Search Results - (Author, Cooperation:M. Godard)
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1Latest Papers from Table of Contents or Articles in PressR. Schulz ; M. Hilchenbach ; Y. Langevin ; J. Kissel ; J. Silen ; C. Briois ; C. Engrand ; K. Hornung ; D. Baklouti ; A. Bardyn ; H. Cottin ; H. Fischer ; N. Fray ; M. Godard ; H. Lehto ; L. Le Roy ; S. Merouane ; F. R. Orthous-Daunay ; J. Paquette ; J. Ryno ; S. Siljestrom ; O. Stenzel ; L. Thirkell ; K. Varmuza ; B. Zaprudin
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-01-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressK. M. Gillis ; J. E. Snow ; A. Klaus ; N. Abe ; A. B. Adriao ; N. Akizawa ; G. Ceuleneer ; M. J. Cheadle ; K. Faak ; T. J. Falloon ; S. A. Friedman ; M. Godard ; G. Guerin ; Y. Harigane ; A. J. Horst ; T. Hoshide ; B. Ildefonse ; M. M. Jean ; B. E. John ; J. Koepke ; S. Machi ; J. Maeda ; N. E. Marks ; A. M. McCaig ; R. Meyer ; A. Morris ; T. Nozaka ; M. Python ; A. Saha ; R. P. Wintsch
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-12-03Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Articles: DFG German National LicensesLamy, T. ; Drenou, B. ; Grulois, I. ; Leberre, C. ; Dauriac, C. ; Amiot, L. ; Godard, M. ; Fauchet, R. ; LePrise, P. Y.
Springer
Published 1994Staff ViewISSN: 1432-0584Keywords: GM-CSF ; Autologous blood stem cells TransplantationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary We have tested the efficiency of GM-CSF to mobilize peripheral blood progenitor cells (PBPC) and evaluated the hematological reconstitution after GM-CSF primed-PBPC infusion following myeloablative therapy. Twenty three patients suffering from hematological malignancies were included in this study. Starting 24 hours after completion of a standard dose chemotherapy including vindesine, cyclophosphamide, adriblastine, prednisone, (VCAP), 5 (μg/kg sub-cutaneous daily dose GM-CSF was given for a median time of 14 days followed by three consecutives cycles of leukapheresis. Fifteen of these 23 patients underwent GM-CSF primed-PBPC autotransplantation following high dosed intensification regimen. PBPC collection and hematopoietic recovery were compared with a 15 patients control group who did not receive GM-CSF. No marrow or growth factors were administred after PBPC reinfusion in the two groups. VCAP/GM-CSF mobilization induced significantly higher yields of CFU-GM (3.8 fold) than did VCAP mobilization alone, 19×104/kg (2–73) vs 5×104/kg (2–27), (p〈0.005). The median number of days to achieve 1.109/l neutrophils, platelet count 〉20.109/l and 〉50.109/l was significantly lower in the GM-CSF group than in the control group, respectively 13 vs 19 days (p=0.04), 15.5 vs 27 days (p〈0.02), 19 vs 51 days (p〈0.01). When compared with the control group, transfusion requirements and median of hospital stay were both significantly decreased for the patients receiving GM-CSF primed-PBPC. Our study confirms that infusion of GM-CSF primed-PBPC as a sole source of hematopoietic support improves hematopoietic reconstitution following myeloablative therapy.Type of Medium: Electronic ResourceURL: