Search Results - (Author, Cooperation:M. Greaves)
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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2012-01-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Clonal Evolution ; Clone Cells/metabolism/pathology ; Genomics ; Humans ; Mutation ; Neoplasms/*genetics/*pathology ; Neoplastic Stem Cells/metabolism/pathology ; Tumor MicroenvironmentPublished by: -
2Latest Papers from Table of Contents or Articles in PressL. B. Alexandrov ; S. Nik-Zainal ; D. C. Wedge ; S. A. Aparicio ; S. Behjati ; A. V. Biankin ; G. R. Bignell ; N. Bolli ; A. Borg ; A. L. Borresen-Dale ; S. Boyault ; B. Burkhardt ; A. P. Butler ; C. Caldas ; H. R. Davies ; C. Desmedt ; R. Eils ; J. E. Eyfjord ; J. A. Foekens ; M. Greaves ; F. Hosoda ; B. Hutter ; T. Ilicic ; S. Imbeaud ; M. Imielinski ; N. Jager ; D. T. Jones ; D. Jones ; S. Knappskog ; M. Kool ; S. R. Lakhani ; C. Lopez-Otin ; S. Martin ; N. C. Munshi ; H. Nakamura ; P. A. Northcott ; M. Pajic ; E. Papaemmanuil ; A. Paradiso ; J. V. Pearson ; X. S. Puente ; K. Raine ; M. Ramakrishna ; A. L. Richardson ; J. Richter ; P. Rosenstiel ; M. Schlesner ; T. N. Schumacher ; P. N. Span ; J. W. Teague ; Y. Totoki ; A. N. Tutt ; R. Valdes-Mas ; M. M. van Buuren ; L. van 't Veer ; A. Vincent-Salomon ; N. Waddell ; L. R. Yates ; J. Zucman-Rossi ; P. A. Futreal ; U. McDermott ; P. Lichter ; M. Meyerson ; S. M. Grimmond ; R. Siebert ; E. Campo ; T. Shibata ; S. M. Pfister ; P. J. Campbell ; M. R. Stratton
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-08-16Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/genetics ; Algorithms ; Cell Transformation, Neoplastic/*genetics/pathology ; Cytidine Deaminase/genetics ; DNA/genetics/metabolism ; DNA Mutational Analysis ; Humans ; Models, Genetic ; Mutagenesis/*genetics ; Mutagenesis, Insertional/genetics ; Mutagens/pharmacology ; Mutation/*genetics ; Neoplasms/enzymology/*genetics/pathology ; Organ Specificity ; Reproducibility of Results ; Sequence Deletion/genetics ; Transcription, Genetic/geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2014-02-08Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Chicago ; Chromosome Banding/history ; Genetics/*history ; History, 20th Century ; History, 21st Century ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/*history ; Translocation, GeneticPublished by: -
4Latest Papers from Table of Contents or Articles in PressY. Gil ; M. Greaves ; J. Hendler ; H. Hirsh
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: *Artificial Intelligence ; Humans ; *Research Design ; Statistics as TopicPublished by: -
5Latest Papers from Table of Contents or Articles in PressH. Elderfield ; P. Ferretti ; M. Greaves ; S. Crowhurst ; I. N. McCave ; D. Hodell ; A. M. Piotrowski
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-08-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
6Latest Papers from Table of Contents or Articles in PressK. Anderson ; C. Lutz ; F. W. van Delft ; C. M. Bateman ; Y. Guo ; S. M. Colman ; H. Kempski ; A. V. Moorman ; I. Titley ; J. Swansbury ; L. Kearney ; T. Enver ; M. Greaves
Nature Publishing Group (NPG)
Published 2010Staff ViewPublication Date: 2010-12-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Clone Cells/metabolism/*pathology ; Core Binding Factor Alpha 2 Subunit ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; Disease Progression ; Genetic Variation/*genetics ; Genotype ; Humans ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Interleukin Receptor Common gamma Subunit/deficiency/genetics ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Transplantation ; Oncogene Proteins, Fusion/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/*pathologyPublished by: -
7Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2014-02-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Female ; Hematopoietic Stem Cells/*cytology ; Humans ; Leukemia, Myeloid, Acute/*pathology ; Neoplastic Stem Cells/*cytologyPublished by: -
8Articles: DFG German National LicensesGallo, R. ; Sabroe, R. A. ; Black, A. K. ; Greaves, M. W.
Oxford, UK : Blackwell Science Ltd
Published 2000Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We report two cases of Schnitzler's syndrome in which anti-interleukin-1α autoantibodies and functional autoantibodies against the high affinity IgE receptor (FcεRIα) or against IgE were absent. One patient responded well to TL-01 phototherapy, a treatment which may be considered in patients with Schnitzler's syndrome if, as is usually the case, they are unresponsive to antihistamine therapy.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesO'Donnell, B F ; O'Neill, C M ; Francis, D M ; Niimi, N ; Barr, R M ; Barlow, R J ; Kobza Black, A ; Welsh, K I ; Greaves, M W
Oxford BSL : Blackwell Science Ltd
Published 1999Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The major histocompatibility complex (MHC) acts as a marker for self during T-cell ontogeny and is associated with the pathogenesis of many autoimmune diseases. Recent investigations have shown about 30% of patients with chronic idiopathic urticaria (CIU) have IgG autoantibodies against the high-affinity IgE receptor, FcεRI, or IgE. A link between MHC class II alleles and CIU has not been reported previously. DNA was extracted from blood of 100 Caucasian patients with CIU, and the MHC class II type determined using the polymerase chain reaction with sequence-specific primers, testing for DRB and DQB1 alleles. The frequency of alleles in CIU patients was compared with that found in 603 controls. Further human leucocyte antigen (HLA) typing on patient subsets, classified by the patients' responses to intradermal injection of autologous serum and their serum-induced histamine release from basophil leucocytes of healthy donors, was undertaken. HLA DRB1*04 (DR4) and its associated allele, DQB1*0302 (DQ8), are raised in CIU patients compared with a control population (P = 2 × 10−5 and P = 2 × 10−4, respectively). HLA DRB1*15 (DR15) and its associated allele, DQB1*06 (DQ6), are significantly less frequently associated with CIU. The HLA DRB1*04 association is particularly strong (corrected P = 3.6 × 10−6) for patients whose serum has in vivo and in vitro histamine-releasing activity. HLA class II typing is consistent with the concept that CIU is a heterogeneous disease, and supports an autoimmune pathogenesis in a subset of patients.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesMacDonald, D.M. ; Morrison, J.G.L. ; Greaves, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1976Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesGREAVES, M. W. ; SNEDDON, I.E. ; SMITH, A. K. ; STANWORTH, D. R.
Oxford, UK : Blackwell Publishing Ltd
Published 1974Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A case is reported of urticaria as a local response to heating the skin. The clinical, pharmacological and immunological features of this rare condition are described.Urticaria as a local response to heating of skin is extremely rare. We describe here a patient with localized heat urticaria, and report some clinical, pharmacological and immunological characteristics of the condition.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY. .Three bed-wetting patients are described in whom the use of enuresis blankets with electric buzzer alarms led to skin ulceration and scarring. In each case the cause was faulty design of the apparatus, resulting in failure of the alarm to ring despite flow of current due to bed-wetting. In two the buzzer alarm could be switched off although the circuit remained live. In the third a run-down battery failed to activate the alarm. Certain design modifications are suggested which would greatly reduce the risk of electrical injury with this apparatus.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY.— Two cases of the Morquio syndrome, with associated mucopolysacchariduria, are described. Striking cutaneous abnormalities were found in each, the skin being loose, thickened, tough and inelastic particularly at the extremities. Generalized telangiectasia was present especially on the face and limbs. Similar changes have frequently been reported in the closely related Hurler syndrome. The presence of common features in the skin in these two conditions indicates that the cutaneous abnormalities of the Hurler syndrome are not unique.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesLotti, T. ; Steinman, H. K. ; Greaves, M. W. ; Fabbri, P. ; Brunetti, L. ; Panconesi, E.
Oxford, UK : Blackwell Publishing Ltd
Published 1986Staff ViewISSN: 1365-4632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: : Aquagenic pruritus is a disease in which itchy prickling skin discomfort is evoked by contact with water at any temperature without observable cutaneous lesions. Little is known about its etiology and pathogenesis. Previous reports show that increased levels of blood histamine and cutaneous mast cell degranulation are present before water exposure and that they increase stilt further with water challenge. This paper shows that fibrinolytic activity is markedly increased both before and after water exposure, while circulating fibrinolytic activity is normal before water exposure in three cases of aquagenic pruritus. A patient who was asymptomatic at the time of the study had no observed increase in fibrinolytic activity either before or after water challenge, suggesting that the remission of symptoms of aquagenic pruritus and normalization of cutaneous fibrinolytic activity are interdependent factors.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY.— The responses to topical application of tetrahydrofurfuryl nicotinate (Trafuril) cream were studied using a continuous skin perfusion method in clinically uninvolved skin of patients with chronic urticaria and in control patients. Trafuril causes inflammation but also renders the skin susceptible to dermographism.In non-urticarial subjects little pharmacological activity was detected during Trafuril inflammation or after stroking the skin to induce dermographism. This suggests that Trafuril causes inflammation by a direct effect on the cutaneous vasculature. By contrast in urticarial patients histamine was recovered more frequently than in non-urticarial patients during Trafuril inflammation, both before and after the skin was stroked. Perfusates from urticarial subjects also contained unidentified smooth muscle contracting activity which was not due to histamine, kinins, serotonin or acetyl choline. These results suggest that the skin of patients with chronic urticaria releases histamine and some other pharmacological agents more readily than that of normal subjects in response to inflammation producing stimuli.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesAiuti, F. ; Cerottini, J.C. ; Coombs, R. R. A. ; Cooper, M. ; Dickler, H. B. ; Froland, S. ; Fudenberg, H. H. ; Greaves, M. F. ; Grey, H. M. ; Kunkel, H. G. ; Natvig, J. B. ; Preu?homme, J.L. ; Rabellino, E. ; Ritts, R. E. ; Rowe, D. S. ; Seligmann, M. ; Siegal, F. P. ; Stjernswärd, J. ; Terry, W. D. ; Wybran, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1974Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract. This paper gives a review of the field of virus-lymphocyte interactions and virus receptors on lymphocytes as well as the use of viruses as markers for various lymphocyte populations.Type of Medium: Electronic ResourceURL: