ; Synaptic Transmission/drug effects ; Thiourea/analogs & derivatives/pharmacology ; Unfolded Protein Response/physiologyPublished by: -
3Staff View
ISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: The literature describing the biology and control of Myxosoma cerebralis (whirling disease) is reviewed. New data on the world distribution of the parasite are presented. It is concluded that the presence of M. cerebralis is not an important limiting factor in salmonid fanning per se but only limits methods of production.Type of Medium: Electronic ResourceURL: -
4Zhang, J. Z. ; Halliday, M. D. ; Poole, P. ; Bowen, P.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1460-2695Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract— A three dimensional, elastic-plastic, finite element analysis of fatigue crack growth and plasticity-induced crack closure has been performed for a range of small, semi-circular cracks. Predicted crack opening displacements have been compared with data obtained from in-situ SEM measurements for a coarse-grained aluminium alloy 2024-T351. The magnitude of fatigue crack closure measured from in-situ SEM measurements was consistently higher than that predicted from the finite element analysis. It is deduced that the higher closure stresses obtained from in-situ SEM measurements are due to the contact of asperities on the fatigue crack surfaces. A simple mathematical model is suggested to describe the fatigue crack closure stress caused by the combination of both a plastic wake and asperities on the fatigue crack surfaces. The predicted fatigue crack closure stresses and their dependence on crack size are consistent with experimental measurement.Type of Medium: Electronic ResourceURL: -
5Arthur, Tansy A. A. ; Hitch, Graham J. ; Halliday, M. S.
London, etc. : Periodicals Archive Online (PAO)
Published 1994Staff ViewISSN: 0007-1269Topics: PsychologyURL: -
6Staff View
ISSN: 1572-9486Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract Coarse grained (∼0·3 mm) α-titanium has been fatigued in tension-compression about a zero mean load to ∼100 cycles/sec at normal temperature. Sections through fatigued specimens revealed that twin formation had occurred in grains completely constrained by surrounding material during cyclic loading and that fatigue damage was associated with some of these twins. A micro-beam X-ray and single face sterographic analysis technique combined with metallographic observations of the specimens revealed that {10¯12}, {11¯21} and {11¯22} twins had formed and that the internal fatigue damage was preferentially formed at the twin-matrix interface of the {11¯21} twins.Type of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 0026-7937Topics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
8Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The subjects in this experiment were twenty-four satiated female hooded rats about 100 days old. They were given three days of pretraining in which they were allowed to move around a table-top for a few minutes and were picked up and handled a number of times. The animals were then randomly ...Type of Medium: Electronic ResourceURL: -
9Ennis, M. ; Clements, B. ; Campbell, G. R. ; Halliday, M. I. ; Barclay, R. G. ; Rowlands, B. J.
Springer
Published 1993Staff ViewISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Systemic endotoxaemia contributes to the high morbidity and mortality of jaundiced patiens undergoing surgery. In this study, correlations between systemic endotoxaemia (assessed by measuring antibodies to the core-glycolipid region of endotoxin, a-CGL), bile acids and blood histamine were investigated in a bile duct ligation (BDL) animal model of obstructive jaundice. Three weeks after BDL, systemic a-CGL (p〈0.0001), total blood histamine (p〈0.02) and bile acid concentrations (e.g. taurocholate,p〈0.001) were significantly elevated in BDL animals compared to control or sham operated rats. Additionally, total blood histamine correlated significantly with plasma taurocholate (r=0.83,p=0.011). High circulating levels of endotoxin and bile acids may result in mast cell activation and/ or histamine synthesis in jaundiced animals, which may contribute to the pathophysiology of complications seen in cholestasis.Type of Medium: Electronic ResourceURL: -
10Toon, S. ; Holt, B. L. ; Langley, S. J. ; Mullins, F. G. P. ; Rowland, M. ; Halliday, M. S. ; Salvadori, C. ; Delalleau, B.
Springer
Published 1990Staff ViewISSN: 1432-2072Keywords: Pharmacokinetics ; Pharmacodynamics ; Antidepressants ; Tianeptine ; OxazepamSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract To assess if any pharmacokinetic or pharmacodynamic interaction at steady-state occurs between the new antidepressant tianeptine and a benzodiazepine (oxazepam) following multiple oral dosing of both drugs, 12 healthy male volunteers entered a balanced three-way double blind cross-over study. Tianeptine (12.5 mg) and/or oxazepam (10 mg) were given three times daily for 4 days. Pharmacokinetic data within a dosing interval at steady-state showed that there were no statistically significant changes in the pharmacokinetics of either tianeptine (and its two major metabolites) or oxazepam when both drugs were co-administered. Psychometric data showed that there was no synergistic negative interaction between the two drugs and that their combination may result in beneficial effects on “alertness” and “happiness”Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 1573-2673Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsType of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1573-9295Keywords: all living systems and subsystems ; stability ; equilibrium ; network analysisSource: Springer Online Journal Archives 1860-2000Topics: SociologyNotes: Abstract Analyzing communication data within a social structure represented by a wholesale agricultural market demonstrates the utility of network analysis techniques for identifying systems. A representation of these data in matrix form permits exploration of the stability properties of the system. The stability analyses lend some support for theoretical arguments pertaining to the conditions leading to system equilibrium.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1573-4803Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsType of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1573-4803Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: Abstract Bicrystals of pure aluminium, aluminium/0.05 wt% and aluminium/0.30 wt% copper have been deformed in shear within the temperature range 350 to 600°C at a constant rate of grip displacement (300 μm/h) and constant rates of increase of grain-boundary shear stress (0.30 to 1.04 g/mm−2 min−1). The stress/time, sliding/time and sliding/stress curves for these tests are presented together with metallographic observations. The stress/time curves exhibited changes in the strain-hardening rates which were accompanied by the occurrence of extensive crystal deformation. In many cases, following the change in strain-hardening rate and onset of extensive crystal slip, the extent of grain-boundary sliding was proportional to the shear stress on the boundary. The ratio of the extent of sliding to the grain-boundary shear stress increased with increasing test temperature. The temperature-dependence of the sliding behaviour, as reflected by the sliding/stress results, yielded apparent activation energies of ∼ 31 Kcal/mole in the temperature range 600 to 475°C and ∼ 8 Kcal/mole in the range 475 to 350°C.Type of Medium: Electronic ResourceURL: