Search Results - (Author, Cooperation:M. H. Heim)
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1Latest Papers from Table of Contents or Articles in PressJ. Lucifora ; Y. Xia ; F. Reisinger ; K. Zhang ; D. Stadler ; X. Cheng ; M. F. Sprinzl ; H. Koppensteiner ; Z. Makowska ; T. Volz ; C. Remouchamps ; W. M. Chou ; W. E. Thasler ; N. Huser ; D. Durantel ; T. J. Liang ; C. Munk ; M. H. Heim ; J. L. Browning ; E. Dejardin ; M. Dandri ; M. Schindler ; M. Heikenwalder ; U. Protzer
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-02-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Monoclonal ; Antiviral Agents/*pharmacology/therapeutic use ; Cell Line ; Cell Nucleus/virology ; Cytidine/metabolism ; Cytidine Deaminase/biosynthesis ; DNA, Circular/*metabolism ; DNA, Viral/*metabolism ; Hepatitis B/*drug therapy ; Hepatitis B virus/*drug effects/metabolism ; Hepatocytes/*drug effects/metabolism/virology ; Humans ; Interferon-alpha/*pharmacology/therapeutic use ; Liver/drug effects/metabolism/virology ; Lymphotoxin beta Receptor/*agonists/antagonists & inhibitors ; Mice, SCID ; Proteins ; Up-RegulationPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. Trajkovski ; J. Hausser ; J. Soutschek ; B. Bhat ; A. Akin ; M. Zavolan ; M. H. Heim ; M. Stoffel
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-06-10Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adipocytes/cytology/metabolism ; Animals ; Caveolin 1/metabolism ; Cell Size ; Diabetes Mellitus, Type 2/physiopathology ; Disease Models, Animal ; Gene Expression ; Gene Expression Regulation ; Gene Silencing ; Glucose/metabolism ; Homeostasis ; Hyperglycemia/physiopathology ; Insulin/*metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics/*metabolism ; Signal Transduction ; Up-RegulationPublished by: -
3Latest Papers from Table of Contents or Articles in PressVan Renne, N., Roca Suarez, A. A., Duong, F. H. T., Gondeau, C., Calabrese, D., Fontaine, N., Ababsa, A., Bandiera, S., Croonenborghs, T., Pochet, N., De Blasi, V., Pessaux, P., Piardi, T., Sommacale, D., Ono, A., Chayama, K., Fujita, M., Nakagawa, H., Hoshida, Y., Zeisel, M. B., Heim, M. H., Baumert, T. F., Lupberger, J.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-04-07Publisher: BMJ Publishing GroupPrint ISSN: 0017-5749Electronic ISSN: 1468-3288Topics: MedicineKeywords: Open accessPublished by: -
4Articles: DFG German National LicensesHeim, M. H. ; Blum, M. ; Beer, M. ; Meyer, U. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Two rabbit arylamine N-acetyltransferases (NAT1 and NAT2, EC 2.3.1.5) have been cloned and characterized recently in this laboratory. They catalyze the acetylation of primary arylamine and hydrazine drugs and other substrates in the liver, including sulfamethazine, ρ-aminosalicylic acid, and ρ-aminobenzoic acid. In the pineal gland, serotonin is metabolized to N-acetylserotonin by an unknown N-acetyltransferase. Similarity of the liver enzymes and the pineal gland arylalkylamine N-acetyltransferase (AA-NAT) has been suggested, because pineal gland homogenates were shown to metabolize arylamine substrates as ρ-phenetidine, aniline, or phenylethylamine, and liver homogenates or partially purified liver enzyme preparations catalyzed the N-acetylation of serotonin. The present study was undertaken to elucidate the possible role of NAT1 or NAT2 in serotonin acetylation in the pineal gland. We transiently expressed rNAT1 and rNAT2 genes in COS cells, studied the kinetics of the enzymes produced with various substrates, and compared these data with activities of rabbit pineal glands and livers. These enzymatic studies were complemented with western blot analysis with antibodies against NAT1 and NAT2. Cross-hybridization of rNAT1 or rNAT2 to the gene for the pineal gland AA-NAT was tested by Southern blot studies of genomic rabbit DNA. Our results indicate that although NAT1 is expressed in the pineal gland, it is not involved in the physiologically important step of N-acetylation of serotonin.Type of Medium: Electronic ResourceURL: