Search Results - (Author, Cooperation:M. Gore)
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1Latest Papers from Table of Contents or Articles in PressE. Ruark ; K. Snape ; P. Humburg ; C. Loveday ; I. Bajrami ; R. Brough ; D. N. Rodrigues ; A. Renwick ; S. Seal ; E. Ramsay ; V. Duarte Sdel ; M. A. Rivas ; M. Warren-Perry ; A. Zachariou ; A. Campion-Flora ; S. Hanks ; A. Murray ; N. Ansari Pour ; J. Douglas ; L. Gregory ; A. Rimmer ; N. M. Walker ; T. P. Yang ; J. W. Adlard ; J. Barwell ; J. Berg ; A. F. Brady ; C. Brewer ; G. Brice ; C. Chapman ; J. Cook ; R. Davidson ; A. Donaldson ; F. Douglas ; D. Eccles ; D. G. Evans ; L. Greenhalgh ; A. Henderson ; L. Izatt ; A. Kumar ; F. Lalloo ; Z. Miedzybrodzka ; P. J. Morrison ; J. Paterson ; M. Porteous ; M. T. Rogers ; S. Shanley ; L. Walker ; M. Gore ; R. Houlston ; M. A. Brown ; M. J. Caufield ; P. Deloukas ; M. I. McCarthy ; J. A. Todd ; C. Turnbull ; J. S. Reis-Filho ; A. Ashworth ; A. C. Antoniou ; C. J. Lord ; P. Donnelly ; N. Rahman
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-12-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Breast Neoplasms/*genetics ; Cluster Analysis ; Exons ; Female ; Genetic Predisposition to Disease/*genetics ; Humans ; Isoenzymes/genetics ; Lymphocytes/metabolism ; *Mosaicism ; *Mutation ; Ovarian Neoplasms/*genetics ; Phosphoprotein Phosphatases/*genetics ; Sequence Analysis, DNA ; Tumor Suppressor Protein p53/metabolismPublished by: -
2Articles: DFG German National LicensesERVIN, M. GORE ; TERRY, KIMBERLY A. ; CALVARIO, GLENDA C. ; ROSS, MICHAEL G. ; LEAKE, ROSEMARY D. ; FISHER, DELBERT A.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
3FIS Bildung LiteraturdatenbankStaff View
Type of Medium: bookPublication Date: 1999Keywords: Lehrer ; ZeitökonomieLanguage: English -
4FIS Bildung LiteraturdatenbankStaff View
Type of Medium: bookPublication Date: 2010Keywords: Schüler ; Integrierender Unterricht ; Behinderung ; USALanguage: English -
5Latest Papers from Table of Contents or Articles in PressPauli, D., Ziegler, G., Ren, M., Jenks, M. A., Hunsaker, D. J., Zhang, M., Baxter, I., Gore, M. A.
Genetics Society of America (GSA)
Published 2018Staff ViewPublication Date: 2018-03-29Publisher: Genetics Society of America (GSA)Electronic ISSN: 2160-1836Topics: BiologyPublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Scleroderma has been associated with exposure to many substances in the past ranging from vinyl chloride to silicon dioxide. In recent years there have been a number of case reports linking modern chemotherapy agents, such as the taxanes to the development of scleroderma like changes. We present a further case of scleroderma in association with chemotherapy but question the role of some of the agents previously implicated. A brief review of the current literature is included.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesFearfield, L. A. ; Rowe, A. ; Francis, N. ; Fisher, C. ; Gore, M. E. ; Bunker, C. B.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: In the UK the incidence of malignant melanoma is increasing and more patients with thinner primary lesions are diagnosed earlier. Most patients with very thin melanoma (〈 0.76 mm Breslow thickness) are cured by surgical excision, however, 2–18% relapse over 0–11 years with local or distant metastatic disease and may die. There are still no recognized prognostic or predictive, clinical, serological or molecular markers that accurately determine which of these very thin melanoma will relapse: the Breslow thickness remains the single most important prognostic factor for melanoma in general. Improved prognostic indicators are therefore needed for this rare, but important, unusually aggressive group, to better direct new invasive and expensive investigations and treatment. This article reviews the clinical and histological aspects of relapsing very thin melanoma and discusses the findings of several recent studies, including our own. There is no clinical or biological evidence to support either wide surgical excision or sentinel node biopsy in these patients.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract— The effects of spermine and spermidine tetrahydrochloride on female Agus rat brain caudate nucleus homogenates, soluble acetylcholinesterase from the electric organ of Electrophorus electricus and acetylthiocholine iodide were studied. Measurements were made using an autoanalytical spectrophotometric method which measured the initial rate of reaction rapidly and accurately. Both polyamines interacted with the substrate, acetylthiocholine, causing an increase in the rate of its non-enzymatic hydrolysis. Slight inhibitory effects on acetylcholinesterase were also observed. Combined effect of the polyamine on the substrate and the enzyme showed an inhibition at low and activation at high (above 1 mm) substrate concentrations.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStratton, JF ; Gayther, SA ; Russell, P ; Dearden, J ; Gore, M ; Blake, P ; Smith, SK ; Easton, D ; Ponder, BAJ
Oxford, UK : Blackwell Publishing Ltd
Published 1998Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesTU, S.-I. ; UKNALIS, J. ; GORE, M. ; IRWIN, P. ; FEDER, I.
Oxford, UK : Blackwell Publishing Ltd
Published 2003Staff ViewISSN: 1745-4581Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Abstract Biotinylated anti E. coli O157 antibodies were linked to streptavidin coated magnetic and polystyrene beads of different sizes and densities. These beads were then used to capture cultured E. coli O157:H7. Complexes formed between fluorescein-conjugated anti E. coli O157 antibodies and urease-conjugated anti-fluorescein antibodies further labeled bead-captured bacteria. The extent of the bacterial capture was related to the signal intensity of a light addressable potentiometric sensor (LAPS) that measured the pH changes associated with urease-catalyzed hydrolysis of urea. Under the conditions of applying the same amounts of biotinylated anti E. coli O157 antibody to beads, analyses of the capture kinetics indicated that heavier beads exhibited a better efficiency in capturing the target bacteria than that associated with the lighter beads of the same size. Furthermore, with the same density, larger bead diameters were more effective in capturing the bacteria. Since sedimentation volumes for the heavier and larger beads are greater than those of the lighter and smaller beads, more interactions with the target by the heavier and larger beads are expected. Consequently, the observation is in agreement with a hydrodynamic kinetic model that predicts the bacterial capture is controlled by the sedimentation motion of the beads.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesKUMTA, U. S. ; MAVINKURVE, S. S. ; GORE, M. S. ; SAWANT, P. L. ; GANGAL, S. V. ; SREENIVASAN, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1970Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: SUMMARY— The storage life of fresh, peeled and deveined tropical shrimps at 10—12°C is extended to 10—14 and 18—21 days with 0.15 and 0.25 Mrad, respectively, as against spoilage of unirradiated samples within 4 days. Blanching treatment (steaming for 4 min) with or without brine (3.0% NaCl) extends the storage life up to 30 days at lo—12°C. the former retaining the shell-fish flavor. However, the blanched products develop musty odor and slimy texture during storage; subjected to irradiation (0.15 Mrad) these are devoid of undesirable attributes and are acceptable for 60 and 130 days, respectively, at 10—1°C and 2—4°C. Bacterial counts exceeding 108/g and high levels of TMAN and TVBN concur with spoilage of unirradiated shrimps. In contrast, low levels of TMAN and TVBN, despite high TBC, corroborate with high acceptability of radiation processed shrimps. In blanched as well as in blanched and irradiated shrimps TBC, TMAN and TVBN are low. Samples subjected to blanching only have low acceptability as against the improvement in quality by irradiation. These alterations in storage property have been discussed in the light of shifts in microflora.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: SUMMARY— Bombay duck (Harpodon nehereus), a tropical fish, is readily susceptible to drip losses leading to textural alterations. These changes occur during storage at 0 or −20°C for 3 days and also by irradiation and storage at 0 or 10°C for 3 days. In situ denaturation of fibrillar proteins of Bombay duck occurs as evidenced by a decrease in salt-soluble proteins. Loss in extractability occurring at 0 or −20°C parallels increased drip loss, but appears to be arrested by pre-dip treatment in 10% sodium tripolyphosphate solution for 15 min. The radiation-induced drip loss also correlates with loss in the extractability at a radiation dose of 3 Mrad, but at 0.5 Mrad the drip loss occurs without appreciable decrease in the extractability. Pre-dip treatment in 10% sodium tripolyphosphate solution reduces the drip loss caused by 3 Mrad, but this is not reflected in the recovery of extractable proteins. Loss in the extractability could be attributed to the aggregation phenomenon of fibrillar proteins induced by irradiation. The radiation-induced off-odors appear to originate from the sarcoplasmic proteins.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Cathepsin B from the skeletal muscle of a fresh water fish Tilapia mossambica was purified 4280-fold with 9% recovery. The electrophoretic homogeneity of the preparation was established both under native and denatured conditions. The molecular weight of cathepsin B on the basis of its gel filtration profile was 23,500 daltons. The enzyme, an endopeptidase, hydrolysed Z-arg-arg-NNap and Bz-arg-NNap, with Km values of 0.57 and 3.23 mM, respectively. Cathepsin B did not display aminopeptidase activity, but cleaved Bz-arg-NH2, exhibiting the specificity of a carboxypeptidase. Among protein substrates tested, only azocoll was hydrolyzed at lower pH values. Leu-peptin, antipain and thiol blockers abolished the enzyme activity completely. The Kcat set-1 value of fish cathepsin B seemed to be lower than that of mammalian enzyme.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0010-3802Topics: Political ScienceSociologyNotes: IndiaURL: -
15Articles: DFG German National LicensesCHANDER, RAMESH ; SHEREKAR, S. V. ; GORE, M. S.
Oxford, UK : Blackwell Publishing Ltd
Published 1981Staff ViewISSN: 1745-4514Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: The interaction of malonaldehyde with lysozyme has been assessed with reference to incubation time, pH, concentration and aging. Gel filtration studies revealed that freshly prepared malonaldehyde contains a small proportion of compounds absorbing at 267 and 350 nm, which shows significant increase upon incubation of malonaldehyde. While higher concentration of malonaldehyde leads to inactivation of enzyme, lower concentration (2.5 mM) stimulates the lytic function of lysozyme. Stimulation and inactivation of the enzyme have been discussed in the context of degradation of malonaldehyde.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1569-8041Keywords: ovarian cancer ; dose intensity ; peripheral stem cell transplantation ; autologous bone marrow transplantation ; intraperitoneal therapySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background: There has been a longstanding controversy regarding the role of high-dose chemotherapy in patients with advanced ovarian cancer. Based on retrospective studies, it has been suggested that there will be improved results when doses of platinum compounds in particular are increased. High-dose therapy can be administered using an intraperitoneal route of drug delivery or with haematologic support in the form of autologous bone marrow transplantation (ABMT) or peripheral blood stem cell transfusions (PBSCT). Methods: Experienced clinical investigators reviewed published data available on high-dose chemotherapy and intraperitoneal drug delivery. In addition, ongoing clinical trials of ABMT or PBSCT were also reviewed. Results: Prospective randomised trials have failed to demonstrate that doubling the dose of platinum compounds increases survival in patients with advanced ovarian cancer. Intraperitoneal chemotherapy with cisplatin or paclitaxel remains an area of investigation and prospective randomised trials in previously untreated patients as well as part of consolidation therapy in patients achieving a complete remission are in progress. Phase II trials of high-dose chemotherapy with ABMT or PBSCT in previously treated patients with advanced ovarian cancer have produced higher response rates than achieved with conventional doses although there has been no proven impact upon survival. Prospective randomised trials in previously untreated patients are in progress. Until the completion of these trials, high-dose chemotherapy with ABMT or PBSCT and intraperitoneal chemotherapy should be considered investigational.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesVaughan, M. M. ; Moore, J. ; Riches, P. G. ; Johnston, S. R. D. ; A'Hern, R. P. ; Hill, M. E. ; Eisen, T. ; Ayliffe, M. J. ; Thomas, J. M. ; Gore, M. E.
Springer
Published 2000Staff ViewISSN: 1569-8041Keywords: biochemotherapy ; cytokines ; GM-CSF ; melanomaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Background:Ineffective tumour antigen processing is recognisedas an important cause of failure of immunotherapy in melanoma. GM-CSF mayaugment the cytotoxic lymphocyte response by activating antigen-presentingcells. This study evaluates a schedule combining GM-CSF with biochemotherapy. Patients and methods:Nineteen patients with advanced malignantmelanoma received cisplatin (25 mg/m2 days 1–3), dacarbazine(220 mg/m2 days 1–3), interleukin-2 (9 MIU/m2/24h)and interferon-α2b (5 MIU/m2) both days 6–10 and days17–21, and tamoxifen 40 mg/day continuously. Subcutaneous GM-CSF wasgiven in escalating doses to three cohorts: 1) 450 µg/m2 days4–5 and 15–16; 2) as 1) plus 225 µg/m2 days6–10 and 17–21; 3) 450 µg/m2 days 4–10 and15–21. Each cycle was 28 days. Results:Constitutional side effects were the majornon-haematological toxicity and lymphopaenia the main haematological toxicity.Six patients responded (32%, 95% confidence interval:13%–57%), two patients had complete remission. There wasan apparent trend for increasing responses with increasing GM-CSF dose; zeroof six responses in cohort 1, two of seven in cohort 2 and three of six incohort 3 (P = 0.016). Median overall survival was 6.2 months.Increasing GM-CSF doses significantly increased serum concentrations ofneopterin and TNF-α. Conclusions:The combination of GM-CSF with biochemotherapy isfeasible and there appears to be a dose-response relationship with GM-CSF interms of host immunological response, and possibly clinical efficacy.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-0428Keywords: Liver cirrhosis ; glucagon ; somatotropin ; portal vein ; collateral circulation ; liver function testsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Plasma glucagon and growth hormone concentrations were measured fasting and after oral glucose in 19 patients with portal vein block with extensive portal-systemic shunting but minimal liver cell damage, 11 cirrhotic patients and 12 matched control subjects. Portal vein block patients and controls had similar fasting glucose and glucagon levels (glucose 3.8 ±0.1 mmol/l vs control 3.4±0.1 mmol/l (mean±SEM); glucagon 57.5 ±9.1 pg/ml vs control 51.3±7.8 pg/ml). Cirrhotic patients were hyperglycaemic (cirrhosis 4.3±0.2 mmol/l vs control 3.4 ±0.1 mmol/l, p 〈 0.01) with significantly elevated glucagon levels (167.3±61.1 pg/ml vs control 51.3 ±7.8 pg/ml, p 〈 0.05), which suppressed towards control values after oral glucose. There was no correlation between fasting plasma glucagon levels and the degree of portal-systemic shunting in cirrhotic patients. There was a strong correlation between fasting plasma glucagon concentrations and aspartate transaminase levels (r = 0.68; p 〈 0.01) in cirrhotic and portal vein block patients. Significant elevations of growth hormone were seen only in cirrhotic patients. It is concluded that hyperglucagonaemia is a feature of hepatocellular damage rather than portalsystemic shunting but the relationship between elevated glucagon and growth hormone concentrations and carbohydrate intolerance in cirrhosis remains unclear.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesViner, C. V. ; Selby, P. J. ; Zulian, G. B. ; Gore, M. E. ; Butcher, M. E. ; Wootton, C. M. ; McElwain, T. J.
Springer
Published 1990Staff ViewISSN: 1432-0843Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary A total of 33 patients with myeloma receiving treatment with high-dose melphalan (140–200 mg/m2 i.v.) were given the 5HT3 antagonist Ondansetron (Glaxo) as an antiemetic. In 42% of patients, emetic episodes were either abolished (15%) or reduced to two or less (27%). Efficacy was not related to scheduling (two regimens) or total dose. No sedative or other significant side effects were seen. Ondansetron is a highly effective non-sedative antiemetic that justifies further assessment in combination with other antiemetics in patients receiving cytotoxic drugs associated with the production of severe nausea and vomiting.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesBanerjea, A. C. ; Kedarnath, N. ; Gore, M. M. ; Dayaraj, C. ; Jamkar, A. V. ; Ghosh, S. N.
Springer
Published 1981Staff ViewISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary A comparative study of interferon (IFN) production (type-α and γ) was carried out using Ficoll-hypaque purified fresh and cryopreserved mononuclear cells from eight normal healthy individuals. Newcastle disease virus-NDV (R2B strain) was used as an inducer for type-α and Staphylococcal enterotoxin-A-(SEA) for type-γIFN production. There was no significant difference between the titres of type-α and γ-IFN and lymphocyte subpopulations of fresh and cryopreserved mononuclear cells studied under identical conditions.Type of Medium: Electronic ResourceURL: