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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-03-22Publisher: Royal SocietyElectronic ISSN: 2054-5703Topics: Natural Sciences in GeneralKeywords: structural biology, biomaterials, analytical chemistryPublished by: -
2Latest Papers from Table of Contents or Articles in PressBurrack, A. L., Landry, L. G., Siebert, J., Coulombe, M., Gill, R. G., Nakayama, M.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-02-10Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
3Latest Papers from Table of Contents or Articles in PressFarnsworth, C. W., Schott, E. M., Benvie, A., Kates, S. L., Schwarz, E. M., Gill, S. R., Zuscik, M. J., Mooney, R. A.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-07-10Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
4Latest Papers from Table of Contents or Articles in PressDe; Silva, J. M., Gill, C. M., Prang, T. C., Bredella, M. A., Alemseged, Z.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-07-05Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
5Latest Papers from Table of Contents or Articles in PressV. Vacic ; S. McCarthy ; D. Malhotra ; F. Murray ; H. H. Chou ; A. Peoples ; V. Makarov ; S. Yoon ; A. Bhandari ; R. Corominas ; L. M. Iakoucheva ; O. Krastoshevsky ; V. Krause ; V. Larach-Walters ; D. K. Welsh ; D. Craig ; J. R. Kelsoe ; E. S. Gershon ; S. M. Leal ; M. Dell Aquila ; D. W. Morris ; M. Gill ; A. Corvin ; P. A. Insel ; J. McClellan ; M. C. King ; M. Karayiorgou ; D. L. Levy ; L. E. DeLisi ; J. Sebat
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-02-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cell Line ; Chromosomes, Human, Pair 7/genetics ; Cohort Studies ; Cyclic AMP/metabolism ; DNA Copy Number Variations/*genetics ; Female ; Gene Dosage/genetics ; Genes, Duplicate/*genetics ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Humans ; Inheritance Patterns/genetics ; Male ; Pedigree ; Receptors, Vasoactive Intestinal Peptide, Type II/*genetics/metabolism ; Reproducibility of Results ; Schizophrenia/*genetics/metabolism ; Signal Transduction ; Transcription, Genetic/geneticsPublished by: -
6Latest Papers from Table of Contents or Articles in PressS. De Rubeis ; X. He ; A. P. Goldberg ; C. S. Poultney ; K. Samocha ; A. E. Cicek ; Y. Kou ; L. Liu ; M. Fromer ; S. Walker ; T. Singh ; L. Klei ; J. Kosmicki ; F. Shih-Chen ; B. Aleksic ; M. Biscaldi ; P. F. Bolton ; J. M. Brownfeld ; J. Cai ; N. G. Campbell ; A. Carracedo ; M. H. Chahrour ; A. G. Chiocchetti ; H. Coon ; E. L. Crawford ; S. R. Curran ; G. Dawson ; E. Duketis ; B. A. Fernandez ; L. Gallagher ; E. Geller ; S. J. Guter ; R. S. Hill ; J. Ionita-Laza ; P. Jimenz Gonzalez ; H. Kilpinen ; S. M. Klauck ; A. Kolevzon ; I. Lee ; I. Lei ; J. Lei ; T. Lehtimaki ; C. F. Lin ; A. Ma'ayan ; C. R. Marshall ; A. L. McInnes ; B. Neale ; M. J. Owen ; N. Ozaki ; M. Parellada ; J. R. Parr ; S. Purcell ; K. Puura ; D. Rajagopalan ; K. Rehnstrom ; A. Reichenberg ; A. Sabo ; M. Sachse ; S. J. Sanders ; C. Schafer ; M. Schulte-Ruther ; D. Skuse ; C. Stevens ; P. Szatmari ; K. Tammimies ; O. Valladares ; A. Voran ; W. Li-San ; L. A. Weiss ; A. J. Willsey ; T. W. Yu ; R. K. Yuen ; E. H. Cook ; C. M. Freitag ; M. Gill ; C. M. Hultman ; T. Lehner ; A. Palotie ; G. D. Schellenberg ; P. Sklar ; M. W. State ; J. S. Sutcliffe ; C. A. Walsh ; S. W. Scherer ; M. E. Zwick ; J. C. Barett ; D. J. Cutler ; K. Roeder ; B. Devlin ; M. J. Daly ; J. D. Buxbaum
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Child Development Disorders, Pervasive/*genetics/pathology ; Chromatin/*genetics/metabolism ; Chromatin Assembly and Disassembly ; Exome/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Germ-Line Mutation/genetics ; Humans ; Male ; Molecular Sequence Data ; Mutation/*genetics ; Mutation, Missense/genetics ; Nerve Net/metabolism ; Odds Ratio ; Synapses/*metabolism ; Transcription, Genetic/*geneticsPublished by: -
7Latest Papers from Table of Contents or Articles in PressM. A. Moritz ; E. Batllori ; R. A. Bradstock ; A. M. Gill ; J. Handmer ; P. F. Hessburg ; J. Leonard ; S. McCaffrey ; D. C. Odion ; T. Schoennagel ; A. D. Syphard
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Australia ; Climate Change ; Conservation of Natural Resources ; *Ecosystem ; Environmental Policy ; *Fires/prevention & control/statistics & numerical data ; Forests ; Geography ; Housing ; Human Activities ; Humans ; Mediterranean Region ; Population Density ; Risk Management ; Southwestern United StatesPublished by: -
8Latest Papers from Table of Contents or Articles in PressGill, M. E., Peters, A. H. F. M.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-10-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: DevelopmentPublished by: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Grass silages made from first-harvest perennial ryegrass in mid-May and early-June and termed high-D and low-D respectively had mean DOMD values of 694 and 633 g kg−1 and were offered ad libitum to twelve Ayrshire cows in a 16-week feeding experiment using a cyclic changeover design. The silages were supplemented with a concentrate containing 363g CP per kg DM at daily rates of 1.5, 3.0 and 4.5 kg per cow. The average daily intakes of silage DM were 12.6 and 11.1 kg per cow on the high- and low-D silage treatments respectively, and were not significantly different on the three concentrate treatments. The mean daily milk yields were 171, 18.6 and 21.0 kg per cow on the low-D silage treatments, and 19.6, 21.2 and 22.8 kg per cow on the high-D silage treatments at the 1.5, 3.0 and 4.5 kg rates of concentrate feeding respectively. Fat and lactose concentrations in the milk were not affected significantly by treatment, whereas the CP and SNF concentrations increased progressively and significantly as the rate of supplementary feeding increased. It is concluded that a high-protein concentrate supplement allows silage to make the maximum contribution in the diet, and gives a high response in terms of milk yield and composition.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Two grass silages made from perennial ryegrass, and with D-values of 0·216 and 0·255, were offered ad libitum to 18 Ayrshire cows in two feeding experiments. On the control treatment the silages were supplemented with soybean meal only, and on the other two treatments with equal weights of DM from either barley or dried molassed sugar-beet pulp plus the same weight of soya as on the control treatment. The daily intakes of silage DM were not significantly different on the barley and beet-pulp treatments, and, on average, the intake of silage DM was reduced by 0·24 and 0·20 kg by feeding 1 kg barley and beet pulp DM respectively.The daily milk yields were not significantly different on the barley and beet-pulp treatments with mean values of 19·2 and 19·2 kg per cow respectively compared with 17·2 kg on the control treatment. On the barley and beet-pulp treatments the fat, SNF, CP and lactose concentrations in the milk and the live weights of the cows were not significantly different. It is concluded that the barley and beet pulp had similar feeding values and replacement rates when used as supplements with grass silage, and that the two feeds were interchangeable on an equal DM basis.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesScheinfeld, N. ; Hu, G. ; Gill, M. ; Austin, C. ; Çelebi, J. T.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary Brooke–Spiegler syndrome is an autosomal dominantly inherited disease with predisposition to neoplasms of the skin appendages. The disease has been mapped to 16q, and mutations in the CYLD gene have been identified in families with this disorder. We describe an individual with BSS exhibiting clinical heterogeneity in which a heterozygous frameshift mutation in CYLD, 2172delA, has been identified. These findings extend the body of evidence that mutations in CYLD are involved in Brooke-Spiegler syndrome and provide additional information for phenotype–genotype correlation.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Grass silage made in May from S24 perennial ryegrass had a DM concentration of 262 g kg-1 and an in vitro D-value of 0·698, and was given ad libitum to twelve Ayrshire cows in a 16-week feeding experiment. In addition supplements of hay with a mean in vitro D-value of 0·603 were offered in one of three forms—long, chopped (12·1 mm) or ground (0·80 modulus of fineness) and cubed—and of concentrates given at either 2 or 4 kg per 10 kg milk. Hay averaged 18·2% of total forage DM intake with mean daily intakes of 1·28, 1·22 and 2·26 kg DM per cow in the long, short and ground forms respectively. The highest daily intakes of forage, i.e. silage plus hay, occurred on the ground hay treatments, with values of 10·24 and 9·25 kg DM per cow on the 2 and 4 kg concentrate treatments respectively. The mean daily milk yields were 18·2,18·2 and 19·2 kg per cow on the long, short and ground hay treatments respectively but the increase in yield with the ground hay was only significant at the low level of concentrate intake. The hay treatments had small and non-significant effects on milk composition. It is concluded that ground hay was superior to either long or chopped hay as a supplement for silage, but the small advantages depended on the level of concentrate intake.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Four grass silages of two chop lengths and two D-values were made from S23 perennial ryegrass, and compared in a feeding experiment with lactating cows and in an eating-behaviour study with non-lactating cows. The median chop lengths were 11·6 and 11·5 mm in the short silages and 18·2 and 19·5 mm in the medium silages. Chop length had negligible effects on D-value and on pH with values of 3·81 and 3·94 on the short and medium silages respectively.Silage DM intakes were higher on the short than on the medium-chop silages in both experiments except where the high D-value silage was supplemented with concentrates. Milk yields were not affected significantly by chop length with daily values of 19·3 and 19·7 kg per cow on the short and medium treatments respectively with the high D-value silage, and 18·2 and 18·3 kg per cow with the low D-value silage. Chop length had only small and non-significant effects on milk composition.Eating times expressed as min per kg DM were significantly lower on the short than on the medium-chop silages.It is concluded that the small differences between the short- and the medium-chop silages were of no economic importance.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: In order to assess the relative effects of protein content and acid on intake, grass silage was given ad libitum to twelve entire male calves, initially 4 months of age and 117 kg liveweight (LW), either alone or supplemented with fishmeal at 50 g dry matter (DM) per kg silage DM. These two diets were offered alone or with additions of lactic acid at 50 g per kg silage DM in a partial changeover design in which lactic acid levels only were reversed between two 28-d measurement periods.In the absence of lactic acid, fishmeal significantly increased absolute intake but not intake relative to LW. There was a significant interaction between treatments in that the addition of lactic acid depressed DM intake in the absence of fishmeal (23·9 vs 21·1 g kg-1 LW) but not in its presence (23·2 vs 23·1 g kg-1 LW). Addition of fishmeal increased the digestibility of DM from a mean of 0·708 to 0·744 (P 〈 0·05), of gross energy from 0·646 to 0·694 (P 〈 0·01) and of N from 0·422 to 0·592 (P 〈 0·001) but had no significant effect on the digestibility of cellulose (0·766 vs 0·788 for treatments without and with fishmeal respectively). Lactic acid addition had no effect on the digestibility of plant components and, further, interaction effects between treatments were not significant. Supplementation with fishmeal reduced the total time spent eating and ruminating (Ro value) from a mean of 284 to 240 min kg-1 DM (P 〈 0·01) and increased urine pH from 8·34 to 8·50. Lactic acid influenced neither Ro value nor urine pH and the interaction effect did not reach significance for these two parameters.The results indicate that the addition of fishmeal can overcome a depressant effect of lactic acid on intake and it is suggested that the responses to treatment were mediated via changes in the ratio of energy to protein supply rather than as a result of treatment effects on digestive efficiency or acid-base balance.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesCohen, J. ; Gill, M. ; Renwick, N. ; Silvers, D. N. ; Celebi, J. T.
Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
Published 2005Staff ViewISSN: 1600-0560Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: BRAF encodes a serine-threonine kinase, which acts in the RAS/RAF/MAPK pathway transducing regulatory signals from RAS to MEK1/2. Somatic mutations in BRAF have been identified in 53–80% of primary melanomas and 70–90% of common melanocytic nevi. More than 90% of these mutations consist of a valine to glutamate substitution at codon 599 (V599E) of exon 15. While a high prevalence of BRAF mutations in common melanocytic nevi has been reported in adults, nevi in children have not been studied. Of interest, we have previously shown that Spitz nevi in children do not harbor mutations in BRAF. To investigate the association of BRAF mutations with patient age, we studied common melanocytic nevi in children for the V599E activating mutation. Tumor cells were microdissected from 6 common melanocytic nevi in children 10 years of age or younger, and analyzed for the V599E mutation in BRAF by allele-specific PCR and gel electrophoresis. In 6 of 6 (100%) nevi, the V599E mutant allele was observed. Our data suggest that similar genetic pathways are involved in the development of common melanocytic nevi in children and adults. The absence of BRAF mutations in Spitz nevi in children is therefore associated with tumor type, not patient age.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesGill, M. ; Cohen, J. ; Renwick, N. ; Mones, J. ; Silvers, D. N. ; Celebi, J. T.
Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
Published 2005Staff ViewISSN: 1600-0560Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Spitzoid melanoma in children is a rare tumor that can mimic Spitz nevus both clinically and histologically. Recently, dysregulation of the RAS-RAF-MAPK signalling pathway was reported in 89% of sporadic melanomas due to activating mutations in the BRAF or NRAS gene. BRAF mutations are found in 53–80% of primary melanomas and 70–90% of common melanocytic nevi, whereas none are present in Spitz nevi. NRAS mutations occur in 5–37% of melanomas and 9–56% of common melanocytic nevi. The mutational status of NRAS in Spitz nevi is unknown. This is the first study analyzing the mutational profile of BRAF and NRAS in Spitzoid melanomas occurring in prepubertal children (10 years of age or younger). Primary tumor cells were isolated via laser capture microdissection from 10 typical Spitz nevi and 10 metastatic Spitzoid melanomas. Exons 11 and 15 of BRAF and exons 2 and 3 of NRAS were amplified by PCR and directly sequenced. Common activating mutations were not identified in BRAF or NRAS. Absence of the V599E hot-spot mutation in BRAF was further confirmed by allele-specific PCR. We conclude that Spitzoid melanomas in children share clinical, histological and genetic similarities to Spitz nevi, and are genetically distinct from other melanoma subtypes.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1365-3091Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: An area of reef margin collapse, gully formation and gully fill sedimentation has been identified and mapped within Left Hand Tunnel, Carlsbad Caverns. It demonstrates that the Capitan Reef did not, at all times, form an unbroken border to the Delaware Basin. Geopetally arranged sediments within cavities from sponge–algal framestones of the reef show that the in situ reef today has a 10° basinwards structural dip. Similar dips in adjacent back-reef sediments, previously considered depositional, probably also have a structural origin. Reoriented geopetal structures have also allowed the identification of a 200-m-wide, 25-m-deep gully within the reef, which has been filled by large (some 〉15 m), randomly orientated and, in places, overturned blocks and boulders, surrounded by finer reef rubble, breccias and grainstones. Block supply continued throughout gully filling, implying that spalling of reef blocks was a longer term process and was not a by-product of the formation of the gully. Gully initiation was probably the result of a reef front collapse, with a continued instability of the gully bordering reef facies demonstrated by their incipient brecciation and by faults containing synsedimentary fills. Gully filling probably occurred during reef growth, and younger reef has prograded over the gully fill. Blocks contain truncated former aragonite botryoidal cements, indicating early aragonite growth within the in situ reef. In contrast, former high-magnesian calcite rind cements post-date sedimentation within the gully. The morphology of cavern passages is controlled by reef facies variation, with narrower passages cut into the in situ reef and wider passages within the gully fill. Gully fills may also constitute more permeable zones in the subsurface.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesMurray, Noreen E. ; Daniel, Anne S. ; Cowan, Gill M. ; Sharp, Paul M.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Type I restriction enzymes comprise three subunits encoded by genes designated hsdR, hsdM, and hsdS; S confers sequence specificity. Three families of enzymes are known and within families, but not between, hsdM and hsdR are conserved. Consequently, interfamily comparisons of M and R sequences focus on regions of putative functional significance, while both inter- and intrafamily comparisons address the origin, nature and role of diversity of type I restriction systems. We have determined the sequence of the hsdR gene for EcoA, thus making available sequences of all three hsd genes of one representative from each family. The predicted R polypeptide sequences share conserved regions with one superfamily of putative helicases, so-called ‘DEAD box’ proteins; these conserved sequences may be associated with the ATP-dependent translocation of DNA that precedes restriction. We also present hsdM and hsdR sequences for EcoE, a member of the same family as EcoA. The sequences of the M and R genes of EcoA and EcoE are at least as divergent as typical genes from Escherichia coli and Salmonella, perhaps as the result of selection favouring diversity of restriction specificities combined with lateral transfer among different species.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0309-1740Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesMant, R. ; Asherson, P. ; Gill, M. ; McGuffin, P. ; Owen, M.
[s.l.] : Nature Publishing Group
Published 1992Staff ViewISSN: 1546-1718Source: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Sir—Jones and colleagues1 report an alanine to valine substitution in codon 713 of the amyloid precursor protein gene (APP) in a single case of chronic schizophrenia. They were unable to detect this mutation in a further 100 unrelated patients with schizophrenia as well as in 105 individuals ...Type of Medium: Electronic ResourceURL: