Search Results - (Author, Cooperation:M. Grabe)

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  1. 1
    Staff View
    Publication Date:
    2013-11-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Anti-Bacterial Agents/chemistry/immunology/*metabolism/pharmacology ; Antigens, Neoplasm/chemistry/immunology/*metabolism ; Biomarkers, Tumor/antagonists & inhibitors/chemistry/immunology/*metabolism ; Cell Membrane Permeability/drug effects ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Gram-Negative Bacteria/drug effects/immunology/metabolism ; Humans ; Immunity, Mucosal/drug effects/immunology ; Intestines/*chemistry/immunology/microbiology ; Lectins, C-Type/antagonists & inhibitors/chemistry/immunology/*metabolism ; Lipopolysaccharides/pharmacology ; Listeria monocytogenes/drug effects/immunology/metabolism ; Microbial Viability/drug effects ; Models, Molecular ; Peptidoglycan/metabolism ; Phospholipids/metabolism ; Porins/antagonists & inhibitors/chemistry/*metabolism ; Symbiosis
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    S. Veshaguri ; S. M. Christensen ; G. C. Kemmer ; G. Ghale ; M. P. Moller ; C. Lohr ; A. L. Christensen ; B. H. Justesen ; I. L. Jorgensen ; J. Schiller ; N. S. Hatzakis ; M. Grabe ; T. G. Pomorski ; D. Stamou
    American Association for the Advancement of Science (AAAS)
    Published 2016
    Staff View
    Publication Date:
    2016-03-26
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Allosteric Regulation ; Arabidopsis Proteins/antagonists & inhibitors/chemistry/*metabolism ; Hydrogen-Ion Concentration ; Ion Transport ; Membrane Potentials/drug effects/physiology ; Molecular Imaging ; Protein Structure, Tertiary ; Proton-Translocating ATPases/antagonists & inhibitors/chemistry/*metabolism ; *Protons ; Valinomycin/pharmacology
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    N. H. Joh ; T. Wang ; M. P. Bhate ; R. Acharya ; Y. Wu ; M. Grabe ; M. Hong ; G. Grigoryan ; W. F. DeGrado
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-12-20
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Carrier Proteins/*chemistry ; Crystallography, X-Ray ; Ion Transport ; Lipid Bilayers ; Membrane Proteins/*chemistry ; Micelles ; Molecular Dynamics Simulation ; *Protein Engineering ; Protein Structure, Secondary ; Zinc/*chemistry
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Grabe, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0375-9601
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0375-9601(92)90087-3

    Articles: DFG German National Licenses
  5. 5
    Grabe, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0361-476X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Education
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0361-476X(81)90016-3

    Articles: DFG German National Licenses
  6. 6
    Grabe, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0361-476X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Education
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0361-476X(85)90012-8

    Articles: DFG German National Licenses
  7. 7
    Grabe, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0361-476X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Education
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/ceps.1994.1005

    Articles: DFG German National Licenses
  8. 8
    Grabe, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0361-476X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Education
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0361-476X(76)90003-5

    Articles: DFG German National Licenses
  9. 9
    Grabe, M. ; Antes, J. ; Kahn, H. ; Kristjanson, A.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0361-476X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Education
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0361-476X(91)90005-6

    Articles: DFG German National Licenses
  10. 10
    Grabe, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0361-476X
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Education
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0361-476X(82)90017-0

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1573-6881
    Keywords:
    Tunneling pathways ; protein electron transfer ; donor-acceptor interactions
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Notes:
    Abstract The simplest views of long-range electron transfer utilize flat one-dimensional barrier tunneling models, neglecting structural details of the protein medium. The pathway model of protein electron transfer reintroduces structure by distinguishing between covalent bonds, hydrogen bonds, and van der Waals contacts. These three kinds of interactions in a tunneling pathway each have distinctive decay factors associated with them. The distribution and arrangement of these bonded and nonbonded contacts in a folded protein varies tremendously between structures, adding a richness to the tunneling problem that is absent in simpler views. We review the pathway model and the predictions that it makes for protein electron transfer rates in small proteins, docked proteins, and the photosynthetic reactions center. We also review the formulation of the protein electron transfer problem as an effective two-level system. New multi-pathway approaches and improved electronic Hamiltonians are described briefly as well.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02110098

    Articles: DFG German National Licenses
  12. 12
    Grabe, M.
    Springer
    Published 1992
    Staff View
    ISSN:
    1439-0973
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01704382

    Articles: DFG German National Licenses
  13. 13
    Grabe, M. ; Hellsten, S. ; Andersson, K. -E. ; Forsgren, A.
    Springer
    Published 1981
    Staff View
    ISSN:
    1439-0973
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Description / Table of Contents:
    Zusammenfassung Die Konzentration von Cefotaxim im Serum wurde bei 11 Patienten nach intramuskulärer Injektion von 1 g Cefotaxim mit Hilfe einer biologischen Methode bestimmt. Die erhaltene Standard-Eliminationskurve ist für eine Gruppe von älteren Männern (mittleres Alter 71 Jahre) repräsentativ. Proben von sieben Patienten wurden gleichzeitig mit der biologischen Methode und Hochdruck-Flüssigkeitschromatographie untersucht, die Ergebnisse waren vergleichbar. Die Untersuchung der Cefotaxim-Urinkonzentrationen bei vier Patienten ergab sehr hohe Spiegel der Substanz (mittlere Konzentration nach zwei Stunden 3395 µg/ml, nach fünf Stunden 1210 µg/ml). 66% der Substanz fanden sich nach fünf Stunden im Urin wieder. Cefotaxim penetrierte in das Drüsengewebe der Prostata; die erreichten Konzentrationen lagen zwischen 1,2 und 3,8 µg/g zwischen der ersten und dritten Stunde nach Injektion von 1 g i. m. Im Nierengewebe wurde die Substanz in der Rinde, in den mittleren Parenchymanteilen und im inneren Bereich der Markzone in Konzentrationen von 4,1, 4,2 und 6,2 µg/g gefunden. Die im Serum, Urin, in der Prostata und in der Niere gemessenen Konzentrationen zeigen, daß Cefotaxim ein wertvolles Medikament zur Behandlung von Harnwegsinfektionen ist.
    Notes:
    Summary Following the injection of 1 g of cetotaxime i. m., the concentration in serum was analysed in 11 patients using a biological method. The standard elimination curve obtained was representative for a group of elderly men (mean age 71 years). Samples from seven patients were analysed simultaneously using the biological method and high pressure liquid chromatography; the results were comparable. In four patients the concentration of cefotaxime in the urine was determined; very high levels of the drug were found (mean concentration 3395 µg/ml at two hours and 1210 µg/ml at five hours). 66% of the drug was found to have been eliminated in the urine at five hours. Cefotaxime penetrated the prostatic tissue, giving concentrations ranging from 1.2 to 3.8 µg/g between the first and third hour after the injection of 1 g i. m. In the kidney tissue the drug was detected in the cortex, the middle part of the parenchyma and the inner medulla, at concentrations of 4.1, 4.2 and 6.2 µg/g, respectively. The concentrations obtained in the serum, in urine, and in the prostate and kidney indicate that cefotaxime is a valuable drug for the treatment of urinary tract infections.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01642125

    Articles: DFG German National Licenses
  14. 14
    Grabe, M. ; Forsgren, A.
    Springer
    Published 1985
    Staff View
    ISSN:
    1435-4373
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The influence of short-term prophylactic courses of cefotaxime on the microbial environment was studied. The distribution of bacterial species and their antibiotic resistance was recorded in isolates collected over a six-year period, during which time cefotaxime was used for perioperative prophylaxis in patients undergoing transurethral prostatic resection. In three consecutive studies covering the six-year observation period, the species distribution and antibiotic resistance patterns remained essentially unchanged for both cefotaxime and ampicillin. Examination of the faecal coliform flora in 23 patients given cefotaxime revealed no marked qualitative or quantitative change in the flora. It is concluded that short-term prophylactic courses of cefotaxime do not promote the emergence of resistance in the aerobic bacterial flora.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02148655

    Articles: DFG German National Licenses
  15. 15
    Grabe, M. ; Forsgren, A. ; Björk, T. ; Hellsten, S.
    Springer
    Published 1987
    Staff View
    ISSN:
    1435-4373
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection for benign hyperplasia or cancer of the prostate and compared with that of controls without antibiotic (Group III). Both regiments significantly reduced the frequency of postoperative bacteriuria (p 〈 0.01) and of severe infectious complications (p=0.004) as compared to the controls. Both regimens were equally effective in preventing perioperative and postoperative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found postoperatively in 35% in Group I and 10% in Group II (p=0.012), but in 82 % of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of ⩽ 1μg/ml. Given orally ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02097183

    Articles: DFG German National Licenses
  16. 16
    Grabe, M. ; Forsgren, A. ; Björk, T.
    Springer
    Published 1986
    Staff View
    ISSN:
    1435-4373
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02013991

    Articles: DFG German National Licenses